Palmitic Acid Reduces the Autophagic Flux and Insulin Sensitivity Through the Activation of the Free Fatty Acid Receptor 1 (FFAR1) in the Hypothalamic Neuronal Cell Line N43/5

Rapamycin improves insulin resistance and hepatic steatosis in type 2 diabetes rats through activation of autophagy

(2018) Wan Zhou et al.   CELL BIOLOGY INTERNATIONAL

Mifepristone enhances insulin-stimulated Akt phosphorylation and glucose uptake in skeletal muscle cells

(2018) Izela Bernal-Sore et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Targeting autophagy in obesity: from pathophysiology to management

(2018) Yingmei Zhang et al.   Nature Reviews Endocrinology

TAp63 contributes to sexual dimorphism in POMC neuron functions and energy homeostasis

(2018) Chunmei Wang et al.   Nature Communications

Autophagy Differentially Regulates Insulin Production and Insulin Sensitivity

(2018) Soh Yamamoto et al.   Cell Reports

Adiponectin improves insulin sensitivity via activation of autophagic flux

(2017) Penny Ahlstrom et al.   JOURNAL OF MOLECULAR ENDOCRINOLOGY

Polyunsaturated fatty acid receptors, GPR40 and GPR120, are expressed in the hypothalamus and control energy homeostasis and inflammation

(2017) Nathalia R. V. Dragano et al.   Journal of Neuroinflammation

Inflammation, metaflammation and immunometabolic disorders

(2017) Gökhan S. Hotamisligil   NATURE

The role of polyunsaturated fatty acids and GPR40 receptor in brain

(2017) Muhammad Zahid Khan et al.   NEUROPHARMACOLOGY

Dysfunctional GPR40/FFAR1 signaling exacerbates pain behavior in mice

(2017) Kazuo Nakamoto et al.   PLoS One

SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling

(2017) Miao Wang et al.   Oncotarget

Hypothalamic AMPK-induced autophagy increases food intake by regulating NPY and POMC expression

(2016) Tae Seok Oh et al.   Autophagy

Autophagy protects human podocytes from high glucose-induced injury by preventing insulin resistance

(2016) Wei Xin et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Sexually dimorphic brain fatty acid composition in low and high fat diet-fed mice

(2016) Carlos Rodriguez-Navas et al.   Molecular Metabolism

Regulation of prohormone convertase 2 protein expression via GPR40/FFA1 in the hypothalamus

(2015) Kazuo Nakamoto et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

A sexually dimorphic hypothalamic response to chronic high-fat diet consumption

(2015) E Morselli et al.   INTERNATIONAL JOURNAL OF OBESITY

Insulin resistance and hyperinsulinaemia in diabetic cardiomyopathy

(2015) Guanghong Jia et al.   Nature Reviews Endocrinology

Dual effects of the non-esterified fatty acid receptor ‘GPR40’ for human health

(2015) Tetsumori Yamashima   PROGRESS IN LIPID RESEARCH

Hypothalamic inflammation and gliosis in obesity

(2015) Mauricio D. Dorfman et al.   Current Opinion in Endocrinology Diabetes and Obesity

Saturated Fatty Acids Modulate Autophagy’s Proteins in the Hypothalamus

(2015) Mariana Portovedo et al.   PLoS One

Mercaptoacetate and fatty acids exert direct and antagonistic effects on nodose neurons via GPR40 fatty acid receptors

(2014) Rebecca A. Darling et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Activation of GPR40 attenuates chronic inflammation induced impact on pancreatic β-cells health and function

(2014) Mahesh Verma et al.   BMC CELL BIOLOGY

Inhibition of soluble epoxide hydrolase modulates inflammation and autophagy in obese adipose tissue and liver: Role for omega-3 epoxides

(2014) Cristina López-Vicario et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microglia Dictate the Impact of Saturated Fat Consumption on Hypothalamic Inflammation and Neuronal Function

(2014) Martin Valdearcos et al.   Cell Reports

Hypothalamic PGC-1α Protects Against High-Fat Diet Exposure by Regulating ERα

(2014) Eugenia Morselli et al.   Cell Reports

Lipid sensing in the brain and regulation of energy balance

(2013) V.-S. Moullé et al.   DIABETES & METABOLISM

FFAR1 Is Involved in Both the Acute and Chronic Effects of Palmitate on Insulin Secretion

(2013) Hjalti Kristinsson et al.   ENDOCRINOLOGY

Hypothalamic GPR40 Signaling Activated by Free Long Chain Fatty Acids Suppresses CFA-Induced Inflammatory Chronic Pain

(2013) Kazuo Nakamoto et al.   PLoS One

Loss of Autophagy in Pro-opiomelanocortin Neurons Perturbs Axon Growth and Causes Metabolic Dysregulation

(2012) Bérengère Coupé et al.   Cell Metabolism

Loss of autophagy in hypothalamic POMC neurons impairs lipolysis

(2012) Susmita Kaushik et al.   EMBO REPORTS

Role of Hypothalamic Proopiomelanocortin Neuron Autophagy in the Control of Appetite and Leptin Response

(2012) Wenying Quan et al.   ENDOCRINOLOGY

Glucose activates free fatty acid receptor 1 gene transcription via phosphatidylinositol-3-kinase-dependent O-GlcNAcylation of pancreas-duodenum homeobox-1

(2012) M. Kebede et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Involvement of the long-chain fatty acid receptor GPR40 as a novel pain regulatory system

(2011) Kazuo Nakamoto et al.   BRAIN RESEARCH

Distinct Hypothalamic Neurons Mediate Estrogenic Effects on Energy Homeostasis and Reproduction

(2011) Yong Xu et al.   Cell Metabolism

Autophagy in the Cellular Energetic Balance

(2011) Rajat Singh et al.   Cell Metabolism

Defective Hypothalamic Autophagy Directs the Central Pathogenesis of Obesity via the IκB Kinase β (IKKβ)/NF-κB Pathway

(2011) Qingyuan Meng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Defective Hepatic Autophagy in Obesity Promotes ER Stress and Causes Insulin Resistance

(2010) Ling Yang et al.   Cell Metabolism

Brain lipid sensing and nervous control of energy balance

(2010) S. Migrenne et al.   DIABETES & METABOLISM

Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

(2009) Stephen C. Benoit et al.   JOURNAL OF CLINICAL INVESTIGATION

Saturated Fatty Acids Produce an Inflammatory Response Predominantly through the Activation of TLR4 Signaling in Hypothalamus: Implications for the Pathogenesis of Obesity

(2009) M. Milanski et al.   JOURNAL OF NEUROSCIENCE

Hypothalamic proinflammatory lipid accumulation, inflammation, and insulin resistance in rats fed a high-fat diet

(2008) Kelly A. Posey et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Autophagy Is Important in Islet Homeostasis and Compensatory Increase of Beta Cell Mass in Response to High-Fat Diet

(2008) Chie Ebato et al.   Cell Metabolism