Astrocytes in Neurodegeneration: Inspiration From Genetics

Disruption of ER‐mitochondria tethering and signalling in C9orf72 ‐associated amyotrophic lateral sclerosis and frontotemporal dementia

(2022) Patricia Gomez‐Suaga et al.   AGING CELL

Amyotrophic lateral sclerosis with SOD1 mutations shows distinct brain metabolic changes

(2022) Antonio Canosa et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Amyloid‐β plaques affect astrocyte Kir4.1 protein expression but not function in the dentate gyrus of APP / PS1 mice

(2022) Christiaan F. M. Huffels et al.   GLIA

Widespread Mislocalization of FUS Is Associated With Mitochondrial Abnormalities in Skeletal Muscle in Amyotrophic Lateral Sclerosis With FUS Mutations

(2022) Meng Yu et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

First-in-human evaluation of 18F-SMBT-1, a novel 18F-labeled MAO-B PET tracer for imaging reactive astrogliosis

(2022) Victor L Villemagne et al.   JOURNAL OF NUCLEAR MEDICINE

Assessing reactive astrogliosis with 18F-SMBT-1 across the Alzheimer’s disease spectrum

(2022) Victor L Villemagne et al.   JOURNAL OF NUCLEAR MEDICINE

Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis

(2022) Thomas E. Mahan et al.   Molecular Neurodegeneration

Antisense oligonucleotide silencing of FUS expression as a therapeutic approach in amyotrophic lateral sclerosis

(2022) Vladislav A. Korobeynikov et al.   NATURE MEDICINE

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

(2022) Chunxing Yang et al.   PLoS One

TDP-43 pathology: From noxious assembly to therapeutic removal

(2022) Sean S. Keating et al.   PROGRESS IN NEUROBIOLOGY

SOD1 mutations associated with amyotrophic lateral sclerosis analysis of variant severity

(2022) Mariusz Berdyński et al.   Scientific Reports

LRRK2, GBA and their interaction in the regulation of autophagy: implications on therapeutics in Parkinson's disease

(2022) Shirley Yin-Yu Pang et al.   Translational Neurodegeneration

Neuroprotection and Disease Modification by Astrocytes and Microglia in Parkinson Disease

(2022) Shinichi Takahashi et al.   Antioxidants

The Role of Voltage Gated Calcium Channels in Basal Ganglia Neurodegenerative Disorders

(2022) Correa et al.   Current Neuropharmacology

Antiepilepticus Effects of Tetrahedral Framework Nucleic Acid via Inhibition of Gliosis-Induced Downregulation of Glutamine Synthetase and Increased AMPAR Internalization in the Postsynaptic Membrane

(2022) Jianwei Zhu et al.   NANO LETTERS

The Specific Role of Reactive Astrocytes in Stroke

(2022) Leiyang Li et al.   Frontiers in Cellular Neuroscience

Astrocyte plasticity in mice ensures continued endfoot coverage of cerebral blood vessels following injury and declines with age

(2022) William A. Mills et al.   Nature Communications

Mitochondrial Dysfunction in Astrocytes: A Role in Parkinson’s Disease?

(2021) Collin M. Bantle et al.   Frontiers in Cell and Developmental Biology

Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds

(2021) Anthony J. Griswold et al.   Alzheimers & Dementia

SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models

(2021) Oh‐Chan Kwon et al.   EMBO Molecular Medicine

Altered expression of clock and clock‐controlled genes in a hSOD1‐linked amyotrophic lateral sclerosis mouse model

(2021) Kelby M. Killoy et al.   FASEB JOURNAL

Parkinson’s Disease–Associated LRRK2 Interferes with Astrocyte-Mediated Alpha-Synuclein Clearance

(2021) Linn Streubel-Gallasch et al.   MOLECULAR NEUROBIOLOGY

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease

(2021) Claudia Salcedo et al.   NEUROCHEMICAL RESEARCH

Modulation of the IGF1R-MTOR pathway attenuates motor neuron toxicity of human ALS SOD1G93A astrocytes

(2021) Veronica Granatiero et al.   Autophagy

Astrocyte senescence and SASP in neurodegeneration: tau joins the loop

(2021) Kyra Ungerleider et al.   CELL CYCLE

Non-neuronal cells in amyotrophic lateral sclerosis — from pathogenesis to biomarkers

(2021) Björn F. Vahsen et al.   Nature Reviews Neurology

Selective removal of astrocytic APOE4 strongly protects against tau-mediated neurodegeneration and decreases synaptic phagocytosis by microglia

(2021) Chao Wang et al.   NEURON

Identification of Genetic Modifiers of TDP-43: Inflammatory Activation of Astrocytes for Neuroinflammation

(2021) Jae-Hong Kim et al.   Cells

Astrocytic atrophy as a pathological feature of Parkinson’s disease with LRRK2 mutation

(2021) Paula Ramos-Gonzalez et al.   npj Parkinsons Disease

Reactive astrocytes: The nexus of pathological and clinical hallmarks of Alzheimer’s disease

(2021) Brittani R. Price et al.   AGEING RESEARCH REVIEWS

18F-THK5351 PET Can Identify Core Lesions in Different Amyotrophic Lateral Sclerosis Phenotypes

(2021) Mana Higashihara et al.   CLINICAL NUCLEAR MEDICINE

Metabolically induced intracellular pH changes activate mitophagy, autophagy and cell protection in familial forms of Parkinson’s disease

(2021) Nafisa R. Komilova et al.   FEBS Journal

Alpha-Synuclein as a Prominent Actor in the Inflammatory Synaptopathy of Parkinson’s Disease

(2021) Antonella Cardinale et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cellular and pathological heterogeneity of primary tauopathies

(2021) Dah-eun Chloe Chung et al.   Molecular Neurodegeneration

Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load

(2021) Valeria Calsolaro et al.   MOLECULAR PSYCHIATRY

C9orf72 deficiency promotes microglial-mediated synaptic loss in aging and amyloid accumulation

(2021) Deepti Lall et al.   NEURON

An autopsy case report of neuronal intermediate filament inclusion disease presenting with predominantly upper motor neuron features

(2021) Aya Murakami et al.   NEUROPATHOLOGY

Systematic review of human post‐mortem immunohistochemical studies and bioinformatics analyses unveil the complexity of astrocyte reaction in Alzheimer's disease

(2021) Lucía Viejo et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Regulation of beta-amyloid production in neurons by astrocyte-derived cholesterol

(2021) Hao Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

(2021) Claudia Salcedo et al.   Frontiers in Aging Neuroscience

APOE4-carrying human astrocytes oversupply cholesterol to promote neuronal lipid raft expansion and Aβ generation

(2021) Se-In Lee et al.   Stem Cell Reports

Treating Parkinson’s disease by astrocyte reprogramming: Progress and challenges

(2021) Zhuang-Yao D. Wei et al.   Science Advances

The PINK1-Mediated Crosstalk between Neural Cells and the Underlying Link to Parkinson’s Disease

(2021) Elvira Pequeno Leites et al.   Cells

Reactive Astrocytosis in a Mouse Model of Chronic Polyamine Catabolism Activation

(2021) Chiara Cervetto et al.   Biomolecules

The Role of Endoplasmic Reticulum in the Differential Endurance against Redox Stress in Cortical and Spinal Astrocytes from the Newborn SOD1G93A Mouse Model of Amyotrophic Lateral Sclerosis

(2021) Cecilia Marini et al.   Antioxidants

Transcriptomic analysis of frontotemporal lobar degeneration with TDP-43 pathology reveals cellular alterations across multiple brain regions

(2021) Rahat Hasan et al.   ACTA NEUROPATHOLOGICA

Interactions between glial cells and the blood-brain barrier and their role in Alzheimer's disease

(2021) Ming Zhao et al.   AGEING RESEARCH REVIEWS

Astrocytes display cell autonomous and diverse early reactive states in familial amyotrophic lateral sclerosis

(2021) Doaa M Taha et al.   BRAIN

APOE4 derived from astrocytes leads to blood–brain barrier impairment

(2021) Rosemary J. Jackson et al.   BRAIN

Microglia‐specific ApoE knock‐out does not alter Alzheimer's disease plaque pathogenesis or gene expression

(2021) Caden M. Henningfield et al.   GLIA

Reduced Levels of ABCA1 Transporter Are Responsible for the Cholesterol Efflux Impairment in β-Amyloid-Induced Reactive Astrocytes: Potential Rescue from Biomimetic HDLs

(2021) Giulia Sierri et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elevated 4R‐tau in astrocytes from asymptomatic carriers of the MAPT 10+16 intronic mutation

(2021) Núria Setó‐Salvia et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer’s disease

(2021) Amit Kumar et al.   JOURNAL OF NEUROCHEMISTRY

Zinc induces reactive astrogliosis through ERK‐dependent activation of Stat3 and promotes synaptic degeneration

(2021) Zhang Huiliang et al.   JOURNAL OF NEUROCHEMISTRY

Salivary GFAP as a potential biomarker for diagnosis of mild cognitive impairment and Alzheimer's disease and its correlation with neuroinflammation and apoptosis

(2021) Georgios Katsipis et al.   JOURNAL OF NEUROIMMUNOLOGY

Downregulating expression of OPTN elevates neuroinflammation via AIM2 inflammasome- and RIPK1-activating mechanisms in APP/PS1 transgenic mice

(2021) Long-Long Cao et al.   Journal of Neuroinflammation

Astrocytic C–X–C motif chemokine ligand-1 mediates β-amyloid-induced synaptotoxicity

(2021) Beatriz G. Perez-Nievas et al.   Journal of Neuroinflammation

Loss of TDP-43 function underlies hippocampal and cortical synaptic deficits in TDP-43 proteinopathies

(2021) Jiangxia Ni et al.   MOLECULAR PSYCHIATRY

Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐Cyclodextrin Treatment

(2021) Javier Jarazo et al.   MOVEMENT DISORDERS

Human ALS/FTD brain organoid slice cultures display distinct early astrocyte and targetable neuronal pathology

(2021) Kornélia Szebényi et al.   NATURE NEUROSCIENCE

Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

(2021) Shahzad S Khan et al.   eLife

Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease

(2021) Yu-En Lin et al.   eLife

The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

(2021) Aurelie de Rus Jacquet et al.   eLife

Mitochondrial Function and Parkinson’s Disease: From the Perspective of the Electron Transport Chain

(2021) Jeng-Lin Li et al.   Frontiers in Molecular Neuroscience

APOE2, E3, and E4 differentially modulate cellular homeostasis, cholesterol metabolism, and inflammatory response in isogenic iPSC-derived astrocytes

(2021) Sherida M. de Leeuw et al.   Stem Cell Reports

Plasma glial fibrillary acidic protein and neurofilament light chain for the diagnostic and prognostic evaluation of frontotemporal dementia

(2021) Nuole Zhu et al.   Translational Neurodegeneration

An Intercellular Flow of Glutathione Regulated by Interleukin 6 Links Astrocytes and the Liver in the Pathophysiology of Amyotrophic Lateral Sclerosis

(2021) Rafael López-Blanch et al.   Antioxidants

An update on human astrocytes and their role in development and disease

(2020) Martina Majo et al.   GLIA

Plasma glial fibrillary acidic protein is raised in progranulin-associated frontotemporal dementia

(2020) Carolin Heller et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Aggressive FUS-Mutant Motor Neuron Disease Without Profound Spinal Cord Pathology

(2020) Yan Chen Wongworawat et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Lysosome and Inflammatory Defects in GBA1 ‐Mutant Astrocytes Are Normalized by LRRK2 Inhibition

(2020) Anwesha Sanyal et al.   MOVEMENT DISORDERS

Insoluble tau aggregates induce neuronal death through modification of membrane ion conductance, activation of voltage‐gated calcium channels and NADPH oxidase

(2020) Noemi Esteras et al.   FEBS Journal

Critical roles of astrocytic‐CCL2‐dependent monocyte infiltration in a DJ‐1 knockout mouse model of delayed brain repair

(2020) Dong‐Joo Choi et al.   GLIA

Astrocytes have the capacity to act as antigen-presenting cells in the Parkinson’s disease brain

(2020) Jinar Rostami et al.   Journal of Neuroinflammation

Mutant TDP-43 Expression Triggers TDP-43 Pathology and Cell Autonomous Effects on Primary Astrocytes: Implications for Non-cell Autonomous Pathology in ALS

(2020) Samantha K. Barton et al.   NEUROCHEMICAL RESEARCH

Astrocytes with TDP-43 inclusions exhibit reduced noradrenergic cAMP and Ca2+ signaling and dysregulated cell metabolism

(2020) Jelena Velebit et al.   Scientific Reports

Mechanistic Insights of Astrocyte-Mediated Hyperactive Autophagy and Loss of Motor Neuron Function in SOD1L39R Linked Amyotrophic Lateral Sclerosis

(2020) Chetan Singh Rajpurohit et al.   MOLECULAR NEUROBIOLOGY

Phase 1–2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS

(2020) Timothy Miller et al.   NEW ENGLAND JOURNAL OF MEDICINE

Immunological Features of Non-neuronal Brain Cells: Implications for Alzheimer’s Disease Immunotherapy

(2020) Giulia Castellani et al.   TRENDS IN IMMUNOLOGY

Knockout of reactive astrocyte activating factors slows disease progression in an ALS mouse model

(2020) Kevin A. Guttenplan et al.   Nature Communications

TDP-43 mediated blood-brain barrier permeability and leukocyte infiltration promote neurodegeneration in a low-grade systemic inflammation mouse model

(2020) Frank Zamudio et al.   Journal of Neuroinflammation

The overexpression of TDP-43 in astrocytes causes neurodegeneration via a PTP1B-mediated inflammatory response

(2020) Shinrye Lee et al.   Journal of Neuroinflammation

Microglia and astrocyte dysfunction in parkinson's disease

(2020) Tae-In Kam et al.   NEUROBIOLOGY OF DISEASE

Astrocyte Crosstalk in CNS Inflammation

(2020) Mathias Linnerbauer et al.   NEURON

Microglia and Astrocytes in Disease: Dynamic Duo or Partners in Crime?

(2020) Shane A. Liddelow et al.   TRENDS IN IMMUNOLOGY

Metabolic alterations in Parkinson’s disease astrocytes

(2020) Tuuli-Maria Sonninen et al.   Scientific Reports

Unique signatures of stress-induced senescent human astrocytes

(2020) Katrin Simmnacher et al.   EXPERIMENTAL NEUROLOGY

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

(2019) Angelique di Domenico et al.   Stem Cell Reports

Enhanced SIRT6 activity abrogates the neurotoxic phenotype of astrocytes expressing ALS-linked mutant SOD1

(2019) Benjamin A. Harlan et al.   FASEB JOURNAL

Astrocyte adenosine deaminase loss increases motor neuron toxicity in amyotrophic lateral sclerosis

(2019) Scott P Allen et al.   BRAIN

p.N345K mutation in TARDBP in a patient with familial amyotrophic lateral sclerosis: An autopsy case

(2019) Takahiro Takeda et al.   NEUROPATHOLOGY

Glia-specific autophagy dysfunction in ALS

(2019) Laura Strohm et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis

(2019) Loqman A. Mohamed et al.   EXPERIMENTAL NEUROLOGY

Globular glial tauopathy caused by MAPT P301T mutation: clinical and neuropathological findings

(2019) M. E. Erro et al.   JOURNAL OF NEUROLOGY

A Parkinson's disease gene, DJ-1, regulates anti-inflammatory roles of astrocytes through prostaglandin D2 synthase expression

(2019) Dong-Joo Choi et al.   NEUROBIOLOGY OF DISEASE

Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study

(2019) Heather Wilson et al.   BRAIN

C9orf72 expansion within astrocytes reduces metabolic flexibility in amyotrophic lateral sclerosis

(2019) Scott P Allen et al.   BRAIN

Autophagy lysosomal pathway dysfunction in Parkinson's disease; evidence from human genetics

(2019) Konstantin Senkevich et al.   PARKINSONISM & RELATED DISORDERS

Astrocytic Oxidative/Nitrosative Stress Contributes to Parkinson’s Disease Pathogenesis: The Dual Role of Reactive Astrocytes

(2019) Asha Rizor et al.   Antioxidants

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death

(2019) Elena Britti et al.   CELL CALCIUM

Mutant C9orf72 human iPSC‐derived astrocytes cause non‐cell autonomous motor neuron pathophysiology

(2019) Chen Zhao et al.   GLIA

G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice

(2019) Nicolas Arbez et al.   HUMAN MOLECULAR GENETICS

A characterization of Gaucher iPS-derived astrocytes: Potential implications for Parkinson's disease

(2019) Elma Aflaki et al.   NEUROBIOLOGY OF DISEASE

TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes

(2019) Thomas J. LaRocca et al.   NEUROBIOLOGY OF DISEASE

Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult

(2019) Michael X. Henderson et al.   NEURON

Human iPSC-derived astrocytes from ALS patients with mutated C9ORF72 show increased oxidative stress and neurotoxicity

(2019) Anastasya Birger et al.   EBioMedicine

NF‐κB activation in astrocytes drives a stage‐specific beneficial neuroimmunological response in ALS

(2018) Najwa Ouali Alami et al.   EMBO JOURNAL

MANF protects dopamine neurons and locomotion defects from a human α-synuclein induced Parkinson's disease model in C. elegans by regulating ER stress and autophagy pathways

(2018) Zhuoyu Zhang et al.   EXPERIMENTAL NEUROLOGY

Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha

(2018) Azadeh Kia et al.   GLIA

Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation

(2018) Fan Liao et al.   JOURNAL OF CLINICAL INVESTIGATION

α‑synuclein induces apoptosis of astrocytes by causing dysfunction of the endoplasmic reticulum‑Golgi compartment

(2018) Mei Liu et al.   Molecular Medicine Reports

Cortical Neurotoxic Astrocytes with Early ALS Pathology and miR-146a Deficit Replicate Gliosis Markers of Symptomatic SOD1G93A Mouse Model

(2018) Cátia Gomes et al.   MOLECULAR NEUROBIOLOGY

Poly(GR) impairs protein translation and stress granule dynamics in C9orf72-associated frontotemporal dementia and amyotrophic lateral sclerosis

(2018) Yong-Jie Zhang et al.   NATURE MEDICINE

Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

(2018) Briana R. De Miranda et al.   NEUROBIOLOGY OF DISEASE

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Silencing of FUS in the common marmoset ( Callithrix jacchus ) brain via stereotaxic injection of an adeno-associated virus encoding shRNA

(2018) Kuniyuki Endo et al.   NEUROSCIENCE RESEARCH

The multi-dimensional roles of astrocytes in ALS

(2018) Koji Yamanaka et al.   NEUROSCIENCE RESEARCH

Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death

(2018) Liuke Sun et al.   Scientific Reports

Glutathione S-Transferase Alpha 4 Prevents Dopamine Neurodegeneration in a Rat Alpha-Synuclein Model of Parkinson’s Disease

(2018) Michael Jewett et al.   Frontiers in Neurology

Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo

(2018) Ann Kristin Frøyset et al.   Redox Biology

Astrocytic degeneration in chronic traumatic encephalopathy

(2018) Eric T. Hsu et al.   ACTA NEUROPATHOLOGICA

The C9ORF72 gene, implicated in ALS/FTD, encodes a protein that functions in control of endothelin and glutamate signaling

(2018) Vitalay Fomin et al.   MOLECULAR AND CELLULAR BIOLOGY

Immunotherapy targeting toll-like receptor 2 alleviates neurodegeneration in models of synucleinopathy by modulating α-synuclein transmission and neuroinflammation

(2018) Changyoun Kim et al.   Molecular Neurodegeneration

CSF biomarkers of neuroinflammation and cerebrovascular dysfunction in early Alzheimer disease

(2018) Shorena Janelidze et al.   NEUROLOGY

A Parkinson’s disease gene, DJ-1, regulates astrogliosis through STAT3

(2018) Dong-Joo Choi et al.   NEUROSCIENCE LETTERS

LRRK2 activation in idiopathic Parkinson’s disease

(2018) Roberto Di Maio et al.   Science Translational Medicine

Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation

(2018) Komudi Singh et al.   GLIA

Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations

(2018) Masashi Takanashi et al.   Acta Neuropathologica Communications

AParkinson's disease gene, DJ-1, repairs brain injury through Sox9 stabilization and astrogliosis

(2017) Dong-Joo Choi et al.   GLIA

TDP-43 mutations causing amyotrophic lateral sclerosis are associated with altered expression of RNA-binding protein hnRNP K and affect the Nrf2 antioxidant pathway

(2017) Diane Moujalled et al.   HUMAN MOLECULAR GENETICS

Overexpression of α-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis

(2017) Adolfo Garcia Erustes et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

The effect of α-synuclein on gliosis and IL-1α, TNFα, IFNγ, TGFβ expression in murine brain

(2017) Anna Sznejder-Pachołek et al.   Pharmacological Reports

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

(2017) Heather D.E. Booth et al.   TRENDS IN NEUROSCIENCES

Changes in the Expression of FUS/TLS in Spinal Cords of SOD1 G93A Transgenic Mice and Correlation with Motor-Neuron Degeneration

(2016) Jiao Li et al.   International Journal of Biological Sciences

C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins

(2016) Yong-Jie Zhang et al.   NATURE NEUROSCIENCE

C9orf72 BAC Mouse Model with Motor Deficits and Neurodegenerative Features of ALS/FTD

(2016) Yuanjing Liu et al.   NEURON

DJ-1 mutation decreases astroglial release of inflammatory mediators

(2016) A.K. Ashley et al.   NEUROTOXICOLOGY

DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression

(2016) Jin-Mo Kim et al.   Scientific Reports

PINK1 expression increases during brain development and stem cell differentiation, and affects the development of GFAP-positive astrocytes

(2016) Insup Choi et al.   Molecular Brain

The C9ORF72 GGGGCC expansion forms RNA G-quadruplex inclusions and sequesters hnRNP H to disrupt splicing in ALS brains

(2016) Erin G Conlon et al.   eLife

Mutant Alpha-Synuclein Causes Age-Dependent Neuropathology in Monkey Brain

(2015) W. Yang et al.   JOURNAL OF NEUROSCIENCE

Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation

(2015) Junchao Tong et al.   NEUROBIOLOGY OF DISEASE

Translational profiling identifies a cascade of damage initiated in motor neurons and spreading to glia in mutant SOD1-mediated ALS

(2015) Shuying Sun et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells

(2015) Fumito Endo et al.   Cell Reports

FUS Interacts with HSP60 to Promote Mitochondrial Damage

(2015) Jianwen Deng et al.   PLoS Genetics

Astrocytosis measured by 11C-deprenyl PET correlates with decrease in gray matter density in the parahippocampus of prodromal Alzheimer’s patients

(2014) IL Han Choo et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Intracellular processing of disease-associated α-synuclein in the human brain suggests prion-like cell-to-cell spread

(2014) Gabor G. Kovacs et al.   NEUROBIOLOGY OF DISEASE

SOD1 Function and Its Implications for Amyotrophic Lateral Sclerosis Pathology

(2014) Rosie K. A. Bunton-Stasyshyn et al.   NEUROSCIENTIST

Astrocytes expressing mutant SOD1 and TDP43 trigger motoneuron death that is mediated via sodium channels and nitroxidative stress

(2014) Fabiola Rojas et al.   Frontiers in Cellular Neuroscience

C9orf72 frontotemporal lobar degeneration is characterised by frequent neuronal sense and antisense RNA foci

(2013) Sarah Mizielinska et al.   ACTA NEUROPATHOLOGICA

Mitochondria and Quality Control Defects in a Mouse Model of Gaucher Disease—Links to Parkinson’s Disease

(2013) Laura D. Osellame et al.   Cell Metabolism

The multifaceted role of glial cells in amyotrophic lateral sclerosis

(2013) Chiara F. Valori et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Expression of ALS-linked TDP-43 mutant in astrocytes causes non-cell-autonomous motor neuron death in rats

(2013) Jianbin Tong et al.   EMBO JOURNAL

Acute isolation and transcriptome characterization of cortical astrocytes and microglia from young and aged mice

(2013) Marie Orre et al.   NEUROBIOLOGY OF AGING

Astrocyte pathology and the absence of non-cell autonomy in an induced pluripotent stem cell model of TDP-43 proteinopathy

(2013) A. Serio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactive astrocytes secrete lcn2 to promote neuron death

(2013) F. Bi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

(2012) C. Di Malta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pathological heterogeneity in amyotrophic lateral sclerosis with FUS mutations: two distinct patterns correlating with disease severity and mutation

(2011) Ian R. A. Mackenzie et al.   ACTA NEUROPATHOLOGICA

Genetic mutations and functions of PINK1

(2011) Sumihiro Kawajiri et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

Glucocerebrosidase mutations in clinical and pathologically proven Parkinson's disease

(2009) Juliane Neumann et al.   BRAIN

Glial Dysfunction in Parkin Null Mice: Effects of Aging

(2008) R. M. Solano et al.   JOURNAL OF NEUROSCIENCE