Perilipin 5 ameliorates high-glucose-induced podocyte injury via Akt/GSK-3β/Nrf2-mediated suppression of apoptosis, oxidative stress, and inflammation

Hepatic PLIN5 signals via SIRT1 to promote autophagy and prevent inflammation during fasting

(2020) Enxiang Zhang et al.   JOURNAL OF LIPID RESEARCH

Perilipin 5 Reduces Oxidative Damage Associated With Lipotoxicity by Activating the PI3K/ERK-Mediated Nrf2-ARE Signaling Pathway in INS-1 Pancreatic β-Cells

(2020) Yunxia Zhu et al.   Frontiers in Endocrinology

Deletion of Perilipin 5 Protects Against Hepatic Injury in Nonalcoholic Fatty Liver Disease via Missing Inflammasome Activation

(2020) Anastasia Asimakopoulou et al.   Cells

LncRNA ANRIL Silencing Alleviates High Glucose-Induced Inflammation, Oxidative Stress, and Apoptosis via Upregulation of MME in Podocytes

(2020) Ruiyu Cai et al.   INFLAMMATION

Down-regulation of SETD6 protects podocyte against high glucose and palmitic acid-induced apoptosis, and mitochondrial dysfunction via activating Nrf2-Keap1 signaling pathway in diabetic nephropathy

(2020) Xiang Wang et al.   JOURNAL OF MOLECULAR HISTOLOGY

Nrf-2 mediated heme oxygenase-1 activation contributes to the anti-inflammatory and renal protective effects of Ginkgo biloba extract in diabetic nephropathy

(2020) Ting-Ting Chang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Perilipin 5 alleviates HCV NS5A-induced lipotoxic injuries in liver

(2019) Jin Zhang et al.   Lipids in Health and Disease

Perilipin 5 deficiency promotes atherosclerosis progression through accelerating inflammation, apoptosis, and oxidative stress

(2019) Peng‐Li Zhou et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Perilipin5 protects against lipotoxicity and alleviates endoplasmic reticulum stress in pancreatic β-cells

(2019) Yunxia Zhu et al.   Nutrition & Metabolism

FGF1ΔHBS ameliorates chronic kidney disease via PI3K/AKT mediated suppression of oxidative stress and inflammation

(2019) Dezhong Wang et al.   Cell Death & Disease

Sulfiredoxin-1 alleviates high glucose-induced podocyte injury though promoting Nrf2/ARE signaling via inactivation of GSK-3β

(2019) Yan Shen et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Plin5 deficiency exacerbates pressure overload-induced cardiac hypertrophy and heart failure by enhancing myocardial fatty acid oxidation and oxidative stress

(2019) Chao Wang et al.   FREE RADICAL BIOLOGY AND MEDICINE

BRD4 contributes to high-glucose-induced podocyte injury by modulating Keap1/Nrf2/ARE signaling

(2019) Hong Zuo et al.   BIOCHIMIE

Perilipin 5 Protects against Cellular Oxidative Stress by Enhancing Mitochondrial Function in HepG2 Cells

(2019) Tan et al.   Cells

A catalogue of somatic NRF2 gain-of-function mutations in cancer

(2018) Michael John Kerins et al.   Scientific Reports

Perilipin 5 promotes hepatic steatosis in dairy cows through increasing lipid synthesis and decreasing very low density lipoprotein assembly

(2018) Hongdou Jia et al.   JOURNAL OF DAIRY SCIENCE

Celastrol antagonizes high glucose-evoked podocyte injury, inflammation and insulin resistance by restoring the HO-1-mediated autophagy pathway

(2018) Xiaojiang Zhan et al.   MOLECULAR IMMUNOLOGY

Plin5 alleviates myocardial ischaemia/reperfusion injury by reducing oxidative stress through inhibiting the lipolysis of lipid droplets

(2017) Pengfei Zheng et al.   Scientific Reports

Perilipin 5 is protective in the ischemic heart

(2016) Christina Drevinge et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Perilipin 5 fine-tunes lipid oxidation to metabolic demand and protects against lipotoxicity in skeletal muscle

(2016) Claire Laurens et al.   Scientific Reports

Structural and functional characterization of Nrf2 degradation by glycogen synthase kinase 3/β-TrCP

(2015) Antonio Cuadrado   FREE RADICAL BIOLOGY AND MEDICINE

Unraveling the roles of PLIN5: linking cell biology to physiology

(2015) Rachael R. Mason et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Activation of the Nrf2-ARE Pathway Attenuates Hyperglycemia-Mediated Injuries in Mouse Podocytes

(2014) Cheng Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Deficiency of a Lipid Droplet Protein, Perilipin 5, Suppresses Myocardial Lipid Accumulation, Thereby Preventing Type 1 Diabetes-Induced Heart Malfunction

(2014) K. Kuramoto et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular and Cellular Events Mediating Glomerular Podocyte Dysfunction and Depletion in Diabetes Mellitus

(2014) P. Anil Kumar et al.   Frontiers in Endocrinology

Thrombomodulin domain 1 ameliorates diabetic nephropathy in mice via anti-NF-κB/NLRP3 inflammasome-mediated inflammation, enhancement of NRF2 antioxidant activity and inhibition of apoptosis

(2013) Shun-Min Yang et al.   DIABETOLOGIA

Regulation of Nrf2—an update

(2013) Suryakant K. Niture et al.   FREE RADICAL BIOLOGY AND MEDICINE

Perilipin 5: putting the brakes on lipolysis

(2013) Dawn L. Brasaemle   JOURNAL OF LIPID RESEARCH

A New Era of Podocyte-Targeted Therapy for Proteinuric Kidney Disease

(2013) Börje Haraldsson   NEW ENGLAND JOURNAL OF MEDICINE

Perilipin 5, a Lipid Droplet-binding Protein, Protects Heart from Oxidative Burden by Sequestering Fatty Acid from Excessive Oxidation

(2012) Kenta Kuramoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Regulation of Adipose Triglyceride Lipase (ATGL) by Perilipin 5, a Lipid Droplet-associated Protein

(2011) Hong Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Perilipin 5, a lipid droplet-associated protein, provides physical and metabolic linkage to mitochondria

(2011) Hong Wang et al.   JOURNAL OF LIPID RESEARCH

SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner

(2011) P. Rada et al.   MOLECULAR AND CELLULAR BIOLOGY

Diabetic Nephropathy in the Arab Gulf Countries

(2011) Youssef M.K. Farag et al.   NEPHRON CLINICAL PRACTICE

Oxidative tissue: perilipin 5 links storage with the furnace

(2011) Hong Wang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

(2010) T. Jiang et al.   DIABETES

Nrf2:INrf2 (Keap1) signaling in oxidative stress

(2009) James W. Kaspar et al.   FREE RADICAL BIOLOGY AND MEDICINE

Oxidative Stress as a Major Culprit in Kidney Disease in Diabetes

(2008) J. M. Forbes et al.   DIABETES

Proteinuria in diabetic kidney disease: A mechanistic viewpoint

(2008) J.A. Jefferson et al.   KIDNEY INTERNATIONAL