Protective effects of luteolin against amyloid beta-induced oxidative stress and mitochondrial impairments through peroxisome proliferator-activated receptor γ-dependent mechanism in Alzheimer's disease

Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated mitochondrial oxidative stress

(2023) Jikai Zhao et al.   Redox Biology

The multifaceted roles of mitochondria

(2023) Thomas J. Pucadyil et al.   MOLECULAR CELL

Myricetin Restores Aβ-Induced Mitochondrial Impairments in N2a-SW Cells

(2022) Xuanbao Yao et al.   ACS Chemical Neuroscience

Reducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription

(2022) De‐Juan Yuan et al.   AGING CELL

Obesity alters pathology and treatment response in inflammatory disease

(2022) Sagar P. Bapat et al.   NATURE

Esculentoside A alleviates cognitive deficits and amyloid pathology through peroxisome proliferator-activated receptor γ-dependent mechanism in an Alzheimer's disease model

(2022) Zhijun He et al.   PHYTOMEDICINE

USP22 regulates lipidome accumulation by stabilizing PPARγ in hepatocellular carcinoma

(2022) Zhen Ning et al.   Nature Communications

Endogenous and Exogenous Estrogen Exposures: How Women’s Reproductive Health Can Drive Brain Aging and Inform Alzheimer’s Prevention

(2022) Steven Jett et al.   Frontiers in Aging Neuroscience

Targeted BACE-1 inhibition in microglia enhances amyloid clearance and improved cognitive performance

(2022) Neeraj Singh et al.   Science Advances

Increasing brain glucose metabolism by ligustrazine piperazine ameliorates cognitive deficits through PPARγ-dependent enhancement of mitophagy in APP/PS1 mice

(2022) Zongyang Li et al.   Alzheimers Research & Therapy

The mechanisms of ferroptosis and its role in alzheimer’s disease

(2022) Hongyue Ma et al.   Frontiers in Molecular Biosciences

The protective effects of Esculentoside A through AMPK in the triple transgenic mouse model of Alzheimer's disease

(2022) Zhijun He et al.   PHYTOMEDICINE

Aducanumab and the FDA — where are we now?

(2021) Howard Fillit et al.   Nature Reviews Neurology

Luteolin alleviates cognitive impairment in Alzheimer’s disease mouse model via inhibiting endoplasmic reticulum stress-dependent neuroinflammation

(2021) Jie-jian Kou et al.   ACTA PHARMACOLOGICA SINICA

The PPARγ-dependent effect of flavonoid luteolin against damage induced by the chemotherapeutic irinotecan in human intestinal cells

(2021) Thaise Boeing et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Aduhelm: The Best Hope for Alzheimer’s Disease Patients or the Worst Decision the FDA Has Ever Made?

(2021) Markku Kurkinen et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotection of retinal cells by Caffeic Acid Phenylethyl Ester（CAPE) is mediated by mitochondrial uncoupling protein UCP2

(2021) Mingliang Zhang et al.   NEUROCHEMISTRY INTERNATIONAL

Amyloid-Related Imaging Abnormalities in 2 Phase 3 Studies Evaluating Aducanumab in Patients With Early Alzheimer Disease

(2021) Stephen Salloway et al.   JAMA Neurology

Neuronal mitochondria-targeted micelles relieving oxidative stress for delayed progression of Alzheimer's disease

(2020) Peng Yang et al.   BIOMATERIALS

The Role of Reactive Oxygen Species in the Life Cycle of the Mitochondrion

(2020) Paola Venditti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances

(2020) Wenzhang Wang et al.   Molecular Neurodegeneration

The Protective Effect of Vanadium on Cognitive Impairment and the Neuropathology of Alzheimer’s Disease in APPSwe/PS1dE9 Mice

(2020) Zhijun He et al.   Frontiers in Molecular Neuroscience

Neuroprotective effects of flavone luteolin in neuroinflammation and neurotrauma

(2020) Duraisamy Kempuraj et al.   BIOFACTORS

PPARγ/PGC1α signaling as a potential therapeutic target for mitochondrial biogenesis in neurodegenerative disorders

(2020) Sumit Jamwal et al.   PHARMACOLOGY & THERAPEUTICS

Blood-brain barrier–penetrating siRNA nanomedicine for Alzheimer’s disease therapy

(2020) Yutong Zhou et al.   Science Advances

Therapeutic potential of targeting mitochondrial dynamics in cancer

(2020) Tiago Rodrigues et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Red Ginseng Attenuates Aβ-Induced Mitochondrial Dysfunction and Aβ-mediated Pathology in an Animal Model of Alzheimer’s Disease

(2019) Soo Jung Shin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer’s models

(2019) Gahee Bahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ghrelin attenuates oxidative stress and neuronal apoptosis via GHSR-1α/AMPK/Sirt1/PGC-1α/UCP2 pathway in a rat model of neonatal HIE

(2019) Juan Huang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Perspectives on Oxidative Stress in Alzheimer’s Disease and Predictions of Future Research Emphases

(2018) D. Allan Butterfield   JOURNAL OF ALZHEIMERS DISEASE

Walnut Supplementation in the Diet Reduces Oxidative Damage and Improves Antioxidant Status in Transgenic Mouse Model of Alzheimer’s Disease

(2018) Mirazkar D. Pandareesh et al.   JOURNAL OF ALZHEIMERS DISEASE

Transitional correlation between inner-membrane potential and ATP levels of neuronal mitochondria

(2018) R. Suzuki et al.   Scientific Reports

Peroxisome Proliferator-Activated Receptor γ2 Controls the Rate of Adipose Tissue Lipid Storage and Determines Metabolic Flexibility

(2018) Sam Virtue et al.   Cell Reports

Sodium selenate activated Wnt/β-catenin signaling and repressed amyloid-β formation in a triple transgenic mouse model of Alzheimer's disease

(2017) Na Jin et al.   EXPERIMENTAL NEUROLOGY

Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer’s disease

(2017) Ramesh Kandimalla et al.   HUMAN MOLECULAR GENETICS

Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition, and Cognitive Impairment in an Alzheimer's Disease Model

(2017) Seung Hyun Baek et al.   JOURNAL OF NEUROSCIENCE

Glia Maturation Factor and Mitochondrial Uncoupling Proteins 2 and 4 Expression in the Temporal Cortex of Alzheimer’s Disease Brain

(2017) Ramasamy Thangavel et al.   Frontiers in Aging Neuroscience

Icariside II Effectively Reduces Spatial Learning and Memory Impairments in Alzheimer’s Disease Model Mice Targeting Beta-Amyloid Production

(2017) Lingli Yan et al.   Frontiers in Pharmacology

Olfactory Ensheathing Cell-Conditioned Medium Reverts Aβ25–35-Induced Oxidative Damage in SH-SY5Y Cells by Modulating the Mitochondria-Mediated Apoptotic Pathway

(2016) Qing-Qing Fu et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Drug treatments in Alzheimers disease

(2016) R. Briggs et al.   CLINICAL MEDICINE

Non-Pharmacological Approaches to the Prevention and Treatment of Alzheimer's Disease with Respect to the Rising Treatment Costs

(2016) Blanka Klimova et al.   Current Alzheimer Research

Ginsenoside Re reduces Aβ production by activating PPARγ to inhibit BACE1 in N2a/APP695 cells

(2016) Guoqiong Cao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease

(2015) Linjie Yu et al.   LIFE SCIENCES

Tripchlorolide Attenuates β-amyloid Generation via Suppressing PPARγ-Regulated BACE1 Activity in N2a/APP695 Cells

(2015) Nan Lin et al.   MOLECULAR NEUROBIOLOGY

Implications of mitochondrial dynamics on neurodegeneration and on hypothalamic dysfunction

(2015) Antonio Zorzano et al.   Frontiers in Aging Neuroscience

Low-dose diet supplement of a natural flavonoid, luteolin, ameliorates diet-induced obesity and insulin resistance in mice

(2014) Na Xu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mitochondrial quality control and communications with the nucleus are important in maintaining mitochondrial function and cell health

(2013) Vassilios N. Kotiadis et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Peroxisome Proliferator-Activated Receptor (PPAR) γ and PPARα Agonists Modulate Mitochondrial Fusion-Fission Dynamics: Relevance to Reactive Oxygen Species (ROS)-Related Neurodegenerative Disorders?

(2013) Juan M. Zolezzi et al.   PLoS One

Conformational states and recognition of amyloidogenic peptides of human insulin-degrading enzyme

(2013) Lauren A. McCord et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Why size matters – balancing mitochondrial dynamics in Alzheimer's disease

(2013) Brian DuBoff et al.   TRENDS IN NEUROSCIENCES

From Mitochondrial Dysfunction to Amyloid Beta Formation: Novel Insights into the Pathogenesis of Alzheimer’s Disease

(2012) Kristina Leuner et al.   MOLECULAR NEUROBIOLOGY

Mitochondrial Fission, Fusion, and Stress

(2012) R. J. Youle et al.   SCIENCE

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

(2011) Ming-Chang Chiang et al.   NEUROBIOLOGY OF DISEASE

Luteolin from Purple Perilla mitigates ROS insult particularly in primary neurons

(2010) Gang Zhao et al.   NEUROBIOLOGY OF AGING