Insights on benzodiazepines' potential in Alzheimer's disease

Effects of α5 GABA A receptor modulation on social interaction, memory, and neuroinflammation in a mouse model of Alzheimer's disease

(2022) Jovana Aranđelović et al.   CNS Neuroscience & Therapeutics

Central effects of Ivermectin in alleviation of Covid-19-induced dysautonomia

(2022) Hayder M. Al-kuraishy et al.   CURRENT DRUG TARGETS

Prevalence of exposure to benzodiazepines among pregnant women in Taiwan: A nationwide longitudinal study

(2022) Yu‐Hsuan Lin et al.   JOURNAL OF SLEEP RESEARCH

Statins Use in Alzheimer Disease: Bane or Boon from Frantic Search and Narrative Review

(2022) Nawal Alsubaie et al.   Brain Sciences

Tendinopathy

(2021) Neal L. Millar et al.   Nature Reviews Disease Primers

First-line management of canine status epilepticus at home and in hospital-opportunities and limitations of the various administration routes of benzodiazepines

(2021) Marios Charalambous et al.   BMC Veterinary Research

Integrating human brain proteomes with genome-wide association data implicates new proteins in Alzheimer’s disease pathogenesis

(2021) Aliza P. Wingo et al.   NATURE GENETICS

Systematic review of coexistent epileptic seizures and Alzheimer's disease: Incidence and prevalence

(2021) Ying Xu et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Time Is Brain: Acute Control of Repetitive Seizures and Status Epilepticus Using Alternative Routes of Administration of Benzodiazepines

(2021) Sulaiman Almohaish et al.   Journal of Clinical Medicine

The preventative effect of of Ro5-4864 (peripheral benzodiazepine receptor agonist) on spinal epidural fibrosis after laminectomy in a rat model

(2021) Emrah Keskin et al.   NEUROLOGICAL RESEARCH

The Role of the GABAergic System in Diseases of the Central Nervous System

(2021) Wen Zhang et al.   NEUROSCIENCE

Prodromal dysfunction of α5GABA-A receptor modulated hippocampal ripples occurs prior to neurodegeneration in the TgF344-AD rat model of Alzheimer's disease

(2021) Marcia H. Ratner et al.   Heliyon

Presenilin mutations and their impact on neuronal differentiation in Alzheimer’s disease

(2021) AlejandroA Canales-Aguirre et al.   Neural Regeneration Research

Benzodiazepine use and neuroimaging markers of Alzheimer’s disease in nondemented older individuals: an MRI and 18F Florbetapir PET study in the MEMENTO cohort

(2021) Quentin Gallet et al.   NEUROPSYCHOPHARMACOLOGY

Therapeutic approaches targeting Apolipoprotein E function in Alzheimer’s disease

(2020) Tosha Williams et al.   Molecular Neurodegeneration

Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer's Disease Dementia

(2020) Miren Ettcheto et al.   Frontiers in Aging Neuroscience

Do Benzodiazepines Cause Alzheimer’s Disease?

(2020) Carl Salzman   AMERICAN JOURNAL OF PSYCHIATRY

Risk of hospitalisation associated with benzodiazepines and z-drugs in Italy: a nationwide multicentre study in emergency departments

(2020) Niccolò Lombardi et al.   Internal and Emergency Medicine

A role of low-density lipoprotein receptor-related protein 4 (LRP4) in astrocytic Aβ clearance

(2020) Hongsheng Zhang et al.   JOURNAL OF NEUROSCIENCE

Seizures in Alzheimer’s disease are highly recurrent and associated with a poor disease course

(2020) Jonathan Vöglein et al.   JOURNAL OF NEUROLOGY

Neuroprotective effects of Sophora secundiflora, Sophora tomentosa leaves and formononetin on scopolamine-induced dementia

(2020) Shaza H. Aly et al.   NATURAL PRODUCT RESEARCH

Slow Wave Sleep Is a Promising Intervention Target for Alzheimer’s Disease

(2020) Yee Fun Lee et al.   Frontiers in Neuroscience

Accumulation of amyloid precursor protein C-terminal fragments triggers mitochondrial structure, function, and mitophagy defects in Alzheimer’s disease models and human brains

(2020) Loan Vaillant-Beuchot et al.   ACTA NEUROPATHOLOGICA

Pharmacological and non‐pharmacological interventions to enhance sleep in mild cognitive impairment and mild Alzheimer's disease: A systematic review

(2020) Jonathan Blackman et al.   JOURNAL OF SLEEP RESEARCH

Interaction of Thalassia testudinum Metabolites with Cytochrome P450 Enzymes and Its Effects on Benzo(a)pyrene-Induced Mutagenicity

(2020) Livan Delgado-Roche et al.   Marine Drugs

Apolipoprotein E: Structural Insights and Links to Alzheimer Disease Pathogenesis

(2020) Yun Chen et al.   NEURON

The α5-Containing GABAA Receptors—a Brief Summary

(2019) Fatin H. Mohamad et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Beyond the neuron–cellular interactions early in Alzheimer disease pathogenesis

(2019) Christopher M. Henstridge et al.   NATURE REVIEWS NEUROSCIENCE

In vivo localization of human acetylcholinesterase-derived species in a β-sheet conformation at the core of senile plaques in Alzheimer’s disease

(2019) Létitia Jean et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Preliminary Report on the Feasibility and Efficacy of the Modified Atkins Diet for Treatment of Mild Cognitive Impairment and Early Alzheimer’s Disease

(2019) Jason Brandt et al.   JOURNAL OF ALZHEIMERS DISEASE

The Contribution of Genetic Factors to Cognitive Impairment and Dementia: Apolipoprotein E Gene, Gene Interactions, and Polygenic Risk

(2019) Jialing Fan et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

GABAergic astrocytes in Alzheimer’s disease

(2019) Olga Garaschuk et al.   Aging-US

GABAA/benzodiazepine receptors in the dorsal periaqueductal gray mediate the panicolytic but not the anxiolytic effect of alprazolam in rats

(2019) Alana Tercino Frias et al.   BEHAVIOURAL BRAIN RESEARCH

Alzheimer’s disease: pathogenesis, diagnostics, and therapeutics

(2019) Sneham Tiwari et al.   International Journal of Nanomedicine

Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies

(2019) Yu Yamazaki et al.   Nature Reviews Neurology

Patterns of Prescription Opioid Use in Women With Endometriosis

(2019) Georgine Lamvu et al.   OBSTETRICS AND GYNECOLOGY

Frequency-dependent exacerbation of Alzheimer’s disease neuropathophysiology

(2019) Ksenia V. Kastanenka et al.   Scientific Reports

Sleep and β-Amyloid Deposition in Alzheimer Disease: Insights on Mechanisms and Possible Innovative Treatments

(2019) Susanna Cordone et al.   Frontiers in Pharmacology

Bidirectional relationship between sleep and Alzheimer’s disease: role of amyloid, tau, and other factors

(2019) Chanung Wang et al.   NEUROPSYCHOPHARMACOLOGY

Prediction of Drug–Drug Interactions Between Opioids and Overdosed Benzodiazepines Using Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation

(2019) Beihong Ji et al.   Drugs in research & development

Is Benzodiazepine Use Associated With the Risk of Dementia and Cognitive Impairment–Not Dementia in Older Persons? The Canadian Study of Health and Aging

(2019) Mohamed Nafti et al.   ANNALS OF PHARMACOTHERAPY

Cognitive Outcomes of Long-term Benzodiazepine and Related Drug (BDZR) Use in People Living With Mild to Moderate Alzheimer's Disease: Results From NILVAD

(2019) Adam H. Dyer et al.   Journal of the American Medical Directors Association

Uncertain Association Between Benzodiazepine Use and the Risk of Dementia: A Cohort Study

(2019) Yeon-Hee Baek et al.   Journal of the American Medical Directors Association

Common Variant in TREM1 Influencing Brain Amyloid Deposition in Mild Cognitive Impairment and Alzheimer’s Disease

(2019) Yue-Song Liu et al.   NEUROTOXICITY RESEARCH

SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model

(2019) Aiwu Cheng et al.   JOURNAL OF NEUROSCIENCE

Benzodiazepine use and brain amyloid load in nondemented older individuals: a florbetapir PET study in the Multidomain Alzheimer Preventive Trial cohort

(2019) Thomas Desmidt et al.   NEUROBIOLOGY OF AGING

The Molecular Mechanism of Alpha-Synuclein Dependent Regulation of Protein Phosphatase 2A Activity

(2018) Jing Qu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Experimental versus theoretical log D7.4 , pKa and plasma protein binding values for benzodiazepines appearing as new psychoactive substances

(2018) Kieran R. Manchester et al.   Drug Testing and Analysis

The interactions of fullerene C 60 and Benzo(α)pyrene influence their bioavailability and toxicity to zebrafish embryos

(2018) Camilla Della Torre et al.   ENVIRONMENTAL POLLUTION

GABAA receptor subunit expression changes in the human Alzheimer's disease hippocampus, subiculum, entorhinal cortex and superior temporal gyrus

(2018) Andrea Kwakowsky et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid-β Increases Tau by Mediating Sirtuin 3 in Alzheimer’s Disease

(2018) Junxiang Yin et al.   MOLECULAR NEUROBIOLOGY

APOE and Alzheimer’s Disease: Evidence Mounts that Targeting APOE4 may Combat Alzheimer’s Pathogenesis

(2018) Md. Sahab Uddin et al.   MOLECULAR NEUROBIOLOGY

Synaptic dysfunction in Alzheimer's disease: the effects of amyloid beta on synaptic vesicle dynamics as a novel target for therapeutic intervention

(2018) Pavlos Alifragis et al.   Neural Regeneration Research

Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling

(2018) Megan L. Brady et al.   NEUROPHARMACOLOGY

Stress as risk factor for Alzheimer’s disease

(2018) Alessandra Caruso et al.   PHARMACOLOGICAL RESEARCH

An acute functional screen identifies an effective antibody targeting amyloid-β oligomers based on calcium imaging

(2018) Xueying Wang et al.   Scientific Reports

On Benzodiazepines, Paradoxical Agitation, Hyperactive Delirium, and Chloride Homeostasis*

(2018) Jan N. M. Schieveld et al.   CRITICAL CARE MEDICINE

Hippocampal GABAergic Neurons are Susceptible to Amyloid-β Toxicity in vitro and are Decreased in Number in the Alzheimer's Disease TgCRND8 Mouse Model

(2018) Slavica Krantic et al.   JOURNAL OF ALZHEIMERS DISEASE

Gamma-aminobutyric acid A receptors in Alzheimer's disease: highly localized remodeling of a complex and diverse signaling pathway

(2018) Andrea Kwakowsky et al.   Neural Regeneration Research

Diazepam Toxicity Presenting as a Dementia Disorder

(2018) Zimple Kurlawala et al.   JOURNAL OF ALZHEIMERS DISEASE

International Union of Basic and Clinical Pharmacology. CVI: GABAA Receptor Subtype- and Function-selective Ligands: Key Issues in Translation to Humans

(2018) Werner Sieghart et al.   PHARMACOLOGICAL REVIEWS

Administration of the benzodiazepine midazolam increases tau phosphorylation in the mouse brain

(2018) Robert A. Whittington et al.   NEUROBIOLOGY OF AGING

Risk of death associated with new benzodiazepine use among persons with Alzheimer disease: A matched cohort study

(2017) Laura Saarelainen et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Selective inhibition of extra-synaptic α5-GABA A receptors by S44819, a new therapeutic agent

(2017) Lori-An Etherington et al.   NEUROPHARMACOLOGY

Optogenetic Restoration of Disrupted Slow Oscillations Halts Amyloid Deposition and Restores Calcium Homeostasis in an Animal Model of Alzheimer’s Disease

(2017) Ksenia V. Kastanenka et al.   PLoS One

Insulin resistance in Alzheimer's disease

(2017) Thomas Diehl et al.   Translational Research

Benzodiazepine Use and Risk of Dementia in the Elderly Population: A Systematic Review and Meta-Analysis

(2016) Md. Mohaimenul Islam et al.   NEUROEPIDEMIOLOGY

Use of Benzodiazepines in Alzheimer’s Disease: A Systematic Review of Literature

(2015) Michaela Defrancesco et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Loss of Munc18-1 long splice variant in GABAergic terminals is associated with cognitive decline and increased risk of dementia in a community sample

(2015) Alfredo Ramos-Miguel et al.   Molecular Neurodegeneration

Synaptic dysfunction and septin protein family members in neurodegenerative diseases

(2015) Mikael Marttinen et al.   Molecular Neurodegeneration

Oligomeric Aβ-induced synaptic dysfunction in Alzheimer’s disease

(2014) Shichun Tu et al.   Molecular Neurodegeneration

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Sleep deprivation impairs memory, tau metabolism, and synaptic integrity of a mouse model of Alzheimer's disease with plaques and tangles

(2014) Antonio Di Meco et al.   NEUROBIOLOGY OF AGING

Chronic treatment with anesthetic propofol attenuates β-amyloid protein levels in brain tissues of aged mice

(2014) Yiying Zhang et al.   Translational Neurodegeneration

Midlife Sleep Characteristics Associated with Late Life Cognitive Function

(2013) Jyri J. Virta et al.   SLEEP

EHT0202 in Alzheimers Disease: A 3-Month, Randomized, Placebo- Controlled, Double-Blind Study

(2012) B. Vellas et al.   Current Alzheimer Research

Tramiprosate in mild-to-moderate Alzheimer’s disease – a randomized, double-blind, placebo-controlled, multi-centre study (the Alphase Study)

(2011) Paul S. Aisen et al.   Archives of Medical Science

Beneficial effects of benzodiazepine diazepam on chronic stress-induced impairment of hippocampal structural plasticity and depression-like behavior in mice

(2011) Yunan Zhao et al.   BEHAVIOURAL BRAIN RESEARCH

Analysis of chiral amino acids in cerebrospinal fluid samples linked to different stages of Alzheimer disease

(2011) Shorena Samakashvili et al.   ELECTROPHORESIS

Dual Functions of Histone-LysineN-Methyltransferase Setdb1 Protein at Promyelocytic Leukemia-Nuclear Body (PML-NB)

(2011) Sunwha Cho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Translocase of Outer Mitochondrial Membrane 40 Homolog (TOMM40) Poly-T Length Modulates Lorazepam-Related Cognitive Toxicity in Healthy APOE ϵ4-Negative Elderly

(2011) Nunzio Pomara et al.   JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY

Benzodiazepine use and risk of dementia: evidence from the Caerphilly Prospective Study (CaPS)

(2011) John Gallacher et al.   JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH

β-Carboline Compounds, Including Harmine, Inhibit DYRK1A and Tau Phosphorylation at Multiple Alzheimer's Disease-Related Sites

(2011) Danielle Frost et al.   PLoS One

Increased caspase activation and decreased TDP-43 solubility in progranulin knockout cortical cultures

(2010) Gernot Kleinberger et al.   JOURNAL OF NEUROCHEMISTRY

Novel positive allosteric modulators of GABAA receptors: Do subtle differences in activity at α1 plus α5 versus α2 plus α3 subunits account for dissimilarities in behavioral effects in rats?

(2010) Miroslav M. Savić et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

GABAergic Interneuron Dysfunction Impairs Hippocampal Neurogenesis in Adult Apolipoprotein E4 Knockin Mice

(2009) Gang Li et al.   Cell Stem Cell

How Do Different Age Groups Use Benzodiazepines and Antidepressants?

(2009) Alesha J Smith et al.   DRUGS & AGING

Double-Blind Crossover Study of the Cognitive Effects of Lorazepam in Healthy Apolipoprotein E (APOE)-ε4 Carriers

(2009) Cynthia M. Stonnington et al.   JOURNAL OF CLINICAL PSYCHIATRY

Synthesis, in Vivo Evaluation, and Molecular Modeling Studies of New Pyrazolo[5,1-c][1,2,4]benzotriazine 5-Oxide Derivatives. Identification of a Bifunctional Hydrogen Bond Area Related to the Inverse Agonism

(2009) Gabriella Guerrini et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective Influence on Contextual Memory: Physiochemical Properties Associated with Selectivity of Benzodiazepine Ligands at GABAAReceptors Containing the α5 Subunit

(2008) Danni Harris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Neuropeptide S-Mediated Control of Fear Expression and Extinction: Role of Intercalated GABAergic Neurons in the Amygdala

(2008) Kay Jüngling et al.   NEURON

GABAA Receptor-Mediated Acceleration of Aging-Associated Memory Decline in APP/PS1 Mice and Its Pharmacological Treatment by Picrotoxin

(2008) Yuji Yoshiike et al.   PLoS One