A current view on Tau protein phosphorylation in Alzheimer's disease

Persistent repression of tau in the brain using engineered zinc finger protein transcription factors

(2021) Susanne Wegmann et al.   Science Advances

Cerebro-spinal fluid biomarker levels: phosphorylated tau (T) and total tau (N) as markers for rate of progression in Alzheimer’s disease

(2020) Carina Wattmo et al.   BMC Neurology

Posttranslational Modifications Mediate the Structural Diversity of Tauopathy Strains

(2020) Tamta Arakhamia et al.   CELL

A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   NATURE MEDICINE

Evolution of Alzheimer's Disease Cerebrospinal Fluid Biomarkers in Early Parkinson's Disease

(2020) David J. Irwin et al.   ANNALS OF NEUROLOGY

Blood plasma phosphorylated-tau isoforms track CNS change in Alzheimer’s disease

(2020) Nicolas R. Barthélemy et al.   JOURNAL OF EXPERIMENTAL MEDICINE

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

(2020) Senthilvelrajan Kaniyappan et al.   Molecular Neurodegeneration

Tau molecular diversity contributes to clinical heterogeneity in Alzheimer’s disease

(2020) Simon Dujardin et al.   NATURE MEDICINE

Regional correlation of biochemical measures of amyloid and tau phosphorylation in the brain

(2020) Kanta Horie et al.   Acta Neuropathologica Communications

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human tau but minimal levels of other key modifications

(2020) Friedel Drepper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau PTM Profiles Identify Patient Heterogeneity and Stages of Alzheimer’s Disease

(2020) Hendrik Wesseling et al.   CELL

Lysine/RNA-interactions drive and regulate biomolecular condensation

(2019) Tina Ukmar-Godec et al.   Nature Communications

Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature

(2019) Isabelle Guisle et al.   SLEEP

Site-Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

(2019) Mahmood Haj-Yahya et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Tau-targeting therapies for Alzheimer disease

(2018) Erin E. Congdon et al.   Nature Reviews Neurology

Tau Kinetics in Neurons and the Human Central Nervous System

(2018) Chihiro Sato et al.   NEURON

Synaptic Tau Seeding Precedes Tau Pathology in Human Alzheimer's Disease Brain

(2018) Sarah L. DeVos et al.   Frontiers in Neuroscience

Quantitative Analysis of the Brain Ubiquitylome in Alzheimer's Disease

(2018) Measho H. Abreha et al.   PROTEOMICS

Novel tau fragments in cerebrospinal fluid: relation to tangle pathology and cognitive decline in Alzheimer’s disease

(2018) Claudia Cicognola et al.   ACTA NEUROPATHOLOGICA

Tau reduction prevents neuronal loss and reverses pathological tau deposition and seeding in mice with tauopathy

(2017) Sarah L. DeVos et al.   Science Translational Medicine

Atypical, non-standard functions of the microtubule associated Tau protein

(2017) Ioannis Sotiropoulos et al.   Acta Neuropathologica Communications

FLEXITau: Quantifying Post-translational Modifications of Tau Protein in Vitro and in Human Disease

(2016) Waltraud Mair et al.   ANALYTICAL CHEMISTRY

Tau Protein Quantification in Human Cerebrospinal Fluid by Targeted Mass Spectrometry at High Sequence Coverage Provides Insights into Its Primary Structure Heterogeneity

(2016) Nicolas R Barthélemy et al.   JOURNAL OF PROTEOME RESEARCH

Tau post-translational modifications in wild-type and human amyloid precursor protein transgenic mice

(2015) Meaghan Morris et al.   NATURE NEUROSCIENCE

Tau and neurodegenerative disease: the story so far

(2015) Khalid Iqbal et al.   Nature Reviews Neurology

Lysine methylation is an endogenous post-translational modification of tau protein in human brain and a modulator of aggregation propensity

(2014) Kristen E. Funk et al.   BIOCHEMICAL JOURNAL

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells

(2014) Katharina Tepper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Distinct Tau Prion Strains Propagate in Cells and Mice and Define Different Tauopathies

(2014) David W. Sanders et al.   NEURON

Phosphorylation of Human Tau Protein by Microtubule Affinity-Regulating Kinase 2

(2013) Martin Schwalbe et al.   BIOCHEMISTRY

Antisense Reduction of Tau in Adult Mice Protects against Seizures

(2013) S. L. DeVos et al.   JOURNAL OF NEUROSCIENCE

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Tau degradation: The ubiquitin–proteasome system versus the autophagy-lysosome system

(2013) Min Jae Lee et al.   PROGRESS IN NEUROBIOLOGY

The fuzzy coat of pathological human Tau fibrils is a two-layered polyelectrolyte brush

(2012) Susanne Wegmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CSF Biomarkers for Amyloid and Tau Pathology in Alzheimer's Disease

(2011) Hanna Rosenmann   JOURNAL OF MOLECULAR NEUROSCIENCE

Developmental regulation of tau phosphorylation, tau kinases, and tau phosphatases

(2009) Yang Yu et al.   JOURNAL OF NEUROCHEMISTRY

Characterization of Tau in Cerebrospinal Fluid Using Mass Spectrometry

(2008) Erik Portelius et al.   JOURNAL OF PROTEOME RESEARCH