DNA Methylation of Alternative Promoters Directs Tissue Specific Expression of Epac2 Isoforms

Diametrically opposite methylome-transcriptome relationships in high- and low-CpG promoter genes in postmitotic neural rat tissue

(2012) Theresa Hartung et al.   Epigenetics

Social, Communication, and Cortical Structural Impairments in Epac2-Deficient Mice

(2012) D. P. Srivastava et al.   JOURNAL OF NEUROSCIENCE

EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation

(2012) Ying Yang et al.   NEURON

Induction of Leptin Resistance by Activation of cAMP-Epac Signaling

(2011) Makoto Fukuda et al.   Cell Metabolism

DNA Methylation of Intronic Enhancers Directs Tissue-Specific Expression of Steroidogenic Factor 1/Adrenal 4 Binding Protein (SF-1/Ad4BP)

(2011) Erling A. Hoivik et al.   ENDOCRINOLOGY

CpG islands and the regulation of transcription

(2011) A. M. Deaton et al.   GENES & DEVELOPMENT

DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter

(2011) Han Han et al.   HUMAN MOLECULAR GENETICS

The nucleoporin RanBP2 tethers the cAMP effector Epac1 and inhibits its catalytic activity

(2011) Martijn Gloerich et al.   JOURNAL OF CELL BIOLOGY

Bile acid stimulates hepatocyte polarization through a cAMP-Epac-MEK-LKB1-AMPK pathway

(2011) D. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A User's Guide to the Encyclopedia of DNA Elements (ENCODE)

(2011)   PLOS BIOLOGY

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Functional Roles of Protein Kinase A (PKA) and Exchange Protein Directly Activated by 3′,5′-Cyclic Adenosine 5′-Monophosphate (cAMP) 2 (EPAC2) in cAMP-Mediated Actions in Adrenocortical Cells

(2010) Linda Aumo et al.   ENDOCRINOLOGY

Sequence features that drive human promoter function and tissue specificity

(2010) J. M. Landolin et al.   GENOME RESEARCH

cAMP Mediators of Pulsatile Insulin Secretion from Glucose-stimulated Single β-Cells

(2010) Olof Idevall-Hagren et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Conserved role of intragenic DNA methylation in regulating alternative promoters

(2010) Alika K. Maunakea et al.   NATURE

Genome-wide screen of promoter methylation identifies novel markers in melanoma

(2009) Y. Koga et al.   GENOME RESEARCH

Critical role of the N-terminal cyclic AMP-binding domain of Epac2 in its subcellular localization and function

(2009) Manabu Niimura et al.   JOURNAL OF CELLULAR PHYSIOLOGY

A species-generalized probabilistic model-based definition of CpG islands

(2009) Rafael A. Irizarry et al.   MAMMALIAN GENOME

Direct Spatial Control of Epac1 by Cyclic AMP

(2009) B. Ponsioen et al.   MOLECULAR AND CELLULAR BIOLOGY

Epac is involved in cAMP-stimulated proglucagon expression and hormone production but not hormone secretion in pancreatic α- and intestinal L-cell lines

(2008) Diana Islam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

An integrated resource for genome-wide identification and analysis of human tissue-specific differentially methylated regions (tDMRs)

(2008) V. K. Rakyan et al.   GENOME RESEARCH

Ras Is Required for the Cyclic AMP-Dependent Activation of Rap1 via Epac2

(2008) C. Liu et al.   MOLECULAR AND CELLULAR BIOLOGY

Role of Epac1, an Exchange Factor for Rap GTPases, in Endothelial Microtubule Dynamics and Barrier Function

(2008) Seema Sehrawat et al.   MOLECULAR BIOLOGY OF THE CELL

Combinatorial patterns of histone acetylations and methylations in the human genome

(2008) Zhibin Wang et al.   NATURE GENETICS

EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation

(2008) E. Huston et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line

(2008) E. N. Gal-Yam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel CpG Island Set Identifies Tissue-Specific Methylation at Developmental Gene Loci

(2008) Robert Illingworth et al.   PLOS BIOLOGY