The possible role of ursolic acid in Covid-19: A real game changer

PDE4 inhibition as a therapeutic strategy for improvement of pulmonary dysfunctions in Covid-19 and cigarette smoking

(2021) Claire Lugnier et al.   BIOCHEMICAL PHARMACOLOGY

The Looming Effects of Estrogen in Covid-19: A Rocky Rollout

(2021) Hayder M. Al-kuraishy et al.   Frontiers in Nutrition

A dual effect of ursolic acid to the treatment of multiple sclerosis through both immunomodulation and direct remyelination

(2020) Yuan Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In silico Molecular Docking Analysis Targeting SARS-CoV-2 Spike Protein and Selected Herbal Constituents

(2020) Anbazhagan Subbaiyan et al.   JOURNAL OF PURE AND APPLIED MICROBIOLOGY

Targeting autophagy by natural product Ursolic acid for prevention and treatment of osteoporosis

(2020) Haoyi Zheng et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Lower Circulating Interferon-Gamma Is a Risk Factor for Lung Fibrosis in COVID-19 Patients

(2020) Zhong-Jie Hu et al.   Frontiers in Immunology

Ursolic acid alleviates heat stress-induced lung injury by regulating endoplasmic reticulum stress signaling in mice

(2020) Ying Yang et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

URSOLIC ACID: A NOVEL ANTIVIRAL COMPOUND INHIBITING ROTAVIRUS INFECTION IN VITRO

(2019) M.J. Tohmé et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Ursolic Acid Protected Lung of Rats From Damage Induced by Cigarette Smoke Extract

(2019) Li Lin et al.   Frontiers in Pharmacology

Ursolic Acid Treatment Alleviates Diabetic Kidney Injury By Regulating The ARAP1/AT1R Signaling Pathway

(2019) Tiankui Ma et al.   Diabetes Metabolic Syndrome and Obesity-Targets and Therapy

Ursolic acid ameliorates oxidative stress, inflammation and fibrosis in diabetic cardiomyopathy rats

(2018) Xu-tao Wang et al.   BIOMEDICINE & PHARMACOTHERAPY

Ursolic acid derivatives for pharmaceutical use: a patent review (2012-2016)

(2017) Hidayat Hussain et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Ursolic acid inhibits breast cancer growth by inhibiting proliferation, inducing autophagy and apoptosis, and suppressing inflammatory responses via the PI3K/AKT and NF-κB signaling pathways in vitro

(2017) Juan Luo et al.   Experimental and Therapeutic Medicine

Ursolic Acid Induces Apoptosis of Prostate Cancer Cells via the PI3K/Akt/mTOR Pathway

(2015) Yan Meng et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

The mechanism of action of ursolic acid as insulin secretagogue and insulinomimetic is mediated by cross-talk between calcium and kinases to regulate glucose balance

(2015) Allisson Jhonatan Gomes Castro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Effects of UGT1A4 genetic polymorphisms on serum lamotrigine concentrations in Chinese children with epilepsy

(2015) Qiuning Wang et al.   Drug Metabolism and Pharmacokinetics

Structure–activity relationships of 3-O-β-chacotriosyl ursolic acid derivatives as novel H5N1 entry inhibitors

(2015) Gaopeng Song et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation

(2014) Seung-ye Baek et al.   ACTA PHARMACOLOGICA SINICA

Ursolic acid protects mouse liver against CCl4-induced oxidative stress and inflammation by the MAPK/NF-κB pathway

(2014) Jie-Qiong Ma et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

The influence of herbal medicine ursolic acid on the uptake of rosuvastatin mediated by OATP1B1*1a and *5

(2014) Wen Jin Hua et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Ursolic acid inhibits nuclear factor-κB signaling in intestinal epithelial cells and macrophages, and attenuates experimental colitis in mice

(2014) Jaeyoung Chun et al.   LIFE SCIENCES

Inhibition of HepG2 cell proliferation by ursolic acid and polysaccharides via the downregulation of cyclooxygenase-2

(2014) LING LIU et al.   Molecular Medicine Reports

Ursolic Acid Increases Glucose Uptake through the PI3K Signaling Pathway in Adipocytes

(2014) Yonghan He et al.   PLoS One

Oleanolic acid and ursolic acid: Novel hepatitis C virus antivirals that inhibit NS5B activity

(2013) Lingbao Kong et al.   ANTIVIRAL RESEARCH

Ursolic Acid Provides Kidney Protection in Diabetic Rats

(2013) Chen Ling et al.   CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL

Ursolic acid inhibits colorectal cancer angiogenesis through suppression of multiple signaling pathways

(2013) JIUMAO LIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Evaluation of toxicity and single-dose pharmacokinetics of intravenous ursolic acid liposomes in healthy adult volunteers and patients with advanced solid tumors

(2012) Xian-Huo Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

Thein vitrostudy of ursolic acid and oleanolic acid inhibiting cariogenic microorganisms as well as biofilm

(2012) L Zhou et al.   ORAL DISEASES

Ursolic Acid Increases Skeletal Muscle and Brown Fat and Decreases Diet-Induced Obesity, Glucose Intolerance and Fatty Liver Disease

(2012) Steven D. Kunkel et al.   PLoS One

Anti-herpes virus activities of bioactive fraction and isolated pure constituent of Mallotus peltatus: an ethnomedicine from Andaman Islands

(2012) Paromita Bag et al.   Virology Journal

Ursolic acid causes DNA-damage, P53-mediated, mitochondria- and caspase-dependent human endothelial cell apoptosis, and accelerates atherosclerotic plaque formation in vivo

(2011) Barbara Messner et al.   ATHEROSCLEROSIS

Uncoupling and Antioxidant Effects of Ursolic Acid in Isolated Rat Heart Mitochondria

(2011) Julius Liobikas et al.   JOURNAL OF NATURAL PRODUCTS

Ursolic acid attenuates lipopolysaccharide-induced cognitive deficits in mouse brain through suppressing p38/NF-κB mediated inflammatory pathways

(2011) Yong-Jian Wang et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Betulin and ursolic acid synthetic derivatives as inhibitors of Papilloma virus

(2010) Oxana B. Kazakova et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Developments towards antiviral therapies against enterovirus 71

(2010) Kan X. Wu et al.   DRUG DISCOVERY TODAY

Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition

(2008) Simone C.B. Gnoatto et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY