Nerve Growth Factor Mediates a Switch in Intracellular Signaling for PGE2-Induced Sensitization of Sensory Neurons from Protein Kinase A to Epac

A role for Piezo2 in EPAC1-dependent mechanical allodynia

(2013) N Eijkelkamp et al.   Nature Communications

Piezo proteins are pore-forming subunits of mechanically activated channels

(2012) Bertrand Coste et al.   NATURE

The role of Drosophila Piezo in mechanical nociception

(2012) Sung Eun Kim et al.   NATURE

Microglial GRK2: A novel regulator of transition from acute to chronic pain

(2011) Annemieke Kavelaars et al.   BRAIN BEHAVIOR AND IMMUNITY

Low Nociceptor GRK2 Prolongs Prostaglandin E2 Hyperalgesia via Biased cAMP Signaling to Epac/Rap1, Protein Kinase C , and MEK/ERK

(2010) N. Eijkelkamp et al.   JOURNAL OF NEUROSCIENCE

The role of PKA and PKCε pathways in prostaglandin E2-mediated hypernociception

(2009) D Sachs et al.   BRITISH JOURNAL OF PHARMACOLOGY

The peripheral pro-nociceptive state induced by repetitive inflammatory stimuli involves continuous activation of protein kinase A and protein kinase C epsilon and its NaV1.8 sodium channel functional regulation in the primary sensory neuron

(2008) Cristiane Flora Villarreal et al.   BIOCHEMICAL PHARMACOLOGY

Neuronal AKAP150 coordinates PKA and Epac-mediated PKB/Akt phosphorylation

(2008) Ingrid M. Nijholt et al.   CELLULAR SIGNALLING

Rap1 Activation Plays a Regulatory Role in Pancreatic Amylase Secretion

(2008) Maria E. Sabbatini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Novel Epac-Rap-PP2A Signaling Module Controls cAMP-dependent Akt Regulation

(2008) Kyoungja Hong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Application of an Epac Activator Enhances Neurotransmitter Release at Excitatory Central Synapses

(2008) I. Gekel et al.   JOURNAL OF NEUROSCIENCE

Protein Kinase A Anchoring via AKAP150 Is Essential for TRPV1 Modulation by Forskolin and Prostaglandin E2 in Mouse Sensory Neurons

(2008) K. Schnizler et al.   JOURNAL OF NEUROSCIENCE

Role of the cAMP sensor Epac as a determinant of KATPchannel ATP sensitivity in human pancreatic β-cells and rat INS-1 cells

(2008) Guoxin Kang et al.   JOURNAL OF PHYSIOLOGY-LONDON

Epac mediates cyclic AMP-dependent axon growth, guidance and regeneration

(2008) Andrew J. Murray et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Epac: effectors and biological functions

(2008) Sara S. Roscioni et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

A-kinase anchoring protein mediates TRPV1 thermal hyperalgesia through PKA phosphorylation of TRPV1

(2008) Nathaniel A. Jeske et al.   PAIN