Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

Blood–brain barrier breakdown is an early biomarker of human cognitive dysfunction

(2019) Daniel A. Nation et al.   NATURE MEDICINE

Sex Differences in the Association of Global Amyloid and Regional Tau Deposition Measured By Positron Emission Tomography in Clinically Normal Older Adults

(2019) Rachel F. Buckley et al.   JAMA Neurology

Selective loss of cortical endothelial tight junction proteins during Alzheimer’s disease progression

(2019) Yu Yamazaki et al.   BRAIN

Sex-specific genetic predictors of Alzheimer’s disease biomarkers

(2018) Yuetiva Deming et al.   ACTA NEUROPATHOLOGICA

Prevalence of the apolipoprotein E ε4 allele in amyloid β positive subjects across the spectrum of Alzheimer's disease

(2018) Niklas Mattsson et al.   Alzheimers & Dementia

2018 Alzheimer's disease facts and figures

(2018)   Alzheimers & Dementia

Sex, amyloid, and APOE ε4 and risk of cognitive decline in preclinical Alzheimer's disease: Findings from three well-characterized cohorts

(2018) Rachel F. Buckley et al.   Alzheimers & Dementia

Apolipoprotein E, Receptors, and Modulation of Alzheimer’s Disease

(2018) Na Zhao et al.   BIOLOGICAL PSYCHIATRY

Longitudinal brain imaging in preclinical Alzheimer disease: impact of APOE ε4 genotype

(2018) Shruti Mishra et al.   BRAIN

Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration

(2018) Aleksandra Deczkowska et al.   CELL

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

(2018) Fan Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

ApoE facilitates the microglial response to amyloid plaque pathology

(2018) Jason D. Ulrich et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Human ApoE Isoforms Differentially Modulate Brain Glucose and Ketone Body Metabolism: Implications for Alzheimer's Disease Risk Reduction and Early Intervention

(2018) Long Wu et al.   JOURNAL OF NEUROSCIENCE

Investigating the genetic architecture of dementia with Lewy bodies: a two-stage genome-wide association study

(2018) Rita Guerreiro et al.   LANCET NEUROLOGY

LRP10 genetic variants in familial Parkinson's disease and dementia with Lewy bodies: a genome-wide linkage and sequencing study

(2018) Marialuisa Quadri et al.   LANCET NEUROLOGY

Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer’s disease

(2018) Srikant Rangaraju et al.   Molecular Neurodegeneration

2D versus 3D human induced pluripotent stem cell-derived cultures for neurodegenerative disease modelling

(2018) Eduarda G Z Centeno et al.   Molecular Neurodegeneration

Gain of toxic apolipoprotein E4 effects in human iPSC-derived neurons is ameliorated by a small-molecule structure corrector

(2018) Chengzhong Wang et al.   NATURE MEDICINE

Midlife insulin resistance,APOEgenotype, and late-life brain amyloid accumulation

(2018) Laura L. Ekblad et al.   NEUROLOGY

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Sex-Specific Association of Apolipoprotein E With Cerebrospinal Fluid Levels of Tau

(2018) Timothy J. Hohman et al.   JAMA Neurology

Enhanced Brain Amyloid-β Clearance by Rifampicin and Caffeine as a Possible Protective Mechanism Against Alzheimer's Disease

(2018) Hisham Qosa et al.   JOURNAL OF ALZHEIMERS DISEASE

Insulin and Alzheimer's Disease: Untangling the Web

(2018) Suzanne Craft et al.   JOURNAL OF ALZHEIMERS DISEASE

In Vivo and In Vitro Effects of an Apolipoprotein E Mimetic Peptide on Amyloid-β Pathology

(2018) Shaila P. Handattu et al.   JOURNAL OF ALZHEIMERS DISEASE

Sex and ApoE Genotype Differences in Treatment Response to Two Doses of Intranasal Insulin in Adults with Mild Cognitive Impairment or Alzheimer's Disease

(2018) Amy Claxton et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau

(2018) Silvia S. Kang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Evaluation of TDP-43 proteinopathy and hippocampal sclerosis in relation to APOE ε4 haplotype status: a community-based cohort study

(2018) Hyun-Sik Yang et al.   LANCET NEUROLOGY

The identity and function of microglia in neurodegeneration

(2018) Wilbur M. Song et al.   NATURE IMMUNOLOGY

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

(2018) Shorena Janelidze et al.   NEUROLOGY

APOE ε4 is associated with severity of Lewy body pathology independent of Alzheimer pathology

(2018) Dennis W. Dickson et al.   NEUROLOGY

Apoε4 disrupts neurovascular regulation and undermines white matter integrity and cognitive function

(2018) Kenzo Koizumi et al.   Nature Communications

The genetic risk of Alzheimer’s disease beyond APOE ε4: systematic review of Alzheimer’s genetic risk scores

(2018) Hannah Stocker et al.   Translational Psychiatry

Blood-brain barrier-associated pericytes internalize and clear aggregated amyloid-β42 by LRP1-dependent apolipoprotein E isoform-specific mechanism

(2018) Qingyi Ma et al.   Molecular Neurodegeneration

Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE

(2018) Samira Parhizkar et al.   NATURE NEUROSCIENCE

Clinical phenotype, atrophy, and small vessel disease in APOEε2 carriers with Alzheimer disease

(2018) Colin Groot et al.   NEUROLOGY

APOE ε2 is associated with increased tau pathology in primary tauopathy

(2018) Na Zhao et al.   Nature Communications

Association of Apolipoprotein E ε4 With Transactive Response DNA-Binding Protein 43

(2018) Alexandra M. Wennberg et al.   JAMA Neurology

APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes

(2017) Jing Zhao et al.   HUMAN MOLECULAR GENETICS

A Tale of Two Genes: Microglial Apoe and Trem2

(2017) Anna A. Pimenova et al.   IMMUNITY

The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases

(2017) Susanne Krasemann et al.   IMMUNITY

Association of Cerebrospinal Fluid (CSF) Insulin with Cognitive Performance and CSF Biomarkers of Alzheimer’s Disease

(2017) Stefan L.C. Geijselaers et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of APOE ε4 Genotype on Metabolic Biomarkers in Aging and Alzheimer’s Disease

(2017) Jill K. Morris et al.   JOURNAL OF ALZHEIMERS DISEASE

Isoform- and cell type-specific structure of apolipoprotein E lipoparticles as revealed by a novel Forster resonance energy transfer assay

(2017) Eleanna Kara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E4 mediates insulin resistance-associated cerebrovascular dysfunction and the post-prandial response

(2017) Lance A Johnson et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Understanding the functions and relationships of the glymphatic system and meningeal lymphatics

(2017) Antoine Louveau et al.   JOURNAL OF CLINICAL INVESTIGATION

The ApoE receptors Vldlr and Apoer2 in central nervous system function and disease

(2017) Courtney Lane-Donovan et al.   JOURNAL OF LIPID RESEARCH

The role of APOE on lipid homeostasis and inflammation in normal brains

(2017) G. William Rebeck   JOURNAL OF LIPID RESEARCH

Astrocytic LRP1 Mediates Brain Aβ Clearance and Impacts Amyloid Deposition

(2017) Chia-Chen Liu et al.   JOURNAL OF NEUROSCIENCE

Glial contributions to neurodegeneration in tauopathies

(2017) Cheryl E. G. Leyns et al.   Molecular Neurodegeneration

Late onset Alzheimer’s disease genetics implicates microglial pathways in disease risk

(2017) Anastasia G. Efthymiou et al.   Molecular Neurodegeneration

TREM2 in Neurodegenerative Diseases

(2017) Taylor R. Jay et al.   Molecular Neurodegeneration

APOE , thought disorder, and SPARE-AD predict cognitive decline in established Parkinson's disease

(2017) Thomas F. Tropea et al.   MOVEMENT DISORDERS

ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy

(2017) Yang Shi et al.   NATURE

APOE ε4 status is associated with white matter hyperintensities volume accumulation rate independent of AD diagnosis

(2017) Carole H. Sudre et al.   NEUROBIOLOGY OF AGING

Diagnosis and management of dementia with Lewy bodies

(2017) Ian G. McKeith et al.   NEUROLOGY

APOE genotype and early β-amyloid accumulation in older adults without dementia

(2017) Yen Ying Lim et al.   NEUROLOGY

Multimodal characterization of older APOE2 carriers reveals selective reduction of amyloid load

(2017) Michel J. Grothe et al.   NEUROLOGY

Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis

(2017) Tien-Phat V. Huynh et al.   NEURON

Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes

(2017) Na Zhao et al.   NEURON

ApoE4 Accelerates Early Seeding of Amyloid Pathology

(2017) Chia-Chen Liu et al.   NEURON

A mechanism for lipid binding to apoE and the role of intrinsically disordered regions coupled to domain–domain interactions

(2017) Carl Frieden et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peripheral apoE isoform levels in cognitively normal APOE ε3/ε4 individuals are associated with regional gray matter volume and cerebral glucose metabolism

(2017) Henrietta M. Nielsen et al.   Alzheimers Research & Therapy

Clearance of beta-amyloid is facilitated by apolipoprotein E and circulating high-density lipoproteins in bioengineered human vessels

(2017) Jerome Robert et al.   eLife

Apolipoprotein E Genotype and Sex Risk Factors for Alzheimer Disease

(2017) Scott C. Neu et al.   JAMA Neurology

The Endosomal–Lysosomal Pathway Is Dysregulated by APOE4 Expression in Vivo

(2017) Tal Nuriel et al.   Frontiers in Neuroscience

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer’s disease

(2016) Mitsuru Shinohara et al.   ACTA NEUROPATHOLOGICA

The role of APOE in cerebrovascular dysfunction

(2016) Leon M. Tai et al.   ACTA NEUROPATHOLOGICA

Molecular genetics of early-onset Alzheimer's disease revisited

(2016) Rita Cacace et al.   Alzheimers & Dementia

APOE2eases cognitive decline during Aging: Clinical and preclinical evaluations

(2016) Mitsuru Shinohara et al.   ANNALS OF NEUROLOGY

Central Nervous System LipoproteinsHighlights

(2016) Robert W. Mahley   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ApoE: In Vitro Studies of a Small Molecule Effector

(2016) Tridib Mondal et al.   BIOCHEMISTRY

Heterozygous PINK1 p.G411S increases risk of Parkinson’s disease via a dominant-negative mechanism

(2016) Andreas Puschmann et al.   BRAIN

Tau PET patterns mirror clinical and neuroanatomical variability in Alzheimer’s disease

(2016) Rik Ossenkoppele et al.   BRAIN

The amyloid hypothesis of Alzheimer's disease at 25 years

(2016) Dennis J Selkoe et al.   EMBO Molecular Medicine

Rescuing effects of RXR agonist bexarotene on aging-related synapse loss depend on neuronal LRP1

(2016) Masaya Tachibana et al.   EXPERIMENTAL NEUROLOGY

An Acrobatic Substrate Metamorphosis Reveals a Requirement for Substrate Conformational Dynamics in Trypsin Proteolysis

(2016) Olumide Kayode et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Central Nervous System (CNS) ApoE Isoforms Are Increased by Age, Differentially Altered by Amyloidosis, and Relative Amounts Reversed in the CNS Compared with Plasma

(2016) Alaina T. Baker-Nigh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E Genotype Affects Size of ApoE Complexes in Cerebrospinal Fluid

(2016) Nicolette Mary Heinsinger et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Genetic Restoration of Plasma ApoE Improves Cognition and Partially Restores Synaptic Defects in ApoE-Deficient Mice

(2016) C. Lane-Donovan et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E*4 (APOE*4) Genotype Is Associated with Altered Levels of Glutamate Signaling Proteins and Synaptic Coexpression Networks in the Prefrontal Cortex in Mild to Moderate Alzheimer Disease

(2016) Robert A. Sweet et al.   MOLECULAR & CELLULAR PROTEOMICS

Apolipoprotein E lipoprotein particles inhibit amyloid-β uptake through cell surface heparan sulphate proteoglycan

(2016) Yuan Fu et al.   Molecular Neurodegeneration

Glymphatic distribution of CSF-derived apoE into brain is isoform specific and suppressed during sleep deprivation

(2016) Thiyagaragan M. Achariyar et al.   Molecular Neurodegeneration

Intracerebral adeno-associated virus gene delivery of apolipoprotein E2 markedly reduces brain amyloid pathology in Alzheimer's disease mouse models

(2016) Lingzhi Zhao et al.   NEUROBIOLOGY OF AGING

Association of APOE with tau-tangle pathology with and without β-amyloid

(2016) Jose M. Farfel et al.   NEUROBIOLOGY OF AGING

Relative effect of APOE ε4 on neuroimaging biomarker changes across the lifespan

(2016) Julie Gonneaud et al.   NEUROLOGY

TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia

(2016) Felix L. Yeh et al.   NEURON

Tau and Aβ imaging, CSF measures, and cognition in Alzheimer’s disease

(2016) Matthew R. Brier et al.   Science Translational Medicine

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Double-blind, placebo-controlled, proof-of-concept trial of bexarotene in moderate Alzheimer’s disease

(2016) Jeffrey L. Cummings et al.   Alzheimers Research & Therapy

Association of Elevated Amyloid Levels With Cognition and Biomarkers in Cognitively Normal People From the Community

(2016) Ronald C. Petersen et al.   JAMA Neurology

Age-dependent effects ofAPOEε4 in preclinical Alzheimer's disease

(2016) Luke W. Bonham et al.   Annals of Clinical and Translational Neurology

Temporal evolution of biomarkers and cognitive markers in the asymptomatic, MCI, and dementia stage of Alzheimer's disease

(2015) Daniela Bertens et al.   Alzheimers & Dementia

APOEε2 is associated with milder clinical and pathological Alzheimer disease

(2015) Alberto Serrano-Pozo et al.   ANNALS OF NEUROLOGY

Activation of the E3 ubiquitin ligase Parkin

(2015) Thomas R. Caulfield et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia

(2015) Willemijn J. Jansen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)

(2015) Yuka Atagi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E

(2015) Charles C. Bailey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accelerated pericyte degeneration and blood–brain barrier breakdown in apolipoprotein E4 carriers with Alzheimer’s disease

(2015) Matthew R Halliday et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Precision medicine: Clarity for the clinical and biological complexity of Alzheimer’s and Parkinson’s diseases

(2015) Thomas J. Montine et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Neuronal LRP1 Regulates Glucose Metabolism and Insulin Signaling in the Brain

(2015) C.-C. Liu et al.   JOURNAL OF NEUROSCIENCE

Opposing effects of viral mediated brain expression of apolipoprotein E2 (apoE2) and apoE4 on apoE lipidation and Aβ metabolism in apoE4-targeted replacement mice

(2015) Jin Hu et al.   Molecular Neurodegeneration

APOE*E2 allele delays age of onset in PSEN1 E280A Alzheimer’s disease

(2015) J I Vélez et al.   MOLECULAR PSYCHIATRY

Clearance systems in the brain—implications for Alzheimer disease

(2015) Jenna M. Tarasoff-Conway et al.   Nature Reviews Neurology

Tau in physiology and pathology

(2015) Yipeng Wang et al.   NATURE REVIEWS NEUROSCIENCE

Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies

(2015) Nga Bien-Ly et al.   NEURON

On the lag phase in amyloid fibril formation

(2015) Paolo Arosio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Age, Sex, andAPOEε4 Effects on Memory, Brain Structure, and β-Amyloid Across the Adult Life Span

(2015) Clifford R. Jack et al.   JAMA Neurology

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

(2015) Auriel A. Willette et al.   JAMA Neurology

Primary age-related tauopathy (PART): a common pathology associated with human aging

(2014) John F. Crary et al.   ACTA NEUROPATHOLOGICA

TDP-43 is a key player in the clinical features associated with Alzheimer’s disease

(2014) Keith A. Josephs et al.   ACTA NEUROPATHOLOGICA

Total apolipoprotein E levels and specific isoform composition in cerebrospinal fluid and plasma from Alzheimer’s disease patients and controls

(2014) Eduardo Martínez-Morillo et al.   ACTA NEUROPATHOLOGICA

Sex modifies theAPOE-related risk of developing Alzheimer disease

(2014) Andre Altmann et al.   ANNALS OF NEUROLOGY

The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation

(2014) Kanchan Garai et al.   BIOCHEMISTRY

Genetic analysis implicates APOE, SNCA and suggests lysosomal dysfunction in the etiology of dementia with Lewy bodies

(2014) Jose Bras et al.   HUMAN MOLECULAR GENETICS

Apolipoprotein E isoforms and lipoprotein metabolism

(2014) Michael C. Phillips   IUBMB LIFE

Amyloid-β Pathology andAPOEGenotype Modulate Retinoid X Receptor Agonist Activityin Vivo

(2014) Leon M. Tai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human Apolipoprotein E ε4 Expression Impairs Cerebral Vascularization and Blood—Brain Barrier Function in Mice

(2014) Wael Alata et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Human APOE4 increases microglia reactivity at Aβ plaques in a mouse model of Aβ deposition

(2014) Gustavo A Rodriguez et al.   Journal of Neuroinflammation

Reversal of apoE4-Driven Brain Pathology and Behavioral Deficits by Bexarotene

(2014) A. Boehm-Cagan et al.   JOURNAL OF NEUROSCIENCE

Anti-ApoE Antibody Given after Plaque Onset Decreases A  Accumulation and Improves Brain Function in a Mouse Model of A  Amyloidosis

(2014) F. Liao et al.   JOURNAL OF NEUROSCIENCE

Liver X receptors in lipid metabolism: opportunities for drug discovery

(2014) Cynthia Hong et al.   NATURE REVIEWS DRUG DISCOVERY

Symptom onset in autosomal dominant Alzheimer disease: A systematic review and meta-analysis

(2014) D. C. Ryman et al.   NEUROLOGY

ApoE and Aβ in Alzheimer’s Disease: Accidental Encounters or Partners?

(2014) Takahisa Kanekiyo et al.   NEURON

Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease

(2014) Stephen Salloway et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genetic variants of ApoE and ApoER2 differentially modulate endothelial function

(2014) Victoria Ulrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ApoE: The role of conserved residues in defining function

(2014) Carl Frieden   PROTEIN SCIENCE

Reduced neuronal signaling in the ageing apolipoprotein-E4 targeted replacement female mice

(2014) Shan-May Yong et al.   Scientific Reports

Phosphorylation by PINK1 Releases the UBL Domain and Initializes the Conformational Opening of the E3 Ubiquitin Ligase Parkin

(2014) Thomas R. Caulfield et al.   PLoS Computational Biology

Effects of the Absence of Apolipoprotein E on Lipoproteins, Neurocognitive Function, and Retinal Function

(2014) Angel C. Y. Mak et al.   JAMA Neurology

Blocking the Interaction between Apolipoprotein E and Aβ Reduces Intraneuronal Accumulation of Aβ and Inhibits Synaptic Degeneration

(2013) Magdalena A. Kuszczyk et al.   AMERICAN JOURNAL OF PATHOLOGY

The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation

(2013) Yong-Jie Zhang et al.   HUMAN MOLECULAR GENETICS

Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

(2013) Shan Liu et al.   JOURNAL OF NEUROCHEMISTRY

APOE associations with severe CAA-associated vasculopathic changes: collaborative meta-analysis

(2013) K. Rannikmae et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

APOE-ε2 and APOE-ε4 Correlate With Increased Amyloid Accumulation in Cerebral Vasculature

(2013) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Neuronal Clearance of Amyloid-  by Endocytic Receptor LRP1

(2013) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

In vivo measurement of apolipoprotein E from the brain interstitial fluid using microdialysis

(2013) Jason D Ulrich et al.   Molecular Neurodegeneration

ApoE4 induces Aβ42, tau, and neuronal pathology in the hippocampus of young targeted replacement apoE4 mice

(2013) Ori Liraz et al.   Molecular Neurodegeneration

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

Apolipoprotein E and Alzheimer disease: risk, mechanisms and therapy

(2013) Chia-Chen Liu et al.   Nature Reviews Neurology

Mapping the effects of ApoE4, age and cognitive status on 18F-florbetapir PET measured regional cortical patterns of beta-amyloid density and growth

(2013) Kelly R. Murphy et al.   NEUROIMAGE

APOE genotype and MRI markers of cerebrovascular disease: Systematic review and meta-analysis

(2013) S. Schilling et al.   NEUROLOGY

Biomarker Modeling of Alzheimer’s Disease

(2013) Clifford R. Jack et al.   NEURON

ApoE influences amyloid-  (A ) clearance despite minimal apoE/A  association in physiological conditions

(2013) P. B. Verghese et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Concerning the structure of apoE

(2013) Carl Frieden et al.   PROTEIN SCIENCE

Motion of transfer RNA from the A/T state into the A-site using docking and simulations

(2013) Thomas Caulfield et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) N. F. Fitz et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) I. Tesseur et al.   SCIENCE

Comment on "ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models"

(2013) A. R. Price et al.   SCIENCE

Gene Transfer of Human Apoe Isoforms Results in Differential Modulation of Amyloid Deposition and Neurotoxicity in Mouse Brain

(2013) E. Hudry et al.   Science Translational Medicine

Neuropathological Alterations in Alzheimer Disease

(2013) A. Serrano-Pozo et al.   Cold Spring Harbor Perspectives in Medicine

Proteolytic Degradation of Amyloid  -Protein

(2013) T. Saido et al.   Cold Spring Harbor Perspectives in Medicine

Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

(2013) Matthew R. Halliday et al.   JAMA Neurology

Effect of Apolipoprotein E Genotype and Diet on Apolipoprotein E Lipidation and Amyloid Peptides

(2013) Angela J. Hanson et al.   JAMA Neurology

Neuropathologic substrates of Parkinson disease dementia

(2012) David J. Irwin et al.   ANNALS OF NEUROLOGY

Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition

(2012) Julie M. Bugg   ARCHIVES OF NEUROLOGY

Apolipoprotein E4 effects in Alzheimer’s disease are mediated by synaptotoxic oligomeric amyloid-β

(2012) Robert M. Koffie et al.   BRAIN

Low-density Lipoprotein Receptor Represents an Apolipoprotein E-independent Pathway of Aβ Uptake and Degradation by Astrocytes

(2012) Jacob M. Basak et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease

(2012) Katherine L. Youmans et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Anti-apoE immunotherapy inhibits amyloid accumulation in a transgenic mouse model of Aβ amyloidosis

(2012) Jungsu Kim et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Small-Molecule Structure Correctors Target Abnormal Protein Structure and Function: Structure Corrector Rescue of Apolipoprotein E4–Associated Neuropathology

(2012) Robert W. Mahley et al.   JOURNAL OF MEDICINAL CHEMISTRY

LRP1 in Brain Vascular Smooth Muscle Cells Mediates Local Clearance of Alzheimer's Amyloid- 

(2012) T. Kanekiyo et al.   JOURNAL OF NEUROSCIENCE

Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent A  Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice

(2012) N. Bien-Ly et al.   JOURNAL OF NEUROSCIENCE

Abca1 Deficiency Affects Alzheimer's Disease-Like Phenotype in Human ApoE4 But Not in ApoE3-Targeted Replacement Mice

(2012) N. F. Fitz et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

LDLR-related protein 10 (LRP10) regulates amyloid precursor protein (APP) trafficking and processing: evidence for a role in Alzheimer’s disease

(2012) Julie Brodeur et al.   Molecular Neurodegeneration

Apolipoprotein E controls cerebrovascular integrity via cyclophilin A

(2012) Robert D. Bell et al.   NATURE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

How can elderly apolipoprotein E ε4 carriers remain free from dementia?

(2012) Camilla Ferrari et al.   NEUROBIOLOGY OF AGING

Apolipoprotein E ε4 and age effects on florbetapir positron emission tomography in healthy aging and Alzheimer disease

(2012) Adam S. Fleisher et al.   NEUROBIOLOGY OF AGING

A large study reveals no association between APOE and Parkinson's disease

(2012) Monica Federoff et al.   NEUROBIOLOGY OF DISEASE

APOE-Mimetic Peptides Reduce Behavioral Deficits, Plaques and Tangles in Alzheimer’s Disease Transgenics

(2012) M.P. Vitek et al.   Neurodegenerative Diseases

The Apolipoprotein-E-Mimetic COG112 Protects Amyloid Precursor Protein Intracellular Domain-Overexpressing Animals from Alzheimer's Disease-Like Pathological Features

(2012) Kaushik Ghosal et al.   Neurodegenerative Diseases

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

TREM2 Variants in Alzheimer's Disease

(2012) Rita Guerreiro et al.   NEW ENGLAND JOURNAL OF MEDICINE

Disruption of Arterial Perivascular Drainage of Amyloid-β from the Brains of Mice Expressing the Human APOE ε4 Allele

(2012) Cheryl A. Hawkes et al.   PLoS One

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

APOE ϵ4 Increases Risk for Dementia in Pure Synucleinopathies

(2012) Debby Tsuang et al.   JAMA Neurology

Amyloid Precursor Protein Processing and Alzheimer's Disease

(2011) Richard J. O'Brien et al.   Annual Review of Neuroscience

Apolipoprotein E isoforms and regulation of the innate immune response in brain of patients with Alzheimer's disease

(2011) C Dirk Keene et al.   CURRENT OPINION IN NEUROBIOLOGY

Small Molecule Structure Correctors Abolish Detrimental Effects of Apolipoprotein E4 in Cultured Neurons

(2011) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure-dependent Impairment of Intracellular Apolipoprotein E4 Trafficking and Its Detrimental Effects Are Rescued by Small-molecule Structure Correctors

(2011) Jens Brodbeck et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apolipoprotein E Promotes β-Amyloid Trafficking and Degradation by Modulating Microglial Cholesterol Levels

(2011) C. Y. Daniel Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid-  Amyloidosis

(2011) J. Kim et al.   JOURNAL OF NEUROSCIENCE

APOE and Alzheimer disease: a major gene with semi-dominant inheritance

(2011) E Genin et al.   MOLECULAR PSYCHIATRY

APOE modifies the association between A  load and cognition in cognitively normal older adults

(2011) K. Kantarci et al.   NEUROLOGY

Longitudinal modeling of frontal cognition in APOE  4 homozygotes, heterozygotes, and noncarriers

(2011) R. J. Caselli et al.   NEUROLOGY

Lack of LDL Receptor Enhances Amyloid Deposition and Decreases Glial Response in an Alzheimer's Disease Mouse Model

(2011) Loukia Katsouri et al.   PLoS One

Topology of human apolipoprotein E3 uniquely regulates its diverse biological functions

(2011) J. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human apoE Isoforms Differentially Regulate Brain Amyloid-  Peptide Clearance

(2011) J. M. Castellano et al.   Science Translational Medicine

Accumulation of intraneuronal Aβ correlates with ApoE4 genotype

(2010) Ditte Z. Christensen et al.   ACTA NEUROPATHOLOGICA

Variants at APOE influence risk of deep and lobar intracerebral hemorrhage

(2010) Alessandro Biffi et al.   ANNALS OF NEUROLOGY

Apolipoprotein E4 Domain Interaction Mediates Detrimental Effects on Mitochondria and Is a Potential Therapeutic Target for Alzheimer Disease

(2010) Hung-Kai Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ATP-binding Cassette Transporter A1 Mediates the Beneficial Effects of the Liver X Receptor Agonist GW3965 on Object Recognition Memory and Amyloid Burden in Amyloid Precursor Protein/Presenilin 1 Mice

(2010) James J. Donkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reduction of Brain β-Amyloid (Aβ) by Fluvastatin, a Hydroxymethylglutaryl-CoA Reductase Inhibitor, through Increase in Degradation of Amyloid Precursor Protein C-terminal Fragments (APP-CTFs) and Aβ Clearance

(2010) Mitsuru Shinohara et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Minimal Interface Between ApoE and LRP

(2010) Miklos Guttman et al.   JOURNAL OF MOLECULAR BIOLOGY

Apolipoprotein E4 Causes Age- and Tau-Dependent Impairment of GABAergic Interneurons, Leading to Learning and Memory Deficits in Mice

(2010) Y. Andrews-Zwilling et al.   JOURNAL OF NEUROSCIENCE

Hippocampal atrophy rates and CSF biomarkers in elderly APOE2 normal subjects

(2010) G. C. Chiang et al.   NEUROLOGY

Progressive loss of synaptic integrity in human apolipoprotein E4 targeted replacement mice and attenuation by apolipoprotein E2

(2010) R.C. Klein et al.   NEUROSCIENCE

ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling

(2010) Y. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apolipoprotein E-dependent accumulation of Alzheimer disease-related lesions begins in middle age

(2009) Eloise Kok et al.   ANNALS OF NEUROLOGY

APOEpredicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging

(2009) John C. Morris et al.   ANNALS OF NEUROLOGY

Rexinoid Bexarotene Modulates Triglyceride but not Cholesterol Metabolism via Gene-Specific Permissivity of the RXR/LXR Heterodimer in the Liver

(2009) Fanny Lalloyer et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

ApoE4 Decreases Spine Density and Dendritic Complexity in Cortical Neurons In Vivo

(2009) S. B. Dumanis et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E and its receptors in Alzheimer's disease: pathways, pathogenesis and therapy

(2009) Guojun Bu   NATURE REVIEWS NEUROSCIENCE

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

(2009) Tim Vanmierlo et al.   NEUROBIOLOGY OF AGING

APOE  2 is associated with intact cognition but increased Alzheimer pathology in the oldest old

(2009) D. J. Berlau et al.   NEUROLOGY

Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance

(2009) Jungsu Kim et al.   NEURON

The Role of Apolipoprotein E in Alzheimer's Disease

(2009) Jungsu Kim et al.   NEURON

Longitudinal Modeling of Age-Related Memory Decline and theAPOEε4 Effect

(2009) Richard J. Caselli et al.   NEW ENGLAND JOURNAL OF MEDICINE

Improving physical realism, stereochemistry, and side-chain accuracy in homology modeling: Four approaches that performed well in CASP8

(2009) Elmar Krieger et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

APOE ε4 lowers age at onset and is a high risk factor for Alzheimer's disease; A case control study from central Norway

(2008) Sigrid B Sando et al.   BMC Neurology

apoE isoform–specific disruption of amyloid β peptide clearance from mouse brain

(2008) Rashid Deane et al.   JOURNAL OF CLINICAL INVESTIGATION

Impact of Apolipoprotein E (ApoE) Polymorphism on Brain ApoE Levels

(2008) D. R. Riddell et al.   JOURNAL OF NEUROSCIENCE

A molecular pathway of neurodegeneration linking α-synuclein to ApoE and Aβ peptides

(2008) Gilbert Gallardo et al.   NATURE NEUROSCIENCE

ApoE Promotes the Proteolytic Degradation of Aβ

(2008) Qingguang Jiang et al.   NEURON

β-amyloid burden is not associated with rates of brain atrophy

(2007) Keith A. Josephs et al.   ANNALS OF NEUROLOGY