The link between metabolic syndrome and Alzheimer disease: A mutual relationship and long rigorous investigation

NF‐κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective

(2023) Mohammed Alrouji et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Insights on benzodiazepines' potential in Alzheimer's disease

(2023) Hayder M. Al-Kuraishy et al.   LIFE SCIENCES

The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer’s diseases

(2023) Mohammed Alrouji et al.   Diabetology & Metabolic Syndrome

Brain insulin resistance linked Alzheimer’s and Parkinson’s disease pathology: An undying implication of epigenetic and autophagy modulation

(2023) Violina Kakoty et al.   INFLAMMOPHARMACOLOGY

Pros and cons for statins use and risk of Parkinson's disease: An updated perspective

(2023) Hayder M. Al‐kuraishy et al.   Pharmacology Research & Perspectives

The conceivable role of prolactin hormone in Parkinson disease: The same goal but with different ways

(2023) Haydar M. Al-kuraishy et al.   AGEING RESEARCH REVIEWS

Association of the Triglyceride-Glucose Index With Risk of Alzheimer's Disease: A Prospective Cohort Study

(2023) Junyi Sun et al.   AMERICAN JOURNAL OF PREVENTIVE MEDICINE

The beneficial role of autophagy in multiple sclerosis: Yes or No?

(2023) Hayder M. Al-kuraishy et al.   Autophagy

Targeting dynamin-related protein-1 as a potential therapeutic approach for mitochondrial dysfunction in Alzheimer's disease

(2023) Jasvinder Singh Bhatti et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Obesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline

(2023) Thea Anderson et al.   JOURNAL OF NEUROCHEMISTRY

Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease

(2023) Zhijun He et al.   Redox Biology

Development and Evaluation of a Blended Self-Management Program for Metabolic Syndrome in Patients With Rheumatic Diseases

(2023) BoAe Im et al.   HEALTH EDUCATION & BEHAVIOR

Cholesterol metabolism in aging simultaneously altered in liver and nervous system

(2022) Valéria Sutti Nunes et al.   Aging-US

Metabolic Syndrome: Updates on Pathophysiology and Management in 2021

(2022) Gracia Fahed et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The possible role of ursolic acid in Covid-19: A real game changer

(2022) Hayder M. Al-kuraishy et al.   Clinical Nutrition ESPEN

Plasma biomarkers and genetics in the diagnosis and prediction of Alzheimer’s disease

(2022) Joshua Stevenson-Hoare et al.   BRAIN

Sirt3 ameliorates mitochondrial dysfunction and oxidative stress through regulating mitochondrial biogenesis and dynamics in cardiomyoblast.

(2022) Paramesha Bugga et al.   CELLULAR SIGNALLING

Alzheimer’s Disease as Type 3 Diabetes: Common Pathophysiological Mechanisms between Alzheimer’s Disease and Type 2 Diabetes

(2022) Michalis Michailidis et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microbiota in neuroinflammation and synaptic dysfunction: a focus on Alzheimer’s disease

(2022) Diane Bairamian et al.   Molecular Neurodegeneration

Association between H2 haplotype of microtubule associated protein tau gene (deletion / insertion) with Alzheimer Disease in Tunisian patients

(2022) Saloua Fray et al.   NEUROLOGICAL RESEARCH

Early metabolic impairment as a contributor to neurodegenerative disease: Mechanisms and potential pharmacological intervention

(2022) Walaa Fakih et al.   Obesity

Prospects in GSK-3 Signaling: From Cellular Regulation to Disease Therapy

(2022) Sara Arciniegas Ruiz et al.   Cells

Exercise with 40-Hz light flicker improves hippocampal insulin signaling in Alzheimer disease mice

(2022) Seong-Hyun Kim et al.   Journal of Exercise Rehabilitation

Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome

(2022) John J. Slate-Romano et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Statins Use in Alzheimer Disease: Bane or Boon from Frantic Search and Narrative Review

(2022) Nawal Alsubaie et al.   Brain Sciences

Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors

(2022) Svetlana Sharifulina et al.   Biomedicines

Diabetes and hypertension are related to amyloid-beta burden in the population-based Rotterdam Study

(2022) Joyce van Arendonk et al.   BRAIN

A Potential Link Between Visceral Obesity and Risk of Alzheimer’s Disease

(2022) Hayder M. Al-Kuraishy et al.   NEUROCHEMICAL RESEARCH

Targeting of neuroinflammation by glibenclamide in Covid-19: old weapon from arsenal

(2022) Gaber El-Saber Batiha et al.   INFLAMMOPHARMACOLOGY

Benzodiazepines in Alzheimer’s disease: beneficial or detrimental effects

(2022) Hayder M. Al-kuraishy et al.   INFLAMMOPHARMACOLOGY

Nutritional implications in the mechanistic link between the intestinal microbiome, renin-angiotensin system, and the development of obesity and metabolic syndrome

(2022) Victor Hugo Dantas Guimarães et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation

(2021) Jie Feng et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease

(2021) Manoj Govindarajulu et al.   NEUROCHEMISTRY INTERNATIONAL

Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration

(2021) Ido Rippin et al.   Cells

Generation of Reactive Oxygen Species by Mitochondria

(2021) Pablo Hernansanz-Agustín et al.   Antioxidants

Brain insulin, insulin‐like growth factor 1 and glucagon‐like peptide 1 signalling in Alzheimer’s disease

(2021) Sergio T. Ferreira   JOURNAL OF NEUROENDOCRINOLOGY

Western diet as a trigger of Alzheimer’s disease: From metabolic syndrome and systemic inflammation to neuroinflammation and neurodegeneration

(2021) Angelika Więckowska-Gacek et al.   AGEING RESEARCH REVIEWS

A current view on Tau protein phosphorylation in Alzheimer's disease

(2021) Susanne Wegmann et al.   CURRENT OPINION IN NEUROBIOLOGY

Brain Renin–Angiotensin System as Novel and Potential Therapeutic Target for Alzheimer’s Disease

(2021) Raúl Loera-Valencia et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Extracellular protein components of amyloid plaques and their roles in Alzheimer’s disease pathology

(2021) M. Mahafuzur Rahman et al.   Molecular Neurodegeneration

The Amyloid-β Pathway in Alzheimer’s Disease

(2021) Harald Hampel et al.   MOLECULAR PSYCHIATRY

Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

(2021) Velda X. Han et al.   Nature Reviews Neurology

Plasma Free Fatty Acid Concentration as a Modifiable Risk Factor for Metabolic Disease

(2021) Gregory C. Henderson   Nutrients

Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective

(2021) Hayder M. Al-kuraishy et al.   BIOMEDICINE & PHARMACOTHERAPY

Increased oxidative stress contributes to enhance brain amyloidogenesis and blunts energy metabolism in sucrose-fed rat: effect of AMPK activation

(2021) Luz Camacho-Castillo et al.   Scientific Reports

Binding of Metal-Ion-Induced Tau Oligomers to Lipid Surfaces Is Enhanced by GSK-3β-Mediated Phosphorylation

(2020) Georg S. Nuebling et al.   ACS Chemical Neuroscience

Targeting tau hyperphosphorylation via kinase inhibition- Strategy to address Alzheimers' disease

(2020) Ahmad Abu TurabNaqvi et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Alzheimer’s Disease and Diabetes: Insulin Signaling as the Bridge Linking Two Pathologies

(2020) Jonathan Chang-Cheng Shieh et al.   MOLECULAR NEUROBIOLOGY

Adipose Tissue Macrophage Phenotypes and Characteristics: The Key to Insulin Resistance in Obesity and Metabolic Disorders

(2020) Yinhua Ni et al.   Obesity

GSK-3β in DNA repair, apoptosis, and resistance of chemotherapy, radiotherapy of cancer

(2020) Jintao Lin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Perspectives on the Potential Benefits of Antihypertensive Peptides towards Metabolic Syndrome

(2020) Forough Jahandideh et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Serum triglycerides in Alzheimer disease

(2020) Megan M. Bernath et al.   NEUROLOGY

Tryptophan metabolites modify brain Aβ peptide degradation: A role in Alzheimer’s disease?

(2020) Michel Maitre et al.   PROGRESS IN NEUROBIOLOGY

The Important Interface Between Apolipoprotein E and Neuroinflammation in Alzheimer’s Disease

(2020) Courtney M. Kloske et al.   Frontiers in Immunology

Deletion of Cardiomyocyte Glycogen Synthase Kinase-3 Beta (GSK-3β) Improves Systemic Glucose Tolerance with Maintained Heart Function in Established Obesity

(2020) Manisha Gupte et al.   Cells

Brain Insulin Signaling, Alzheimer Disease Pathology, and Cognitive Function

(2020) Zoe Arvanitakis et al.   ANNALS OF NEUROLOGY

Trends in the Prevalence of Metabolic Syndrome in the United States, 2011-2016

(2020) Grishma Hirode et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Activation of the renin-angiotensin system in high fructose-induced metabolic syndrome

(2020) Mina Kim et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

Brain insulin resistance in Alzheimer's disease and related disorders: mechanisms and therapeutic approaches

(2020) Derek Kellar et al.   LANCET NEUROLOGY

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

(2020) Tiantian Guo et al.   Molecular Neurodegeneration

Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease

(2020) Alexandra Chadt et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Metabolic Syndrome Pathophysiology and Predisposing Factors

(2020) António Bovolini et al.   INTERNATIONAL JOURNAL OF SPORTS MEDICINE

Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice

(2020) Leah K. Cuddy et al.   Science Translational Medicine

Penetrating Ballistic-Like Brain Injury Leads to MicroRNA Dysregulation, BACE1 Upregulation, and Amyloid Precursor Protein Loss in Lesioned Rat Brain Tissues

(2020) Bharani Thangavelu et al.   Frontiers in Neuroscience

The Role of Microglia and the Nlrp3 Inflammasome in Alzheimer's Disease

(2020) Kendra L. Hanslik et al.   Frontiers in Neurology

Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3

(2019) Judith Houtman et al.   EMBO JOURNAL

Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5

(2019) María Paz Hernández-Cáceres et al.   Frontiers in Endocrinology

Central and Peripheral Inflammation Link Metabolic Syndrome and Major Depressive Disorder

(2019) Kenny L. Chan et al.   PHYSIOLOGY

Pathobiological mechanisms underlying metabolic syndrome (MetS) in chronic obstructive pulmonary disease (COPD): clinical significance and therapeutic strategies

(2019) Stanley M.H. Chan et al.   PHARMACOLOGY & THERAPEUTICS

What is the Physiological Function of Amyloid-Beta Protein?

(2019) John E. Morley et al.   Journal of Nutrition Health & Aging

Metabolic Syndrome, Mild Cognitive Impairment, and Dementia: A Meta-Analysis of Longitudinal Studies

(2019) Anna Rita Atti et al.   AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY

High molecular weight amyloid β1-42 oligomers induce neurotoxicity via plasma membrane damage

(2019) Taro Yasumoto et al.   FASEB JOURNAL

Hydroxytyrosol protects from aging process via AMPK and autophagy; a review of its effects on cancer, metabolic syndrome, osteoporosis, immune-mediated and neurodegenerative diseases

(2019) Rocío M. de Pablos et al.   PHARMACOLOGICAL RESEARCH

Cannabis: From a Plant That Modulates Feeding Behaviors toward Developing Selective Inhibitors of the Peripheral Endocannabinoid System for the Treatment of Obesity and Metabolic Syndrome

(2019) Shira Hirsch et al.   Toxins

High-fat diet induced central adiposity (visceral fat) is associated with increased fibrosis and decreased immune cellularity of the mesenteric lymph node in mice

(2019) Aaron M. Magnuson et al.   EUROPEAN JOURNAL OF NUTRITION

Deciphering the Role of WNT Signaling in Metabolic Syndrome–Linked Alzheimer’s Disease

(2019) Abuzer Ali et al.   MOLECULAR NEUROBIOLOGY

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

What lipodystrophies teach us about the metabolic syndrome

(2019) Jake P. Mann et al.   JOURNAL OF CLINICAL INVESTIGATION

Glutaredoxin 2 (GRX2) deficiency exacerbates high fat diet (HFD)-induced insulin resistance, inflammation and mitochondrial dysfunction in brain injury: A mechanism involving GSK-3β

(2019) Zhao Wohua et al.   BIOMEDICINE & PHARMACOTHERAPY

MiR-22-3p regulates amyloid β deposit in mice model of Alzheimer's disease by targeting mitogen-activated protein kinase 14

(2019) Qiling Ji et al.   CURRENT NEUROVASCULAR RESEARCH

Diabetes mellitus and Alzheimer’s disease: GSK-3β as a potential link

(2018) Ying Zhang et al.   BEHAVIOURAL BRAIN RESEARCH

iPSC-derived familial Alzheimer’s PSEN2 N141I cholinergic neurons exhibit mutation-dependent molecular pathology corrected by insulin signaling

(2018) Cesar L. Moreno et al.   Molecular Neurodegeneration

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

(2018) Irene Maeve Rea et al.   Frontiers in Immunology

Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease

(2018) Laura Mateos et al.   JOURNAL OF ALZHEIMERS DISEASE

Hippocampal GABAergic Neurons are Susceptible to Amyloid-β Toxicity in vitro and are Decreased in Number in the Alzheimer's Disease TgCRND8 Mouse Model

(2018) Slavica Krantic et al.   JOURNAL OF ALZHEIMERS DISEASE

Impact of Metabolic Syndrome on Neuroinflammation and the Blood–Brain Barrier

(2018) Peter Van Dyken et al.   Frontiers in Neuroscience

Hypothalamic inflammation in obesity and metabolic disease

(2017) Alexander Jais et al.   JOURNAL OF CLINICAL INVESTIGATION

The role of APOE on lipid homeostasis and inflammation in normal brains

(2017) G. William Rebeck   JOURNAL OF LIPID RESEARCH

Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

(2017) Antero Salminen et al.   JOURNAL OF NEUROCHEMISTRY

Transcriptional Effects of ApoE4: Relevance to Alzheimer’s Disease

(2017) Veena Theendakara et al.   MOLECULAR NEUROBIOLOGY

Obesity as a risk factor for Alzheimer's disease: weighing the evidence

(2017) S. Alford et al.   Obesity Reviews

Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB

(2017) Leen Catrysse et al.   TRENDS IN CELL BIOLOGY

Metabolic Syndrome and Cognitive Impairment: Current Epidemiology and Possible Underlying Mechanisms

(2017) Francesco Panza et al.   JOURNAL OF ALZHEIMERS DISEASE

Glycogen Synthase Kinase 3β Inhibition Improves Myocardial Angiogenesis and Perfusion in a Swine Model of Metabolic Syndrome

(2016) Brittany A. Potz et al.   Journal of the American Heart Association

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

(2015) Robert Baranello et al.   Current Alzheimer Research

Cognitive and affective functions in Alzheimer's disease patients with metabolic syndrome

(2015) N. Hishikawa et al.   EUROPEAN JOURNAL OF NEUROLOGY

Hypertension enhances Aβ-induced neurovascular dysfunction, promotes β-secretase activity, and leads to amyloidogenic processing of APP

(2015) Giuseppe Faraco et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Metabolomic investigation of systemic manifestations associated with Alzheimer's disease in the APP/PS1 transgenic mouse model

(2015) Raúl González-Domínguez et al.   Molecular BioSystems

Mitochondrial Sirt3 Expression is Decreased in APP/PS1 Double Transgenic Mouse Model of Alzheimer’s Disease

(2015) Wenxiu Yang et al.   NEUROCHEMICAL RESEARCH

Role of Medium Chain Triglycerides (Axona®) in the Treatment of Mild to Moderate Alzheimer’s Disease

(2014) Alok Sharma et al.   American Journal of Alzheimers Disease and Other Dementias

Decreased γ-aminobutyric acid levels in the parietal region of patients with Alzheimer's disease

(2014) Xue Bai et al.   JOURNAL OF MAGNETIC RESONANCE IMAGING

Oxidative Stress and Metabolic Syndrome: Cause or Consequence of Alzheimer's Disease?

(2014) Diana Luque-Contreras et al.   Oxidative Medicine and Cellular Longevity

The association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease

(2014) Hadassa M Jochemsen et al.   Alzheimers Research & Therapy

Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation

(2014) John S. K. Kauwe et al.   PLoS Genetics

Anti-obesity effects of 3-hydroxychromone derivative, a novel small-molecule inhibitor of glycogen synthase kinase-3

(2013) Sooho Lee et al.   BIOCHEMICAL PHARMACOLOGY

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Brain Insulin Resistance and Deficiency as Therapeutic Targets in Alzheimers Disease

(2012) Suzanne M. de la Monte   Current Alzheimer Research

Regional differences in cortical benzodiazepine receptors of Alzheimer, vascular, and mixed dementia patients

(2012) Haruo Hanyu et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

SIRT3 Weighs Heavily in the Metabolic Balance: A New Role for SIRT3 in Metabolic Syndrome

(2012) M. F. Green et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

SIRT3 Deficiency and Mitochondrial Protein Hyperacetylation Accelerate the Development of the Metabolic Syndrome

(2011) Matthew D. Hirschey et al.   MOLECULAR CELL

Metabolic-cognitive syndrome: A cross-talk between metabolic syndrome and Alzheimer's disease

(2010) Vincenza Frisardi et al.   AGEING RESEARCH REVIEWS

Association of Higher Levels of High-Density Lipoprotein Cholesterol in Elderly Individuals and Lower Risk of Late-Onset Alzheimer Disease

(2010) Christiane Reitz et al.   ARCHIVES OF NEUROLOGY

Biomarkers of oxidative damage and inflammation in Alzheimer’s disease

(2010) Douglas Galasko et al.   Biomarkers in Medicine

Neurotoxicity of Alzheimer's disease Aβ peptides is induced by small changes in the Aβ42 to Aβ40 ratio

(2010) Inna Kuperstein et al.   EMBO JOURNAL

Caspase activation precedes and leads to tangles

(2010) Alix de Calignon et al.   NATURE

Metabolic Syndrome and Risk for Incident Alzheimer's Disease or Vascular Dementia: The Three-City Study

(2008) C. Raffaitin et al.   DIABETES CARE

An NF-κB-sensitive Micro RNA-146a-mediated Inflammatory Circuit in Alzheimer Disease and in Stressed Human Brain Cells

(2008) Walter J. Lukiw et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic syndrome and the role of dietary lifestyles in Alzheimer’s disease

(2008) Giulio Maria Pasinetti et al.   JOURNAL OF NEUROCHEMISTRY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY