CB1 receptors down-regulate a cAMP/Epac2/PLC pathway to silence the nerve terminals of cerebellar granule cells

The signaling module cAMP/Epac/Rap1/PLCε/IP 3 mobilizes acrosomal calcium during sperm exocytosis

(2016) Ornella Lucchesi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Epac2 Mediates cAMP-Dependent Potentiation of Neurotransmission in the Hippocampus

(2015) H. B. Fernandes et al.   JOURNAL OF NEUROSCIENCE

Cannabinoid Type 1 Receptors Transiently Silence Glutamatergic Nerve Terminals of Cultured Cerebellar Granule Cells

(2014) Jorge Ramírez-Franco et al.   PLoS One

β-Adrenergic Receptors Activate Exchange Protein Directly Activated by cAMP (Epac), Translocate Munc13-1, and Enhance the Rab3A-RIM1α Interaction to Potentiate Glutamate Release at Cerebrocortical Nerve Terminals

(2013) Jose J. Ferrero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role of RIM1α in short- and long-term synaptic plasticity at cerebellar parallel fibres

(2013) Michael Kintscher et al.   Nature Communications

Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages

(2012) D. Bartolome-Martin et al.   JOURNAL OF CELL SCIENCE

Release probability of hippocampal glutamatergic terminals scales with the size of the active zone

(2012) Noemi Holderith et al.   NATURE NEUROSCIENCE

EPAC Null Mutation Impairs Learning and Social Interactions via Aberrant Regulation of miR-124 and Zif268 Translation

(2012) Ying Yang et al.   NEURON

Endocannabinoid Signaling and Synaptic Function

(2012) Pablo E. Castillo et al.   NEURON

Isoform-specific antagonists of exchange proteins directly activated by cAMP

(2012) T. Tsalkova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIM Proteins Tether Ca2+ Channels to Presynaptic Active Zones via a Direct PDZ-Domain Interaction

(2011) Pascal S. Kaeser et al.   CELL

Extensive Remodeling of the Presynaptic Cytomatrix upon Homeostatic Adaptation to Network Activity Silencing

(2011) V. Lazarevic et al.   JOURNAL OF NEUROSCIENCE

Munc13 mediates the transition from the closed syntaxin–Munc18 complex to the SNARE complex

(2011) Cong Ma et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Presynaptic silencing is an endogenous neuroprotectant during excitotoxic insults

(2011) Joshua Hogins et al.   NEUROBIOLOGY OF DISEASE

RIM Proteins Activate Vesicle Priming by Reversing Autoinhibitory Homodimerization of Munc13

(2011) Lunbin Deng et al.   NEURON

RIM Determines Ca2+ Channel Density and Vesicle Docking at the Presynaptic Active Zone

(2011) Yunyun Han et al.   NEURON

Phospholipase C-ε links Epac2 activation to the potentiation of glucose-stimulated insulin secretion from mouse islets of Langerhans

(2011) Igor Dzhura et al.   Islets

RIM proteins and their role in synapse function

(2010) Tobias Mittelstaedt et al.   BIOLOGICAL CHEMISTRY

Presynaptic CB1 Receptors Regulate Synaptic Plasticity at Cerebellar Parallel Fiber Synapses

(2010) Megan R. Carey et al.   JOURNAL OF NEUROPHYSIOLOGY

A Role for the Ubiquitin-Proteasome System in Activity-Dependent Presynaptic Silencing

(2010) X. Jiang et al.   JOURNAL OF NEUROSCIENCE

CDK5 Serves as a Major Control Point in Neurotransmitter Release

(2010) Sung Hyun Kim et al.   NEURON

Suppression of guanylyl cyclase (β1 subunit) expression impairs neurite outgrowth and synapse maturation in cultured cerebellar granule cells

(2009) M E López-Jiménez et al.   CELL DEATH AND DIFFERENTIATION

Epac Activates the Small G Proteins Rap1 and Rab3A to Achieve Exocytosis

(2009) María T. Branham et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of an Epac Activator Enhances Neurotransmitter Release at Excitatory Central Synapses

(2008) I. Gekel et al.   JOURNAL OF NEUROSCIENCE

A Specific Role for Ca2+-Dependent Adenylyl Cyclases in Recovery from Adaptive Presynaptic Silencing

(2008) K. L. Moulder et al.   JOURNAL OF NEUROSCIENCE