The potential role of human islet amyloid polypeptide in type 2 diabetes mellitus and Alzheimer’s diseases

The human islet amyloid polypeptide reduces hippocampal tauopathy and behavioral impairments in P301S mice without inducing neurotoxicity or seeding amyloid aggregation

(2023) Ying-Ying Yang et al.   EXPERIMENTAL NEUROLOGY

Long-term use of metformin and Alzheimer’s disease: beneficial or detrimental effects

(2023) Hayder M. Al-kuraishy et al.   INFLAMMOPHARMACOLOGY

Mechanistic insight into the role of metformin in Alzheimer's disease

(2022) Mehdi Sanati et al.   LIFE SCIENCES

Islet amyloid polypeptide cross-seeds tau and drives the neurofibrillary pathology in Alzheimer’s disease

(2022) Guoxin Zhang et al.   Molecular Neurodegeneration

Metformin in Alzheimer’s disease: An overview of potential mechanisms, preclinical and clinical findings

(2022) Mohammad Rafi Khezri et al.   BIOCHEMICAL PHARMACOLOGY

Common variants in genes involved in islet amyloid polypeptide (IAPP) processing and the degradation pathway are associated with T2DM risk: A Chinese population study

(2022) Jie Xu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Impaired insulin signalling and allostatic load in Alzheimer disease

(2022) Fernanda G. De Felice et al.   NATURE REVIEWS NEUROSCIENCE

Exploring the dual character of metformin in Alzheimer's disease

(2022) Pingping Ning et al.   NEUROPHARMACOLOGY

Human islet amyloid polypeptide: A therapeutic target for the management of type 2 diabetes mellitus

(2022) Pratiksha H. Roham et al.   Journal of Pharmaceutical Analysis

Factors That Contribute to hIAPP Amyloidosis in Type 2 Diabetes Mellitus

(2022) Adriana Sevcuka et al.   Life-Basel

Targeting hIAPP fibrillation: A new paradigm to prevent β-cell death?

(2022) Ghislaine Guillemain et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Human Islet Amyloid Polypeptide (hIAPP) Protofibril‐Specific Antibodies for Detection and Treatment of Type 2 Diabetes

(2022) Angelina S. Bortoletto et al.   Advanced Science

Is sitagliptin effective for SARS-CoV-2 infection: false or true prophecy?

(2022) Basil Mohammed Alomair et al.   INFLAMMOPHARMACOLOGY

Statins Use in Alzheimer Disease: Bane or Boon from Frantic Search and Narrative Review

(2022) Nawal Alsubaie et al.   Brain Sciences

A Potential Link Between Visceral Obesity and Risk of Alzheimer’s Disease

(2022) Hayder M. Al-Kuraishy et al.   NEUROCHEMICAL RESEARCH

Metformin and growth differentiation factor 15 ( GDF15 ) in type 2 diabetes mellitus: A hidden treasure

(2022) Hayder M. Al‐kuraishy et al.   Journal of Diabetes

Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes

(2021) Danilo Milardi et al.   CHEMICAL REVIEWS

The interplay between lipid and Aβ amyloid homeostasis in Alzheimer’s Disease: risk factors and therapeutic opportunities

(2021) Sara García-Viñuales et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Targeting Insulin-Degrading Enzyme in Insulin Clearance

(2021) Malcolm A. Leissring et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Heparan Sulfate Proteoglycans in Diabetes

(2021) Linda M. Hiebert   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Investigation of the effects of two major secretory granules components, insulin and zinc, on human-IAPP amyloid aggregation and membrane damage

(2021) Lucie Khemtemourian et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Protein S-nitrosylation and oxidation contribute to protein misfolding in neurodegeneration

(2021) Tomohiro Nakamura et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metformin attenuates vascular pathology by increasing expression of insulin-degrading enzyme in a mixed model of cerebral amyloid angiopathy and type 2 diabetes mellitus

(2021) Yasuteru Inoue et al.   NEUROSCIENCE LETTERS

Metformin activates chaperone-mediated autophagy and improves disease pathologies in an Alzheimer disease mouse model

(2021) Xiaoyan Xu et al.   Protein & Cell

Impact of Sitagliptin in Non-Diabetic Covid-19 Patients

(2021) Hayder M. Al-kuraishy et al.   Current Molecular Pharmacology

Metformin a Potential Pharmacological Strategy in Late Onset Alzheimer’s Disease Treatment

(2021) Saghar Rabiei Poor et al.   Pharmaceuticals

A mechanistic survey of Alzheimer's disease

(2021) Yijing Tang et al.   BIOPHYSICAL CHEMISTRY

The human cathelicidin LL-37 is a nanomolar inhibitor of amyloid self-assembly of islet amyloid polypeptide (IAPP)

(2020) Valentina Armiento et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Non-polyphenolic natural inhibitors of amyloid aggregation

(2020) Liang Ma et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Heparan Sulfate Proteoglycans Undergo Differential Expression Alterations in Alzheimer Disease Brains

(2020) Laura Lorente-Gea et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Dietary Supplementation with Curcumin Reduce Circulating Levels of Glycogen Synthase Kinase-3β and Islet Amyloid Polypeptide in Adults with High Risk of Type 2 Diabetes and Alzheimer’s Disease

(2020) Rohith N Thota et al.   Nutrients

Islet Amyloid Polypeptide: A Partner in Crime With Aβ in the Pathology of Alzheimer's Disease

(2020) Ana F. Raimundo et al.   Frontiers in Molecular Neuroscience

Low concentration IL-1β promotes islet amyloid formation by increasing hIAPP release from humanised mouse islets in vitro

(2020) Andrew T. Templin et al.   DIABETOLOGIA

Amylin and beta amyloid proteins interact to form amorphous heterocomplexes with enhanced toxicity in neuronal cells

(2020) Prashant Bharadwaj et al.   Scientific Reports

Human islet amyloid polypeptide (hIAPP) - a curse in type II diabetes mellitus: insights from structure and toxicity studies

(2020) Ajit Kumar Bishoyi et al.   BIOLOGICAL CHEMISTRY

Myricetin protects pancreatic β-cells from human islet amyloid polypeptide (hIAPP) induced cytotoxicity and restores islet function

(2020) Richa Dubey et al.   BIOLOGICAL CHEMISTRY

Multifunctional roles of zinc in Alzheimer’s disease

(2020) Zhuoya Xie et al.   NEUROTOXICOLOGY

The human islet amyloid polypeptide in protein misfolding disorders: Mechanisms of aggregation and interaction with biomembranes

(2020) Adam El Saghir et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Anti-Neuroinflammatory Potential of Polyphenols by Inhibiting NF-κB to Halt Alzheimer's Disease

(2020) Md. Sahab Uddin et al.   CURRENT PHARMACEUTICAL DESIGN

Markers of adiposity, insulin resistance, prediabetes and cognitive function at baseline of the Brazilian Longitudinal Study of Adult Health (ELSA – Brasil)

(2020) Mônica Maria Teixeira et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Probing the aggregation and immune response of human islet amyloid polypeptide with ligand-stabilized gold nanoparticles

(2019) Ibrahim Javed et al.   ACS Applied Materials & Interfaces

Early-Stage Alzheimer’s Disease Is Associated with Simultaneous Systemic and Central Nervous System Dysregulation of Insulin-Linked Metabolic Pathways

(2019) Suzanne M. de la Monte et al.   JOURNAL OF ALZHEIMERS DISEASE

Azadirachtin inhibits amyloid formation, disaggregates pre-formed fibrils and protects pancreatic β-cells from human islet amyloid polypeptide/amylin-induced cytotoxicity

(2019) Richa Dubey et al.   BIOCHEMICAL JOURNAL

Glycated Insulin Exacerbates the Cytotoxicity of Human Islet Amyloid Polypeptides: a Vicious Cycle in Type 2 Diabetes

(2019) Liang Ma et al.   ACS Chemical Biology

Metformin Improves Learning and Memory in the SAMP8 Mouse Model of Alzheimer’s Disease

(2019) Susan A. Farr et al.   JOURNAL OF ALZHEIMERS DISEASE

Neuroprotective Effects of the Amylin Analog, Pramlintide, on Alzheimer’s Disease Are Associated with Oxidative Stress Regulation Mechanisms

(2019) Sarah Patrick et al.   JOURNAL OF ALZHEIMERS DISEASE

Levels of islet amyloid polypeptide in cerebrospinal fluid and plasma from patients with Alzheimer’s disease

(2019) Nina Schultz et al.   PLoS One

Human Amylin: From Pathology to Physiology and Pharmacology

(2019) Wei Ling et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Neurocognitive impairment in type 2 diabetes mellitus

(2019) Marianna Karvani et al.   Hormones-International Journal of Endocrinology and Metabolism

A systematic literature review of the effect of insulin sensitizers on the cognitive symptoms of Alzheimer’s Disease in transgenic mice

(2019) Amy Craig et al.   BEHAVIOURAL BRAIN RESEARCH

Thiazolidinediones: the Forgotten Diabetes Medications

(2019) Harold E. Lebovitz   Current Diabetes Reports

Metformin and risk of Alzheimer’s disease among community-dwelling people with diabetes: a national case-control study

(2019) Janet K Sluggett et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Preparation of a new type 2 diabetic miniature pig model via the CRISPR/Cas9 system

(2019) Xiaodong Zou et al.   Cell Death & Disease

Type 2 Diabetes Mellitus Increases The Risk of Late-Onset Alzheimer’s Disease: Ultrastructural Remodeling of the Neurovascular Unit and Diabetic Gliopathy

(2019) Hayden   Brain Sciences

Lixisenatide reduces amyloid plaques, neurofibrillary tangles and neuroinflammation in an APP/PS1/tau mouse model of Alzheimer's disease

(2018) Hong-Yan Cai et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Amyloid growth and membrane damage: Current themes and emerging perspectives from theory and experiments on Aβ and hIAPP

(2018) Michele F.M. Sciacca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Incidence of Dementia is Increased in Type 2 Diabetes and Reduced by the Use of Sulfonylureas and Metformin

(2018) Chih-Cheng Hsu et al.   JOURNAL OF ALZHEIMERS DISEASE

Differential Effects of Thiazolidinediones and Dipeptidyl Peptidase-4 Inhibitors on Insulin Resistance and β-Cell Function in Type 2 Diabetes Mellitus: A Propensity Score-Matched Analysis

(2018) Jaehyun Bae et al.   Diabetes Therapy

Influence of ADAM10 Polymorphisms on Plasma Level of Soluble Receptor for Advanced Glycation End Products and The Association With Alzheimer’s Disease Risk

(2018) Wen-Hui Huang et al.   Frontiers in Genetics

The methanolic extract of Thymus praecox subsp. skorpilii var. skorpilii restores glucose homeostasis, ameliorates insulin resistance and improves pancreatic β-cell function on streptozotocin/nicotinamide-induced type 2 diabetic rats

(2018) Muhammet Emin Cam et al.   JOURNAL OF ETHNOPHARMACOLOGY

Amyloid-β and islet amyloid pathologies link Alzheimer’s disease and type 2 diabetes in a transgenic model

(2017) Nadeeja Wijesekara et al.   FASEB JOURNAL

Common fibrillar spines of amyloid-β and human islet amyloid polypeptide revealed by microelectron diffraction and structure-based inhibitors

(2017) Pascal Krotee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tau deletion promotes brain insulin resistance

(2017) Elodie Marciniak et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Islet amyloid polypeptide: Another key molecule in Alzheimer’s pathogenesis?

(2017) Yun Zhang et al.   PROGRESS IN NEUROBIOLOGY

Autophagy is a major regulator of beta cell insulin homeostasis

(2016) Yael Riahi et al.   DIABETOLOGIA

Differential Activation of Innate Immune Pathways by Distinct Islet Amyloid Polypeptide (IAPP) Aggregates

(2016) Clara Westwell-Roper et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cognitively impaired elderly exhibit insulin resistance and no memory improvement with infused insulin

(2016) Jill K. Morris et al.   NEUROBIOLOGY OF AGING

Targeting Insulin-Degrading Enzyme to Treat Type 2 Diabetes Mellitus

(2016) Wei-Jen Tang   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Pancreatic β-Cell Membrane Fluidity and Toxicity Induced by Human Islet Amyloid Polypeptide Species

(2016) Emily H. Pilkington et al.   Scientific Reports

Cross-Seeding Interaction between β-Amyloid and Human Islet Amyloid Polypeptide

(2015) Rundong Hu et al.   ACS Chemical Neuroscience

In Vivo Seeding and Cross-Seeding of Localized Amyloidosis

(2015) Marie E. Oskarsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Exenatide reduces TNF-α expression and improves hippocampal neuron numbers and memory in streptozotocin treated rats

(2015) Volkan Solmaz et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Probing the Sources of the Apparent Irreproducibility of Amyloid Formation: Drastic Changes in Kinetics and a Switch in Mechanism Due to Micellelike Oligomer Formation at Critical Concentrations of IAPP

(2015) Jeffrey R. Brender et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Causative factors for formation of toxic islet amyloid polypeptide oligomer in type 2 diabetes mellitus

(2015) Seong Soo An et al.   Clinical Interventions in Aging

Human IAPP amyloidogenic properties and pancreatic β-cell death

(2014) Marta S. Fernández   CELL CALCIUM

Islet Amyloid Polypeptide (IAPP): A Second Amyloid in Alzheimer's Disease

(2014) Janelle Fawver et al.   Current Alzheimer Research

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

(2014) Juan Pablo Maianti et al.   NATURE

Promoting Autophagic Clearance: Viable Therapeutic Targets in Alzheimer’s Disease

(2014) Lauren G. Friedman et al.   Neurotherapeutics

Apoptosis induced by islet amyloid polypeptide soluble oligomers is neutralized by diabetes-associated specific antibodies

(2014) Yaron Bram et al.   Scientific Reports

Clinicopathologic assessment and imaging of tauopathies in neurodegenerative dementias

(2014) Melissa E Murray et al.   Alzheimers Research & Therapy

Amylin deposition in the brain: A second amyloid in Alzheimer disease?

(2013) Kaleena Jackson et al.   ANNALS OF NEUROLOGY

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   NEUROPHARMACOLOGY

Lessons from two prevalent amyloidoses—what amylin and Aβ have in common

(2013) Jürgen Götz et al.   Frontiers in Aging Neuroscience

Mild exposure of RIN-5F β-cells to human islet amyloid polypeptide aggregates upregulates antioxidant enzymes via NADPH oxidase-RAGE: An hormetic stimulus

(2013) Elisabetta Borchi et al.   Redox Biology

Effects of Heparin on Amylin Fibrillization

(2012) Andrei T. Alexandrescu et al.   BIOPHYSICAL JOURNAL

Actions of β-Amyloid Protein on Human Neurons Are Expressed through the Amylin Receptor

(2011) Jack H. Jhamandas et al.   AMERICAN JOURNAL OF PATHOLOGY

Rosiglitazone and Pioglitazone for the Treatment of Alzheimer's Disease

(2011) Benjamin W Miller et al.   ANNALS OF PHARMACOTHERAPY

Involvement of ATP-sensitive Potassium (KATP) Channels in the Loss of Beta-cell Function Induced by Human Islet Amyloid Polypeptide

(2011) Maud Soty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

IL-1 Blockade Attenuates Islet Amyloid Polypeptide-Induced Proinflammatory Cytokine Release and Pancreatic Islet Graft Dysfunction

(2011) C. Westwell-Roper et al.   JOURNAL OF IMMUNOLOGY

A Two-Site Mechanism for the Inhibition of IAPP Amyloidogenesis by Zinc

(2011) Samer Salamekh et al.   JOURNAL OF MOLECULAR BIOLOGY

AMP-activated protein kinase: a potential player in Alzheimer’s disease

(2011) Antero Salminen et al.   JOURNAL OF NEUROCHEMISTRY

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Selection for Nonamyloidogenic Mutants of Islet Amyloid Polypeptide (IAPP) Identifies an Extended Region for Amyloidogenicity

(2010) Ayano Fox et al.   BIOCHEMISTRY

Increased serum HSP70 levels are associated with the duration of diabetes

(2010) Manouchehr Nakhjavani et al.   CELL STRESS & CHAPERONES

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Role of Zinc in Human Islet Amyloid Polypeptide Aggregation

(2010) Jeffrey R. Brender et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evidence for Proteotoxicity in β Cells in Type 2 Diabetes

(2009) Tatyana Gurlo et al.   AMERICAN JOURNAL OF PATHOLOGY

Beneficial Endocrine but Adverse Exocrine Effects of Sitagliptin in the Human Islet Amyloid Polypeptide Transgenic Rat Model of Type 2 Diabetes: Interactions With Metformin

(2009) A. V. Matveyenko et al.   DIABETES

Role of Copper Ion in the Pathogenesis of Type 2 Diabetes

(2009) Ayako TANAKA et al.   ENDOCRINE JOURNAL

Long-term inhibition of dipeptidyl peptidase-4 in Alzheimer’s prone mice

(2009) Michele D’Amico et al.   EXPERIMENTAL GERONTOLOGY

Phosphorylation of IRS proteins, insulin action, and insulin resistance

(2008) Sigalit Boura-Halfon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

(2008) Judith Miklossy et al.   NEUROBIOLOGY OF AGING

Aggregation Propensity of the Human Proteome

(2008) Elodie Monsellier et al.   PLoS Computational Biology

Low levels of asparagine deamidation can have a dramatic effect on aggregation of amyloidogenic peptides: Implications for the study of amyloid formation

(2002) Melanie R. Nilsson et al.   PROTEIN SCIENCE