NF‐κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective
Published 2023 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
NF‐κB/NLRP3 inflammasome axis and risk of Parkinson's disease in Type 2 diabetes mellitus: A narrative review and new perspective
Authors
Keywords
-
Journal
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
Volume -, Issue -, Pages -
Publisher
Wiley
Online
2023-05-21
DOI
10.1111/jcmm.17784
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Assessment of subclinical left ventricular systolic dysfunction in patients with type 2 diabetes: Relationship with HbA1c and microvascular complications
- (2023) Yanyan Chen et al. Journal of Diabetes
- Convergent Molecular Pathways in Type 2 Diabetes Mellitus and Parkinson’s Disease: Insights into Mechanisms and Pathological Consequences
- (2022) Sandeep XXXX et al. MOLECULAR NEUROBIOLOGY
- Long-term hyperglycemia aggravates α-synuclein aggregation and dopaminergic neuronal loss in a Parkinson’s disease mouse model
- (2022) Yi-Qing Lv et al. Translational Neurodegeneration
- Vinpocetine is the forthcoming adjuvant agent in the management of COVID-19
- (2022) Hayder M Al-kuraishy et al. Future Science OA
- Polystyrene nanoplastics deteriorate LPS-modulated duodenal permeability and inflammation in mice via ROS drived-NF-κB/NLRP3 pathway
- (2022) Yujiao He et al. CHEMOSPHERE
- Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes
- (2021) Danilo Milardi et al. CHEMICAL REVIEWS
- NLRP3 Inflammasome at the Interface of Inflammation, Endothelial Dysfunction, and Type 2 Diabetes
- (2021) Ilona M. Gora et al. Cells
- Acinar cell NLRP3 inflammasome and GSDMD activation mediates pyroptosis and systemic inflammation in acute pancreatitis
- (2021) Lin Gao et al. BRITISH JOURNAL OF PHARMACOLOGY
- An update on the regulatory mechanisms of NLRP3 inflammasome activation
- (2021) Seungwha Paik et al. Cellular & Molecular Immunology
- Nuclear factor‐kappa B (NF‐κB) in pathophysiology of Parkinson disease: Diverse patterns and mechanisms contributing to neurodegeneration
- (2021) Mahsa Dolatshahi et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- Prodromal Parkinson disease subtypes — key to understanding heterogeneity
- (2021) Daniela Berg et al. Nature Reviews Neurology
- Therapies modulating insulin resistance in Parkinson’s disease: A cross talk
- (2021) Tanya Sharma et al. NEUROSCIENCE LETTERS
- Mixed pathologies in pancreatic β cells from subjects with neurodegenerative diseases and their interaction with prion protein
- (2021) Ivan Martinez-Valbuena et al. Acta Neuropathologica Communications
- The potential role of neopterin in Covid-19: a new perspective
- (2021) Hayder M. Al-kuraishy et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
- Impaired brain insulin signalling in Parkinson's disease
- (2021) Fares Bassil et al. NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
- Prediabetes, type 2 diabetes mellitus and risk of Parkinson’s disease: A population-based cohort study
- (2021) Almudena Sánchez-Gómez et al. PARKINSONISM & RELATED DISORDERS
- Metformin Repurposing for Parkinson Disease Therapy: Opportunities and Challenges
- (2021) Francesco Agostini et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- NLRP3 Inflammasome Blocking as a Potential Treatment of Central Insulin Resistance in Early-Stage Alzheimer’s Disease
- (2021) Yulia K. Komleva et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Chronic and progressive dopaminergic neuronal death in substantia nigra associates with a decrease in serum levels of glucose and free fatty acids, the role of interlokin-1 beta
- (2021) Ali Sarbazi-Golezari et al. METABOLIC BRAIN DISEASE
- Global Trends in the Incidence, Prevalence, and Years Lived With Disability of Parkinson's Disease in 204 Countries/Territories From 1990 to 2019
- (2021) Zejin Ou et al. Frontiers in Public Health
- Shared cerebral metabolic pathology in non-transgenic animal models of Alzheimer's and Parkinson's disease
- (2020) Jelena Osmanovic Barilar et al. JOURNAL OF NEURAL TRANSMISSION
- Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease
- (2020) Zheng Fan et al. Journal of Neuroinflammation
- Probiotic mediated NF-κB regulation for prospective management of type 2 diabetes
- (2020) Rabia Bhardwaj et al. MOLECULAR BIOLOGY REPORTS
- Cynomolgus Monkeys With Spontaneous Type-2-Diabetes-Mellitus-Like Pathology Develop Alpha-Synuclein Alterations Reminiscent of Prodromal Parkinson’s Disease and Related Diseases
- (2020) Yan Sun et al. Frontiers in Neuroscience
- Parkinson disease and the immune system — associations, mechanisms and therapeutics
- (2020) Eng-King Tan et al. Nature Reviews Neurology
- Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus
- (2020) Habib Yaribeygi et al. Oxidative Medicine and Cellular Longevity
- The Association Between Type 2 Diabetes Mellitus and Parkinson’s Disease
- (2020) Julia L.Y. Cheong et al. Journal of Parkinsons Disease
- Glutamate-induced excitotoxicity in Parkinson's disease: The role of glial cells
- (2020) L. Iovino et al. JOURNAL OF PHARMACOLOGICAL SCIENCES
- Crosstalk Between Alpha-Synuclein and Other Human and Non-Human Amyloidogenic Proteins: Consequences for Amyloid Formation in Parkinson’s Disease
- (2020) Tony Werner et al. Journal of Parkinsons Disease
- Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications
- (2020) Marta Pajares et al. Cells
- Diabetes medications and risk of Parkinson’s disease: a cohort study of patients with diabetes
- (2020) Ruth Brauer et al. BRAIN
- Enhanced accumulation of reduced glutathione by Scopoletin improves survivability of dopaminergic neurons in Parkinson’s model
- (2020) Priyadarshika Pradhan et al. Cell Death & Disease
- Metformin improves depressive-like symptoms in mice via inhibition of peripheral and central NF-κB-NLRP3 inflammation activation
- (2020) Ren-Wei Du et al. EXPERIMENTAL BRAIN RESEARCH
- Association of Glycemic Indices (Hyperglycemia, Glucose Variability, and Hypoglycemia) with Oxidative Stress and Diabetic Complications
- (2020) Eleftheria Papachristoforou et al. Journal of Diabetes Research
- Cardiac Autonomic Neuropathy: A Progressive Consequence of Chronic Low-Grade Inflammation in Type 2 Diabetes and Related Metabolic Disorders
- (2020) Nour-Mounira Z. Bakkar et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Stingless bee honey protects against lipopolysaccharide induced-chronic subclinical systemic inflammation and oxidative stress by modulating Nrf2, NF-κB and p38 MAPK
- (2019) Yazan Ranneh et al. Nutrition & Metabolism
- Plasma alpha-synuclein levels in patients with Parkinson’s disease: a systematic review and meta-analysis
- (2019) Anastasia Bougea et al. NEUROLOGICAL SCIENCES
- NF-κB as the mediator of metformin's effect on ageing and ageing-related diseases
- (2019) Gönül Kanigur Sultuybek et al. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
- Dysregulation of Inflammasome Priming and Activation by MicroRNAs in Human Immune-Mediated Diseases
- (2019) Nina Boxberger et al. JOURNAL OF IMMUNOLOGY
- Parkinson’s Disease in Women and Men: What’s the Difference?
- (2019) Silvia Cerri et al. Journal of Parkinsons Disease
- Parkinson’s disease in China: a forty-year growing track of bedside work
- (2019) Gen Li et al. Translational Neurodegeneration
- Rifampicin and Its Derivative Rifampicin Quinone Reduce Microglial Inflammatory Responses and Neurodegeneration Induced In Vitro by α-Synuclein Fibrillary Aggregates
- (2019) Acuña et al. Cells
- The genetic architecture of Parkinson's disease
- (2019) Cornelis Blauwendraat et al. LANCET NEUROLOGY
- NLRP3 inflammasome promotes diabetes-induced endothelial inflammation and atherosclerosis
- (2019) Zhaofei Wan et al. Diabetes Metabolic Syndrome and Obesity-Targets and Therapy
- Targeting the microglial NLRP3 inflammasome and its role in Parkinson's disease
- (2019) Md. Ezazul Haque et al. MOVEMENT DISORDERS
- No genetic evidence for involvement of alcohol dehydrogenase genes in risk for Parkinson's disease
- (2019) Jonggeol Jeffrey Kim et al. NEUROBIOLOGY OF AGING
- Trends in the incidence and prevalence of Parkinson’s disease in Korea: a nationwide, population-based study
- (2019) Joo-Hyun Park et al. BMC Geriatrics
- A new research hot spot: The role of NLRP3 inflammasome activation, a key step in pyroptosis, in diabetes and diabetic complications
- (2019) Zi-Wei Yu et al. LIFE SCIENCES
- Saxagliptin mitigates airway inflammation in a mouse model of acute asthma via modulation of NF-kB and TLR4
- (2019) Manar G. Helal et al. LIFE SCIENCES
- Inhibition of JAK-STAT and NF-κB signalling systems could be a novel therapeutic target against insulin resistance and type 2 diabetes
- (2019) Hauwa'u Yakubu Bako et al. LIFE SCIENCES
- NF-κB-Mediated Neuroinflammation in Parkinson’s Disease and Potential Therapeutic Effect of Polyphenols
- (2019) Saumitra Sen Singh et al. NEUROTOXICITY RESEARCH
- Emerging neuroprotective effect of metformin in Parkinson’s disease: A molecular crosstalk
- (2019) Yam Nath Paudel et al. PHARMACOLOGICAL RESEARCH
- Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes
- (2019) Sujuan Ding et al. Biomolecules
- Interaction of amyloidogenic proteins in pancreatic β cells from subjects with synucleinopathies
- (2018) Ivan Martinez-Valbuena et al. ACTA NEUROPATHOLOGICA
- Inhibition of the hepatic Nlrp3 protects dopaminergic neurons via attenuating systemic inflammation in a MPTP/p mouse model of Parkinson’s disease
- (2018) Chen Qiao et al. Journal of Neuroinflammation
- Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View
- (2018) Alice Biosa et al. MOLECULAR NEUROBIOLOGY
- Diabetes mellitus and Parkinson disease
- (2018) Gennaro Pagano et al. NEUROLOGY
- Association between diabetes and subsequent Parkinson disease
- (2018) Eduardo De Pablo-Fernandez et al. NEUROLOGY
- Protective effects of the GLP-1 mimetic exendin-4 in Parkinson's disease
- (2018) Dilan Athauda et al. NEUROPHARMACOLOGY
- Basal ganglia and beyond: The interplay between motor and cognitive aspects in Parkinson’s disease rehabilitation
- (2018) Davide Ferrazzoli et al. NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
- Age-related selection bias in Parkinson's disease research: are we recruiting the right participants?
- (2018) Angus D. Macleod et al. PARKINSONISM & RELATED DISORDERS
- Glucose dysregulation in Parkinson's disease: Too much glucose or not enough insulin?
- (2018) Ana Marques et al. PARKINSONISM & RELATED DISORDERS
- Neuropathology of Parkinson disease
- (2018) Dennis W. Dickson PARKINSONISM & RELATED DISORDERS
- Effects of antidiabetic drugs on NLRP3 inflammasome activity, with a focus on diabetic kidneys
- (2018) Habib Yaribeygi et al. DRUG DISCOVERY TODAY
- Detrimental effect of type 2 diabetes mellitus in a large case series of Parkinson's disease
- (2018) Seok Jong Chung et al. PARKINSONISM & RELATED DISORDERS
- Cerebrospinal Fluid Inflammatory Cytokine Aberrations in Alzheimer's Disease, Parkinson's Disease and Amyotrophic Lateral Sclerosis: A Systematic Review and Meta-Analysis
- (2018) Xi Chen et al. Frontiers in Immunology
- Peripheral blood inflammatory markers in early Parkinson’s disease
- (2018) Ryul Kim et al. JOURNAL OF CLINICAL NEUROSCIENCE
- The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in Parkinson's disease
- (2018) Shuo Wang et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Increased risk of Parkinson disease with diabetes mellitus in a population-based study
- (2017) Yu-Wan Yang et al. MEDICINE
- Epidemiology, environmental risk factors and genetics of Parkinson's disease
- (2017) Anna Delamarre et al. PRESSE MEDICALE
- Metformin ameliorates sepsis-induced brain injury by inhibiting apoptosis, oxidative stress and neuroinflammation via the PI3K/Akt signaling pathway
- (2017) Guangming Tang et al. Oncotarget
- Neuropathological Staging of Brain Pathology in Sporadic Parkinson’s disease: Separating the Wheat from the Chaff
- (2017) Heiko Braak et al. Journal of Parkinsons Disease
- Microglia activation due to obesity programs metabolic failure leading to type two diabetes
- (2017) R Maldonado-Ruiz et al. Nutrition & Diabetes
- Parkinson disease
- (2017) Werner Poewe et al. Nature Reviews Disease Primers
- Crosstalk between reactive oxygen species and pro-inflammatory markers in developing various chronic diseases: a review
- (2017) Yazan Ranneh et al. Applied Biological Chemistry
- IKKβ Is Essential for Adipocyte Survival and Adaptive Adipose Remodeling in Obesity
- (2016) Se-Hyung Park et al. DIABETES
- Priming of the neutrophil respiratory burst: role in host defense and inflammation
- (2016) Jamel El-Benna et al. IMMUNOLOGICAL REVIEWS
- Association Between Parkinsonʼs Disease and Inflammatory Bowel Disease
- (2016) Jung-Chun Lin et al. INFLAMMATORY BOWEL DISEASES
- Metformin Prevents Dopaminergic Neuron Death in MPTP/P-Induced Mouse Model of Parkinson’s Disease via Autophagy and Mitochondrial ROS Clearance
- (2016) Ming Lu et al. INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
- Mitochondrial dysfunction in Parkinson's disease
- (2016) Anindita Bose et al. JOURNAL OF NEUROCHEMISTRY
- Risk of Parkinson Disease in Diabetes Mellitus
- (2016) Xuejing Yue et al. MEDICINE
- Glycation in Parkinson's disease and Alzheimer's disease
- (2016) Hugo Vicente Miranda et al. MOVEMENT DISORDERS
- Mechanism and Regulation of NLRP3 Inflammasome Activation
- (2016) Yuan He et al. TRENDS IN BIOCHEMICAL SCIENCES
- Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways
- (2015) Rania M. Abdelsalam et al. JOURNAL OF NEUROCHEMISTRY
- Correlation between decreased CSF α-synuclein and Aβ1–42 in Parkinson disease
- (2015) Chandana Buddhala et al. NEUROBIOLOGY OF AGING
- Relationship between Cognitive Performance and Motor Dysfunction in Patients with Parkinson’s Disease: A Pilot Cross-Sectional Study
- (2015) Valentina Varalta et al. Biomed Research International
- DPP-4 Inhibitors Repress NLRP3 Inflammasome and Interleukin-1beta via GLP-1 Receptor in Macrophages Through Protein Kinase C Pathway
- (2014) Yao Dai et al. CARDIOVASCULAR DRUGS AND THERAPY
- Chronic Inflammatory Disorders and Risk of Type 2 Diabetes Mellitus, Coronary Heart Disease, and Stroke
- (2014) Alex Dregan et al. CIRCULATION
- Anti-inflammatory agents to treat or prevent type 2 diabetes, metabolic syndrome and cardiovascular disease
- (2014) Nathalie Esser et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The association of oxidative stress and pro-inflammatory cytokines in diabetic patients with hyperglycemic crisis
- (2014) Juan Li et al. JOURNAL OF DIABETES AND ITS COMPLICATIONS
- Insulin resistance and gray matter volume in neurodegenerative disease
- (2014) J.K. Morris et al. NEUROSCIENCE
- Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease
- (2014) Nicolaas I. Bohnen et al. PARKINSONISM & RELATED DISORDERS
- Diabetes and Risk of Parkinson's Disease: An Updated Meta-Analysis of Case-Control Studies
- (2014) Lin Lu et al. PLoS One
- Effects of Dipeptidyl-Peptidase 4 Inhibitor about Vascular Inflammation in a Metabolic Syndrome Model
- (2014) Nicolas F. Renna et al. PLoS One
- Insulin resistance, neuroinflammation, and Alzheimer’s disease
- (2014) Dema Najem et al. REVIEWS IN THE NEUROSCIENCES
- Aβ1–42 reduces P-glycoprotein in the blood–brain barrier through RAGE–NF-κB signaling
- (2014) R Park et al. Cell Death & Disease
- Metabolic inflammation exacerbates dopaminergic neuronal degeneration in response to acute MPTP challenge in type 2 diabetes mice
- (2013) Ling Wang et al. EXPERIMENTAL NEUROLOGY
- Bidirectional regulation of NF-κB by reactive oxygen species: A role of unfolded protein response
- (2013) Shotaro Nakajima et al. FREE RADICAL BIOLOGY AND MEDICINE
- Pharmacological approaches to restore mitochondrial function
- (2013) Pénélope A. Andreux et al. NATURE REVIEWS DRUG DISCOVERY
- Molecular links between Alzheimer’s disease and diabetes mellitus
- (2013) Y. Yang et al. NEUROSCIENCE
- Triggering of Inflammasome by Aggregated α–Synuclein, an Inflammatory Response in Synucleinopathies
- (2013) Gaia Codolo et al. PLoS One
- Shared dysregulated pathways lead to Parkinson's disease and diabetes
- (2013) Jose A. Santiago et al. TRENDS IN MOLECULAR MEDICINE
- Diabetes Alters Activation and Repression of Pro- and Anti-Inflammatory Signaling Pathways in the Vasculature
- (2013) Elyse Di Marco et al. Frontiers in Endocrinology
- Inflammatory cytokines and NT-proCNP in Parkinson’s disease patients
- (2012) Dariusz Koziorowski et al. CYTOKINE
- Risk of Parkinson Disease Onset in Patients With Diabetes: A 9-year population-based cohort study with age and sex stratifications
- (2012) Y. Sun et al. DIABETES CARE
- Inflammatory Markers and Risk of Type 2 Diabetes: A systematic review and meta-analysis
- (2012) X. Wang et al. DIABETES CARE
- A pathway-based analysis provides additional support for an immune-related genetic susceptibility to Parkinson's disease
- (2012) Peter Holmans et al. HUMAN MOLECULAR GENETICS
- Advanced glycation end products and neurodegenerative diseases: Mechanisms and perspective
- (2012) Jinlong Li et al. JOURNAL OF THE NEUROLOGICAL SCIENCES
- Metabolic markers or conditions preceding Parkinson's disease: A case-control study
- (2012) Rodolfo Savica et al. MOVEMENT DISORDERS
- Metformin-inclusive sulfonylurea therapy reduces the risk of Parkinson's disease occurring with Type 2 diabetes in a Taiwanese population cohort
- (2012) Mark L. Wahlqvist et al. PARKINSONISM & RELATED DISORDERS
- Subsequent Risks of Parkinson Disease in Patients with Autoimmune and Related Disorders: A Nationwide Epidemiological Study from Sweden
- (2011) Xinjun Li et al. Neurodegenerative Diseases
- Cerebrospinal fluid biomarkers for Parkinson disease diagnosis and progression
- (2010) Min Shi et al. ANNALS OF NEUROLOGY
- Alpha-Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection
- (2010) He-Jin Lee et al. Oxidative Medicine and Cellular Longevity
- The NLRP3 Inflammasome: A Sensor for Metabolic Danger?
- (2010) K. Schroder et al. SCIENCE
- Exenatide: a review from pharmacology to clinical practice
- (2009) R. Gentilella et al. DIABETES OBESITY & METABOLISM
- Non-motor symptoms in Parkinson’s disease
- (2008) W. Poewe EUROPEAN JOURNAL OF NEUROLOGY
- Oxidative stress of the newborn in the pre- and postnatal period and the clinical utility of melatonin
- (2008) Eloisa Gitto et al. JOURNAL OF PINEAL RESEARCH
- Oxidative and Inflammatory Pathways in Parkinson’s Disease
- (2008) Rebecca L. Miller et al. NEUROCHEMICAL RESEARCH
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started