Inflammatory Mechanisms in Obesity

The Effects of Salsalate on Glycemic Control in Patients With Type 2 Diabetes

(2013) Allison B. Goldfine   ANNALS OF INTERNAL MEDICINE

Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in U.S. Adults

(2013) Dariush Mozaffarian et al.   ANNALS OF INTERNAL MEDICINE

Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes

(2010) Dariush Mozaffarian et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Propensity to high-fat diet-induced obesity in rats is associated with changes in the gut microbiota and gut inflammation

(2010) Claire Barbier de La Serre et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Macrophages, Inflammation, and Insulin Resistance

(2010) Jerrold M. Olefsky et al.   Annual Review of Physiology

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Tauroursodeoxycholic Acid May Improve Liver and Muscle but Not Adipose Tissue Insulin Sensitivity in Obese Men and Women

(2010) Marleen Kars et al.   DIABETES

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

(2010) Giovanni Solinas et al.   FASEB JOURNAL

Role of the hypothalamic-pituitary-thyroid axis in metabolic regulation by JNK1

(2010) G. Sabio et al.   GENES & DEVELOPMENT

Prevalence and Trends in Obesity Among US Adults, 1999-2008

(2010) Katherine M. Flegal   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Prevalence of High Body Mass Index in US Children and Adolescents, 2007-2008

(2010) Cynthia L. Ogden   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

TNF-α Antagonism with Etanercept Decreases Glucose and Increases the Proportion of High Molecular Weight Adiponectin in Obese Subjects with Features of the Metabolic Syndrome

(2010) Takara L. Stanley et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Small Molecule JNK (c-Jun N-Terminal Kinase) Inhibitors

(2010) M. Arshad Siddiqui et al.   JOURNAL OF MEDICINAL CHEMISTRY

An essential role for XBP-1 in host protection against immune activation in C. elegans

(2010) Claire E. Richardson et al.   NATURE

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Inflammatory lipid mediators in adipocyte function and obesity

(2010) Abishek Iyer et al.   Nature Reviews Endocrinology

Fatty acids from fish: the anti-inflammatory potential of long-chain omega-3 fatty acids

(2010) Rebecca Wall et al.   NUTRITION REVIEWS

Hypothalamic and pituitary c-Jun N-terminal kinase 1 signaling coordinately regulates glucose metabolism

(2010) B. F. Belgardt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Metabolic Syndrome and Altered Gut Microbiota in Mice Lacking Toll-Like Receptor 5

(2010) M. Vijay-Kumar et al.   SCIENCE

The NLRP3 Inflammasome: A Sensor for Metabolic Danger?

(2010) K. Schroder et al.   SCIENCE

Natural Killer T Cells Are Involved in Adipose Tissues Inflammation and Glucose Intolerance in Diet-Induced Obese Mice

(2009) Kazue Ohmura et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The Protein Kinase IKKɛ Regulates Energy Balance in Obese Mice

(2009) Shian-Huey Chiang et al.   CELL

MyD88 Signaling in the CNS Is Required for Development of Fatty Acid-Induced Leptin Resistance and Diet-Induced Obesity

(2009) André Kleinridders et al.   Cell Metabolism

Prevention of Steatosis by Hepatic JNK1

(2009) Guadalupe Sabio et al.   Cell Metabolism

Hematopoietic Cell-Specific Deletion of Toll-like Receptor 4 Ameliorates Hepatic and Adipose Tissue Insulin Resistance in High-Fat-Fed Mice

(2009) Maziyar Saberi et al.   Cell Metabolism

Tlr2 is critical for diet-induced metabolic syndrome in a murine model

(2009) Ryan W. Himes et al.   FASEB JOURNAL

Kupffer cells in non-alcoholic fatty liver disease: The emerging view

(2009) György Baffy   JOURNAL OF HEPATOLOGY

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Role of Muscle c-Jun NH2-Terminal Kinase 1 in Obesity-Induced Insulin Resistance

(2009) G. Sabio et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice

(2009) Jian Liu et al.   NATURE MEDICINE

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Normalization of obesity-associated insulin resistance through immunotherapy

(2009) Shawn Winer et al.   NATURE MEDICINE

High-Fat Diet Induces Apoptosis of Hypothalamic Neurons

(2009) Juliana C. Moraes et al.   PLoS One

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Adipocyte-Derived Th2 Cytokines and Myeloid PPARδ Regulate Macrophage Polarization and Insulin Sensitivity

(2008) Kihwa Kang et al.   Cell Metabolism

Ablation of CD11c-Positive Cells Normalizes Insulin Sensitivity in Obese Insulin Resistant Animals

(2008) David Patsouris et al.   Cell Metabolism

HIV therapy, metabolic syndrome, and cardiovascular risk

(2008) Vivian Pao et al.   Current Atherosclerosis Reports

Glucose Metabolism and Insulin Resistance in Sepsis

(2008) S. Van Cromphaut et al.   CURRENT PHARMACEUTICAL DESIGN

Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet-Induced Obesity and Diabetes in Mice

(2008) P. D. Cani et al.   DIABETES

Islet Inflammation in Type 2 Diabetes: From metabolic stress to therapy

(2008) M. Y. Donath et al.   DIABETES CARE

Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-β inductionvia X-box binding protein 1

(2008) Judith A. Smith et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Glucose and leptin induce apoptosis in human β-cells and impair glucose-stimulated insulin secretion through activation of c-Jun N-terminal kinases

(2008) Kathrin Maedler et al.   FASEB JOURNAL

Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice

(2008) Mathieu Membrez et al.   FASEB JOURNAL

Emerging role of adipose tissue hypoxia in obesity and insulin resistance

(2008) J Ye   INTERNATIONAL JOURNAL OF OBESITY

Role of CC Chemokine Receptor 2 in Bone Marrow Cells in the Recruitment of Macrophages into Obese Adipose Tissue

(2008) Ayaka Ito et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Variations in DNA elucidate molecular networks that cause disease

(2008) Yanqing Chen et al.   NATURE

Genetics of gene expression and its effect on disease

(2008) Valur Emilsson et al.   NATURE

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

Adipocyte dysfunctions linking obesity to insulin resistance and type 2 diabetes

(2008) Adilson Guilherme et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Predominant Role for Parenchymal c-Jun Amino Terminal Kinase (JNK) in the Regulation of Systemic Insulin Sensitivity

(2008) Sara N. Vallerie et al.   PLoS One

A Stress Signaling Pathway in Adipose Tissue Regulates Hepatic Insulin Resistance

(2008) G. Sabio et al.   SCIENCE

Metabolic syndrome in rheumatic diseases: epidemiology, pathophysiology, and clinical implications

(2008) Prodromos I Sidiropoulos et al.   ARTHRITIS RESEARCH & THERAPY

Activation of the Unfolded Protein Response Is Required for Defenses against Bacterial Pore-Forming Toxin In Vivo

(2008) Larry J. Bischof et al.   PLoS Pathogens

c-Jun amino terminal kinase 1 deficient mice are protected from streptozotocin-induced islet injury

(2007) Kyoichi Fukuda et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS