Expression of Amyloid Precursor Protein, Caveolin-1, Alpha-, Beta-, and Gamma-Secretases in Penumbra Cells after Photothrombotic Stroke and Evaluation of Neuroprotective Effect of Secretase and Caveolin-1 Inhibitors

Selective Secretase Targeting for Alzheimer’s Disease Therapy

(2021) Alvaro Miranda et al.   JOURNAL OF ALZHEIMERS DISEASE

The BACE1 inhibitor LY2886721 improves diabetic phenotypes of BACE1 knock-in mice

(2021) Ruta Dekeryte et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Caveolin-1, a novel player in cognitive decline

(2021) Wenxin Tang et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

The Alzheimer’s Disease Amyloid-Beta Hypothesis in Cardiovascular Aging and Disease

(2020) Dimitrios A. Stakos et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Pathophysiology of ischemic stroke: role of oxidative stress

(2020) Sofía Orellana-Urzúa et al.   CURRENT PHARMACEUTICAL DESIGN

Participation of Amyloid and Tau Protein in Neuronal Death and Neurodegeneration after Brain Ischemia

(2020) Ryszard Pluta et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Functions of amyloid precursor protein in metabolic diseases

(2020) Yanjun Guo et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Trafficking and proteolytic processing of amyloid precursor protein and secretases in Alzheimer's disease development: An up-to-date review

(2019) Melike Yuksel et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Notch signaling pathway inhibitor Dapt alleviates autism-like behavior, autophagy and dendritic spine density abnormalities in a valproic acid-induced animal model of autism

(2019) Yinghua Zhang et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Neuroprotective effects of irisin against cerebral ischemia/ reperfusion injury via Notch signaling pathway

(2019) Zhao Jin et al.   BIOMEDICINE & PHARMACOTHERAPY

LIPID RAFTS AND NEURODEGENERATION: Structural and functional roles in physiologic aging and neurodegenerative diseases

(2019) Sara Grassi et al.   JOURNAL OF LIPID RESEARCH

Mechanisms of action of amyloid-beta and its precursor protein in neuronal cell death

(2019) Yong Qi Leong et al.   METABOLIC BRAIN DISEASE

Targeting RNS/caveolin-1/MMP signaling cascades to protect against cerebral ischemia-reperfusion injuries: potential application for drug discovery

(2018) Han-sen Chen et al.   ACTA PHARMACOLOGICA SINICA

Secretase inhibitors for the treatment of Alzheimer's disease: Long road ahead

(2018) Devendra Kumar et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Cellular Trafficking of Amyloid Precursor Protein in Amyloidogenesis Physiological and Pathological Significance

(2018) Noralyn Basco Mañucat-Tan et al.   MOLECULAR NEUROBIOLOGY

Reactive astrocytes in Alzheimer’s disease: A double-edged sword

(2018) Heejung Chun et al.   NEUROSCIENCE RESEARCH

Activation of the α-Secretase Processing of AβPP as a Therapeutic Approach in Alzheimer's Disease

(2018) Bruno Vincent et al.   JOURNAL OF ALZHEIMERS DISEASE

Involvement of caveolin-1 in neurovascular unit remodeling after stroke: Effects on neovascularization and astrogliosis

(2018) Camille Blochet et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

A review of the role of cav-1 in neuropathology and neural recovery after ischemic stroke

(2018) Qianyi Huang et al.   Journal of Neuroinflammation

Adjunctive Therapy Approaches for Ischemic Stroke: Innovations to Expand Time Window of Treatment

(2017) Talia Knecht et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Specificity of presenilin-1- and presenilin-2-dependent γ-secretases towards substrate processing

(2017) Serena Stanga et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stroke

(2017) Graeme J Hankey   LANCET

Not just amyloid: physiological functions of the amyloid precursor protein family

(2017) Ulrike C. Müller et al.   NATURE REVIEWS NEUROSCIENCE

Neutrophil Infiltration and Matrix Metalloproteinase-9 in Lacunar Infarction

(2017) Wolfgang Walz et al.   NEUROCHEMICAL RESEARCH

Chronic Cerebral Hypoperfusion Promotes Amyloid-Beta Pathogenesis via Activating β/γ-Secretases

(2017) Zhiyou Cai et al.   NEUROCHEMICAL RESEARCH

Regulation of Alpha-Secretase ADAM10 In vitro and In vivo: Genetic, Epigenetic, and Protein-Based Mechanisms

(2017) Kristina Endres et al.   Frontiers in Molecular Neuroscience

APP as a Protective Factor in Acute Neuronal Insults

(2017) Dimitri Hefter et al.   Frontiers in Molecular Neuroscience

Caveolin-1 Regulates γ-Secretase-Mediated AβPP Processing by Modulating Spatial Distribution of γ-Secretase in Membrane

(2017) Arun Kapoor et al.   JOURNAL OF ALZHEIMERS DISEASE

Physiological and pathological roles of the γ-secretase complex

(2016) Courtney M. Carroll et al.   BRAIN RESEARCH BULLETIN

Regulation of the α-secretase ADAM10 at transcriptional, translational and post-translational levels

(2016) Bruno Vincent   BRAIN RESEARCH BULLETIN

Alternative Processing of the Amyloid Precursor Protein Family by Rhomboid Protease RHBDL4

(2016) Sandra Paschkowsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex

(2016) Svetlana Demyanenko et al.   MOLECULAR NEUROBIOLOGY

Protein Profile and Morphological Alterations in Penumbra after Focal Photothrombotic Infarction in the Rat Cerebral Cortex

(2016) Anatoly Uzdensky et al.   MOLECULAR NEUROBIOLOGY

Treadmill Exercise Promotes Neurogenesis in Ischemic Rat Brains via Caveolin-1/VEGF Signaling Pathways

(2016) Yun Zhao et al.   NEUROCHEMICAL RESEARCH

Alzheimer-associated presenilin 2 gene is dysregulated in rat medial temporal lobe cortex after complete brain ischemia due to cardiac arrest

(2016) Ryszard Pluta et al.   Pharmacological Reports

Expression of neuronal and signaling proteins in penumbra around a photothrombotic infarction core in rat cerebral cortex

(2015) S. V. Demyanenko et al.   BIOCHEMISTRY-MOSCOW

The Potent BACE1 Inhibitor LY2886721 Elicits Robust Central A  Pharmacodynamic Responses in Mice, Dogs, and Humans

(2015) P. C. May et al.   JOURNAL OF NEUROSCIENCE

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

Acute Blockage of Notch Signaling by DAPT Induces Neuroprotection and Neurogenesis in the Neonatal Rat Brain After Stroke

(2015) Zhongxia Li et al.   Translational Stroke Research

Lessons from a Failed γ-Secretase Alzheimer Trial

(2014) Bart De Strooper   CELL

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Postnatal Disruption of the Disintegrin/Metalloproteinase ADAM10 in Brain Causes Epileptic Seizures, Learning Deficits, Altered Spine Morphology, and Defective Synaptic Functions

(2013) J. Prox et al.   JOURNAL OF NEUROSCIENCE

Activity-Induced Convergence of APP and BACE-1 in Acidic Microdomains via an Endocytosis-Dependent Pathway

(2013) Utpal Das et al.   NEURON

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

The γ-Secretase Blocker DAPT Reduces the Permeability of the Blood-Brain Barrier by Decreasing the Ubiquitination and Degradation of Occludin During Permanent Brain Ischemia

(2012) Gen-Sheng Zhang et al.   CNS Neuroscience & Therapeutics

DAPT protects brain against cerebral ischemia by down-regulating the expression of Notch 1 and Nuclear factor kappa B in rats

(2012) Shuya Li et al.   NEUROLOGICAL SCIENCES

Notch Signaling Inhibits Axon Regeneration

(2012) Rachid El Bejjani et al.   NEURON

Caveolin-1 Deletion Reduces Early Brain Injury after Experimental Intracerebral Hemorrhage

(2011) Che-Feng Chang et al.   AMERICAN JOURNAL OF PATHOLOGY

Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin

(2011) Robyn M Carey et al.   BMC CELL BIOLOGY

APP physiological and pathophysiological functions: insights from animal models

(2011) Qinxi Guo et al.   CELL RESEARCH

Stroke research at a crossroad: asking the brain for directions

(2011) Costantino Iadecola et al.   NATURE NEUROSCIENCE

ADP ribosylation factor 6 (ARF6) controls amyloid precursor protein (APP) processing by mediating the endosomal sorting of BACE1

(2011) R. Sannerud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Loss of Caveolin-1 Accelerates Neurodegeneration and Aging

(2010) Brian P. Head et al.   PLoS One

Targeting ADAM10 to lipid rafts in neuroblastoma SH-SY5Y cells impairs amyloidogenic processing of the amyloid precursor protein

(2009) Benjamin Harris et al.   BRAIN RESEARCH

Amyloid precursor protein and its homologues: a family of proteolysis-dependent receptors

(2009) Kristin T. Jacobsen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Amyloid Precursor Protein Mediates a Tyrosine Kinase-Dependent Activation Response in Endothelial Cells

(2009) S. A. Austin et al.   JOURNAL OF NEUROSCIENCE

Genetic deletion of BACE1 in mice affects remyelination of sciatic nerves

(2008) Xiangyou Hu et al.   FASEB JOURNAL

Adaptor Protein Sorting Nexin 17 Regulates Amyloid Precursor Protein Trafficking and Processing in the Early Endosomes

(2008) Jiyeon Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Structure and function of γ-secretase

(2008) Alexandra Tolia et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY