Perspectives on the Potential Benefits of Antihypertensive Peptides towards Metabolic Syndrome

Egg white hydrolysate enhances insulin sensitivity in high fat diet induced insulin resistant rats via AKT activation

(2019) F. Jahandideh et al.   BRITISH JOURNAL OF NUTRITION

Biomarkers of Oxidative Stress in Metabolic Syndrome and Associated Diseases

(2019) Rosa Vona et al.   Oxidative Medicine and Cellular Longevity

In Vitro Vascular-Protective Effects of a Tilapia By-Product Oligopeptide on Angiotensin II-Induced Hypertensive Endothelial Injury in HUVEC by Nrf2/NF-κB Pathways

(2019) Jiali Chen et al.   Marine Drugs

Structure, Function, and Therapeutic Potential of Marine Bioactive Peptides

(2019) Tatiana V. Ovchinnikova   Marine Drugs

Impaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus

(2018) Ioannis Akoumianakis et al.   ANTIOXIDANTS & REDOX SIGNALING

Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children

(2018) Kara A. Nerenberg et al.   CANADIAN JOURNAL OF CARDIOLOGY

Egg white hydrolysate and peptide reverse insulin resistance associated with tumor necrosis factor-α (TNF-α) stimulated mitogen-activated protein kinase (MAPK) pathway in skeletal muscle cells

(2018) Myoungjin Son et al.   EUROPEAN JOURNAL OF NUTRITION

Purification and identification of adipogenic-differentiating peptides from egg white hydrolysate

(2018) Forough Jahandideh et al.   FOOD CHEMISTRY

Egg White Ovotransferrin-Derived ACE Inhibitory Peptide Ameliorates Angiotensin II-Stimulated Insulin Resistance in Skeletal Muscle Cells

(2018) Myoungjin Son et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Pepsin egg white hydrolysate ameliorates metabolic syndrome in high-fat/high-dextrose fed rats

(2018) S. Moreno-Fernández et al.   Food & Function

Egg and Soy-Derived Peptides and Hydrolysates: A Review of Their Physiological Actions against Diabetes and Obesity

(2018) Stepheny C. de Campos Zani et al.   Nutrients

ACE-inhibition induces a cardioprotective transcriptional response in the metabolic syndrome heart

(2018) Aziza Yakubova et al.   Scientific Reports

Egg White-Derived Tripeptide IRW (Ile-Arg-Trp) Is an Activator of Angiotensin Converting Enzyme 2

(2018) Wang Liao et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Two Novel Multi-Functional Peptides from Meat and Visceral Mass of Marine Snail Neptunea arthritica cumingii and Their Activities In Vitro and In Vivo

(2018) Shan-Shan Zhang et al.   Marine Drugs

Angiotensin-I-Converting Enzyme (ACE)-Inhibitory Peptides from Plants

(2017) Ceren Daskaya-Dikmen et al.   Nutrients

Egg white hydrolysate shows insulin mimetic and sensitizing effects in 3T3-F442A pre-adipocytes

(2017) Forough Jahandideh et al.   PLoS One

Milk-derived bioactive peptides and their health promoting effects: a potential role in atherosclerosis

(2016) Simone Marcone et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Serum high-sensitivity C-reactive protein as a biomarker in patients with metabolic syndrome: evidence-based study with 7284 subjects

(2016) S R Mirhafez et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Hyperglycemia-associated alterations in cellular signaling and dysregulated mitochondrial bioenergetics in human metabolic disorders

(2016) George B. Stefano et al.   EUROPEAN JOURNAL OF NUTRITION

On Endogenous Angiotensin II Antagonism in Hypertension

(2016) María Paz Ocaranza et al.   HYPERTENSION

Short- and long-term antihypertensive effect of egg protein-derived peptide QIGLF

(2016) Zhipeng Yu et al.   JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE

Role of phytochemicals in the management of metabolic syndrome

(2016) Arrigo F.G. Cicero et al.   PHYTOMEDICINE

Metabolic syndrome update

(2016) Scott M. Grundy   TRENDS IN CARDIOVASCULAR MEDICINE

Egg white protein hydrolysate reduces blood pressure, improves vascular relaxation and modifies aortic angiotensin II receptors expression in spontaneously hypertensive rats

(2016) Forough Jahandideh et al.   Journal of Functional Foods

Pepsin Egg White Hydrolysate Ameliorates Obesity-Related Oxidative Stress, Inflammation and Steatosis in Zucker Fatty Rats

(2016) M. Garcés-Rimón et al.   PLoS One

Antioxidant and anti-inflammatory effects of curcuminoid-piperine combination in subjects with metabolic syndrome: A randomized controlled trial and an updated meta-analysis

(2015) Yunes Panahi et al.   CLINICAL NUTRITION

A Review of Potential Marine-derived Hypotensive and Anti-obesity Peptides

(2015) V. Manikkam et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Egg white hydrolysates with in vitro biological multiactivities to control complications associated with the metabolic syndrome

(2015) Marta Garcés-Rimón et al.   EUROPEAN FOOD RESEARCH AND TECHNOLOGY

Impact of non-starter lactobacilli on release of peptides with angiotensin-converting enzyme inhibitory and antioxidant activities during bovine milk fermentation

(2015) Lisa Solieri et al.   FOOD MICROBIOLOGY

Red-fleshed sweet orange juice improves the risk factors for metabolic syndrome

(2015) Jacqueline Q. Silveira et al.   INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION

Diabetic Cardiovascular Disease Induced by Oxidative Stress

(2015) Yosuke Kayama et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Antioxidant Peptides Identified from Ovotransferrin by the ORAC Method Did Not Show Anti-Inflammatory and Antioxidant Activities in Endothelial Cells

(2015) Forough Jahandideh et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Normal or High Polyphenol Concentration in Orange Juice Affects Antioxidant Activity, Blood Pressure, and Body Weight in Obese or Overweight Adults

(2015) Oscar D Rangel-Huerta et al.   JOURNAL OF NUTRITION

Marine Peptides: Bioactivities and Applications

(2015) Randy Cheung et al.   Marine Drugs

Egg ovotransferrin-derived ACE inhibitory peptide IRW increases ACE2 but decreases proinflammatory genes expression in mesenteric artery of spontaneously hypertensive rats

(2015) Kaustav Majumder et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Egg-derived ACE-inhibitory peptides IQW and LKP reduce blood pressure in spontaneously hypertensive rats

(2015) Kaustav Majumder et al.   Journal of Functional Foods

Blueberries Improve Endothelial Function, but Not Blood Pressure, in Adults with Metabolic Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

(2015) April Stull et al.   Nutrients

Antioxidant and antidiabetic activities of peptides isolated from a hydrolysate of an egg-yolk protein by-product prepared with a proteinase from Asian pumpkin (Cucurbita ficifolia)

(2015) Aleksandra Zambrowicz et al.   RSC Advances

Milk-Derived Tripeptides IPP (Ile-Pro-Pro) and VPP (Val-Pro-Pro) Promote Adipocyte Differentiation and Inhibit Inflammation in 3T3-F442A Cells

(2015) Subhadeep Chakrabarti et al.   PLoS One

Influence of the Lactotripeptides Isoleucine–Proline–Proline and Valine–Proline–Proline on Systolic Blood Pressure in Japanese Subjects: A Systematic Review and Meta-Analysis of Randomized Controlled Trials

(2015) Aurelie Chanson-Rolle et al.   PLoS One

Oral administration of the milk casein-derived tripeptide Val-Pro-Pro attenuates high-fat diet-induced adipose tissue inflammation in mice

(2014) Kotaro Aihara et al.   BRITISH JOURNAL OF NUTRITION

Food-Originating ACE Inhibitors, Including Antihypertensive Peptides, as Preventive Food Components in Blood Pressure Reduction

(2014) Anna Iwaniak et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes

(2014) Nathalie Esser et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats

(2014) Atsuko Nonaka et al.   HYPERTENSION RESEARCH

The Vascular Endothelium and Human Diseases

(2014) Peramaiyan Rajendran et al.   International Journal of Biological Sciences

Molecular Targets of Antihypertensive Peptides: Understanding the Mechanisms of Action Based on the Pathophysiology of Hypertension

(2014) Kaustav Majumder et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Enhanced ROS production and oxidative damage in subcutaneous white adipose tissue mitochondria in obese and type 2 diabetes subjects

(2014) Mrittika Chattopadhyay et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Functional significance of bioactive peptides derived from soybean

(2014) Brij Pal Singh et al.   PEPTIDES

Beneficial Effects of Simulated Gastro-Intestinal Digests of Fried Egg and Its Fractions on Blood Pressure, Plasma Lipids and Oxidative Stress in Spontaneously Hypertensive Rats

(2014) Forough Jahandideh et al.   PLoS One

A Novel Hemp Seed Meal Protein Hydrolysate Reduces Oxidative Stress Factors in Spontaneously Hypertensive Rats

(2014) Abraham Girgih et al.   Nutrients

Effects of the Angiotensin Receptor Blocker Olmesartan on Adipocyte Hypertrophy and Function in Mice with Metabolic Disorders

(2014) Akinobu Maeda et al.   Biomed Research International

Food-Derived Bioactive Peptides on Inflammation and Oxidative Stress

(2014) Subhadeep Chakrabarti et al.   Biomed Research International

ACE-inhibition, but not weight reduction restores cardiomyocyte response to β-adrenergic stimulation in the metabolic syndrome

(2013) Ines Nevelsteen et al.   BMC Cardiovascular Disorders

Angiotensin-converting enzyme inhibition and food restriction restore delayed preconditioning in diabetic mice

(2013) Gerry Van der Mieren et al.   Cardiovascular Diabetology

Discovery and Characterization of Alamandine

(2013) Roberto Queiroga Lautner et al.   CIRCULATION RESEARCH

Glycine restores glutathione and protects against oxidative stress in vascular tissue from sucrose-fed rats

(2013) Angélica Ruiz-Ramírez et al.   CLINICAL SCIENCE

Identification of Bioactive Peptides from Cereal Storage Proteins and Their Potential Role in Prevention of Chronic Diseases

(2013) Ariel Cavazos et al.   COMPREHENSIVE REVIEWS IN FOOD SCIENCE AND FOOD SAFETY

Active peptides from skate (Okamejei kenojei) skin gelatin diminish angiotensin-I converting enzyme activity and intracellular free radical-mediated oxidation

(2013) Dai-Hung Ngo et al.   FOOD CHEMISTRY

Structure and Activity Study of Egg Protein Ovotransferrin Derived Peptides (IRW and IQW) on Endothelial Inflammatory Response and Oxidative Stress

(2013) Kaustav Majumder et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Milk-Derived Peptides, Val-Pro-Pro and Ile-Pro-Pro, Attenuate Atherosclerosis Development in Apolipoprotein E–Deficient Mice: A Preliminary Study

(2013) Teppei Nakamura et al.   JOURNAL OF MEDICINAL FOOD

Increased oxidative stress in obesity: Implications for metabolic syndrome, diabetes, hypertension, dyslipidemia, atherosclerosis, and cancer

(2013) Morihiro Matsuda et al.   Obesity Research & Clinical Practice

Egg-Derived Tri-Peptide IRW Exerts Antihypertensive Effects in Spontaneously Hypertensive Rats

(2013) Kaustav Majumder et al.   PLoS One

Effects of ACE Inhibitors on Insulin Resistance and Lipid Profile in Children with Metabolic Syndrome

(2013) Çelebi Bitkin Eda et al.   Journal of Clinical Research in Pediatric Endocrinology

Hypertension in Metabolic Syndrome: Vascular Pathophysiology

(2013) Yolanda Mendizábal et al.   International Journal of Hypertension

The renin-angiotensin system: a target of and contributor to dyslipidemias, altered glucose homeostasis, and hypertension of the metabolic syndrome

(2012) Kelly Putnam et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Aliskiren prevents and ameliorates metabolic syndrome in fructose-fed rats

(2012) Chu-Lin Chou et al.   Archives of Medical Science

The Renin Angiotensin Aldosterone System and Insulin Resistance in Humans

(2012) Patricia C. Underwood et al.   CURRENT HYPERTENSION REPORTS

Metabolic Syndrome Model Definitions Predicting Type 2 Diabetes and Cardiovascular Disease

(2012) C. M. Povel et al.   DIABETES CARE

Direct renin inhibitor prevents and ameliorates insulin resistance, aortic endothelial dysfunction and vascular remodeling in fructose-fed hypertensive rats

(2012) Chu-Lin Chou et al.   HYPERTENSION RESEARCH

Impact of hyperinsulinemia on the development of hypertension in normotensive, nondiabetic adults: a 4-year follow-up study

(2012) Se Eun Park et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

The role of the renin-angiotensin system in the development of insulin resistance in skeletal muscle

(2012) Erik J. Henriksen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Adipose tissue renin–angiotensin–aldosterone system (RAAS) and progression of insulin resistance

(2012) Yonit Marcus et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Valsartan Improves Adipose Tissue Function in Humans with Impaired Glucose Metabolism: A Randomized Placebo-Controlled Double-Blind Trial

(2012) Gijs H. Goossens et al.   PLoS One

Attenuation of Renovascular Damage in Zucker Diabetic Fatty Rat by NWT-03, an Egg Protein Hydrolysate with ACE- and DPP4-Inhibitory Activity

(2012) Yumei Wang et al.   PLoS One

Metabolic Syndrome: Definition and Therapeutic Implications

(2012) Hari Prasad et al.   POSTGRADUATE MEDICINE

Reactive oxygen species: from health to disease

(2012) K Brieger et al.   SWISS MEDICAL WEEKLY

Metabolic syndrome: its history, mechanisms, and limitations

(2011) Eiji Oda   ACTA DIABETOLOGICA

Angiotensin-(1-7) suppresses oxidative stress and improves glucose uptake via Mas receptor in adipocytes

(2011) Chang Liu et al.   ACTA DIABETOLOGICA

An active peptide purified from gastrointestinal enzyme hydrolysate of Pacific cod skin gelatin attenuates angiotensin-1 converting enzyme (ACE) activity and cellular oxidative stress

(2011) S.W.A. Himaya et al.   FOOD CHEMISTRY

Oxidative stress and endothelial dysfunction in hypertension

(2011) Eberhard Schulz et al.   HYPERTENSION RESEARCH

Free radical scavenging and angiotensin-I converting enzyme inhibitory peptides from Pacific cod (Gadus macrocephalus) skin gelatin

(2011) Dai-Hung Ngo et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Renin-Angiotensin-Aldosterone System in Diabetes and Hypertension

(2011) Willa A. Hsueh et al.   Journal of Clinical Hypertension

Food Protein-Derived Bioactive Peptides: Production, Processing, and Potential Health Benefits

(2011) Chibuike C. Udenigwe et al.   JOURNAL OF FOOD SCIENCE

Adipose Tissue–Specific Regulation of Angiotensinogen in Obese Humans and Mice: Impact of Nutritional Status and Adipocyte Hypertrophy

(2010) Shintaro Yasue et al.   AMERICAN JOURNAL OF HYPERTENSION

Oxidative Stress as Pathogenesis of Cardiovascular Risk Associated with Metabolic Syndrome

(2010) Hajime Otani   ANTIOXIDANTS & REDOX SIGNALING

Improved Lipid and Glucose Metabolism in Transgenic Rats With Increased Circulating Angiotensin-(1-7)

(2010) Sérgio Henrique S. Santos et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Angiotensin I-Converting Enzyme Type 2 (ACE2) Gene Therapy Improves Glycemic Control in Diabetic Mice

(2010) S. M. Bindom et al.   DIABETES

Oxygen radical absorbance capacity of peptides from egg white protein ovotransferrin and their interaction with phytochemicals

(2010) Wu-Yang Huang et al.   FOOD CHEMISTRY

Purification and characterisation of angiotensin I converting enzyme (ACE) inhibitory peptides derived from enzymatic hydrolysate of ovotransferrin

(2010) Kaustav Majumder et al.   FOOD CHEMISTRY

Different Effects of Aliskiren and Losartan on Fibrinolysis and Insulin Sensitivity in Hypertensive Patients with Metabolic Syndrome

(2010) R. Fogari et al.   HORMONE AND METABOLIC RESEARCH

Egg-Derived Peptide IRW Inhibits TNF-α-Induced Inflammatory Response and Oxidative Stress in Endothelial Cells

(2010) Wuyang Huang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Beneficial effects of oligopeptides from marine salmon skin in a rat model of type 2 diabetes

(2010) Cui-Feng Zhu et al.   NUTRITION

IPP-rich milk protein hydrolysate lowers blood pressure in subjects with stage 1 hypertension, a randomized controlled trial

(2010) Esther Boelsma et al.   Nutrition Journal

Effects of extensively oxidized low-density lipoprotein on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells

(2009) Subir K. Roy Chowdhury et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

NADPH Oxidases: Functions and Pathologies in the Vasculature

(2009) Bernard Lassègue et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inflammatory cytokines in vascular dysfunction and vascular disease

(2009) Alexander H. Sprague et al.   BIOCHEMICAL PHARMACOLOGY

Cell specificity, anti-inflammatory activity, and plausible bactericidal mechanism of designed Trp-rich model antimicrobial peptides

(2009) Ka Hyon Park et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Sardine Peptide with Angiotensin I-Converting Enzyme Inhibitory Activity Improves Glucose Tolerance in Stroke-Prone Spontaneously Hypertensive Rats

(2009) Lila OTANI et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Role of nitrosative stress in the pathogenesis of diabetic vascular dysfunction

(2009) Csaba Szabo   BRITISH JOURNAL OF PHARMACOLOGY

Molecular Insights and Therapeutic Targets for Diabetic Endothelial Dysfunction

(2009) Jian Xu et al.   CIRCULATION

Plant Food-Derived Angiotensin I Converting Enzyme Inhibitory Peptides

(2009) Cuie Guang et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems

(2009) Jian-Ming Lü et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Mitochondrial H2O2 emission and cellular redox state link excess fat intake to insulin resistance in both rodents and humans

(2009) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Chronic infusion of angiotensin-(1–7) improves insulin resistance and hypertension induced by a high-fructose diet in rats

(2008) Jorge F. Giani et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Decrease in oxidative stress through supplementation of vitamins C and E is associated with a reduction in blood pressure in patients with essential hypertension

(2008) Ramón Rodrigo et al.   CLINICAL SCIENCE

Redox-based regulation of signal transduction: Principles, pitfalls, and promises

(2008) Yvonne M.W. Janssen-Heininger et al.   FREE RADICAL BIOLOGY AND MEDICINE

Metabolic and Antihypertensive Effects of Combined Angiotensin Receptor Blocker and Diuretic Therapy in Prediabetic Hypertensive Patients With the Cardiometabolic Syndrome

(2008) Dion H. Zappe et al.   Journal of Clinical Hypertension

The possible roles of food-derived bioactive peptides in reducing the risk of cardiovascular disease

(2008) Kati Erdmann et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Angiotensin receptor blockers improve insulin resistance in type 2 diabetic rats by modulating adipose tissue

(2008) Mi H. Lee et al.   KIDNEY INTERNATIONAL

Angiotensin II and the development of insulin resistance: Implications for diabetes

(2008) J. Alberto Olivares-Reyes et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Lactotripeptides Show No Effect on Human Blood Pressure

(2007) Mariëlle F. Engberink et al.   HYPERTENSION