cAMP-guanine exchange factor protection from bile acid-induced hepatocyte apoptosis involves glycogen synthase kinase regulation of c-Jun NH2-terminal kinase

Rap-linked cAMP signaling Epac proteins: Compartmentation, functioning and disease implications

(2011) Magali Breckler et al.   CELLULAR SIGNALLING

Rap1 GTPases: An emerging role in the cardiovasculature

(2011) Selvi C. Jeyaraj et al.   LIFE SCIENCES

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

GSK3β: role in therapeutic landscape and development of modulators

(2010) S Phukan et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of glycogen synthase kinase-3 in Alzheimer’s disease pathogenesis and glycogen synthase kinase-3 inhibitors

(2010) Jesús Avila et al.   Expert Review of Neurotherapeutics

Silencing Glycogen Synthase Kinase-3β Inhibits Acetaminophen Hepatotoxicity and Attenuates JNK Activation and Loss of Glutamate Cysteine Ligase and Myeloid Cell Leukemia Sequence 1

(2010) Mie Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphatidylinositol-3-kinase p110γ contributes to bile salt-induced apoptosis in primary rat hepatocytes and human hepatoma cells

(2010) Simon Hohenester et al.   JOURNAL OF HEPATOLOGY

Glycogen synthase kinase-3 (GSK-3) inhibition attenuates hepatocyte lipoapoptosis

(2010) Samar H. Ibrahim et al.   JOURNAL OF HEPATOLOGY

Endoplasmic reticulum stress in liver disease

(2010) Harmeet Malhi et al.   JOURNAL OF HEPATOLOGY

Indirubin-3′-oxime prevents hepatic I/R damage by inhibiting GSK-3β and mitochondrial permeability transition

(2010) Ana T. Varela et al.   MITOCHONDRION

Hepatocyte Death: A Clear and Present Danger

(2010) Harmeet Malhi et al.   PHYSIOLOGICAL REVIEWS

Beta-catenin signaling, liver regeneration and hepatocellular cancer: Sorting the good from the bad

(2010) Kari Nichole Nejak-Bowen et al.   SEMINARS IN CANCER BIOLOGY

The Bile Salt Export Pump: Clinical and Experimental Aspects of Genetic and Acquired Cholestatic Liver Disease

(2010) Ping Lam et al.   SEMINARS IN LIVER DISEASE

Development of Phosphoinositide-3 Kinase Pathway Inhibitors for Advanced Cancer

(2010) James M. Cleary et al.   Current Oncology Reports

The BH3-Only Protein Bid Does Not Mediate Death-Receptor-Induced Liver Injury in Obstructive Cholestasis

(2009) Padmavathi devi Nalapareddy et al.   AMERICAN JOURNAL OF PATHOLOGY

cAMP-GEF cytoprotection by Src tyrosine kinase activation of phosphoinositide-3-kinase p110 β/α in rat hepatocytes

(2009) Anna Gates et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Thienylhalomethylketones: Irreversible glycogen synthase kinase 3 inhibitors as useful pharmacological tools

(2009) Daniel I. Perez et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The role of GSK3 in Alzheimer disease

(2009) Félix Hernández et al.   BRAIN RESEARCH BULLETIN

Inhibiting glycogen synthase kinase-3 reduces endotoxaemic acute renal failure by down-regulating inflammation and renal cell apoptosis

(2009) Y Wang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Glycogen synthase kinase 3: more than a namesake

(2009) Geetha Vani Rayasam et al.   BRITISH JOURNAL OF PHARMACOLOGY

Forskolin increases angiogenesis through the coordinated cross-talk of PKA-dependent VEGF expression and Epac-mediated PI3K/Akt/eNOS signaling

(2009) Seung Namkoong et al.   CELLULAR SIGNALLING

GSK-3β, a Therapeutic Target for Cardiomyocyte Protection

(2009) Tetsuji Miura et al.   CIRCULATION JOURNAL

Role of Glycogen Synthase Kinase-3β in Cardioprotection

(2009) Magdalena Juhaszova et al.   CIRCULATION RESEARCH

Targeting the PI3K signaling pathway in cancer

(2009) Kwok-Kin Wong et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

GSK-3 inhibitors and insulin receptor signaling in health, disease, and therapeutics

(2009) Akihiko Wada   Frontiers in Bioscience-Landmark

Antiapoptotic Effect of c-Jun N-terminal Kinase-1 through Mcl-1 Stabilization in TNF-Induced Hepatocyte Apoptosis

(2009) Yuzo Kodama et al.   GASTROENTEROLOGY

Modulation of Hepatic Fibrosis by c-Jun-N-Terminal Kinase Inhibition

(2009) Johannes Kluwe et al.   GASTROENTEROLOGY

New molecular insights into the mechanisms of cholestasis

(2009) Martin Wagner et al.   JOURNAL OF HEPATOLOGY

GSK3 Inhibitors and Disease

(2009) Felix Hernandez et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Involvement of cAMP/Epac/PI3K-dependent pathway in the antiproteolytic effect of epinephrine on rat skeletal muscle

(2009) Amanda Martins Baviera et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Mitochondrial membrane permeabilization in neuronal injury

(2009) Lorenzo Galluzzi et al.   NATURE REVIEWS NEUROSCIENCE

Bile-acid-induced cell injury and protection

(2009) Maria J Perez et al.   WORLD JOURNAL OF GASTROENTEROLOGY

CHOP deficiency attenuates cholestasis-induced liver fibrosis by reduction of hepatocyte injury

(2008) Nobuyuki Tamaki et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Ser9 phosphorylation of mitochondrial GSK-3β is a primary mechanism of cardiomyocyte protection by erythropoietin against oxidant-induced apoptosis

(2008) Katsuhiko Ohori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

C-Jun N-Terminal Kinase 2 Promotes Graft Injury via the Mitochondrial Permeability Transition After Mouse Liver Transplantation

(2008) T. P. Theruvath et al.   AMERICAN JOURNAL OF TRANSPLANTATION

PDE4 inhibitor, roflumilast protects cardiomyocytes against NO-induced apoptosis via activation of PKA and Epac dual pathways

(2008) Hyun-Jeong Kwak et al.   CELLULAR SIGNALLING

Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation

(2008) Ingrid M. Nijholt et al.   CELLULAR SIGNALLING

The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages

(2008) Uma K. Misra et al.   CELLULAR SIGNALLING

Glucagon Receptor Signaling Is Essential for Control of Murine Hepatocyte Survival

(2008) Elaine M. Sinclair et al.   GASTROENTEROLOGY

Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways

(2008) Takashi Nitta et al.   HEPATOLOGY

Multiple Cyclin Kinase Inhibitors Promote Bile Acid-induced Apoptosis and Autophagy in Primary Hepatocytes via p53-CD95-dependent Signaling

(2008) Guo Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bile Acid-induced Apoptosis in Hepatocytes Is Caspase-6-dependent

(2008) Christian Rust et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress

(2008) Irina M Bochkis et al.   NATURE MEDICINE

Mitochondrial Permeability Transition in Liver Ischemia and Reperfusion: Role of c-Jun N-Terminal Kinase 2

(2008) Tom P. Theruvath et al.   TRANSPLANTATION

Epac-selective cAMP analogs: New tools with which to evaluate the signal transduction properties of cAMP-regulated guanine nucleotide exchange factors

(2007) George G. Holz et al.   CELLULAR SIGNALLING