Brain Renin–Angiotensin System as Novel and Potential Therapeutic Target for Alzheimer’s Disease

Protein Expression of Angiotensin-Converting Enzyme 2 (ACE2) is Upregulated in Brains with Alzheimer’s Disease

(2021) Qiyue Ding et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

High levels of 27-hydroxycholesterol results in synaptic plasticity alterations in the hippocampus

(2021) Raul Loera-Valencia et al.   Scientific Reports

Aminopeptidase A contributes to biochemical, anatomical and cognitive defects in Alzheimer’s disease (AD) mouse model and is increased at early stage in sporadic AD brain

(2021) Audrey Valverde et al.   ACTA NEUROPATHOLOGICA

Agonist that activates the µ-opioid receptor in acidified microenvironments inhibits colitis pain without side effects

(2021) Nestor Nivardo Jiménez-Vargas et al.   GUT

ACE2 activation protects against cognitive decline and reduces amyloid pathology in the Tg2576 mouse model of Alzheimer’s disease

(2020) Charles E. Evans et al.   ACTA NEUROPATHOLOGICA

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

AT2R’s (Angiotensin II Type 2 Receptor’s) Role in Cognitive and Cerebrovascular Deficits in a Mouse Model of Alzheimer Disease

(2020) Jessika Royea et al.   HYPERTENSION

Endosomal signaling of delta opioid receptors is an endogenous mechanism and therapeutic target for relief from inflammatory pain

(2020) Nestor N. Jimenez-Vargas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain angiotensin II and angiotensin IV receptors as potential Alzheimer’s disease therapeutic targets

(2020) Jessika Royea et al.   GeroScience

Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice

(2020) Leah K. Cuddy et al.   Science Translational Medicine

A single-cell atlas of the human substantia nigra reveals cell-specific pathways associated with neurological disorders

(2020) Devika Agarwal et al.   Nature Communications

Circadian control of brain glymphatic and lymphatic fluid flow

(2020) Lauren M. Hablitz et al.   Nature Communications

Centrally Acting Angiotensin-Converting Enzyme Inhibitor Suppresses Type I Interferon Responses and Decreases Inflammation in the Periphery and the CNS in Lupus-Prone Mice

(2020) Cassandra Nocito et al.   Frontiers in Immunology

Chronically infused angiotensin II induces depressive-like behavior via microglia activation

(2020) Hyun-Sun Park et al.   Scientific Reports

24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo

(2019) Spyridon Theofilopoulos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transferrin-Conjugated Polymeric Nanoparticle for Receptor-Mediated Delivery of Doxorubicin in Doxorubicin-Resistant Breast Cancer Cells

(2019) Zar Chi Soe et al.   Pharmaceutics

Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing

(2019) Brian W. Kunkle et al.   NATURE GENETICS

Delivery of Antisense Oligonucleotide LOR-2501 Using Transferrin-conjugated Polyethylenimine-based Lipid Nanoparticle

(2019) BIN ZHENG et al.   ANTICANCER RESEARCH

A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer’s disease pathology in mice

(2019) Shuyu Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Improvements of symptoms of Alzheimer`s disease by inhibition of the angiotensin system

(2019) Ursula Quitterer et al.   PHARMACOLOGICAL RESEARCH

Efficacy and Safety of Firibastat, A First-in-Class Brain Aminopeptidase A Inhibitor, in Hypertensive Overweight Patients of Multiple Ethnic Origins

(2019) Keith C. Ferdinand et al.   CIRCULATION

NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension

(2019) Mathilde Keck et al.   HYPERTENSION

Current and emerging avenues for Alzheimer's disease drug targets

(2019) R. Loera‐Valencia et al.   JOURNAL OF INTERNAL MEDICINE

Impaired Glymphatic Transport in Spontaneously Hypertensive Rats

(2019) Kristian Nygaard Mortensen et al.   JOURNAL OF NEUROSCIENCE

Protective Effects of Nanoparticle-Loaded Aliskiren on Cardiovascular System in Spontaneously Hypertensive Rats

(2019) Olga Pechanova et al.   MOLECULES

Multicenter Alzheimer's and Parkinson's disease immune biomarker verification study

(2019) Frederic Brosseron et al.   Alzheimers & Dementia

Organoid single-cell genomic atlas uncovers human-specific features of brain development

(2019) Sabina Kanton et al.   NATURE

Evolution of a New Class of Antihypertensive Drugs

(2019) Catherine Llorens-Cortes et al.   HYPERTENSION

Memory and cerebrovascular deficits recovered following angiotensin IV intervention in a mouse model of Alzheimer's disease

(2019) Jessika Royea et al.   NEUROBIOLOGY OF DISEASE

Imaging the effect of the circadian light–dark cycle on the glymphatic system in awake rats

(2019) Xuezhu Cai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Coming of Age of the Angiotensin Hypothesis in Alzheimer’s Disease: Progress Toward Disease Prevention and Treatment?

(2018) Patrick Gavin Kehoe   JOURNAL OF ALZHEIMERS DISEASE

Central antihypertensive effects of chronic treatment with RB150

(2018) Yannick Marc et al.   JOURNAL OF HYPERTENSION

Cognitive benefits of angiotensin IV and angiotensin-(1–7): A systematic review of experimental studies

(2018) Jean K. Ho et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Microglial Activation Is Modulated by Captopril: in Vitro and in Vivo Studies

(2018) Keren Asraf et al.   Frontiers in Cellular Neuroscience

Upregulation of Brain Renin Angiotensin System by 27-Hydroxycholesterol in Alzheimer's Disease

(2018) Laura Mateos et al.   JOURNAL OF ALZHEIMERS DISEASE

The Effects of Ramipril in Individuals at Risk for Alzheimer's Disease: Results of a Pilot Clinical Trial

(2018) Whitney Wharton et al.   JOURNAL OF ALZHEIMERS DISEASE

Lupus antibodies induce behavioral changes mediated by microglia and blocked by ACE inhibitors

(2018) Jacquelyn Nestor et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Connecting the brain cholesterol and renin-angiotensin (RAS) systems. Potential role of statins and RAS-modifying medications in dementia

(2018) B. Petek et al.   JOURNAL OF INTERNAL MEDICINE

Chronic treatment with the ACE inhibitor enalapril attenuates the development of frailty and differentially modifies pro-and anti-inflammatory cytokines in aging male and female C57BL/6 mice

(2018) Kaitlyn Keller et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

27-Hydroxycholesterol Induces Aberrant Morphology and Synaptic Dysfunction in Hippocampal Neurons

(2018) Paula Merino-Serrais et al.   CEREBRAL CORTEX

Identification of insulin-regulated aminopeptidase (IRAP) in the rat pineal gland and the modulation of melatonin synthesis by angiotensin IV

(2018) Mariana Vieira Abrahão et al.   BRAIN RESEARCH

Brain Renin–Angiotensin SystemNovelty and Significance

(2017) Bibi S. van Thiel et al.   HYPERTENSION

No Brain Renin–Angiotensin System

(2017) Curt D. Sigmund et al.   HYPERTENSION

27-Hydroxycholesterol impairs neuronal glucose uptake through an IRAP/GLUT4 system dysregulation

(2017) Muhammad-Al-Mustafa Ismail et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Angiotensin IV Receptors Mediate the Cognitive and Cerebrovascular Benefits of Losartan in a Mouse Model of Alzheimer's Disease

(2017) Jessika Royea et al.   JOURNAL OF NEUROSCIENCE

Cholesterol-metabolizing enzyme cytochrome P450 46A1 as a pharmacologic target for Alzheimer's disease

(2017) Natalia Mast et al.   NEUROPHARMACOLOGY

Neuron-Targeted Nanoparticle for siRNA Delivery to Traumatic Brain Injuries

(2016) Ester J. Kwon et al.   ACS Nano

CYP46A1, the rate-limiting enzyme for cholesterol degradation, is neuroprotective in Huntington’s disease

(2016) Lydie Boussicault et al.   BRAIN

Older Adults Taking AT1-Receptor Blockers Exhibit Reduced Cerebral Amyloid Retention

(2016) Daniel A. Nation et al.   JOURNAL OF ALZHEIMERS DISEASE

Losartan improves cerebrovascular function in a mouse model of Alzheimer's disease with combined overproduction of amyloid-β and transforming growth factor-β1

(2016) Panayiota Papadopoulos et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Renin-angiotensin system blockade use and risks of cognitive decline and dementia: A meta-analysis

(2016) Shan Zhuang et al.   NEUROSCIENCE LETTERS

PPARγ-coactivator-1α gene transfer reduces neuronal loss and amyloid-β generation by reducing β-secretase in an Alzheimer’s disease model

(2016) Loukia Katsouri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Angiotensin-converting enzyme 2 is reduced in Alzheimer’s disease in association with increasing amyloid-β and tau pathology

(2016) Patrick Gavin Kehoe et al.   Alzheimers Research & Therapy

Telmisartan Modulates Glial Activation: In Vitro and In Vivo Studies

(2016) Nofar Torika et al.   PLoS One

Amyloid-Beta Protein Clearance and Degradation (ABCD) Pathways and their Role in Alzheimer’s Disease

(2015) Robert Baranello et al.   Current Alzheimer Research

Cholesterol 24-hydroxylase defect is implicated in memory impairments associated with Alzheimer-like Tau pathology

(2015) Marie-Anne Burlot et al.   HUMAN MOLECULAR GENETICS

Biomarkers of Traumatic Injury Are Transported from Brain to Blood via the Glymphatic System

(2015) B. A. Plog et al.   JOURNAL OF NEUROSCIENCE

Cell types in the mouse cortex and hippocampus revealed by single-cell RNA-seq

(2015) A. Zeisel et al.   SCIENCE

Association Between Angiotensin Receptor Blockers and Longitudinal Decline in Tau in Mild Cognitive Impairment

(2015) Ihab Hajjar et al.   JAMA Neurology

Neuroprotective Effects of Angiotensin Receptor Blockers

(2014) Sonia Villapol et al.   AMERICAN JOURNAL OF HYPERTENSION

Pathways to Alzheimer's disease

(2014) J. Hardy et al.   JOURNAL OF INTERNAL MEDICINE

Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model

(2014) Brice Ongali et al.   NEUROBIOLOGY OF DISEASE

The association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease

(2014) Hadassa M Jochemsen et al.   Alzheimers Research & Therapy

Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation

(2014) John S. K. Kauwe et al.   PLoS Genetics

Cerebroprotective action of angiotensin peptides in stroke

(2013) Robert W. Regenhardt et al.   CLINICAL SCIENCE

The angiotensin converting enzyme inhibitor captopril protects nigrostriatal dopamine neurons in animal models of parkinsonism

(2013) Patricia K. Sonsalla et al.   EXPERIMENTAL NEUROLOGY

Targeting of hepatic angiotensinogen using chemically modified siRNAs results in significant and sustained blood pressure lowering in a rat model of hypertension

(2013) Jeffrey Olearczyk et al.   HYPERTENSION RESEARCH

ACE Inhibition with Captopril Retards the Development of Signs of Neurodegeneration in an Animal Model of Alzheimer’s Disease

(2013) Said AbdAlla et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antihypertensive Therapy and Cerebral Hemodynamics in Executive Mild Cognitive Impairment: Results of a Pilot Randomized Clinical Trial

(2013) Ihab Hajjar et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

Impact of Angiotensin Receptor Blockers on Alzheimer Disease Neuropathology in a Large Brain Autopsy Series

(2012) Ihab Hajjar et al.   ARCHIVES OF NEUROLOGY

Side-Chain-Oxidized Oxysterols Upregulate ACE2 and Mas Receptor in Rat Primary Neurons

(2012) Laura Mateos et al.   Neurodegenerative Diseases

Shuttle-Mediated Nanoparticle Delivery to the Blood-Brain Barrier

(2012) Daniela Guarnieri et al.   Small

Perindopril, a centrally active angiotensin-converting enzyme inhibitor, prevents cognitive impairment in mouse models of Alzheimer's disease

(2011) Yi-Fei Dong et al.   FASEB JOURNAL

Effects of telmisartan on cognition and regional cerebral blood flow in hypertensive patients with Alzheimer's disease

(2011) Kazumasa Kume et al.   Geriatrics & Gerontology International

Effect of a centrally active angiotensin-converting enzyme inhibitor, perindopril, on cognitive performance in a mouse model of Alzheimer's disease

(2010) Koji Yamada et al.   BRAIN RESEARCH

Teaching old receptors new tricks: biasing seven-transmembrane receptors

(2010) Sudarshan Rajagopal et al.   NATURE REVIEWS DRUG DISCOVERY

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Hypertension, dementia, and antihypertensive treatment: Implications for the very elderly

(2009) Ruth Peters et al.   CURRENT HYPERTENSION REPORTS

Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling

(2009) Shuko Takeda et al.   HYPERTENSION

Duration of antihypertensive drug use and risk of dementia: A prospective cohort study

(2009) M.D.M. Haag et al.   NEUROLOGY

Telmisartan prevented cognitive decline partly due to PPAR-γ activation

(2008) Masaki Mogi et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

(2008) Anthony L. Albiston et al.   FASEB JOURNAL

Mesoporous silicon particles as a multistage delivery system for imaging and therapeutic applications

(2008) Ennio Tasciotti et al.   Nature Nanotechnology