Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice
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Title
Aβ-accelerated neurodegeneration caused by Alzheimer’s-associated ACE variant R1279Q is rescued by angiotensin system inhibition in mice
Authors
Keywords
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Journal
Science Translational Medicine
Volume 12, Issue 563, Pages eaaz2541
Publisher
American Association for the Advancement of Science (AAAS)
Online
2020-10-01
DOI
10.1126/scitranslmed.aaz2541
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Note: Only part of the references are listed.- Brain angiotensin II and angiotensin IV receptors as potential Alzheimer’s disease therapeutic targets
- (2020) Jessika Royea et al. GeroScience
- Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer’s disease risk
- (2019) Iris E. Jansen et al. NATURE GENETICS
- Genetic meta-analysis of diagnosed Alzheimer’s disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
- (2019) Brian W. Kunkle et al. NATURE GENETICS
- Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia
- (2019) et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- A clinical dose of angiotensin-converting enzyme (ACE) inhibitor and heterozygous ACE deletion exacerbate Alzheimer’s disease pathology in mice
- (2019) Shuyu Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Improvements of symptoms of Alzheimer`s disease by inhibition of the angiotensin system
- (2019) Ursula Quitterer et al. PHARMACOLOGICAL RESEARCH
- The basis of cellular and regional vulnerability in Alzheimer’s disease
- (2019) Dunja Mrdjen et al. ACTA NEUROPATHOLOGICA
- The neuropathological diagnosis of Alzheimer’s disease
- (2019) Michael A. DeTure et al. Molecular Neurodegeneration
- Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studies
- (2019) Jie Ding et al. LANCET NEUROLOGY
- Clinical Trials of Blood Pressure Lowering and Antihypertensive Medication: Is Cognitive Measurement State-of-the-Art?
- (2018) Merrill F Elias et al. AMERICAN JOURNAL OF HYPERTENSION
- Mitochondrial Function, Dynamics, and Permeability Transition: A Complex Love Triangle as A Possible Target for the Treatment of Brain Aging and Alzheimer’s Disease
- (2018) Carola Stockburger et al. JOURNAL OF ALZHEIMERS DISEASE
- The Coming of Age of the Angiotensin Hypothesis in Alzheimer’s Disease: Progress Toward Disease Prevention and Treatment?
- (2018) Patrick Gavin Kehoe JOURNAL OF ALZHEIMERS DISEASE
- GWAS on family history of Alzheimer’s disease
- (2018) Riccardo E. Marioni et al. Translational Psychiatry
- Into the Fourth Dimension: Dysregulation of Genome Architecture in Aging and Alzheimer’s Disease
- (2018) Warren Winick-Ng et al. Frontiers in Molecular Neuroscience
- Sex Differences in Autophagy Contribute to Female Vulnerability in Alzheimer's Disease
- (2018) Erin E. Congdon Frontiers in Neuroscience
- Pleiotropic Benefits of the Angiotensin Receptor Blocker Candesartan in a Mouse Model of Alzheimer Disease
- (2018) Lianne J. Trigiani et al. HYPERTENSION
- Peripheral immune system in aging and Alzheimer’s disease
- (2018) Wei Cao et al. Molecular Neurodegeneration
- Advances in developing novel therapeutic strategies for Alzheimer’s disease
- (2018) Jiqing Cao et al. Molecular Neurodegeneration
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- TREM2 deficiency attenuates neuroinflammation and protects against neurodegeneration in a mouse model of tauopathy
- (2017) Cheryl E. G. Leyns et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Brain Renin-Angiotensin System and Microglial Polarization: Implications for Aging and Neurodegeneration
- (2017) Jose L. Labandeira-Garcia et al. Frontiers in Aging Neuroscience
- Angiotensin II Causes Apoptosis of Adult Hippocampal Neural Stem Cells and Memory Impairment Through the Action on AMPK-PGC1α Signaling in Heart Failure
- (2017) Min-Seok Kim et al. Stem Cells Translational Medicine
- Detrimental Effects of Centrally Administered Angiotensin II are Enhanced in a Mouse Model of Alzheimer Disease Independently of Blood Pressure
- (2017) Koki Takane et al. Journal of the American Heart Association
- Why Women Have More Alzheimer's Disease Than Men: Gender and Mitochondrial Toxicity of Amyloid-β Peptide
- (2017) Jose Viña et al. JOURNAL OF ALZHEIMERS DISEASE
- The endocytic pathway in microglia during health, aging and Alzheimer’s disease
- (2016) Santiago Solé-Domènech et al. AGEING RESEARCH REVIEWS
- Evidence to Consider Angiotensin II Receptor Blockers for the Treatment of Early Alzheimer’s Disease
- (2016) Juan M. Saavedra CELLULAR AND MOLECULAR NEUROBIOLOGY
- Stroke, Vascular Dementia, and Alzheimer’s Disease: Molecular Links
- (2016) Murali Vijayan et al. JOURNAL OF ALZHEIMERS DISEASE
- The association of renin-angiotensin system blockade use with the risks of cognitive impairment of aging and Alzheimer’s disease: A meta-analysis
- (2016) Shan Zhuang et al. JOURNAL OF CLINICAL NEUROSCIENCE
- Angiotensin Converting Enzyme Inhibitors Ameliorate Brain Inflammation Associated with Microglial Activation: Possible Implications for Alzheimer’s Disease
- (2016) Nofar Torika et al. Journal of Neuroimmune Pharmacology
- Selective vulnerability in neurodegeneration: insights from clinical variants of Alzheimer's disease
- (2016) Niklas Mattsson et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
- Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer’s Disease
- (2016) Celeste Sassi et al. PLoS One
- Involvement of Luteinizing Hormone in Alzheimer Disease Development in Elderly Women
- (2016) C. V. Rao Reproductive Sciences
- Antihypertensive Drugs, Prevention of Cognitive Decline and Dementia: A Systematic Review of Observational Studies, Randomized Controlled Trials and Meta-Analyses, with Discussion of Potential Mechanisms
- (2015) Laure Rouch et al. CNS DRUGS
- R47H Variant ofTREM2Associated With Alzheimer Disease in a Large Late-Onset Family
- (2015) Olena Korvatska et al. JAMA Neurology
- Age-dependent metabolic dysregulation in cancer and Alzheimer’s disease
- (2014) Richard A. Harris et al. BIOGERONTOLOGY
- Angiotensin II type 1 receptor blocker losartan prevents and rescues cerebrovascular, neuropathological and cognitive deficits in an Alzheimer’s disease model
- (2014) Brice Ongali et al. NEUROBIOLOGY OF DISEASE
- The association of angiotensin-converting enzyme with biomarkers for Alzheimer’s disease
- (2014) Hadassa M Jochemsen et al. Alzheimers Research & Therapy
- Genome-Wide Association Study of CSF Levels of 59 Alzheimer's Disease Candidate Proteins: Significant Associations with Proteins Involved in Amyloid Processing and Inflammation
- (2014) John S. K. Kauwe et al. PLoS Genetics
- Do angiotensin receptor blockers prevent Alzheimerʼs disease?
- (2013) Ihab Hajjar et al. CURRENT OPINION IN CARDIOLOGY
- Do Angiotensin Receptor Blockers Protect Against Alzheimer’s Disease?
- (2013) Hitomi Kurinami et al. DRUGS & AGING
- ACE Inhibition with Captopril Retards the Development of Signs of Neurodegeneration in an Animal Model of Alzheimer’s Disease
- (2013) Said AbdAlla et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Sodium Channel Cleavage Is Associated with Aberrant Neuronal Activity and Cognitive Deficits in a Mouse Model of Alzheimer's Disease
- (2013) B. F. Corbett et al. JOURNAL OF NEUROSCIENCE
- DNA targeting specificity of RNA-guided Cas9 nucleases
- (2013) Patrick D Hsu et al. NATURE BIOTECHNOLOGY
- Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
- (2013) Jean-Charles Lambert et al. NATURE GENETICS
- Effects of centrally acting ACE inhibitors on the rate of cognitive decline in dementia
- (2013) Yang Gao et al. BMJ Open
- Cognitive reserve in ageing and Alzheimer's disease
- (2012) Yaakov Stern LANCET NEUROLOGY
- Inhibition of central angiotensin II enhances memory function and reduces oxidative stress status in rat hippocampus
- (2012) Walther Bild et al. PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
- Renin-Angiotensin System and Sympathetic Neurotransmitter Release in the Central Nervous System of Hypertension
- (2012) Kazushi Tsuda International Journal of Hypertension
- The carboxypeptidase ACE shapes the MHC class I peptide repertoire
- (2011) Xiao Z Shen et al. NATURE IMMUNOLOGY
- Altered intrinsic neuronal excitability and reduced Na+ currents in a mouse model of Alzheimer's disease
- (2011) Jon T. Brown et al. NEUROBIOLOGY OF AGING
- An Angiotensin I-Converting Enzyme Mutation (Y465D) Causes a Dramatic Increase in Blood ACE via Accelerated ACE Shedding
- (2011) Sergei M. Danilov et al. PLoS One
- Aging-related changes in the nigral angiotensin system enhances proinflammatory and pro-oxidative markers and 6-OHDA-induced dopaminergic degeneration
- (2010) Begoña Villar-Cheda et al. NEUROBIOLOGY OF AGING
- Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease
- (2010) Lusine Danielyan et al. REJUVENATION RESEARCH
- Angiotensin Receptor Blocker Prevented β-Amyloid-Induced Cognitive Impairment Associated With Recovery of Neurovascular Coupling
- (2009) Shuko Takeda et al. HYPERTENSION
- The role of the central renin-angiotensin system in Parkinson’s disease
- (2009) Birgit Mertens et al. JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM
- Angiotensin I-Converting Enzyme Mutation (Trp1197Stop) Causes a Dramatic Increase in Blood ACE
- (2009) Andrew B. Nesterovitch et al. PLoS One
- Angiotensins and Alzheimer's disease: a bench to bedside overview
- (2009) Patrick G Kehoe Alzheimers Research & Therapy
- The latest suspect
- (2008) Rudolph E. Tanzi et al. NATURE
- Predictive Genomics of Cardioembolic Stroke
- (2008) R. B. Ramoni et al. STROKE
- Angiotensin receptor subtype mediated physiologies and behaviors: New discoveries and clinical targets
- (2007) J WRIGHT et al. PROGRESS IN NEUROBIOLOGY
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