Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis

Expression Pattern of 12-Lipoxygenase in Human Islets With Type 1 Diabetes and Type 2 Diabetes

(2015) Wojciech J. Grzesik et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Fasting Serum Taurine-Conjugated Bile Acids Are Elevated in Type 2 Diabetes and Do Not Change With Intensification of Insulin

(2014) Marlene Wewalka et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Incretin Receptor Null Mice Reveal Key Role of GLP-1 but Not GIP in Pancreatic Beta Cell Adaptation to Pregnancy

(2014) R. Charlotte Moffett et al.   PLoS One

GPBA: a GPCR for bile acids and an emerging therapeutic target for disorders of digestion and sensation

(2013) T Lieu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Human Insulin Resistance Is Associated With Increased Plasma Levels of 12 -Hydroxylated Bile Acids

(2013) R. A. Haeusler et al.   DIABETES

GLP-1 Effects on Islets: Hormonal, Neuronal, or Paracrine?

(2013) M. Y. Donath et al.   DIABETES CARE

Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease

(2013) Y. Imai et al.   DIABETES OBESITY & METABOLISM

Higher circulating bile acid concentrations in obese patients with type 2 diabetes

(2013) R. P. Vincent et al.   ANNALS OF CLINICAL BIOCHEMISTRY

Activation of transmembrane bile acid receptor TGR5 stimulates insulin secretion in pancreatic β cells

(2012) Divya P. Kumar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control

(2012) Dimitri J. Pournaras et al.   ENDOCRINOLOGY

Bile Acid Metabolism and the Pathogenesis of Type 2 Diabetes

(2011) Janne Prawitt et al.   Current Diabetes Reports

Upregulation of alpha cell glucagon-like peptide 1 (GLP-1) in Psammomys obesus—an adaptive response to hyperglycaemia?

(2011) A. M. K. Hansen et al.   DIABETOLOGIA

Processing of proglucagon to GLP-1 in pancreatic α-cells: is this a paracrine mechanism enabling GLP-1 to act on β-cells?

(2011) N M Whalley et al.   JOURNAL OF ENDOCRINOLOGY

Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans

(2011) Rayner Rodriguez-Diaz et al.   NATURE MEDICINE

Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells

(2011) Helga Ellingsgaard et al.   NATURE MEDICINE

Two incretin hormones GLP-1 and GIP: Comparison of their actions in insulin secretion and β cell preservation

(2011) Daisuke Yabe et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Standard operating procedures for describing and performing metabolic tests of glucose homeostasis in mice

(2010) J. E. Ayala et al.   Disease Models & Mechanisms

Intraislet production of GLP-1 by activation of prohormone convertase 1/3 in pancreatic α-cells in mouse models of β-cell regeneration

(2010) German Kilimnik et al.   Islets

Upregulation of RGS4 expression by IL-1β in colonic smooth muscle is enhanced by ERK1/2 and p38 MAPK and inhibited by the PI3K/Akt/GSK3β pathway

(2009) Wenhui Hu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Surrogate measures of insulin resistance: of rats, mice, and men

(2009) Kieren Mather   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

A Practical Guide to Rodent Islet Isolation and Assessment

(2009) Jeffrey D. Carter et al.   BIOLOGICAL PROCEDURES ONLINE

Bile acids as regulatory molecules

(2009) Phillip B. Hylemon et al.   JOURNAL OF LIPID RESEARCH

Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity

(2009) Roberto Pellicciari et al.   JOURNAL OF MEDICINAL CHEMISTRY

Serum bile acid along with plasma incretins and serum high–molecular weight adiponectin levels are increased after bariatric surgery

(2009) Hiroshi Nakatani et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism

(2009) Mary-Elizabeth Patti et al.   Obesity

Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation

(2009) Philippe Lefebvre et al.   PHYSIOLOGICAL REVIEWS

Transplantation of PC1/3-Expressing α-cells Improves Glucose Handling and Cold Tolerance in Leptin-resistant Mice

(2008) Rhonda D Wideman et al.   MOLECULAR THERAPY