Obesity as a risk factor for Alzheimer's disease: weighing the evidence

Association Between Midlife Vascular Risk Factors and Estimated Brain Amyloid Deposition

(2017) Rebecca F. Gottesman et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Autotaxin is Related to Metabolic Dysfunction and Predicts Alzheimer’s Disease Outcomes

(2017) Kelsey E. McLimans et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of a long-term intensive lifestyle intervention on prevalence of cognitive impairment

(2017) Mark A. Espeland et al.   NEUROLOGY

Glucagon-like Peptide-1 and the Central/Peripheral Nervous System: Crosstalk in Diabetes

(2017) Giovanna Muscogiuri et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Intranasal Insulin Administration Dose-Dependently Modulates Verbal Memory and Plasma Amyloid-β in Memory-Impaired Older Adults

(2017) Mark A. Reger et al.   JOURNAL OF ALZHEIMERS DISEASE

Amyloid-β, Tau, and Dementia

(2017) Akihiko Takashima   JOURNAL OF ALZHEIMERS DISEASE

Forxiga (dapagliflozin): Plausible role in the treatment of diabetes-associated neurological disorders

(2016) Sibhghatulla Shaikh et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Neuroprotective effects of metformin against Aβ-mediated inhibition of long-term potentiation in rats fed a high-fat diet

(2016) Masoumeh Asadbegi et al.   BRAIN RESEARCH BULLETIN

GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial

(2016) Olivia M. Farr et al.   DIABETOLOGIA

Metabolic health and weight: Understanding metabolically unhealthy normal weight or metabolically healthy obese patients

(2016) Hannah Mathew et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Glimepiride protects neurons against amyloid-β-induced synapse damage

(2016) Craig Osborne et al.   NEUROPHARMACOLOGY

In Alzheimer’s Disease, 6-Month Treatment with GLP-1 Analog Prevents Decline of Brain Glucose Metabolism: Randomized, Placebo-Controlled, Double-Blind Clinical Trial

(2016) Michael Gejl et al.   Frontiers in Aging Neuroscience

The dual roles of cytokines in Alzheimer’s disease: update on interleukins, TNF-α, TGF-β and IFN-γ

(2016) Cong Zheng et al.   Translational Neurodegeneration

Clinical pharmacology of dipeptidyl peptidase 4 inhibitors indicated for the treatment of type 2 diabetes mellitus

(2015) Xiao-Wu Chen et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Novel GLP-1 (Glucagon-Like Peptide-1) Analogues and Insulin in the Treatment for Alzheimer’s Disease and Other Neurodegenerative Diseases

(2015) Valeria Calsolaro et al.   CNS DRUGS

DPP-4 Inhibitor Linagliptin Attenuates Aβ-induced Cytotoxicity through Activation of AMPK in Neuronal Cells

(2015) Edy Kornelius et al.   CNS Neuroscience & Therapeutics

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, improves recognition memory, oxidative stress and hippocampal neurogenesis and upregulates key genes involved in cognitive decline

(2015) V. A. Gault et al.   DIABETES OBESITY & METABOLISM

Expression and Distribution of Glucagon-Like Peptide-1 Receptor mRNA, Protein and Binding in the Male Nonhuman Primate (Macaca mulatta) Brain

(2015) Kristy M. Heppner et al.   ENDOCRINOLOGY

Efficacy of Liraglutide for Weight Loss Among Patients With Type 2 Diabetes

(2015) Melanie J. Davies et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Leptin and the brain: Influences on brain development, cognitive functioning and psychiatric disorders

(2015) Olivia M. Farr et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

(2015) Matthias Blüher et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Midlife adiposity predicts earlier onset of Alzheimer’s dementia, neuropathology and presymptomatic cerebral amyloid accumulation

(2015) Y-F Chuang et al.   MOLECULAR PSYCHIATRY

The relationship of weight change trajectory with medial temporal lobe atrophy in patients with mild Alzheimer’s disease: results from a cohort study

(2015) Erika Droogsma et al.   Alzheimers Research & Therapy

Association of Insulin Resistance With Cerebral Glucose Uptake in Late Middle–Aged Adults at Risk for Alzheimer Disease

(2015) Auriel A. Willette et al.   JAMA Neurology

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

(2015) Xiaohua Li et al.   Clinical Interventions in Aging

Distribution and characterisation of Glucagon-like peptide-1 receptor expressing cells in the mouse brain

(2015) Simon C. Cork et al.   Molecular Metabolism

Alzheimer disease: Epidemiology, diagnostic criteria, risk factors and biomarkers

(2014) Christiane Reitz et al.   BIOCHEMICAL PHARMACOLOGY

Thiazolidinediones and the Promise of Insulin Sensitization in Type 2 Diabetes

(2014) Raymond E. Soccio et al.   Cell Metabolism

Invokana (Canagliflozin) as a Dual Inhibitor of Acetylcholinesterase and Sodium Glucose Co-Transporter 2: Advancement in Alzheimer’s Disease- Diabetes Type 2 Linkage via an Enzoinformatics Study

(2014) Syed Rizvi et al.   CNS & Neurological Disorders-Drug Targets

Inflammation, Defective Insulin Signaling, and Mitochondrial Dysfunction as Common Molecular Denominators Connecting Type 2 Diabetes to Alzheimer Disease

(2014) F. G. De Felice et al.   DIABETES

Insulin Action in Brain Regulates Systemic Metabolism and Brain Function

(2014) A. Kleinridders et al.   DIABETES

Glucagon-like peptide-1 protects synaptic and learning functions from neuroinflammation in rodents

(2014) Takashi Iwai et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Dipeptidyl Peptidase-4 Inhibitors Have Protective Effect on Cognitive Impairment in Aged Diabetic Patients With Mild Cognitive Impairment

(2014) M. R. Rizzo et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Adipokines: a link between obesity and dementia?

(2014) Amanda J Kiliaan et al.   LANCET NEUROLOGY

Lixisenatide, a drug developed to treat type 2 diabetes, shows neuroprotective effects in a mouse model of Alzheimer's disease

(2014) Paula L. McClean et al.   NEUROPHARMACOLOGY

Renal sodium glucose cotransporter 2 inhibitors as a novel therapeutic approach to treatment of type 2 diabetes: Clinical data and mechanism of action

(2014) Yoshihito Fujita et al.   Journal of Diabetes Investigation

Cognitive Function and Brain Structure in Persons With Type 2 Diabetes Mellitus After Intensive Lowering of Blood Pressure and Lipid Levels

(2014) Jeff D. Williamson et al.   JAMA Internal Medicine

Intranasal Insulin as a Treatment for Alzheimer’s Disease: A Review of Basic Research and Clinical Evidence

(2013) Jessica Freiherr et al.   CNS DRUGS

Increased Risk of Cognitive Impairment in Patients With Diabetes Is Associated With Metformin

(2013) E. M. Moore et al.   DIABETES CARE

Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Impaired glucose tolerance in midlife and longitudinal changes in brain function during aging

(2013) Madhav Thambisetty et al.   NEUROBIOLOGY OF AGING

Saxagliptin: A dipeptidyl peptidase-4 inhibitor ameliorates streptozotocin induced Alzheimer's disease

(2013) Jayasankar Kosaraju et al.   NEUROPHARMACOLOGY

Glimepiride attenuates Aβ production via suppressing BACE1 activity in cortical neurons

(2013) Feiyang Liu et al.   NEUROSCIENCE LETTERS

Midlife obesity and dementia: Meta-analysis and adjusted forecast of dementia prevalence in the united states and china

(2013) Martin Loef et al.   Obesity

High adiposity: risk factor for dementia and Alzheimer’s disease?

(2013) Deborah R Gustafson et al.   Alzheimers Research & Therapy

Animal Models of Alzheimer Disease

(2013) F. M. LaFerla et al.   Cold Spring Harbor Perspectives in Medicine

Regional distribution of SGLT activity in rat brain in vivo

(2012) Amy S. Yu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Neuroprotective and neurotrophic actions of glucagon-like peptide-1: an emerging opportunity to treat neurodegenerative and cerebrovascular disorders

(2012) Isidro Salcedo et al.   BRITISH JOURNAL OF PHARMACOLOGY

Relationship Between Markers of Insulin Resistance, Markers of Adiposity, HbA1c, and Cognitive Functions in a Middle-Aged Population-Based Sample: the MONA LISA Study

(2012) C. M. Sanz et al.   DIABETES CARE

Insulin Resistance, Brain Atrophy, and Cognitive Performance in Late Middle-Aged Adults

(2012) A. A. Willette et al.   DIABETES CARE

DPP4-inhibitor improves neuronal insulin receptor function, brain mitochondrial function and cognitive function in rats with insulin resistance induced by high-fat diet consumption

(2012) Noppamas Pipatpiboon et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Liraglutide improves hippocampal synaptic plasticity associated with increased expression of Mash1 in ob/ob mice

(2012) W D Porter et al.   INTERNATIONAL JOURNAL OF OBESITY

Liraglutide, a Long-Acting GLP-1 Mimetic, and its Metabolite Attenuate Inflammation after Intracerebral Hemorrhage

(2012) Jack Hou et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Demonstrated brain insulin resistance in Alzheimer’s disease patients is associated with IGF-1 resistance, IRS-1 dysregulation, and cognitive decline

(2012) Konrad Talbot et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin, Other Antidiabetic Drugs, and Risk of Alzheimer's Disease: A Population-Based Case-Control Study

(2012) Patrick Imfeld et al.   JOURNAL OF THE AMERICAN GERIATRICS SOCIETY

Sitagliptin increases tau phosphorylation in the hippocampus of rats with type 2 diabetes and in primary neuron cultures

(2012) Dong-Hou Kim et al.   NEUROBIOLOGY OF DISEASE

Obesity, Insulin Resistance, and Alzheimer's Disease

(2012) Kerry L. Hildreth et al.   Obesity

Dementia prevention: current epidemiological evidence and future perspective

(2012) Francesca Mangialasche et al.   Alzheimers Research & Therapy

National estimates of the prevalence of Alzheimer’s disease in the United States

(2011) Ron Brookmeyer et al.   Alzheimers & Dementia

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Intranasal Insulin Therapy for Alzheimer Disease and Amnestic Mild Cognitive Impairment

(2011) Suzanne Craft   ARCHIVES OF NEUROLOGY

Rosiglitazone Does Not Improve Cognition or Global Function when Used as Adjunctive Therapy to AChE Inhibitors in Mild-to-Moderate Alzheimers Disease: Two Phase 3 Studies

(2011) C. Harrington et al.   Current Alzheimer Research

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Ischemia-induced changes in glucagon-like peptide-1 receptor and neuroprotective effect of its agonist, exendin-4, in experimental transient cerebral ischemia

(2011) Choong Hyun Lee et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of intensive glucose lowering on brain structure and function in people with type 2 diabetes (ACCORD MIND): a randomised open-label substudy

(2011) Lenore J Launer et al.   LANCET NEUROLOGY

Body mass index in midlife and late-life as a risk factor for dementia: a meta-analysis of prospective studies

(2011) K. J. Anstey et al.   Obesity Reviews

A Randomized Pilot Clinical Trial of the Safety of Pioglitazone in Treatment of Patients With Alzheimer Disease

(2010) David S. Geldmacher et al.   ARCHIVES OF NEUROLOGY

Insulin Resistance and Alzheimer-like Reductions in Regional Cerebral Glucose Metabolism for Cognitively Normal Adults With Prediabetes or Early Type 2 Diabetes

(2010) Laura D. Baker et al.   ARCHIVES OF NEUROLOGY

Rosiglitazone Monotherapy in Mild-to-Moderate Alzheimer’s Disease: Results from a Randomized, Double-Blind, Placebo-Controlled Phase III Study

(2010) Michael Gold et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

Study of the effect of inhibiting galanin in Alzheimer's disease induced in rats

(2010) Azza Baraka et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The glucagon-like peptide 1 receptor agonist exendin-4 improves reference memory performance and decreases immobility in the forced swim test

(2010) Ruben Isacson et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Different patterns of memory impairments accompany short- and longer-term maintenance on a high-energy diet.

(2010) Scott E. Kanoski et al.   JOURNAL OF EXPERIMENTAL PSYCHOLOGY-ANIMAL LEARNING AND COGNITION

Insulin metabolism and the risk of Alzheimer disease: The Rotterdam Study

(2010) E. M. C. Schrijvers et al.   NEUROLOGY

Insulin resistance is associated with the pathology of Alzheimer disease: The Hisayama Study

(2010) T. Matsuzaki et al.   NEUROLOGY

The Role of Metabolic Disorders in Alzheimer Disease and Vascular Dementia

(2009) Suzanne Craft   ARCHIVES OF NEUROLOGY

Impairment of synaptic plasticity and memory formation in GLP-1 receptor KO mice: Interaction between type 2 diabetes and Alzheimer's disease

(2009) Talib Abbas et al.   BEHAVIOURAL BRAIN RESEARCH

Meta-Analysis of Alzheimer's Disease Risk with Obesity, Diabetes, and Related Disorders

(2009) Louis A. Profenno et al.   BIOLOGICAL PSYCHIATRY

The Role of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) in Alzheimer’s Disease

(2009) Qingguang Jiang et al.   CNS DRUGS

Cognitive impairment in nondiabetic middle-aged and older adults is associated with insulin resistance

(2009) H. Bruehl et al.   JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY

Memory performance is related to amyloid and tau pathology in the hippocampus

(2009) C Reitz et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Key Role of Sulfonylurea Receptor 1 in Progressive Secondary Hemorrhage after Brain Contusion

(2009) J. Marc Simard et al.   JOURNAL OF NEUROTRAUMA

Insulin resistance and hippocampal volume in women at risk for Alzheimer's disease

(2009) Natalie L. Rasgon et al.   NEUROBIOLOGY OF AGING

Leptin reduces Alzheimer’s disease-related tau phosphorylation in neuronal cells

(2008) Steven J. Greco et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adiposity and Alzheimerʼs disease

(2008) José A Luchsinger et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Incident dementia and blood pressure lowering in the Hypertension in the Very Elderly Trial cognitive function assessment (HYVET-COG): a double-blind, placebo controlled trial

(2008) Ruth Peters et al.   LANCET NEUROLOGY

Central obesity and increased risk of dementia more than three decades later

(2008) R. A. Whitmer et al.   NEUROLOGY

Diet-induced obesity and spatial cognition in young male rats

(2008) Nicole Jurdak et al.   NUTRITIONAL NEUROSCIENCE

Obesity and central obesity as risk factors for incident dementia and its subtypes: a systematic review and meta-analysis

(2008) M. A. Beydoun et al.   Obesity Reviews