Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease
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Title
Nutraceutical based SIRT3 activators as therapeutic targets in Alzheimer's disease
Authors
Keywords
Alzheimer's disease, SIRT3, Polyphenols, Mitochondria, Beta-amyloid, Oxidative stress
Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 144, Issue -, Pages 104958
Publisher
Elsevier BV
Online
2021-01-13
DOI
10.1016/j.neuint.2021.104958
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Note: Only part of the references are listed.- Mitochondrial Functions in Infection and Immunity
- (2020) Varnesh Tiku et al. TRENDS IN CELL BIOLOGY
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- Magnolol alleviates Alzheimer's disease-like pathology in transgenic C. elegans by promoting microglia phagocytosis and the degradation of beta-amyloid through activation of PPAR-γ
- (2020) Zhishen Xie et al. BIOMEDICINE & PHARMACOTHERAPY
- Mitochondria dysfunction in the pathogenesis of Alzheimer’s disease: recent advances
- (2020) Wenzhang Wang et al. Molecular Neurodegeneration
- Trilobatin Protects Against Aβ25–35-Induced Hippocampal HT22 Cells Apoptosis Through Mediating ROS/p38/Caspase 3-Dependent Pathway
- (2020) Nana Chen et al. Frontiers in Pharmacology
- Protective Effects of Polydatin Against Dementia-Related Disorders
- (2020) Kim San Tang Current Neuropharmacology
- Trilobatin ameliorates insulin resistance through IRS-AKT-GLUT4 signaling pathway in C2C12 myotubes and ob/ob mice
- (2020) Min Liu et al. Chinese Medicine
- Quantitative profiling brain proteomes revealed mitochondrial dysfunction in Alzheimer’s disease
- (2019) Sunil S Adav et al. Molecular Brain
- Honokiol-Mediated Mitophagy Ameliorates Postoperative Cognitive Impairment Induced by Surgery/Sevoflurane via Inhibiting the Activation of NLRP3 Inflammasome in the Hippocampus
- (2019) Ji-Shi Ye et al. Oxidative Medicine and Cellular Longevity
- Oxidative Stress: A Key Modulator in Neurodegenerative Diseases
- (2019) Anju Singh et al. MOLECULES
- The neuropathological diagnosis of Alzheimer’s disease
- (2019) Michael A. DeTure et al. Molecular Neurodegeneration
- Dihydromyricetin attenuates inflammation through TLR4/NF-kappaB pathway
- (2019) Nianshui Jing et al. Open Medicine
- Melatonin ameliorates cerebral ischemia/reperfusion injury through SIRT3 activation
- (2019) Lili Liu et al. LIFE SCIENCES
- Honokiol Alleviates Oxidative Stress-Induced Neurotoxicity via Activation of Nrf2
- (2018) Yanan Hou et al. ACS Chemical Neuroscience
- Metformin regulates mitochondrial biogenesis and senescence through AMPK mediated H3K79 methylation: Relevance in age-associated vascular dysfunction
- (2018) Santosh Karnewar et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Dihydromyricetin inhibits microglial activation and neuroinflammation by suppressing NLRP3 inflammasome activation in APP/PS1 transgenic mice
- (2018) Jie Feng et al. CNS Neuroscience & Therapeutics
- Role of D-galactose-induced brain aging and its potential used for therapeutic interventions
- (2018) Thazin Shwe et al. EXPERIMENTAL GERONTOLOGY
- Trilobatin as an HIV-1 entry inhibitor targeting the HIV-1 Gp41 envelope
- (2018) Shuwen Yin et al. FEBS LETTERS
- Honokiol Alleviates Cognitive Deficits of Alzheimer’s Disease (PS1V97L) Transgenic Mice by Activating Mitochondrial SIRT3
- (2018) Haitao Li et al. JOURNAL OF ALZHEIMERS DISEASE
- Plasma vascular non-inflammatory molecule 3 is associated with gastrointestinal acute graft-versus-host disease in mice
- (2018) Na Wang et al. Journal of Inflammation-London
- Adjudin attenuates cerebral edema and improves neurological function in mice with experimental traumatic brain injury
- (2018) Ying-liang Liu et al. JOURNAL OF NEUROTRAUMA
- Honokiol ameliorates cognitive impairment by attenuating amyloidosis and neuroinflammation in a transgenic mouse model of Alzheimer's disease
- (2018) DONGMEI WANG et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Salidroside attenuates endothelial cellular senescence via decreasing the expression of inflammatory cytokines and increasing the expression of SIRT3
- (2018) Sha-Sha Xing et al. MECHANISMS OF AGEING AND DEVELOPMENT
- Trans ε -viniferin is an amyloid-β disaggregating and anti-inflammatory drug in a mouse primary cellular model of Alzheimer's disease
- (2018) Elodie Vion et al. MOLECULAR AND CELLULAR NEUROSCIENCE
- Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury
- (2018) Xin Xu et al. NEUROBIOLOGY OF DISEASE
- SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway
- (2018) Sindhu Ramesh et al. PLoS One
- Brain Energy and Oxygen Metabolism: Emerging Role in Normal Function and Disease
- (2018) Michelle E. Watts et al. Frontiers in Molecular Neuroscience
- 4-O-Methylhonokiol Attenuated Memory Impairment Through Modulation of Oxidative Damage of Enzymes Involving Amyloid-β Generation and Accumulation in a Mouse Model of Alzheimer's Disease
- (2018) Im Seop Choi et al. JOURNAL OF ALZHEIMERS DISEASE
- Abnormal Hyperphosphorylation of Tau: Sites, Regulation, and Molecular Mechanism of Neurofibrillary Degeneration
- (2018) Jian-Zhi Wang et al. JOURNAL OF ALZHEIMERS DISEASE
- Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes
- (2018) Uta Rickert et al. JOURNAL OF NEUROIMMUNOLOGY
- Protective role of Dihydromyricetin in Alzheimer’s disease rat model associated with activating AMPK/SIRT1 signaling pathway
- (2018) Ping Sun et al. BIOSCIENCE REPORTS
- A small molecule activator of SIRT3 promotes deacetylation and activation of manganese superoxide dismutase
- (2017) Jiaqi Lu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Oxidative Stress, Synaptic Dysfunction, and Alzheimer’s Disease
- (2017) Eric Tönnies et al. JOURNAL OF ALZHEIMERS DISEASE
- Correction for Papa and Germain, “SirT3 Regulates a Novel Arm of the Mitochondrial Unfolded Protein Response”
- (2017) Luena Papa et al. MOLECULAR AND CELLULAR BIOLOGY
- The Alzheimer's Disease Mitochondrial Cascade Hypothesis
- (2017) Russell H. Swerdlow et al. JOURNAL OF ALZHEIMERS DISEASE
- PI3K/AKT signaling mediated by G protein-coupled receptors is involved in neurodegenerative Parkinson's disease (Review)
- (2016) Noriko Nakano et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Microbes and Alzheimer’s Disease
- (2016) Ruth F. Itzhaki et al. JOURNAL OF ALZHEIMERS DISEASE
- Dihydromyricetin Ameliorates 3NP-induced Behavioral Deficits and Striatal Injury in Rats
- (2016) Shuhua Mu et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Salidroside suppresses inflammation in a D-galactose-induced rat model of Alzheimer’s disease via SIRT1/NF-κB pathway
- (2016) Jin Gao et al. METABOLIC BRAIN DISEASE
- Dihydromyricetin suppresses TNF-α-induced NF-κB activation and target gene expression
- (2016) Nina Tang et al. MOLECULAR AND CELLULAR BIOCHEMISTRY
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- (2016) Xican Li et al. MOLECULES
- Neuroprotective effects of honokiol against beta-amyloid-induced neurotoxicity via GSK-3β and β-catenin signaling pathway in PC12 cells
- (2016) Yan-Fang Xian et al. NEUROCHEMISTRY INTERNATIONAL
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- (2016) Xianjuan Kou et al. Oncotarget
- Leaf Extract from Lithocarpus polystachyus Rehd. Promote Glycogen Synthesis in T2DM Mice
- (2016) Jinfei Wang et al. PLoS One
- Amyloid β oligomers in Alzheimer’s disease pathogenesis, treatment, and diagnosis
- (2015) Kirsten L. Viola et al. ACTA NEUROPATHOLOGICA
- Silibinin suppresses astroglial activation in a mouse model of acute Parkinson׳s disease by modulating the ERK and JNK signaling pathways
- (2015) Yujeong Lee et al. BRAIN RESEARCH
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- (2015) Yan-Fang Xian et al. EUROPEAN JOURNAL OF PHARMACOLOGY
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- (2015) X. L. Hou et al. JOURNAL OF NATURAL PRODUCTS
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- (2015) Peng Liu et al. MOLECULAR NEUROBIOLOGY
- Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: A randomized controlled trial
- (2015) Shihui Chen et al. PHARMACOLOGICAL RESEARCH
- Extract of Caragana sinica as a potential therapeutic option for increasing alpha-secretase gene expression
- (2015) Florian Schuck et al. PHYTOMEDICINE
- Soluble amyloid-β oligomers as synaptotoxins leading to cognitive impairment in Alzheimer’s disease
- (2015) Sergio T. Ferreira et al. Frontiers in Cellular Neuroscience
- Dihydromyricetin ameliorates the oxidative stress response induced by methylglyoxal via the AMPK/GLUT4 signaling pathway in PC12 cells
- (2014) Baoping Jiang et al. BRAIN RESEARCH BULLETIN
- A study on the association between infectious burden and Alzheimer's disease
- (2014) X.-L. Bu et al. EUROPEAN JOURNAL OF NEUROLOGY
- Honokiol abrogates lipopolysaccharide-induced depressive like behavior by impeding neuroinflammation and oxido-nitrosative stress in mice
- (2014) Kunjbihari Sulakhiya et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Adjudin protects against cerebral ischemia reperfusion injury by inhibition of neuroinflammation and blood-brain barrier disruption
- (2014) Tengyuan Liu et al. Journal of Neuroinflammation
- Beneficial synergistic effects of microdose lithium with pyrroloquinoline quinone in an Alzheimer's disease mouse model
- (2014) Lei Zhao et al. NEUROBIOLOGY OF AGING
- Dihydromyricetin Ameliorates Behavioral Deficits and Reverses Neuropathology of Transgenic Mouse Models of Alzheimer’s Disease
- (2014) Jing Liang et al. NEUROCHEMICAL RESEARCH
- Herpes simplex virus type 1 and Alzheimer’s disease: increasing evidence for a major role of the virus
- (2014) Ruth F. Itzhaki Frontiers in Aging Neuroscience
- 3D NMR structure of a complex between the amyloid beta peptide (1–40) and the polyphenol ε-viniferin glucoside: Implications in Alzheimer's disease
- (2013) Tristan Richard et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Honokiol Inhibits Tumor Necrosis Factor-α-Stimulated Rat Aortic Smooth Muscle Cell Proliferation via Caspase- and Mitochondrial-Dependent Apoptosis
- (2013) Shuli Fan et al. INFLAMMATION
- Magnolia polyphenols attenuate oxidative and inflammatory responses in neurons and microglial cells
- (2013) Dennis Y Chuang et al. Journal of Neuroinflammation
- SIRT3 Deacetylates and Activates OPA1 To Regulate Mitochondrial Dynamics during Stress
- (2013) Sadhana A. Samant et al. MOLECULAR AND CELLULAR BIOLOGY
- Pyrroloquinoline Quinine Protects Rat Brain Cortex Against Acute Glutamate-Induced Neurotoxicity
- (2013) Qi Zhang et al. NEUROCHEMICAL RESEARCH
- Glucose Levels and Risk of Dementia
- (2013) Paul K. Crane et al. NEW ENGLAND JOURNAL OF MEDICINE
- Presenilins and -Secretase: Structure, Function, and Role in Alzheimer Disease
- (2013) B. De Strooper et al. Cold Spring Harbor Perspectives in Medicine
- SIRT3, a pivotal actor in mitochondrial functions: metabolism, cell death and aging
- (2012) Albert Giralt et al. BIOCHEMICAL JOURNAL
- A Comparison between Extract Products of Magnolia officinalis on Memory Impairment and Amyloidogenesis in a Transgenic Mouse Model of Alzheimer's Disease
- (2012) Young-Jung Lee et al. Biomolecules & Therapeutics
- Honokiol: A Novel Natural Agent for Cancer Prevention and Therapy
- (2012) S. Arora et al. CURRENT MOLECULAR MEDICINE
- Pyrroloquinoline quinone rescues hippocampal neurons from glutamate-induced cell death through activation of Nrf2 and up-regulation of antioxidant genes
- (2012) Q. Zhang et al. GENETICS AND MOLECULAR RESEARCH
- trans-(−)-ϵ-Viniferin Increases Mitochondrial Sirtuin 3 (SIRT3), Activates AMP-activated Protein Kinase (AMPK), and Protects Cells in Models of Huntington Disease
- (2012) Jinrong Fu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adjudin attenuates lipopolysaccharide (LPS)- and ischemia-induced microglial activation
- (2012) Jiaxiang Shao et al. JOURNAL OF NEUROIMMUNOLOGY
- Dihydromyricetin As a Novel Anti-Alcohol Intoxication Medication
- (2012) Y. Shen et al. JOURNAL OF NEUROSCIENCE
- Honokiol traverses the blood-brain barrier and induces apoptosis of neuroblastoma cells via an intrinsic bax-mitochondrion-cytochrome c-caspase protease pathway
- (2012) J.-W. Lin et al. NEURO-ONCOLOGY
- The natural products magnolol and honokiol are positive allosteric modulators of both synaptic and extra-synaptic GABAA receptors
- (2012) Mikhail Alexeev et al. NEUROPHARMACOLOGY
- Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells
- (2012) Peng Zhang et al. NEUROSCIENCE LETTERS
- Polydatin protects learning and memory impairments in a rat model of vascular dementia
- (2012) Run-Ping Li et al. PHYTOMEDICINE
- Protective Effects of a Rhodiola Crenulata Extract and Salidroside on Hippocampal Neurogenesis against Streptozotocin-Induced Neural Injury in the Rat
- (2012) Ze-qiang Qu et al. PLoS One
- Anti-inflammatory effect of transduced PEP-1-heme oxygenase-1 in Raw 264.7 cells and a mouse edema model
- (2011) Soon Won Kwon et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- SIRT3 and cancer: Tumor promoter or suppressor?
- (2011) Turki Y. Alhazzazi et al. BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
- Ampelopsin reduces endotoxic inflammation via repressing ROS-mediated activation of PI3K/Akt/NF-κB signaling pathways
- (2011) Shimei Qi et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Alzheimer's Disease: Diagnosis and Treatment Across the Spectrum of Disease Severity
- (2011) Judith Neugroschl et al. MOUNT SINAI JOURNAL OF MEDICINE
- Therapeutic applications of compounds in the Magnolia family
- (2011) Young-Jung Lee et al. PHARMACOLOGY & THERAPEUTICS
- Honokiol Crosses BBB and BCSFB, and Inhibits Brain Tumor Growth in Rat 9L Intracerebral Gliosarcoma Model and Human U251 Xenograft Glioma Model
- (2011) Xianhuo Wang et al. PLoS One
- Adjudin, a potential male contraceptive, exerts its effects locally in the seminiferous epithelium of mammalian testes
- (2011) Ka-Wai Mok et al. REPRODUCTION
- The neuroprotective action of pyrroloquinoline quinone against glutamate-induced apoptosis in hippocampal neurons is mediated through the activation of PI3K/Akt pathway
- (2011) Qi Zhang et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Neuropsychiatric Symptoms and Syndromes in a Large Cohort of Newly Diagnosed, Untreated Patients With Alzheimer Disease
- (2010) Gianfranco Spalletta et al. AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
- Leaf and stem of Vitis amurensis and its active components protect against amyloid β protein (25–35)-induced neurotoxicity
- (2010) Ha Yeon Jeong et al. ARCHIVES OF PHARMACAL RESEARCH
- Mitochondrial SIRT3 and heart disease
- (2010) V. B. Pillai et al. CARDIOVASCULAR RESEARCH
- Tau in Alzheimer Disease and Related Tauopathies
- (2010) K. Iqbal et al. Current Alzheimer Research
- Calcium Signaling and Amyloid Toxicity in Alzheimer Disease
- (2010) Angelo Demuro et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Prevalence of Neuropsychiatric Symptoms and Their Association with Functional Limitations in Older Adults in the United States: The Aging, Demographics, and Memory Study
- (2010) Toru Okura et al. JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
- Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease
- (2010) Dimitrios Kapogiannis et al. LANCET NEUROLOGY
- Neuropathology of Alzheimer's Disease
- (2010) Daniel P. Perl MOUNT SINAI JOURNAL OF MEDICINE
- Silymarin protects spinal cord and cortical cells against oxidative stress and lipopolysaccharide stimulation
- (2010) May-Jywan Tsai et al. NEUROCHEMISTRY INTERNATIONAL
- Neuroprotective effects of salidroside against beta-amyloid-induced oxidative stress in SH-SY5Y human neuroblastoma cells
- (2010) Li Zhang et al. NEUROCHEMISTRY INTERNATIONAL
- Silibinin: A novel inhibitor of Aβ aggregation
- (2010) Fei Yin et al. NEUROCHEMISTRY INTERNATIONAL
- Sirtuin 3, a New Target of PGC-1α, Plays an Important Role in the Suppression of ROS and Mitochondrial Biogenesis
- (2010) Xingxing Kong et al. PLoS One
- Biochemical characterization, localization, and tissue distribution of the longer form of mouse SIRT3
- (2010) Lei Jin et al. PROTEIN SCIENCE
- Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling
- (2010) Eric Verdin et al. TRENDS IN BIOCHEMICAL SCIENCES
- Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology
- (2009) Paula I. Moreira et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice
- (2009) Nobuaki Matsui et al. BRAIN RESEARCH
- Honokiol induces cell apoptosis in human chondrosarcoma cells through mitochondrial dysfunction and endoplasmic reticulum stress
- (2009) Ying-Ju Chen et al. CANCER LETTERS
- Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease
- (2009) J. Yao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mechanisms and Molecular Probes of Sirtuins
- (2008) Brian C. Smith et al. CHEMISTRY & BIOLOGY
- Amyloid Precursor Protein Trafficking, Processing, and Function
- (2008) Gopal Thinakaran et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Pyrroloquinoline Quinone (PQQ) Prevents Cognitive Deficit Caused by Oxidative Stress in Rats
- (2008) Kei Ohwada et al. JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION
- Localization of mouse mitochondrial SIRT proteins: Shift of SIRT3 to nucleus by co-expression with SIRT5
- (2007) Yasuhiko Nakamura et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Oxidative Stress and Neurotoxicity
- (2007) Lawrence M. Sayre et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Antidepressant-like effects of the mixture of honokiol and magnolol from the barks of Magnolia officinalis in stressed rodents
- (2007) Qun Xu et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
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