Irisin reduces inflammatory signaling pathways in inflammation-mediated metabolic syndrome

The Time-Course of Antioxidant Irisin Activity: Role of the Nrf2/HO-1/HMGB1 Axis

(2021) Agnieszka Irena Mazur-Bialy et al.   Antioxidants

Irisin Protects Against LPS-Stressed Cardiac Damage through Inhibiting Inflammation, Apoptosis and Pyroptosis

(2021) Qian Li et al.   SHOCK

Beneficial effects of whole-body cryotherapy on glucose homeostasis and amino acid profile are associated with a reduced myostatin serum concentration

(2021) Marta Kozłowska et al.   Scientific Reports

Changes in Brain-derived Neurotrophic Factor From Active and Sham Transcranial Direct Current Stimulation in Older Adults With Knee Osteoarthritis

(2021) Robert Suchting et al.   CLINICAL JOURNAL OF PAIN

Irisin attenuates inflammation in a mouse model of ulcerative colitis by altering the intestinal microbiota

(2021) Lu Huangfu et al.   Experimental and Therapeutic Medicine

Exercise-Induced Irisin Decreases Inflammation and Improves NAFLD by Competitive Binding with MD2

(2021) Weiwei Zhu et al.   Cells

Irisin Stimulates the Release of CXCL1 From Differentiating Human Subcutaneous and Deep-Neck Derived Adipocytes via Upregulation of NFκB Pathway

(2021) Abhirup Shaw et al.   Frontiers in Cell and Developmental Biology

Mechanisms involved in AMPK-mediated deposition of tight junction components to the plasma membrane

(2020) Jingshing Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Serum Irisin Concentrations in Severely Inflamed Patients

(2020) Silvio Buscemi et al.   HORMONE AND METABOLIC RESEARCH

Combination of melatonin and irisin ameliorates lipopolysaccharide‐induced cardiac dysfunction through suppressing the Mst1–JNK pathways

(2020) Haichun Ouyang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Irisin induces trophoblast differentiation via AMPK activation in the human placenta

(2020) Sascha Drewlo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effects of Irisin Compared with Exercise on Specific Metabolic and Obesity Parameters in Female Mice with Obesity

(2020) Bahar Yuksel Ozgor et al.   Metabolic Syndrome and Related Disorders

Effect of sitagliptin on expression of skeletal muscle peroxisome proliferator-activated receptor γ coactivator-1α and irisin in a rat model of type 2 diabetes mellitus

(2020) Yuntao Liu et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

Effects of whole-body cryotherapy on 25-hydroxyvitamin D, irisin, myostatin, and interleukin-6 levels in healthy young men of different fitness levels

(2020) Ewa Śliwicka et al.   Scientific Reports

Irisin inhibits osteocyte apoptosis by activating the Erk signaling pathway in vitro and attenuates ALCT-induced osteoarthritis in mice

(2020) Zihao He et al.   BONE

FNDC4, a novel adipokine that reduces lipogenesis and promotes fat browning in human visceral adipocytes

(2020) Gema Frühbeck et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin directly stimulates osteoclastogenesis and bone resorption in vitro and in vivo

(2020) Eben G Estell et al.   eLife

Exercise hormone irisin mitigates endothelial barrier dysfunction and microvascular leakage–related diseases

(2020) Jianbin Bi et al.   JCI Insight

The effects of royal jelly and tocotrienol‐rich fraction on impaired glycemic control and inflammation through irisin in obese rats

(2020) Pardis Irandoost et al.   JOURNAL OF FOOD BIOCHEMISTRY

Irisin alleviates LPS-induced liver injury and inflammation through inhibition of NLRP3 inflammasome and NF-κB signaling

(2020) Qian Li et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Dojuksan ameliorates tubulointerstitial fibrosis through irisin-mediated muscle-kidney crosstalk

(2020) Songling Jiang et al.   PHYTOMEDICINE

Effects of Interval Jump Rope Exercise Combined with Dark Chocolate Supplementation on Inflammatory Adipokine, Cytokine Concentrations, and Body Composition in Obese Adolescent Boys

(2020) Mozhgan Eskandari et al.   Nutrients

Serum Irisin Levels, Endothelial Dysfunction, and Inflammation in Pediatric Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome

(2020) Anna S. Huerta-Delgado et al.   Journal of Diabetes Research

IL-1β and TNF-α Modulation of Proliferated and Committed Myoblasts: IL-6 and COX-2-Derived Prostaglandins as Key Actors in the Mechanisms Involved

(2020) Angela M. Alvarez et al.   Cells

Integrin-Ligand Interactions in Inflammation, Cancer, and Metabolic Disease: Insights Into the Multifaceted Roles of an Emerging Ligand Irisin

(2020) Eun Jeong Park et al.   Frontiers in Cell and Developmental Biology

Discovery of the first potent and selective αvβ5 integrin inhibitor based on an amide-containing core

(2020) Rhys A. Lippa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Irisin Mediates Effects on Bone and Fat via αV Integrin Receptors

(2019) Hyeonwoo Kim et al.   CELL

NLRP3 Inflammasome Mediates White Adipose Tissue Browning After Burn

(2019) Roohi Vinaik et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Irisin pretreatment ameliorates intestinal ischemia/reperfusion injury in mice through activation of the Nrf2 pathway

(2019) Juan Du et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Irisin reverses insulin resistance in C2C12 cells via the p38-MAPK-PGC-1α pathway

(2019) Xiao Ye et al.   PEPTIDES

Superiority of the Non-Glycosylated Form Over the Glycosylated Form of Irisin in the Attenuation of Adipocytic Meta-Inflammation: A Potential Factor in the Fight Against Insulin Resistance

(2019) Mazur-Bialy   Biomolecules

Irisin alleviates pulmonary epithelial barrier dysfunction in sepsis-induced acute lung injury via activation of AMPK/SIRT1 pathways

(2019) Xinyi Li et al.   BIOMEDICINE & PHARMACOTHERAPY

Irisin reverses intestinal epithelial barrier dysfunction during intestinal injury via binding to the integrin αVβ5 receptor

(2019) Jianbin Bi et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Inflammation-induced lymphatic architecture and bone turnover changes are ameliorated by irisin treatment in chronic inflammatory bowel disease

(2018) S. Anand Narayanan et al.   FASEB JOURNAL

FNDC5 attenuates adipose tissue inflammation and insulin resistance via AMPK-mediated macrophage polarization in obesity

(2018) Xiao-Qing Xiong et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Irisin alleviates pressure overload-induced cardiac hypertrophy by inducing protective autophagy via mTOR-independent activation of the AMPK-ULK1 pathway

(2018) Ru-Li Li et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Irisin Alleviates Advanced Glycation End Products-Induced Inflammation and Endothelial Dysfunction via Inhibiting ROS-NLRP3 Inflammasome Signaling

(2017) Xian Deng et al.   INFLAMMATION

Anti-Inflammatory Properties of Irisin, Mediator of Physical Activity, Are Connected with TLR4/MyD88 Signaling Pathway Activation

(2017) Agnieszka Irena Mazur-Bialy et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Increased FNDC5/Irisin expression in human hepatocellular carcinoma

(2017) Melania Gaggini et al.   PEPTIDES

Beneficial Effect of Voluntary Exercise on Experimental Colitis in Mice Fed a High-Fat Diet: The Role of Irisin, Adiponectin and Proinflammatory Biomarkers

(2017) Agnieszka Mazur-Bialy et al.   Nutrients

The relationship between circulating irisin, retinol binding protein-4, adiponectin and inflammatory mediators in patients with metabolic syndrome

(2017) Omur Tabak et al.   Archives of Endocrinology Metabolism

Irisin exerts dual effects on browning and adipogenesis of human white adipocytes

(2016) Yuan Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Diet quality and diet patterns in relation to circulating cardiometabolic biomarkers

(2016) Byung-Joon Ko et al.   CLINICAL NUTRITION

Effects of physical exercise on myokines expression and brown adipose-like phenotype modulation in rats fed a high-fat diet

(2016) Sílvia Rocha-Rodrigues et al.   LIFE SCIENCES

Irisin Is Regulated by CAR in Liver and Is a Mediator of Hepatic Glucose and Lipid Metabolism

(2016) Li Mo et al.   MOLECULAR ENDOCRINOLOGY

Mitochondrial Dysfunction Prevents Repolarization of Inflammatory Macrophages

(2016) Jan Van den Bossche et al.   Cell Reports

Protective Effect of Irisin on Atherosclerosis via Suppressing Oxidized Low Density Lipoprotein Induced Vascular Inflammation and Endothelial Dysfunction

(2016) Yuzhu Zhang et al.   PLoS One

Skeletal muscle as an endocrine organ: PGC-1α, myokines and exercise

(2015) Svenia Schnyder et al.   BONE

Irisin inhibits hepatic gluconeogenesis and increases glycogen synthesis via the PI3K/Akt pathway in type 2 diabetic mice and hepatocytes

(2015) T.-Y. Liu et al.   CLINICAL SCIENCE

Inhibition of myostatin in mice improves insulin sensitivity via irisin-mediated cross talk between muscle and adipose tissues

(2015) J Dong et al.   INTERNATIONAL JOURNAL OF OBESITY

Association of metabolic parameters and rs726344 in FNDC5 with serum irisin concentrations

(2015) T Ebert et al.   INTERNATIONAL JOURNAL OF OBESITY

Moderate Exercise Training Attenuates the Severity of Experimental Rodent Colitis: The Importance of Crosstalk between Adipose Tissue and Skeletal Muscles

(2015) Jan Bilski et al.   MEDIATORS OF INFLAMMATION

The myokine irisin increases cortical bone mass

(2015) Graziana Colaianni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leptin administration activates irisin-induced myogenesis via nitric oxide-dependent mechanisms, but reduces its effect on subcutaneous fat browning in mice

(2014) A Rodríguez et al.   INTERNATIONAL JOURNAL OF OBESITY

Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans

(2014) J Y Huh et al.   INTERNATIONAL JOURNAL OF OBESITY

Non-muscle Mlck is required for  -catenin- and FoxO1-dependent downregulation of Cldn5 in IL-1 -mediated barrier dysfunction in brain endothelial cells

(2014) R. S. Beard et al.   JOURNAL OF CELL SCIENCE

Exercise-Induced Irisin Secretion Is Independent of Age or Fitness Level and Increased Irisin May Directly Modulate Muscle Metabolism Through AMPK Activation

(2014) Joo Young Huh et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Role of Nrf2 in Oxidative Stress and Toxicity

(2013) Qiang Ma   Annual Review of Pharmacology and Toxicology

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Serum irisin levels in new-onset type 2 diabetes

(2013) Yeon-Kyung Choi et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Irisin mRNA and circulating levels in relation to other myokines in healthy and morbidly obese humans

(2013) Maria T Vamvini et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

The Structure of Irisin Reveals a Novel Intersubunit β-Sheet Fibronectin Type III (FNIII) Dimer

(2013) Maria A. Schumacher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lower circulating irisin is associated with type 2 diabetes mellitus

(2013) Jian-Jun Liu et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Irisin in patients with nonalcoholic fatty liver disease

(2013) Stergios A. Polyzos et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

FNDC5/Irisin Is Not Only a Myokine but Also an Adipokine

(2013) Arturo Roca-Rivada et al.   PLoS One

Irisin and FNDC5 in retrospect

(2013) Harold P Erickson   Adipocyte

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

The Inflammasome and Caspase-1 Activation: A New Mechanism Underlying Increased Inflammatory Activity in Human Visceral Adipose Tissue

(2011) Tim B. Koenen et al.   ENDOCRINOLOGY

Exercise Induces a Marked Increase in Plasma Follistatin: Evidence That Follistatin Is a Contraction-Induced Hepatokine

(2010) Jakob Hansen et al.   ENDOCRINOLOGY

The Role of Exercise-Induced Myokines in Muscle Homeostasis and the Defense against Chronic Diseases

(2010) Claus Brandt et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Mechanisms of TNF-α-induced insulin resistance

(2009) G. Hotamisligil   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Synergistic chondroprotective effects of curcumin and resveratrol in human articular chondrocytes: inhibition of IL-1β-induced NF-κB-mediated inflammation and apoptosis

(2009) Constanze Csaki et al.   ARTHRITIS RESEARCH & THERAPY

Enhanced muscle by myostatin propeptide increases adipose tissue adiponectin, PPAR-α, and PPAR-γ expressions

(2008) Shana T.N. Suzuki et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Muscle as an Endocrine Organ: Focus on Muscle-Derived Interleukin-6

(2008) Bente K. Pedersen et al.   PHYSIOLOGICAL REVIEWS