Hypoxia/ischemia activate processing of Amyloid Precursor Protein: impact of vascular dysfunction in the pathogenesis of Alzheimer's disease

Lipid Alterations in Lipid Rafts from Alzheimer's Disease Human Brain Cortex

(2017) Virginia Martín et al.   JOURNAL OF ALZHEIMERS DISEASE

Brain imaging of neurovascular dysfunction in Alzheimer’s disease

(2016) Axel Montagne et al.   ACTA NEUROPATHOLOGICA

Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer’s disease

(2016) Raj N. Kalaria   ACTA NEUROPATHOLOGICA

Chronic hypoxia facilitates Alzheimer's disease through demethylation of γ-secretase by downregulating DNA methyltransferase 3b

(2016) Hui Liu et al.   Alzheimers & Dementia

Novel imaging techniques in cerebral small vessel diseases and vascular cognitive impairment

(2016) Gargi Banerjee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Restricted Location of PSEN2/γ-Secretase Determines Substrate Specificity and Generates an Intracellular Aβ Pool

(2016) Ragna Sannerud et al.   CELL

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

The Utility of Cerebral Blood Flow as a Biomarker of Preclinical Alzheimer’s Disease

(2016) Chelsea C. Hays et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Beyond γ-secretase activity: The multifunctional nature of presenilins in cell signalling pathways

(2016) Stephen P. Duggan et al.   CELLULAR SIGNALLING

The Zebrafish Equivalent of Alzheimer’s Disease-Associated PRESENILIN Isoform PS2V Regulates Inflammatory and Other Responses to Hypoxic Stress

(2016) Esmaeil Ebrahimie et al.   JOURNAL OF ALZHEIMERS DISEASE

Discrepancy in Expression of β-Secretase and Amyloid-β Protein Precursor in Alzheimer-Related Genes in the Rat Medial Temporal Lobe Cortex Following Transient Global Brain Ischemia

(2016) Ryszard Pluta et al.   JOURNAL OF ALZHEIMERS DISEASE

Non-Catalytic Roles of Presenilin Throughout Evolution

(2016) Grant P. Otto et al.   JOURNAL OF ALZHEIMERS DISEASE

Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments

(2016) Xavier Meckler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Divergent regional patterns of cerebral hypoperfusion and gray matter atrophy in mild cognitive impairment patients

(2016) Miranka Wirth et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Amyloid precursor protein–mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration

(2016) Wei Xu et al.   JOURNAL OF CLINICAL INVESTIGATION

The amyloid cascade hypothesis: are we poised for success or failure?

(2016) Eric Karran et al.   JOURNAL OF NEUROCHEMISTRY

Amyloid pathology and axonal injury after brain trauma

(2016) Gregory Scott et al.   NEUROLOGY

Hyperhomocysteinemia impairs regional blood flow: involvements of endothelial and neuronal nitric oxide

(2016) Noboru Toda et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Alzheimer-associated presenilin 2 gene is dysregulated in rat medial temporal lobe cortex after complete brain ischemia due to cardiac arrest

(2016) Ryszard Pluta et al.   Pharmacological Reports

BACE1 Physiological Functions May Limit Its Use as Therapeutic Target for Alzheimer's Disease

(2016) Soraia Barão et al.   TRENDS IN NEUROSCIENCES

APP Receptor? To Be or Not To Be

(2016) Carole Deyts et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Early role of vascular dysregulation on late-onset Alzheimer’s disease based on multifactorial data-driven analysis

(2016) Y. Iturria-Medina et al.   Nature Communications

Presenilin 2 Modulates Endoplasmic Reticulum-Mitochondria Coupling by Tuning the Antagonistic Effect of Mitofusin 2

(2016) Riccardo Filadi et al.   Cell Reports

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase

(2016) David M Bolduc et al.   eLife

Hypoxia-Inducible Histone Lysine Demethylases: Impact on the Aging Process and Age-Related Diseases

(2016) Salminen Antero et al.   Aging and Disease

News about VDAC1 in Hypoxia

(2016) N. M. Mazure   Frontiers in Oncology

Critical Role of Endoplasmic Reticulum Stress in Chronic Intermittent Hypoxia-Induced Deficits in Synaptic Plasticity and Long-Term Memory

(2015) Lin-Hao Xu et al.   ANTIOXIDANTS & REDOX SIGNALING

ER stress: Autophagy induction, inhibition and selection

(2015) Harun-Or Rashid et al.   Autophagy

2-Oxoglutarate-dependent dioxygenases are sensors of energy metabolism, oxygen availability, and iron homeostasis: potential role in the regulation of aging process

(2015) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Human brain proteins showing neuron-specific interactions with γ-secretase

(2015) Mitsuhiro Inoue et al.   FEBS Journal

Alzheimer's disease-related peptide PS2V plays ancient, conserved roles in suppression of the unfolded protein response under hypoxia and stimulation of γ-secretase activity

(2015) Seyyed Hani Moussavi Nik et al.   HUMAN MOLECULAR GENETICS

Ischemic conditions and β-secretase activation: The impact of membrane cholesterol enrichment as triggering factor in rat brain endothelial cells

(2015) Anna Brambilla et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Cerebral Hypoperfusion and Hypometabolism Detected by Arterial Spin Labeling MRI and FDG-PET in Early-Onset Alzheimer's Disease

(2015) Sebastien Verclytte et al.   JOURNAL OF NEUROIMAGING

Vascular dementia

(2015) John T O'Brien et al.   LANCET

APP intracellular domain–WAVE1 pathway reduces amyloid-β production

(2015) Ilaria Ceglia et al.   NATURE MEDICINE

Quercetin reduces eIF2α phosphorylation by GADD34 induction

(2015) Miki Hayakawa et al.   NEUROBIOLOGY OF AGING

Vascular dysfunction in the pathogenesis of Alzheimer's disease — A review of endothelium-mediated mechanisms and ensuing vicious circles

(2015) Luigi Yuri Di Marco et al.   NEUROBIOLOGY OF DISEASE

Hypoxic preconditioning and cell death from oxygen/glucose deprivation co-opt a subset of the unfolded protein response in hippocampal neurons

(2015) P.E. Bickler et al.   NEUROSCIENCE

Notch-1 signaling regulates astrocytic proliferation and activation after hypoxia exposure

(2015) Yanmin Zhang et al.   NEUROSCIENCE LETTERS

Effect of Cardiac Arrest on Cognitive Impairment and Hippocampal Plasticity in Middle-Aged Rats

(2015) Charles H. Cohan et al.   PLoS One

The alpha secretase ADAM10: A metalloprotease with multiple functions in the brain

(2015) Paul Saftig et al.   PROGRESS IN NEUROBIOLOGY

Complex regulation of γ-secretase: from obligatory to modulatory subunits

(2015) Natalya Gertsik et al.   Frontiers in Aging Neuroscience

The amyloid hypothesis, time to move on: Amyloid is the downstream result, not cause, of Alzheimer's disease

(2014) David A. Drachman   Alzheimers & Dementia

Cytoplasmic Fragment of Alcadein α Generated by Regulated Intramembrane Proteolysis Enhances Amyloid β-Protein Precursor (APP) Transport into the Late Secretory Pathway and Facilitates APP Cleavage

(2014) Norio Takei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alzheimer Presenilin-1 Mutations Dramatically Reduce Trimming of Long Amyloid β-Peptides (Aβ) by γ-Secretase to Increase 42-to-40-Residue Aβ

(2014) Marty A. Fernandez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An ancestral non-proteolytic role for presenilin proteins in multicellular development of the social amoeba Dictyostelium discoideum

(2014) M. H. R. Ludtmann et al.   JOURNAL OF CELL SCIENCE

Gamma-secretase subunits associate in intracellular membrane compartments in Arabidopsis thaliana

(2014) Michalina Smolarkiewicz et al.   JOURNAL OF EXPERIMENTAL BOTANY

Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects

(2014) Robert Vassar et al.   JOURNAL OF NEUROCHEMISTRY

Insights into the physiological function of the β-amyloid precursor protein: beyond Alzheimer's disease

(2014) Edgar Dawkins et al.   JOURNAL OF NEUROCHEMISTRY

Three-dimensional structure of human γ-secretase

(2014) Peilong Lu et al.   NATURE

Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer′s disease

(2014) Lin Yuan et al.   Neural Regeneration Research

PERK mediates eIF2α phosphorylation responsible for BACE1 elevation, CREB dysfunction and neurodegeneration in a mouse model of Alzheimer's disease

(2014) Latha Devi et al.   NEUROBIOLOGY OF AGING

Endoplasmic reticulum stress in cerebral ischemia

(2014) Qing Xin et al.   NEUROCHEMISTRY INTERNATIONAL

Nontranscriptional Role of Hif-1α in Activation of γ-Secretase and Notch Signaling in Breast Cancer

(2014) Jennifer C. Villa et al.   Cell Reports

Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase

(2014) Maho Morishima-Kawashima   Frontiers in Physiology

Using the zebrafish model for Alzheimer’s disease research

(2014) Morgan Newman et al.   Frontiers in Genetics

Notch signaling in the brain: In good and bad times

(2013) Lavinia Alberi et al.   AGEING RESEARCH REVIEWS

Upregulation of PGC-1α expression by Alzheimer's disease-associated pathway: presenilin 1/amyloid precursor protein (APP)/intracellular domain of APP

(2013) Ari Robinson et al.   AGING CELL

Origins of amyloid-β

(2013) William G Tharp et al.   BMC GENOMICS

Notch as a hub for signaling in angiogenesis

(2013) Rui Benedito et al.   EXPERIMENTAL CELL RESEARCH

Redundancy and divergence in the amyloid precursor protein family

(2013) S. Ali M. Shariati et al.   FEBS LETTERS

Signature Amyloid β Profiles Are Produced by Different γ-Secretase Complexes

(2013) Hermien Acx et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia Increases Aβ-Induced Tau Phosphorylation by Calpain and Promotes Behavioral Consequences in AD Transgenic Mice

(2013) Lianbo Gao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Dysregulation of Hypoxia-Inducible Factor by Presenilin/ -Secretase Loss-of-Function Mutations

(2013) M. R. Kaufmann et al.   JOURNAL OF NEUROSCIENCE

Palmitoylation of Amyloid Precursor Protein Regulates Amyloidogenic Processing in Lipid Rafts

(2013) R. Bhattacharyya et al.   JOURNAL OF NEUROSCIENCE

Monitoring of β-Amyloid Dynamics after Human Traumatic Brain Injury

(2013) Niklas Marklund et al.   JOURNAL OF NEUROTRAUMA

Oxygen sensing and hypoxia signalling pathways in animals: the implications of physiology for cancer

(2013) Peter J. Ratcliffe   JOURNAL OF PHYSIOLOGY-LONDON

Asynchronous Evolutionary Origins of A  and BACE1

(2013) D. B. Moore et al.   MOLECULAR BIOLOGY AND EVOLUTION

Sporadic Alzheimer’s Disease Begins as Episodes of Brain Ischemia and Ischemically Dysregulated Alzheimer’s Disease Genes

(2013) Ryszard Pluta et al.   MOLECULAR NEUROBIOLOGY

ADAM10 Missense Mutations Potentiate β-Amyloid Accumulation by Impairing Prodomain Chaperone Function

(2013) Jaehong Suh et al.   NEURON

Hypoxic stress, brain vascular system, and β-amyloid: A primary cell culture study

(2013) Abebe Muche et al.   NUTRITIONAL NEUROSCIENCE

Notch-1 Signaling Regulates Microglia Activation via NF-κB Pathway after Hypoxic Exposure In Vivo and In Vitro

(2013) Linli Yao et al.   PLoS One

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Trafficking and Proteolytic Processing of APP

(2013) C. Haass et al.   Cold Spring Harbor Perspectives in Medicine

Hypoxia-Inducible Factors in Physiology and Medicine

(2012) Gregg L. Semenza   CELL

AICD Nuclear Signaling and Its Possible Contribution to Alzheimers Disease

(2012) Uwe Konietzko   Current Alzheimer Research

APL-1, the Alzheimer's Amyloid Precursor Protein in Caenorhabditis elegans, Modulates Multiple Metabolic Pathways Throughout Development

(2012) C. Y. Ewald et al.   GENETICS

Identification of Novel γ-Secretase-associated Proteins in Detergent-resistant Membranes from Brain

(2012) Ji-Yeun Hur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aβ42 production in brain capillary endothelial cells after oxygen and glucose deprivation

(2012) Alessandra Bulbarelli et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Brain Ischemia Activates β- and γ-Secretase Cleavage of Amyloid Precursor Protein: Significance in Sporadic Alzheimer’s Disease

(2012) Ryszard Pluta et al.   MOLECULAR NEUROBIOLOGY

APP Knockout Mice Experience Acute Mortality as the Result of Ischemia

(2012) Maya A. Koike et al.   PLoS One

Negative regulation of NEP expression by hypoxia

(2012) Ranjana Mitra et al.   PROSTATE

Positive Evolutionary Selection of an HD Motif on Alzheimer Precursor Protein Orthologues Suggests a Functional Role

(2012) István Miklós et al.   PLoS Computational Biology

The response of HMGA1 to changes in oxygen availability is evolutionarily conserved

(2011) Seyyed Hani Moussavi Nik et al.   EXPERIMENTAL CELL RESEARCH

Local cholesterol increase triggers amyloid precursor protein-Bace1 clustering in lipid rafts and rapid endocytosis

(2011) Catherine Marquer et al.   FASEB JOURNAL

Functions of Aβ, sAPPα and sAPPβ : similarities and differences

(2011) Stéphanie Chasseigneaux et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of β-site APP-cleaving enzyme 1 gene expression and its role in Alzheimer’s Disease

(2011) Xiulian Sun et al.   JOURNAL OF NEUROCHEMISTRY

Cerebral ischemia aggravates cognitive impairment in a rat model of Alzheimer's disease

(2011) Jing Li et al.   LIFE SCIENCES

Autophagy failure in Alzheimer's disease—locating the primary defect

(2011) Ralph A. Nixon et al.   NEUROBIOLOGY OF DISEASE

Is hyperhomocysteinemia an Alzheimer's disease (AD) risk factor, an AD marker, or neither?

(2011) Jia-Min Zhuo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Membrane Organization and Lipid Rafts

(2011) K. Simons et al.   Cold Spring Harbor Perspectives in Biology

Induction of ER stress in response to oxygen-glucose deprivation of cortical cultures involves the activation of the PERK and IRE-1 pathways and of caspase-12

(2011) N Badiola et al.   Cell Death & Disease

Autophagy impairment stimulates PS1 expression and γ-secretase activity

(2010) Kazunori Ohta et al.   Autophagy

Transient brain ischemia due to cardiac arrest causes irreversible long-lasting cognitive injury

(2010) Anna Kiryk et al.   BEHAVIOURAL BRAIN RESEARCH

Membrane rafts in Alzheimer's disease beta-amyloid production

(2010) Kulandaivelu S. Vetrivel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dictyostelium possesses highly diverged presenilin/ -secretase that regulates growth and cell-fate specification and can accurately process human APP: a system for functional studies of the presenilin/ -secretase complex

(2010) V. C. McMains et al.   Disease Models & Mechanisms

The amyloid precursor protein intracellular domain alters gene expression and induces neuron-specific apoptosis

(2010) Takeshi Ohkawara et al.   GENE

The Transcriptionally Active Amyloid Precursor Protein (APP) Intracellular Domain Is Preferentially Produced from the 695 Isoform of APP in a β-Secretase-dependent Pathway

(2010) Nikolai D. Belyaev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

(2010) Rita De Gasperi et al.   Molecular Neurodegeneration

Alzheimer's Disease

(2010) Henry W. Querfurth et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteases and Proteolysis in Alzheimer Disease: A Multifactorial View on the Disease Process

(2010) Bart De Strooper   PHYSIOLOGICAL REVIEWS

Ancient Atmospheres and the Evolution of Oxygen Sensing Via the Hypoxia-Inducible Factor in Metazoans

(2010) Cormac T. Taylor et al.   PHYSIOLOGY

A lipid matrix model of membrane raft structure

(2010) Peter J. Quinn   PROGRESS IN LIPID RESEARCH

Amyloid precursor protein is required for convergent-extension movements during Zebrafish development

(2009) Powrnima Joshi et al.   DEVELOPMENTAL BIOLOGY

Hypoxia-inducible factor 1: a new hope to counteract neurodegeneration?

(2009) Sónia C. Correia et al.   JOURNAL OF NEUROCHEMISTRY

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Analysis of the γ-secretase interactome and validation of its association with tetraspanin-enriched microdomains

(2009) Tomoko Wakabayashi et al.   NATURE CELL BIOLOGY

Regulation of endocytosis via the oxygen-sensing pathway

(2009) Yi Wang et al.   NATURE MEDICINE

Upregulation of BACE1 and β-Amyloid Protein Mediated by Chronic Cerebral Hypoperfusion Contributes to Cognitive Impairment and Pathogenesis of Alzheimer’s Disease

(2009) Cai Zhiyou et al.   NEUROCHEMICAL RESEARCH

Alzheimer's disease-like pathological features in transgenic mice expressing the APP intracellular domain

(2009) K. Ghosal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cerebral amyloid angiopathy and its relationship to Alzheimer’s disease

(2008) Dietmar Rudolf Thal et al.   ACTA NEUROPATHOLOGICA

Beta-Secretase: Structure, Function, and Evolution

(2008) Chitra Venugopal et al.   CNS & Neurological Disorders-Drug Targets

Direct and Potent Regulation of γ-Secretase by Its Lipid Microenvironment

(2008) Pamela Osenkowski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hypoxia-induced modifications in plasma membranes and lipid microdomains in A549 cells and primary human alveolar cells

(2008) Laura Botto et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1α

(2008) Michela Guglielmotto et al.   JOURNAL OF NEUROCHEMISTRY

Phosphorylation of the Translation Initiation Factor eIF2α Increases BACE1 Levels and Promotes Amyloidogenesis

(2008) Tracy O'Connor et al.   NEURON

Hypoxia increases Aβ generation by altering β- and γ-cleavage of APP

(2007) Liang Li et al.   NEUROBIOLOGY OF AGING