The LRRK2 G2019S mutation alters astrocyte-to-neuron communication via extracellular vesicles and induces neuron atrophy in a human iPSC-derived model of Parkinson’s disease

Direct comparison of optical and electron microscopy methods for structural characterization of extracellular vesicles

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Loss-of-function BK channel mutation causes impaired mitochondria and progressive cerebellar ataxia

(2020) Xiaofei Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

24(S),25-Epoxycholesterol and cholesterol 24S-hydroxylase (CYP46A1) overexpression promote midbrain dopaminergic neurogenesis in vivo

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Extracellular Vesicles Secreted by Astroglial Cells Transport Apolipoprotein D to Neurons and Mediate Neuronal Survival Upon Oxidative Stress

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Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease

(2019) Zhen-Hua Zhao et al.   Frontiers in Aging Neuroscience

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

(2019) Angelique di Domenico et al.   Stem Cell Reports

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Exosomes

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Lzts1 controls both neuronal delamination and outer radial glial-like cell generation during mammalian cerebral development

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Distinct mechanisms of microRNA sorting into cancer cell-derived extracellular vesicle subtypes

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Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

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Assessing Neuronal and Astrocyte Derived Exosomes From Individuals With Mild Traumatic Brain Injury for Markers of Neurodegeneration and Cytotoxic Activity

(2019) Charisse N. Winston et al.   Frontiers in Neuroscience

Astrocyte-Derived Paracrine Signals: Relevance for Neurogenic Niche Regulation and Blood–Brain Barrier Integrity

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Cholesterol Metabolism in the Brain and Its Association with Parkinson’s Disease

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Exosomes From Astrocyte Processes: Signaling to Neurons

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Dissociable Structural and Functional Hippocampal Outputs via Distinct Subiculum Cell Classes

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Normal aging induces A1-like astrocyte reactivity

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LRRK2 kinase in Parkinson's disease

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TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

(2018) Amrita Datta Chaudhuri et al.   Cell Death & Disease

Glia as architects of central nervous system formation and function

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Astrocytes integrate and drive action potential firing in inhibitory subnetworks

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Portrait of blood-derived extracellular vesicles in patients with Parkinson’s disease

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Reactive Astrocytes: Production, Function, and Therapeutic Potential

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Neurotoxic reactive astrocytes are induced by activated microglia

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Cell Biology of Astrocyte-Synapse Interactions

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Extracellular vesicle docking at the cellular port: Extracellular vesicle binding and uptake

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A Refined Bead-Free Method to Identify Astrocytic Exosomes in Primary Glial Cultures and Blood Plasma

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An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells

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Elevated LRRK2 autophosphorylation in brain-derived and peripheral exosomes in LRRK2 mutation carriers

(2017) Shijie Wang et al.   Acta Neuropathologica Communications

Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice

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Complex heatmaps reveal patterns and correlations in multidimensional genomic data

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Altered Development of Synapse Structure and Function in Striatum Caused by Parkinson's Disease-Linked LRRK2-G2019S Mutation

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Ser(P)-1292 LRRK2 in urinary exosomes is elevated in idiopathic Parkinson's disease

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Extracellular vesicles in neurodegenerative disease — pathogenesis to biomarkers

(2016) Alexander G. Thompson et al.   Nature Reviews Neurology

Urinary LRRK2 phosphorylation predicts parkinsonian phenotypes in G2019SLRRK2carriers

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DJ-1 deficiency impairs glutamate uptake into astrocytes via the regulation of flotillin-1 and caveolin-1 expression

(2016) Jin-Mo Kim et al.   Scientific Reports

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

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Identification of preclinical Alzheimer's disease by a profile of pathogenic proteins in neurally derived blood exosomes: A case-control study

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PAK1 regulates cortical development via promoting neuronal migration and progenitor cell proliferation

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Cholesterol metabolism and homeostasis in the brain

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Plasma exosomal α-synuclein is likely CNS-derived and increased in Parkinson’s disease

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Disruption of astrocyte-neuron cholesterol cross talk affects neuronal function in Huntington’s disease

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Proteomic analysis of cerebrospinal fluid extracellular vesicles: A comprehensive dataset

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More than Cholesterol Transporters: Lipoprotein Receptors in CNS Function and Neurodegeneration

(2014) Courtney Lane-Donovan et al.   NEURON

Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis

(2014) T. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tetraspanins in Extracellular Vesicle Formation and Function

(2014) Zoraida Andreu et al.   Frontiers in Immunology

EBSeq: an empirical Bayes hierarchical model for inference in RNA-seq experiments

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Genetic Correction of a LRRK2 Mutation in Human iPSCs Links Parkinsonian Neurodegeneration to ERK-Dependent Changes in Gene Expression

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Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

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Hrs- and CD63-Dependent Competing Mechanisms Make Different Sized Endosomal Intraluminal Vesicles

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Clinical Approach to Parkinson's Disease: Features, Diagnosis, and Principles of Management

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The Role of Autophagy in Parkinson's Disease

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Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

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Genomic Analysis of Reactive Astrogliosis

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Generation of Regionally Specified Neural Progenitors and Functional Neurons from Human Embryonic Stem Cells under Defined Conditions

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Integration of CNS survival and differentiation by HIF2α

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Dopamine neurons derived from human ES cells efficiently engraft in animal models of Parkinson’s disease

(2011) Sonja Kriks et al.   NATURE

Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

(2011) Amanda M Haidet-Phillips et al.   NATURE BIOTECHNOLOGY

A more efficient method to generate integration-free human iPS cells

(2011) Keisuke Okita et al.   NATURE METHODS

Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT

(2011) M Laura Cremona et al.   NATURE NEUROSCIENCE

Cholesterol metabolism in neurons and astrocytes

(2011) Frank W. Pfrieger et al.   PROGRESS IN LIPID RESEARCH

Flotillin-1 mediates neurite branching induced by synaptic adhesion-like molecule 4 in hippocampal neurons

(2010) Catherine Croft Swanwick et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

Multivesicular Body Formation Requires OSBP–Related Proteins and Cholesterol

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Differential expression analysis for sequence count data

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Parkinson's Disease Patient-Derived Induced Pluripotent Stem Cells Free of Viral Reprogramming Factors

(2009) Frank Soldner et al.   CELL

LRRK2 in Parkinson’s disease: genetic and clinical studies from patients

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Rab27a and Rab27b control different steps of the exosome secretion pathway

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Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

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Human Induced Pluripotent Stem Cells Free of Vector and Transgene Sequences

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HtrA1-dependent proteolysis of TGF-β controls both neuronal maturation and developmental survival

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Human Embryonic Stem Cell-Derived Motor Neurons Are Sensitive to the Toxic Effect of Glial Cells Carrying an ALS-Causing Mutation

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Late Endocytic Multivesicular Bodies Intersect the Chlamydial Inclusion in the Absence of CD63

(2008) W. L. Beatty   INFECTION AND IMMUNITY

Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers

(2008) Johan Skog et al.   NATURE CELL BIOLOGY

Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists

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