Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain

Low-dose endotoxin potentiates capsaicin-induced pain in man: Evidence for a pain neuroimmune connection

(2013) Mark R. Hutchinson et al.   BRAIN BEHAVIOR AND IMMUNITY

Peripheral Administration of Translation Inhibitors Reverses Increased Hyperalgesia in a Model of Chronic Pain in the Rat

(2013) Luiz F. Ferrari et al.   JOURNAL OF PAIN

Pain experience in children with juvenile idiopathic arthritis treated with anti-TNF agents compared to non-biologic standard treatment

(2013) Johanne Jeppesen Lomholt et al.   Pediatric Rheumatology

A role for Piezo2 in EPAC1-dependent mechanical allodynia

(2013) N Eijkelkamp et al.   Nature Communications

Different expression of adrenoceptors and GRKs in the human myocardium depends on heart failure ethiology and correlates to clinical variables

(2012) Fermí Montó et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

MicroRNA-124 as a novel treatment for persistent hyperalgesia

(2012) Hanneke LDM Willemen et al.   Journal of Neuroinflammation

Gene therapy for the treatment of chronic peripheral nervous system pain

(2012) William F. Goins et al.   NEUROBIOLOGY OF DISEASE

Transient decrease in nociceptor GRK2 expression produces long-term enhancement in inflammatory pain

(2012) L.F. Ferrari et al.   NEUROSCIENCE

Targeted drug delivery to the peripheral nervous system using gene therapy

(2012) Darren Wolfe et al.   NEUROSCIENCE LETTERS

GRK2: multiple roles beyond G protein-coupled receptor desensitization

(2012) Tama Evron et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons

(2012) Michael S. Minett et al.   Nature Communications

Gene therapy for pain: Results of a phase I clinical trial

(2011) David J. Fink et al.   ANNALS OF NEUROLOGY

Microglial GRK2: A novel regulator of transition from acute to chronic pain

(2011) Annemieke Kavelaars et al.   BRAIN BEHAVIOR AND IMMUNITY

Noxious mechanosensation – molecules and circuits

(2011) John N Wood et al.   CURRENT OPINION IN PHARMACOLOGY

Axonal protein synthesis: a potential target for pain relief?

(2011) Ilona Obara et al.   CURRENT OPINION IN PHARMACOLOGY

Long-term IL-1β exposure causes subpopulation-dependent alterations in rat dorsal root ganglion neuron excitability

(2011) Patrick L. Stemkowski et al.   JOURNAL OF NEUROPHYSIOLOGY

Spinal Protein Kinase M   Underlies the Maintenance Mechanism of Persistent Nociceptive Sensitization

(2011) M. N. Asiedu et al.   JOURNAL OF NEUROSCIENCE

GRK2 in sensory neurons regulates epinephrine-induced signalling and duration of mechanical hyperalgesia

(2011) Huijing Wang et al.   PAIN

A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain

(2011) M. C. Lagerstrom et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Epac: Defining a New Mechanism for cAMP Action

(2010) Martijn Gloerich et al.   Annual Review of Pharmacology and Toxicology

Gabapentin Extended-Release Tablets for the Treatment of Patients with Postherpetic Neuralgia

(2010) Mark S. Wallace et al.   CLINICAL DRUG INVESTIGATION

Differential Roles of Epac in Regulating Cell Death in Neuronal and Myocardial Cells

(2010) Sayaka Suzuki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

What is this thing called pain?

(2010) Clifford J. Woolf   JOURNAL OF CLINICAL INVESTIGATION

Low Nociceptor GRK2 Prolongs Prostaglandin E2 Hyperalgesia via Biased cAMP Signaling to Epac/Rap1, Protein Kinase C , and MEK/ERK

(2010) N. Eijkelkamp et al.   JOURNAL OF NEUROSCIENCE

GRK2: A Novel Cell-Specific Regulator of Severity and Duration of Inflammatory Pain

(2010) N. Eijkelkamp et al.   JOURNAL OF NEUROSCIENCE

IL-6- and NGF-Induced Rapid Control of Protein Synthesis and Nociceptive Plasticity via Convergent Signaling to the eIF4F Complex

(2010) O. K. Melemedjian et al.   JOURNAL OF NEUROSCIENCE

Nociceptor sensitization in pain pathogenesis

(2010) Michael S Gold et al.   NATURE MEDICINE

Hyperalgesic priming is restricted to isolectin B4-positive nociceptors

(2010) E.K. Joseph et al.   NEUROSCIENCE

Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

(2010) Hanneke L.D.M. Willemen et al.   PAIN

Peripheral mechanisms of pain and analgesia

(2009) Christoph Stein et al.   BRAIN RESEARCH REVIEWS

Cellular and Molecular Mechanisms of Pain

(2009) Allan I. Basbaum et al.   CELL

Epac1-induced cellular proliferation in prostate cancer cells is mediated by B-Raf/ERK and mTOR signaling cascades

(2009) Uma Kant Misra et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

A Rapamycin-Sensitive Signaling Pathway Is Essential for the Full Expression of Persistent Pain States

(2009) S. M. Geranton et al.   JOURNAL OF NEUROSCIENCE

Central Sensitization: A Generator of Pain Hypersensitivity by Central Neural Plasticity

(2009) Alban Latremoliere et al.   JOURNAL OF PAIN

Nociceptor subpopulations involved in hyperalgesic priming

(2009) L.F. Ferrari et al.   NEUROSCIENCE

Critical role of nociceptor plasticity in chronic pain

(2009) David B. Reichling et al.   TRENDS IN NEUROSCIENCES

GPCR signalling in hypertension: role of GRKs

(2008) David M. Harris et al.   CLINICAL SCIENCE

Local Translation in Primary Afferent Fibers Regulates Nociception

(2008) Lydia Jiménez-Díaz et al.   PLoS One

The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain

(2008) B. Abrahamsen et al.   SCIENCE