Mechanisms and Therapeutic Implications of GSK-3 in Treating Neurodegeneration

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selective inhibition of glycogen synthase kinase 3α corrects pathophysiology in a mouse model of fragile X syndrome

(2020) Patrick K. McCamphill et al.   Science Translational Medicine

GSK-3-TSC axis governs lysosomal acidification through autophagy and endocytic pathways

(2020) Limor Avrahami et al.   CELLULAR SIGNALLING

A Phase 2 Study of AMO-02 (tideglusib) in Congenital and Childhood Onset Myotonic Dystrophy Type 1 (DM1)

(2020) Joseph Horrigan et al.   PEDIATRIC NEUROLOGY

Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2016–2019)

(2020) Carlos Roca et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

GSK3β inhibition restores cortical gamma oscillation and cognitive behavior in a mouse model of NMDA receptor hypofunction relevant to schizophrenia

(2020) Kazuhito Nakao et al.   NEUROPSYCHOPHARMACOLOGY

Machine Learning for Discovery of GSK3β Inhibitors

(2020) Patricia A. Vignaux et al.   ACS Omega

Mitophagy and the Brain

(2020) Natalie S. Swerdlow et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Discovery and Design of Novel Small Molecule GSK-3 Inhibitors Targeting the Substrate Binding Site

(2020) Ido Rippin et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Mitochondria, OxPhos, and neurodegeneration: cells are not just running out of gas

(2019) Estela Area-Gomez et al.   JOURNAL OF CLINICAL INVESTIGATION

6-Bromoindirubin-3′-Oxime (6BIO) Suppresses the mTOR Pathway, Promotes Autophagy, and Exerts Anti-aging Effects in Rodent Liver

(2019) Donghao Guo et al.   Frontiers in Pharmacology

Efficacy and Safety of Glycogen Synthase Kinase 3 Inhibitors for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

(2019) Shinji Matsunaga et al.   JOURNAL OF ALZHEIMERS DISEASE

Underlying mechanisms of recombinant adeno-associated virus-mediated bicaudal C homolog 1 overexpression in the medial prefrontal cortex of mice with induced depressive-like behaviors

(2019) Zhengchun Wang et al.   BRAIN RESEARCH BULLETIN

Autophagosome Biogenesis Machinery

(2019) Simon A. Walker et al.   JOURNAL OF MOLECULAR BIOLOGY

Glycogen synthase kinase-3 and its inhibitors: Potential target for various therapeutic conditions

(2018) A. Prasanth Saraswati et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Crossing the blood-brain barrier with nanoparticles

(2018) Yiqun Zhou et al.   JOURNAL OF CONTROLLED RELEASE

GSK-3β/mTORC1 Couples Synaptogenesis and Axonal Repair to Reduce Hypoxia Ischemia-Mediated Brain Injury in Neonatal Rats

(2018) Tao Xiong et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Mechanism and medical implications of mammalian autophagy

(2018) Ivan Dikic et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Autophagy as a promoter of longevity: insights from model organisms

(2018) Malene Hansen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Amyloid-beta-dependent phosphorylation of collapsin response mediator protein-2 dissociates kinesin in Alzheimer's disease

(2018) Steven Petratos et al.   Neural Regeneration Research

Exploiting an Asp-Glu “switch” in glycogen synthase kinase 3 to design paralog-selective inhibitors for use in acute myeloid leukemia

(2018) Florence F. Wagner et al.   Science Translational Medicine

Mitochondria-associated membranes (MAMs) and pathologies

(2018) Paolo Pinton   Cell Death & Disease

GSK3β Regulates Brain Energy Metabolism

(2018) Stephen A. Martin et al.   Cell Reports

GSK3 and Tau: Two Convergence Points in Alzheimer's Disease

(2018) Felix Hernandez et al.   JOURNAL OF ALZHEIMERS DISEASE

New insights into autophagosome–lysosome fusion

(2017) Shuhei Nakamura et al.   JOURNAL OF CELL SCIENCE

Structural basis for CRMP2-induced axonal microtubule formation

(2017) Shinsuke Niwa et al.   Scientific Reports

GSK-3 Inhibitors: A Ray of Hope for the Treatment of Alzheimer's Disease?

(2017) Ana Martinez et al.   JOURNAL OF ALZHEIMERS DISEASE

mTOR kinase is needed for the development and stabilization of dendritic arbors in newly born olfactory bulb neurons

(2016) Agnieszka Skalecka et al.   Developmental Neurobiology

ALS/FTD‐associated FUS activates GSK‐3β to disrupt the VAPB–PTPIP51 interaction and ER–mitochondria associations

(2016) Radu Stoica et al.   EMBO REPORTS

Glycogen synthase kinase 3 (GSK-3) inhibitors: a patent update (2014-2015)

(2016) Valle Palomo et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

From blood–brain barrier to blood–brain interface: new opportunities for CNS drug delivery

(2016) William A. Banks   NATURE REVIEWS DRUG DISCOVERY

The cytoskeleton as a novel therapeutic target for old neurodegenerative disorders

(2016) Jessica Eira et al.   PROGRESS IN NEUROBIOLOGY

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

A unique type of GSK-3 inhibitor brings new opportunities to the clinic

(2016) A. Licht-Murava et al.   Science Signaling

Regional metabolic heterogeneity of the hippocampus is nonuniformly impacted by age and caloric restriction

(2015) Stephen A. Martin et al.   AGING CELL

GSK-3β Inhibition Affects Singing Behavior and Neurogenesis in Adult Songbirds

(2015) Etay Aloni et al.   BRAIN BEHAVIOR AND EVOLUTION

Role of the Akt/GSK-3β/CRMP-2 pathway in axon degeneration of dopaminergic neurons resulting from MPP+ toxicity

(2015) Wei Fang et al.   BRAIN RESEARCH

Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation

(2015) Junghui Koo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of Improved Glycogen Synthase Kinase-3α Inhibitors in Models of Acute Myeloid Leukemia

(2015) Theresa Neumann et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lanthionine ketimine ester provides benefit in a mouse model of multiple sclerosis

(2015) Jeffrey L. Dupree et al.   JOURNAL OF NEUROCHEMISTRY

Loss of GSK-3 Causes Abnormal Astrogenesis and Behavior in Mice

(2015) Eui-Man Jung et al.   MOLECULAR NEUROBIOLOGY

Tau is linked to cognitive decline in Huntington disease

(2015) Heather Wood   Nature Reviews Neurology

Blockage of GSK3β-mediated Drp1 phosphorylation provides neuroprotection in neuronal and mouse models of Alzheimer's disease

(2015) Jing Yan et al.   NEUROBIOLOGY OF AGING

Biophysical Challenges to Axonal Transport: Motor-Cargo Deficiencies and Neurodegeneration

(2014) Sandra E. Encalada et al.   Annual Review of Biophysics

Roles of ESCRT in autophagy-associated neurodegeneration

(2014) Jin-A Lee et al.   Autophagy

Neuronal deletion of GSK3β increases microtubule speed in the growth cone and enhances axon regeneration via CRMP-2 and independently of MAP1B and CLASP2

(2014) Márcia A Liz et al.   BMC BIOLOGY

Autophagy and human disease: emerging themes

(2014) Jaime L Schneider et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Localized changes to glycogen synthase kinase-3 and collapsin response mediator protein-2 in the Huntington's disease affected brain

(2014) N. K. H. Lim et al.   HUMAN MOLECULAR GENETICS

Collapsin Response Mediator Protein 4 Regulates Growth Cone Dynamics through the Actin and Microtubule Cytoskeleton

(2014) Mohamad R. Khazaei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocation of Glycogen Synthase Kinase-3β (GSK-3β), a Trigger of Permeability Transition, Is Kinase Activity-dependent and Mediated by Interaction with Voltage-dependent Anion Channel 2 (VDAC2)

(2014) Masaya Tanno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of neuronal GSK3β reduces dendritic spine stability and attenuates excitatory synaptic transmission via β-catenin

(2014) S M Ochs et al.   MOLECULAR PSYCHIATRY

A phase 2 trial of the GSK-3 inhibitor tideglusib in progressive supranuclear palsy

(2014) Eduardo Tolosa et al.   MOVEMENT DISORDERS

The Neurology of mTOR

(2014) Jonathan O. Lipton et al.   NEURON

Combined regulation of mTORC1 and lysosomal acidification by GSK-3 suppresses autophagy and contributes to cancer cell growth

(2014) I Azoulay-Alfaguter et al.   ONCOGENE

Targeting autophagy in neurodegenerative diseases

(2014) René L. Vidal et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

GSK-3 signaling in developing cortical neurons is essential for radial migration and dendritic orientation

(2014) Meghan Morgan-Smith et al.   eLife

An Overview of Autophagy: Morphology, Mechanism, and Regulation

(2013) Katherine R. Parzych et al.   ANTIOXIDANTS & REDOX SIGNALING

Autophagy and human diseases

(2013) Peidu Jiang et al.   CELL RESEARCH

Presenilin influences glycogen synthase kinase-3 β (GSK-3β) for kinesin-1 and dynein function during axonal transport

(2013) Kunsang Dolma et al.   HUMAN MOLECULAR GENETICS

A Rare Motor Neuron Deleterious Missense Mutation in theDPYSL3(CRMP4) Gene is Associated with ALS

(2013) Hélène Blasco et al.   HUMAN MUTATION

APC binds intermediate filaments and is required for their reorganization during cell migration

(2013) Yasuhisa Sakamoto et al.   JOURNAL OF CELL BIOLOGY

GSK-3α is a central regulator of age-related pathologies in mice

(2013) Jibin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Regulation of Th1 Cells and Experimental Autoimmune Encephalomyelitis by Glycogen Synthase Kinase-3

(2013) E. Beurel et al.   JOURNAL OF IMMUNOLOGY

Tau pathology and neurodegeneration

(2013) Maria Grazia Spillantini et al.   LANCET NEUROLOGY

Inhibition of AMPK Catabolic Action by GSK3

(2013) Tsukasa Suzuki et al.   MOLECULAR CELL

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Amelioration of β-amyloid-induced cognitive dysfunction and hippocampal axon degeneration by curcumin is associated with suppression of CRMP-2 hyperphosphorylation

(2013) Yunliang Wang et al.   NEUROSCIENCE LETTERS

Autophagy in Human Health and Disease

(2013) Augustine M.K. Choi et al.   NEW ENGLAND JOURNAL OF MEDICINE

Glycogen synthase kinase-3 inhibitors: Rescuers of cognitive impairments

(2013) Margaret K. King et al.   PHARMACOLOGY & THERAPEUTICS

The Role of Autophagy in Parkinson's Disease

(2013) M. A. Lynch-Day et al.   Cold Spring Harbor Perspectives in Medicine

Neurological characterization of mice deficient in GSK3α highlight pleiotropic physiological functions in cognition and pathological activity as Tau kinase

(2013) Hervé Maurin et al.   Molecular Brain

Limiting multiple sclerosis related axonopathy by blocking Nogo receptor and CRMP-2 phosphorylation

(2012) Steven Petratos et al.   BRAIN

Inhibition of Glycogen Synthase Kinase-3 Ameliorates β-Amyloid Pathology and Restores Lysosomal Acidification and Mammalian Target of Rapamycin Activity in the Alzheimer Disease Mouse Model

(2012) Limor Avrahami et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of GSK3β-mediated BACE1 expression reduces Alzheimer-associated phenotypes

(2012) Philip T.T. Ly et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Glycogen Synthase Kinase-3 Inhibitors with a Selective Sting for Glycogen Synthase Kinase-3α

(2012) Fabio Lo Monte et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selectively Silencing GSK-3 Isoforms Reduces Plaques and Tangles in Mouse Models of Alzheimer's Disease

(2012) D. E. Hurtado et al.   JOURNAL OF NEUROSCIENCE

Glycogen Synthase Kinase 3 Inhibition Promotes Lysosomal Biogenesis and Autophagic Degradation of the Amyloid-  Precursor Protein

(2012) C. Parr et al.   MOLECULAR AND CELLULAR BIOLOGY

Autophagy modulation as a potential therapeutic target for diverse diseases

(2012) David C. Rubinsztein et al.   NATURE REVIEWS DRUG DISCOVERY

Selective deletion of forebrain glycogen synthase kinase 3  reveals a central role in serotonin-sensitive anxiety and social behaviour

(2012) C. Latapy et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Endogenous GSK-3/Shaggy Regulates Bidirectional Axonal Transport of the Amyloid Precursor Protein

(2012) Carole Weaver et al.   TRAFFIC

Coordinating Gene Expression and Axon Assembly to Control Axon Growth: Potential Role of GSK3 Signaling

(2012) Chang-Mei Liu et al.   Frontiers in Molecular Neuroscience

Cyclin-Dependent Kinases in Brain Development and Disease

(2011) Susan C. Su et al.   Annual Review of Cell and Developmental Biology

Lysosomal Function and Dysfunction: Mechanism and Disease

(2011) Patricia Boya   ANTIOXIDANTS & REDOX SIGNALING

Selective loss of glycogen synthase kinase-3α in birds reveals distinct roles for GSK-3 isozymes in tau phosphorylation

(2011) Lina Tsaadon Alon et al.   FEBS LETTERS

Elucidating Substrate and Inhibitor Binding Sites on the Surface of GSK-3β and the Refinement of a Competitive Inhibitor

(2011) Avital Licht-Murava et al.   JOURNAL OF MOLECULAR BIOLOGY

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

(2011) Joungmok Kim et al.   NATURE CELL BIOLOGY

Fighting neurodegeneration with rapamycin: mechanistic insights

(2011) Jordi Bové et al.   NATURE REVIEWS NEUROSCIENCE

GSK3β Is Involved in the Relief of Mitochondria Pausing in a Tau-Dependent Manner

(2011) María Llorens-Martín et al.   PLoS One

Glycogen synthase kinase (GSK)-3 promotes p70 ribosomal protein S6 kinase (p70S6K) activity and cell proliferation

(2011) S. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

TFEB Links Autophagy to Lysosomal Biogenesis

(2011) C. Settembre et al.   SCIENCE

GSK-3 Inhibitors: Preclinical and Clinical Focus on CNS

(2011) Hagit Eldar-Finkelman et al.   Frontiers in Molecular Neuroscience

Reversal of autophagy dysfunction in the TgCRND8 mouse model of Alzheimer's disease ameliorates amyloid pathologies and memory deficits

(2010) Dun-Sheng Yang et al.   BRAIN

Evidence that glycogen synthase kinase-3 isoforms have distinct substrate preference in the brain

(2010) Marc P. M. Soutar et al.   JOURNAL OF NEUROCHEMISTRY

Collapsin Response Mediator Protein 4a (CRMP4a) Is Upregulated in Motoneurons of Mutant SOD1 Mice and Can Trigger Motoneuron Axonal Degeneration and Cell Death

(2010) L. Duplan et al.   JOURNAL OF NEUROSCIENCE

GSK3  Regulates Myelin-Dependent Axon Outgrowth Inhibition through CRMP4

(2010) Y. Z. Alabed et al.   JOURNAL OF NEUROSCIENCE

Dysregulation of mTOR Signaling in Fragile X Syndrome

(2010) A. Sharma et al.   JOURNAL OF NEUROSCIENCE

LKB1-Mediated Spatial Control of GSK3  and Adenomatous Polyposis Coli Contributes to Centrosomal Forward Movement and Neuronal Migration in the Developing Neocortex

(2010) N. Asada et al.   JOURNAL OF NEUROSCIENCE

Identification of eukaryotic elongation factor-2 as a novel cellular target of lithium and glycogen synthase kinase-3

(2010) Racheli Karyo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

GSK3 signalling in neural development

(2010) Eun-Mi Hur et al.   NATURE REVIEWS NEUROSCIENCE

Tau Mislocalization to Dendritic Spines Mediates Synaptic Dysfunction Independently of Neurodegeneration

(2010) Brian R. Hoover et al.   NEURON

Deficiency in the Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3 Increases Sensitivity to Mood Disturbances

(2010) Abigail Polter et al.   NEUROPSYCHOPHARMACOLOGY

Glycogen synthase kinase-3β and the p25 activator of cyclin dependent kinase 5 increase pausing of mitochondria in neurons

(2010) M. Morel et al.   NEUROSCIENCE

Regulation of Mammalian Autophagy in Physiology and Pathophysiology

(2010) Brinda Ravikumar et al.   PHYSIOLOGICAL REVIEWS

GSK3 Influences Social Preference and Anxiety-Related Behaviors during Social Interaction in a Mouse Model of Fragile X Syndrome and Autism

(2010) Marjelo A. Mines et al.   PLoS One

A small-molecule scaffold induces autophagy in primary neurons and protects against toxicity in a Huntington disease model

(2010) A. S. Tsvetkov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A kinesin signaling complex mediates the ability of GSK-3  to affect mood-associated behaviors

(2010) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Suppression of glycogen synthase kinase 3 activity reduces tumor growth of prostate cancer in vivo

(2010) Qing Zhu et al.   PROSTATE

Protein kinases: evolution of dynamic regulatory proteins

(2010) Susan S. Taylor et al.   TRENDS IN BIOCHEMICAL SCIENCES

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

(2009) Rozalyn M. Anderson et al.   AGING CELL

Current Status and Challenges Associated with Targeting mTOR for Cancer Therapy

(2009) Ryan J.O. Dowling et al.   BIODRUGS

Blocked Inhibitory Serine-Phosphorylation of Glycogen Synthase Kinase-3α/β Impairs In Vivo Neural Precursor Cell Proliferation

(2009) Tae-Yeon Eom et al.   BIOLOGICAL PSYCHIATRY

From signaling pathways to microtubule dynamics: the key players

(2009) Sandrine Etienne-Manneville   CURRENT OPINION IN CELL BIOLOGY

Opposite-polarity motors activate one another to trigger cargo transport in live cells

(2009) Shabeen Ally et al.   JOURNAL OF CELL BIOLOGY

GSK-3 is a master regulator of neural progenitor homeostasis

(2009) Woo-Yang Kim et al.   NATURE NEUROSCIENCE

Tau-knockout mice show reduced GSK3-induced hippocampal degeneration and learning deficits

(2009) Elena Gómez de Barreda et al.   NEUROBIOLOGY OF DISEASE

Abnormalities in brain structure and behavior in GSK-3alpha mutant mice

(2009) Oksana Kaidanovich-Beilin et al.   Molecular Brain

Amyloid Activates GSK-3β to Aggravate Neuronal Tauopathy in Bigenic Mice

(2008) Dick Terwel et al.   AMERICAN JOURNAL OF PATHOLOGY

Glycogen synthase kinase-3?? heterozygote knockout mice as a model of findings in postmortem schizophrenia brain or as a model of behaviors mimicking lithium action: negative results

(2008) Yuly Bersudsky et al.   BEHAVIOURAL PHARMACOLOGY

Rapamycin and mTOR-independent autophagy inducers ameliorate toxicity of polyglutamine-expanded huntingtin and related proteinopathies

(2008) S Sarkar et al.   CELL DEATH AND DIFFERENTIATION

Molecular landmarks along the axonal route: axonal transport in health and disease

(2008) Sara Salinas et al.   CURRENT OPINION IN CELL BIOLOGY

SCFCdc4 acts antagonistically to the PGC-1  transcriptional coactivator by targeting it for ubiquitin-mediated proteolysis

(2008) B. L. Olson et al.   GENES & DEVELOPMENT

Unique and Overlapping Functions of GSK-3 Isoforms in Cell Differentiation and Proliferation and Cardiovascular Development

(2008) Thomas Force et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of GSK-3β in mice leads to hypertrophic cardiomyopathy secondary to cardiomyoblast hyperproliferation

(2008) Risto Kerkela et al.   JOURNAL OF CLINICAL INVESTIGATION

Role of adenomatous polyposis coli (APC) and microtubules in directional cell migration and neuronal polarization

(2008) Angela I.M. Barth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain

Sequential phosphorylation of insulin receptor substrate-2 by glycogen synthase kinase-3 and c-Jun NH2-terminal kinase plays a role in hepatic insulin signaling

(2007) Hadar Sharfi et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM