Obesity during preclinical Alzheimer's disease development exacerbates brain metabolic decline

Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer's disease

(2023) Michael A. Kelberman et al.   NEUROBIOLOGY OF AGING

Sexual dimorphism in the peripheral metabolic homeostasis and behavior in the TgF344‐AD rat model of Alzheimer's disease

(2023) Hemant Srivastava et al.   AGING CELL

Long-Term High-Fat Diet Consumption Depletes Glial Cells and Tyrosine Hydroxylase–Containing Neurons in the Brain of Middle-Aged Rats

(2022) Mei-Chuan Chou et al.   Cells

LRcell: detecting the source of differential expression at the sub–cell-type level from bulk RNA-seq data

(2022) Wenjing Ma et al.   BRIEFINGS IN BIOINFORMATICS

X-linked ubiquitin-specific peptidase 11 increases tauopathy vulnerability in women

(2022) Yan Yan et al.   CELL

Amyloid‐β plus cholesterol treatment impairs the ability of microglia to efflux excess cholesterol

(2022) Oscar M. Muñoz et al.   Alzheimers & Dementia

The UCSC Genome Browser database: 2023 update

(2022) Luis R Nassar et al.   NUCLEIC ACIDS RESEARCH

ApoE4 Impairs Neuron-Astrocyte Coupling of Fatty Acid Metabolism

(2021) Guoyuan Qi et al.   Cell Reports

APOE4 disrupts intracellular lipid homeostasis in human iPSC-derived glia

(2021) Grzegorz Sienski et al.   Science Translational Medicine

In vivo and neuropathology data support locus coeruleus integrity as indicator of Alzheimer’s disease pathology and cognitive decline

(2021) Heidi I. L. Jacobs et al.   Science Translational Medicine

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

(2021) Se-In Lee et al.   Stem Cell Reports

Memory and eating: A bidirectional relationship implicated in obesity

(2021) Marise B. Parent et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Dietary lipids from body to brain

(2021) Custers et al.   PROGRESS IN LIPID RESEARCH

Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging

(2020) Shuai Ma et al.   CELL

Visceral adipose NLRP3 impairs cognition in obesity via IL-1R1 on CX3CR1+ cells

(2020) De-Huang Guo et al.   JOURNAL OF CLINICAL INVESTIGATION

Direct and indirect cholesterol effects on membrane proteins with special focus on potassium channels

(2020) Florina Zakany et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Behavioral Phenotype in the TgF344-AD Rat Model of Alzheimer’s Disease

(2020) Rachel Michelle Saré et al.   Frontiers in Neuroscience

Interplay between Peripheral and Central Inflammation in Obesity-Promoted Disorders: The Impact on Synaptic Mitochondrial Functions

(2020) Marianna Crispino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Regulation of Memory Function by Feeding-Relevant Biological Systems: Following the Breadcrumbs to the Hippocampus

(2019) Andrea N. Suarez et al.   Frontiers in Molecular Neuroscience

Duration of preclinical, prodromal, and dementia stages of Alzheimer's disease in relation to age, sex, and APOE genotype

(2019) Lisa Vermunt et al.   Alzheimers & Dementia

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Impairment of Long-term Memory by a Short-term High-fat Diet via Hippocampal Oxidative Stress and Alterations in Synaptic Plasticity

(2019) Zhengjun Wang et al.   NEUROSCIENCE

Obesity trajectories and risk of dementia: 28 years of follow-up in the Whitehall II Study

(2018) Archana Singh-Manoux et al.   Alzheimers & Dementia

Impact of nutrient overload on metabolic homeostasis

(2018) Haowen Qiu et al.   NUTRITION REVIEWS

Long Road to Ruin: Noradrenergic Dysfunction in Neurodegenerative Disease

(2018) David Weinshenker   TRENDS IN NEUROSCIENCES

Hypothalamic Alterations in Neurodegenerative Diseases and Their Relation to Abnormal Energy Metabolism

(2018) Pauline Vercruysse et al.   Frontiers in Molecular Neuroscience

Long Feeding High-Fat Diet Induces Hypothalamic Oxidative Stress and Inflammation, and Prolonged Hypothalamic AMPK Activation in Rat Animal Model

(2018) Gina Cavaliere et al.   Frontiers in Physiology

The Synergistic Effects of APOE Genotype and Obesity on Alzheimer’s Disease Risk

(2018) Nahdia Jones et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Sex-biased hippocampal pathology in the 5XFAD mouse model of Alzheimer's disease: A multi-omic analysis

(2018) Joseph L. Bundy et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Disorders of Body Weight, Sleep and Circadian Rhythm as Manifestations of Hypothalamic Dysfunction in Alzheimer’s Disease

(2018) Abigail J. Hiller et al.   Frontiers in Cellular Neuroscience

Early functional connectivity deficits and progressive microstructural alterations in the TgF344-AD rat model of Alzheimer’s Disease: A longitudinal MRI study

(2018) Cynthia Anckaerts et al.   NEUROBIOLOGY OF DISEASE

Triglycerides cross the blood–brain barrier and induce central leptin and insulin receptor resistance

(2017) W A Banks et al.   INTERNATIONAL JOURNAL OF OBESITY

Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition

(2017) Rebecca F. Gottesman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Loss of astrocyte cholesterol synthesis disrupts neuronal function and alters whole-body metabolism

(2017) Heather A. Ferris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

(2016) Bruno Dubois et al.   Alzheimers & Dementia

On the Dependency of Cellular Protein Levels on mRNA Abundance

(2016) Yansheng Liu et al.   CELL

Enrichr: a comprehensive gene set enrichment analysis web server 2016 update

(2016) Maxim V. Kuleshov et al.   NUCLEIC ACIDS RESEARCH

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

Metabolic and Non-Cognitive Manifestations of Alzheimer’s Disease: The Hypothalamus as Both Culprit and Target of Pathology

(2015) Makoto Ishii et al.   Cell Metabolism

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Midlife adiposity predicts earlier onset of Alzheimer’s dementia, neuropathology and presymptomatic cerebral amyloid accumulation

(2015) Y-F Chuang et al.   MOLECULAR PSYCHIATRY

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

Impaired insulin action in the human brain: causes and metabolic consequences

(2015) Martin Heni et al.   Nature Reviews Endocrinology

Relationship between differentially expressed mRNA and mRNA-protein correlations in a xenograft model system

(2015) Antonis Koussounadis et al.   Scientific Reports

Working Memory and Executive Function Decline across Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

(2015) Anna-Mariya Kirova et al.   Biomed Research International

Obesity and neuroinflammation: A pathway to cognitive impairment

(2014) Alyson A. Miller et al.   BRAIN BEHAVIOR AND IMMUNITY

Short-Term High-Fat-and-Fructose Feeding Produces Insulin Signaling Alterations Accompanied by Neurite and Synaptic Reduction and Astroglial Activation in the Rat Hippocampus

(2014) Erika Calvo-Ochoa et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

High fat diet produces brain insulin resistance, synaptodendritic abnormalities and altered behavior in mice

(2014) Steven E. Arnold et al.   NEUROBIOLOGY OF DISEASE

What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

(2014) Anders M. Fjell et al.   PROGRESS IN NEUROBIOLOGY

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Obesity in Aging Exacerbates Blood-Brain Barrier Disruption, Neuroinflammation, and Oxidative Stress in the Mouse Hippocampus: Effects on Expression of Genes Involved in Beta-Amyloid Generation and Alzheimer's Disease

(2013) Z. Tucsek et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Predicting the effects of a high-energy diet on fatty liver and hippocampal-dependent memory in male rats

(2013) J.N. Darling et al.   Obesity

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

AMPK: a nutrient and energy sensor that maintains energy homeostasis

(2012) D. Grahame Hardie et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations

(2011) Charina M. Ramirez et al.   JOURNAL OF LIPID RESEARCH

Early steps in steroidogenesis: intracellular cholesterol trafficking

(2011) Walter L. Miller et al.   JOURNAL OF LIPID RESEARCH

Stages of the Pathologic Process in Alzheimer Disease: Age Categories From 1 to 100 Years

(2011) Heiko Braak et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Direct binding of cholesterol to the amyloid precursor protein: An important interaction in lipid–Alzheimer's disease relationships?

(2010) Andrew J. Beel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Midlife and Late-Life Obesity and the Risk of Dementia

(2009) Annette L. Fitzpatrick et al.   ARCHIVES OF NEUROLOGY

Midlife Serum Cholesterol and Increased Risk of Alzheimer’s and Vascular Dementia Three Decades Later

(2009) Alina Solomon et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

Dynamics and Cleavability at the α-Cleavage Site of APP(684-726) in Different Lipid Environments

(2008) Marco Marenchino et al.   BIOPHYSICAL JOURNAL

Global burden of obesity in 2005 and projections to 2030

(2008) T Kelly et al.   INTERNATIONAL JOURNAL OF OBESITY

Independent Inhibition of Alzheimer Disease β- and γ-Secretase Cleavage by Lowered Cholesterol Levels

(2008) Marcus O. W. Grimm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox proteomic identification of 4-Hydroxy-2-nonenal-modified brain proteins in amnestic mild cognitive impairment: Insight into the role of lipid peroxidation in the progression and pathogenesis of Alzheimer's disease

(2008) Tanea Reed et al.   NEUROBIOLOGY OF DISEASE

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY