G2019S-LRRK2 mutation enhances MPTP-linked Parkinsonism in mice

LRRK2 links genetic and sporadic Parkinson's disease

(2019) Jillian H. Kluss et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The genetics of Parkinson disease

(2018) Hao Deng et al.   AGEING RESEARCH REVIEWS

Robust kinase- and age-dependent dopaminergic and norepinephrine neurodegeneration in LRRK2 G2019S transgenic mice

(2018) Yulan Xiong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition

(2018) Kaela Kelly et al.   EXPERIMENTAL NEUROLOGY

Triggers, Facilitators, and Aggravators: Redefining Parkinson’s Disease Pathogenesis

(2018) Michaela E. Johnson et al.   TRENDS IN NEUROSCIENCES

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Epidemiology of Parkinson’s disease

(2017) Ole-Bjørn Tysnes et al.   JOURNAL OF NEURAL TRANSMISSION

A meta-analysis of genome-wide association studies identifies 17 new Parkinson's disease risk loci

(2017) Diana Chang et al.   NATURE GENETICS

Parkinson’s disease and occupational exposures: a systematic literature review and meta-analyses

(2017) Lars-Gunnar Gunnarsson et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Mitochondrial dysfunction in Parkinson's disease

(2016) Anindita Bose et al.   JOURNAL OF NEUROCHEMISTRY

Association between hepatitis C virus infection and Parkinson's disease

(2016) Jong-Min Kim et al.   MOVEMENT DISORDERS

Pharmacological LRRK2 kinase inhibition induces LRRK2 protein destabilization and proteasomal degradation

(2016) E. Lobbestael et al.   Scientific Reports

Selective expression of Parkinson's disease-relatedLeucine-rich repeat kinase 2G2019S missense mutation in midbrain dopaminergic neurons impairs dopamine release and dopaminergic gene expression

(2015) Guoxiang Liu et al.   HUMAN MOLECULAR GENETICS

Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration

(2015) João P. L. Daher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Alternative to LRRK2-IN-1 for Pharmacological Studies of Parkinson's Disease

(2015) Kyoko Koshibu et al.   PHARMACOLOGY

Effect of selective LRRK2 kinase inhibition on nonhuman primate lung

(2015) Reina N. Fuji et al.   Science Translational Medicine

No Dopamine Cell Loss or Changes in Cytoskeleton Function in Transgenic Mice Expressing Physiological Levels of Wild Type or G2019S Mutant LRRK2 and in Human Fibroblasts

(2015) Marta Garcia-Miralles et al.   PLoS One

Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration

(2014) Edward D. Plowey et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Genome-wide mapping of IBD segments in an Ashkenazi PD cohort identifies associated haplotypes

(2014) V. Vacic et al.   HUMAN MOLECULAR GENETICS

M. paratuberculosis and Parkinson’s disease – Is this a trigger

(2014) Coad Thomas Dow   MEDICAL HYPOTHESES

Conditional expression of Parkinson's disease-related R1441C LRRK2 in midbrain dopaminergic neurons of mice causes nuclear abnormalities without neurodegeneration

(2014) Elpida Tsika et al.   NEUROBIOLOGY OF DISEASE

Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity

(2014) Erin E. Watkin et al.   PLoS One

Interplay of LRRK2 with chaperone-mediated autophagy

(2013) Samantha J Orenstein et al.   NATURE NEUROSCIENCE

Loss of Leucine-Rich Repeat Kinase 2 (LRRK2) in Rats Leads to Progressive Abnormal Phenotypes in Peripheral Organs

(2013) Marco A. S. Baptista et al.   PLoS One

LRRK2 regulates mitochondrial dynamics and function through direct interaction with DLP1

(2012) X. Wang et al.   HUMAN MOLECULAR GENETICS

LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor co-ordination behaviors

(2012) Kelly M Hinkle et al.   Molecular Neurodegeneration

LRRK2 kinase activity mediates toxic interactions between genetic mutation and oxidative stress in a Drosophila model: Suppression by curcumin

(2012) Dejun Yang et al.   NEUROBIOLOGY OF DISEASE

Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies

(2011)   LANCET

Animal models of Parkinson's disease

(2011) Vernice Jackson-Lewis et al.   PARKINSONISM & RELATED DISORDERS

Curcumin protects against A53T alpha-synuclein-induced toxicity in a PC12 inducible cell model for Parkinsonism

(2011) Zhaohui Liu et al.   PHARMACOLOGICAL RESEARCH

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

(2011) David Ramonet et al.   PLoS One

Leucine-Rich Repeat Kinase 2 Is Associated With the Endoplasmic Reticulum in Dopaminergic Neurons and Accumulates in the Core of Lewy Bodies in Parkinson Disease

(2010) Jérémie Vitte et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease

(2010) Byoung Dae Lee et al.   NATURE MEDICINE

Unexpected Lack of Hypersensitivity in LRRK2 Knock-Out Mice to MPTP (1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine)

(2009) E. Andres-Mateos et al.   JOURNAL OF NEUROSCIENCE

Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease

(2009) Wataru Satake et al.   NATURE GENETICS

Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease

(2009) Yanping Li et al.   NATURE NEUROSCIENCE

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice

(2009) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA