Penetrating Ballistic-Like Brain Injury Leads to MicroRNA Dysregulation, BACE1 Upregulation, and Amyloid Precursor Protein Loss in Lesioned Rat Brain Tissues

Penetrating Traumatic Brain Injury Triggers Subacute Dysregulation of Cathepsin B Protein Levels Independently of Cysteine Protease Activity in Brain and Cerebral Spinal Fluid

(2020) Angela Boutte et al.   JOURNAL OF NEUROTRAUMA

CHIMERA repetitive mild traumatic brain injury induces chronic behavioural and neuropathological phenotypes in wild-type and APP/PS1 mice

(2019) Wai Hang Cheng et al.   Alzheimers Research & Therapy

The Impact of Traumatic Brain Injury on Amyotrophic Lateral Sclerosis - From Bedside to Bench

(2019) Colin Klaus Franz et al.   JOURNAL OF NEUROPHYSIOLOGY

Brain-related proteins as serum biomarkers of acute, subconcussive blast overpressure exposure: A cohort study of military personnel

(2019) Angela M. Boutté et al.   PLoS One

Loss of amyloid precursor protein exacerbates early inflammation in Niemann-Pick disease type C

(2019) Samuel D. Shin et al.   Journal of Neuroinflammation

Increased miR-21-3p in injured brain microvascular endothelial cells following traumatic brain injury aggravates blood-brain barrier damage by promoting cellular apoptosis and inflammation through targeting MAT2B

(2018) Xintong Ge et al.   JOURNAL OF NEUROTRAUMA

Microglial Inflammasome Activation in Penetrating Ballistic-Like Brain Injury

(2018) Stephanie W. Lee et al.   JOURNAL OF NEUROTRAUMA

Mild TBI and risk of Parkinson disease

(2018) Raquel C. Gardner et al.   NEUROLOGY

Cerebrospinal Fluid Biomarkers Are Associated With Glial Fibrillary Acidic Protein and αII-spectrin Breakdown Products in Brain Tissues Following Penetrating Ballistic-Like Brain Injury in Rats

(2018) Kristen E. DeDominicis et al.   Frontiers in Neurology

Traumatic Brain Injury and Risk of Suicide

(2018) Lee Goldstein et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Rodent models for Alzheimer disease

(2018) Jürgen Götz et al.   NATURE REVIEWS NEUROSCIENCE

Differentially expressed microRNAs in experimental cerebral malaria and their involvement in endocytosis, adherens junctions, FoxO and TGF-β signalling pathways

(2018) Aarón Martin-Alonso et al.   Scientific Reports

The Interplay of MicroRNAs in the Inflammatory Mechanisms Following Ischemic Stroke

(2017) Seyed Esmaeil Khoshnam et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Striatal Mitochondrial Disruption following Severe Traumatic Brain Injury

(2017) Jennifer L. Harmon et al.   JOURNAL OF NEUROTRAUMA

Alterations in brain-derived neurotrophic factor and insulin-like growth factor-1 protein levels after penetrating ballistic-like brain injury in rats

(2017) Sindhu K. Madathil et al.   Journal of Trauma and Acute Care Surgery

Acute and subacute microRNA dysregulation is associated with cytokine responses in the rodent model of penetrating ballistic-like brain injury

(2017) David Johnson et al.   Journal of Trauma and Acute Care Surgery

Amyloid-β plaques enhance Alzheimer's brain tau-seeded pathologies by facilitating neuritic plaque tau aggregation

(2017) Zhuohao He et al.   NATURE MEDICINE

Alterations in brain-derived neurotrophic factor and insulin-like growth factor-1 protein levels after penetrating ballistic-like brain injury in rats

(2017) Sindhu K. Madathil et al.   Journal of Trauma and Acute Care Surgery

Acute and subacute microRNA dysregulation is associated with cytokine responses in the rodent model of penetrating ballistic-like brain injury

(2017) David Johnson et al.   Journal of Trauma and Acute Care Surgery

Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury

(2017) Deborah Kennedy Boone et al.   Scientific Reports

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy

(2016) Stefania Mondello et al.   JOURNAL OF NEUROTRAUMA

Serum Glial Fibrillary Acidic Protein Predicts Tissue Glial Fibrillary Acidic Protein Break-Down Products and Therapeutic Efficacy after Penetrating Ballistic-Like Brain Injury

(2016) Angela M. Boutté et al.   JOURNAL OF NEUROTRAUMA

Simvastatin Treatment in Traumatic Brain Injury: Operation Brain Trauma Therapy

(2016) Andrea Mountney et al.   JOURNAL OF NEUROTRAUMA

MicroRNA-27a Promotes Inefficient Lysosomal Clearance in the Hippocampi of Rats Following Chronic Brain Hypoperfusion

(2016) Hui Che et al.   MOLECULAR NEUROBIOLOGY

Subacute Changes in Cleavage Processing of Amyloid Precursor Protein and Tau following Penetrating Traumatic Brain Injury

(2016) Casandra M. Cartagena et al.   PLoS One

Comprehensive Evaluation of Neuroprotection Achieved by Extended Selective Brain Cooling Therapy in a Rat Model of Penetrating Ballistic-Like Brain Injury

(2016) Xi-Chun May Lu et al.   Therapeutic Hypothermia and Temperature Management

miR-21 alleviates secondary blood–brain barrier damage after traumatic brain injury in rats

(2015) Xintong Ge et al.   BRAIN RESEARCH

Mitochondria-associated microRNAs in rat hippocampus following traumatic brain injury

(2015) Wang-Xia Wang et al.   EXPERIMENTAL NEUROLOGY

Glucose and Oxygen Metabolism after Penetrating Ballistic-Like Brain Injury

(2015) Shyam Gajavelli et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Epidemiology of Adults Receiving Acute Inpatient Rehabilitation for a Primary Diagnosis of Traumatic Brain Injury in the United States

(2015) Jeffrey P. Cuthbert et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Axonal and Schwann Cell BACE1 Is Equally Required for Remyelination of Peripheral Nerves

(2015) X. Hu et al.   JOURNAL OF NEUROSCIENCE

Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing

(2015) Emily D. Niederst et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular genetic mechanisms of allelic specific regulation of murine Comt expression

(2015) Samantha K. Segall et al.   PAIN

A comparative analysis of high-throughput platforms for validation of a circulating microRNA signature in diabetic retinopathy

(2015) Ryan J. Farr et al.   Scientific Reports

miR-21 alleviated apoptosis of cortical neurons through promoting PTEN-Akt signaling pathway in vitro after experimental traumatic brain injury

(2014) Zhaoli Han et al.   BRAIN RESEARCH

MicroRNA-135a and -200b, potential Biomarkers for Alzheimer׳s disease, regulate β secretase and amyloid precursor protein

(2014) Chen-geng Liu et al.   BRAIN RESEARCH

Differential Release of  -Amyloid from Dendrite- Versus Axon-Targeted APP

(2014) S. R. DeBoer et al.   JOURNAL OF NEUROSCIENCE

Evaluation of quantitative miRNA expression platforms in the microRNA quality control (miRQC) study

(2014) Pieter Mestdagh et al.   NATURE METHODS

β-amyloid Peptides and Amyloid Plaques in Alzheimer’s Disease

(2014) Gunnar K. Gouras et al.   Neurotherapeutics

Traumatic Brain Injury Dysregulates MicroRNAs to Modulate Cell Signaling in Rat Hippocampus

(2014) Liang Liu et al.   PLoS One

miR-21 improves the neurological outcome after traumatic brain injury in rats

(2014) Xin-Tong Ge et al.   Scientific Reports

MicroRNA overexpression increases cortical neuronal vulnerability to injury

(2013) Jessie S. Truettner et al.   BRAIN RESEARCH

Military Risk Factors for Cognitive Decline, Dementia and Alzheimer’s Disease

(2013) Dallas Veitch et al.   Current Alzheimer Research

Correlations between Blood–Brain Barrier Disruption and Neuroinflammation in an Experimental Model of Penetrating Ballistic-Like Brain Injury

(2013) Tracy L. Cunningham et al.   JOURNAL OF NEUROTRAUMA

MiR-335 Inhibits Small Cell Lung Cancer Bone Metastases via IGF-IR and RANKL Pathways

(2013) Meng Gong et al.   MOLECULAR CANCER RESEARCH

MicroRNAs in the Brain: It's Regulatory Role in Neuroinflammation

(2013) Menaka C. Thounaojam et al.   MOLECULAR NEUROBIOLOGY

The Response of Cerebral Cortex to Haemorrhagic Damage: Experimental Evidence from a Penetrating Injury Model

(2013) Sivaraman Purushothuman et al.   PLoS One

Astrocyte-Specific Overexpression of Insulin-Like Growth Factor-1 Protects Hippocampal Neurons and Reduces Behavioral Deficits following Traumatic Brain Injury in Mice

(2013) Sindhu K. Madathil et al.   PLoS One

Total Protein Analysis as a Reliable Loading Control for Quantitative Fluorescent Western Blotting

(2013) Samantha L. Eaton et al.   PLoS One

The involvement of microRNAs in neurodegenerative diseases

(2013) Simona Maciotta et al.   Frontiers in Cellular Neuroscience

A clinical comparison of penetrating and blunt traumatic brain injuries

(2012) Luis A. Santiago et al.   BRAIN INJURY

β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects

(2012) Brian Hitt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Changes in Apoptotic Mechanisms Following Penetrating Ballistic-Like Brain Injury

(2012) Casandra M. Cartagena et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Lithium Reduces BACE1 Overexpression, Beta Amyloid Accumulation, and Spatial Learning Deficits in Mice with Traumatic Brain Injury

(2012) Fengshan Yu et al.   JOURNAL OF NEUROTRAUMA

miR-29c regulates BACE1 protein expression

(2011) Yuanyuan Zong et al.   BRAIN RESEARCH

MicroRNA networks surrounding APP and amyloid-β metabolism — Implications for Alzheimer's disease

(2011) Nicole Schonrock et al.   EXPERIMENTAL NEUROLOGY

Controlled Cortical Impact Traumatic Brain Injury in 3xTg-AD Mice Causes Acute Intra-Axonal Amyloid-  Accumulation and Independently Accelerates the Development of Tau Abnormalities

(2011) H. T. Tran et al.   JOURNAL OF NEUROSCIENCE

APP processing in Alzheimer's disease

(2011) Yun-wu Zhang et al.   Molecular Brain

Regulation of mRNA Translation and Stability by microRNAs

(2010) Marc Robert Fabian et al.   Annual Review of Biochemistry

Concomitant detection of β-amyloid peptides with N-terminal truncation and different C-terminal endings in cortical plaques from cases with Alzheimer's disease, senile monkeys and triple transgenic mice

(2010) Wolfgang Härtig et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Altered expression of miRNA-21 and its targets in the hippocampus after traumatic brain injury

(2010) John B. Redell et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3

(2010) M. Shioya et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Microarray based analysis of microRNA expression in rat cerebral cortex after traumatic brain injury

(2009) Ping Lei et al.   BRAIN RESEARCH

The Cleavage Products of Amyloid-  Precursor Protein Are Sorted to Distinct Carrier Vesicles That Are Independently Transported within Neurites

(2009) V. Muresan et al.   JOURNAL OF NEUROSCIENCE

αII-Spectrin Breakdown Product Cerebrospinal Fluid Exposure Metrics Suggest Differences in Cellular Injury Mechanisms after Severe Traumatic Brain Injury

(2009) Gretchen M. Brophy et al.   JOURNAL OF NEUROTRAUMA

Understanding microRNAs in neurodegeneration

(2009) Stephen M. Eacker et al.   NATURE REVIEWS NEUROSCIENCE

An Overview of APP Processing Enzymes and Products

(2009) Vivian W. Chow et al.   NEUROMOLECULAR MEDICINE

Neuroprotective profile of dextromethorphan in an experimental model of penetrating ballistic-like brain injury

(2009) Deborah A. Shear et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Identification of β-Secretase (BACE1) Substrates Using Quantitative Proteomics

(2009) Matthew L. Hemming et al.   PLoS One

A novel and universal method for microRNA RT-qPCR data normalization

(2009) Pieter Mestdagh et al.   GENOME BIOLOGY

Provider Perspectives on Rehabilitation of Patients With Polytrauma

(2008) Greta Friedemann-Sánchez et al.   ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION

MicroRNAs (miRNAs) in Neurodegenerative Diseases

(2008) Peter T. Nelson et al.   BRAIN PATHOLOGY

MicroRNA-298 and MicroRNA-328 Regulate Expression of Mouse β-Amyloid Precursor Protein-converting Enzyme 1

(2008) Vincent Boissonneault et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Role of Amyloid Precursor Protein Processing by BACE1, the β-Secretase, in Alzheimer Disease Pathophysiology

(2008) Sarah L. Cole et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Amyloid-β Rise and γ-Secretase Inhibitor Potency Depend on the Level of Substrate Expression

(2008) Catherine R. Burton et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

miR-21: a small multi-faceted RNA

(2008) Anna M. Krichevsky et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Overexpression of ABCA1 reduces amyloid deposition in the PDAPP mouse model of Alzheimer disease

(2008) Suzanne E. Wahrle et al.   JOURNAL OF CLINICAL INVESTIGATION

Prevalence of Long-Term Disability From Traumatic Brain Injury in the Civilian Population of the United States, 2005

(2008) Eduard Zaloshnja et al.   JOURNAL OF HEAD TRAUMA REHABILITATION

Loss of microRNA cluster miR-29a/b-1 in sporadic Alzheimer's disease correlates with increased BACE1/ -secretase expression

(2008) S. S. Hebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alteration of BACE1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE1-null mice

(2008) A. V. Savonenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA