Functional Metabolic Mapping Reveals Highly Active Branched-Chain Amino Acid Metabolism in Human Astrocytes, Which Is Impaired in iPSC-Derived Astrocytes in Alzheimer's Disease

Downregulation of GABA Transporter 3 (GAT3) is Associated with Deficient Oxidative GABA Metabolism in Human Induced Pluripotent Stem Cell-Derived Astrocytes in Alzheimer's Disease

(2021) Claudia Salcedo et al.   NEUROCHEMICAL RESEARCH

Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration

(2021) Jens V. Andersen et al.   NEUROPHARMACOLOGY

Alzheimer’s disease: targeting the glutamatergic system

(2020) Myra E. Conway   BIOGERONTOLOGY

BCAT-induced autophagy regulates Aβ load through an interdependence of redox state and PKC phosphorylation-implications in Alzheimer's disease

(2020) M. Harris et al.   FREE RADICAL BIOLOGY AND MEDICINE

mTOR at the nexus of nutrition, growth, ageing and disease

(2020) Grace Y. Liu et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extensive astrocyte metabolism of γ‐aminobutyric acid ( GABA ) sustains glutamine synthesis in the mammalian cerebral cortex

(2020) Jens V. Andersen et al.   GLIA

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

(2020) Stephen C. Cunnane et al.   NATURE REVIEWS DRUG DISCOVERY

Disruption of the sodium-dependent citrate transporter SLC13A5 in mice causes alterations in brain citrate levels and neuronal network excitability in the hippocampus

(2020) Christine Henke et al.   NEUROBIOLOGY OF DISEASE

Proteomic analysis links alterations of bioenergetics, mitochondria-ER interactions and proteostasis in hippocampal astrocytes from 3xTg-AD mice

(2020) Giulia Dematteis et al.   Cell Death & Disease

Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?

(2020) Fangda Leng et al.   Nature Reviews Neurology

Deficient astrocyte metabolism impairs glutamine synthesis and neurotransmitter homeostasis in a mouse model of Alzheimer's disease

(2020) Jens V. Andersen et al.   NEUROBIOLOGY OF DISEASE

The Role of NMDA Receptors in Alzheimer’s Disease

(2019) Jinping Liu et al.   Frontiers in Neuroscience

Generation of two isogenic iPSC lines with either a heterozygous or a homozygous E280A mutation in the PSEN1 gene

(2019) Henriette R. Frederiksen et al.   Stem Cell Research

Oxidative stress, dysfunctional glucose metabolism and Alzheimer disease

(2019) D. Allan Butterfield et al.   NATURE REVIEWS NEUROSCIENCE

Microglia-Specific Metabolic Changes in Neurodegeneration

(2019) Blanca I. Aldana   JOURNAL OF MOLECULAR BIOLOGY

PARK2 Mutation Causes Metabolic Disturbances and Impaired Survival of Human iPSC-Derived Neurons

(2019) Helle Bogetofte et al.   Frontiers in Cellular Neuroscience

Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study

(2018) Brian A Gordon et al.   LANCET NEUROLOGY

Distribution of the branched-chain α-ketoacid dehydrogenase complex E1α subunit and glutamate dehydrogenase in the human brain and their role in neuro-metabolism

(2018) Jonathon Hull et al.   NEUROCHEMISTRY INTERNATIONAL

Branched-chain amino acids in health and disease: metabolism, alterations in blood plasma, and as supplements

(2018) Milan Holeček   Nutrition & Metabolism

Oxidative stress and the amyloid beta peptide in Alzheimer’s disease

(2018) C. Cheignon et al.   Redox Biology

The Emerging Role of Glutathione in Alzheimer's Disease

(2018) Sumiti Saharan et al.   JOURNAL OF ALZHEIMERS DISEASE

Branched-chain amino acids promote endothelial dysfunction through increased reactive oxygen species generation and inflammation

(2018) Olha Zhenyukh et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Fundamentals of CNS energy metabolism and alterations in lysosomal storage diseases

(2018) Mary C. McKenna et al.   JOURNAL OF NEUROCHEMISTRY

Generation of two iPSC lines with either a heterozygous V717I or a heterozygous KM670/671NL mutation in the APP gene

(2018) Henriette R. Frederiksen et al.   Stem Cell Research

High concentration of branched-chain amino acids promotes oxidative stress, inflammation and migration of human peripheral blood mononuclear cells via mTORC1 activation

(2017) Olha Zhenyukh et al.   FREE RADICAL BIOLOGY AND MEDICINE

Evaluating the gray and white matter energy budgets of human brain function

(2017) Yuguo Yu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Specificity of exogenous acetate and glutamate as astrocyte substrates examined in acute brain slices from female mice using methionine sulfoximine (MSO) to inhibit glutamine synthesis

(2017) Jens Velde Andersen et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Astrocyte dysfunction in Alzheimer disease

(2017) Crystal Acosta et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Branched-Chain Amino Acids and Brain Metabolism

(2017) Justin E. Sperringer et al.   NEUROCHEMICAL RESEARCH

Comparison of 2D and 3D neural induction methods for the generation of neural progenitor cells from human induced pluripotent stem cells

(2017) Abinaya Chandrasekaran et al.   Stem Cell Research

Divergent Metabolic Regulation of Autophagy and mTORC1—Early Events in Alzheimer’s Disease?

(2017) Mai A. Shafei et al.   Frontiers in Aging Neuroscience

PSEN1 Mutant iPSC-Derived Model Reveals Severe Astrocyte Pathology in Alzheimer's Disease

(2017) Minna Oksanen et al.   Stem Cell Reports

Patient iPSC-Derived Neurons for Disease Modeling of Frontotemporal Dementia with Mutation in CHMP2B

(2017) Yu Zhang et al.   Stem Cell Reports

Branched-chain amino acids and Alzheimer’s disease: a Mendelian randomization analysis

(2017) Susanna C. Larsson et al.   Scientific Reports

Increased susceptibility to metabolic dysregulation in a mouse model of Alzheimer's disease is associated with impaired hypothalamic insulin signaling and elevated BCAA levels

(2016) Henry H. Ruiz et al.   Alzheimers & Dementia

The Cellular Phase of Alzheimer’s Disease

(2016) Bart De Strooper et al.   CELL

Strategies for immunohistochemical protein localization using antibodies: What did we learn from neurotransmitter transporters in glial cells and neurons

(2016) Niels Christian Danbolt et al.   GLIA

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Metabolic Characterization of Acutely Isolated Hippocampal and Cerebral Cortical Slices Using [U-13C]Glucose and [1,2-13C]Acetate as Substrates

(2016) Laura F. McNair et al.   NEUROCHEMICAL RESEARCH

Brain Glutathione Levels – A Novel Biomarker for Mild Cognitive Impairment and Alzheimer’s Disease

(2015) Pravat K. Mandal et al.   BIOLOGICAL PSYCHIATRY

Alteration of mTOR signaling occurs early in the progression of Alzheimer disease (AD): analysis of brain from subjects with pre-clinical AD, amnestic mild cognitive impairment and late-stage AD

(2015) Antonella Tramutola et al.   JOURNAL OF NEUROCHEMISTRY

New insights into the role of the branched-chain aminotransferase proteins in the human brain

(2015) Jonathon Hull et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Metabolite profiling for the identification of altered metabolic pathways in Alzheimer's disease

(2015) Raúl González-Domínguez et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Cell type– and brain region–resolved mouse brain proteome

(2015) Kirti Sharma et al.   NATURE NEUROSCIENCE

NH4+ triggers the release of astrocytic lactate via mitochondrial pyruvate shunting

(2015) Rodrigo Lerchundi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential regulation of mTORC1 by leucine and glutamine

(2015) J. L. Jewell et al.   SCIENCE

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

A Local Glutamate-Glutamine Cycle Sustains Synaptic Excitatory Transmitter Release

(2014) Hiroaki Tani et al.   NEURON

Oxidative stress and mitochondrial dysfunction in Alzheimer's disease

(2013) Xinglong Wang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Oxidative Stress and the Pathogenesis of Alzheimer's Disease

(2013) Yan Zhao et al.   Oxidative Medicine and Cellular Longevity

Efficient Generation of Astrocytes from Human Pluripotent Stem Cells in Defined Conditions

(2013) Atossa Shaltouki et al.   STEM CELLS

Glutamate Pays Its Own Way in Astrocytes

(2013) Mary C. McKenna   Frontiers in Endocrinology

Astrocytic Control of Biosynthesis and Turnover of the Neurotransmitters Glutamate and GABA

(2013) Arne Schousboe et al.   Frontiers in Endocrinology

Distribution of the branched chain aminotransferase proteins in the human brain and their role in glutamate regulation

(2012) Jonathon Hull et al.   JOURNAL OF NEUROCHEMISTRY

Expression of mitochondrial branched-chain aminotransferase and α-keto-acid dehydrogenase in rat brain: implications for neurotransmitter metabolism

(2012) Jeffrey T. Cole et al.   Frontiers in Neuroanatomy

Validation of Plasma Branched Chain Amino Acids as Biomarkers in Huntington Disease

(2011) Fanny Mochel et al.   ARCHIVES OF NEUROLOGY

Brain oxidative stress: Detection and mapping of anti-oxidant marker ‘Glutathione’ in different brain regions of healthy male/female, MCI and Alzheimer patients using non-invasive magnetic resonance spectroscopy

(2011) Pravat K. Mandal et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Naturally Secreted Amyloid-β Increases Mammalian Target of Rapamycin (mTOR) Activity via a PRAS40-mediated Mechanism

(2011) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Age-dependent decrease in glutamine synthetase expression in the hippocampal astroglia of the triple transgenic Alzheimer's disease mouse model: mechanism for deficient glutamatergic transmission?

(2011) Markel Olabarria et al.   Molecular Neurodegeneration

Acute hyperammonemia activates branched-chain amino acid catabolism and decreases their extracellular concentrations: different sensitivity of red and white muscle

(2010) Milan Holecek et al.   AMINO ACIDS

Molecular Interplay between Mammalian Target of Rapamycin (mTOR), Amyloid-β, and Tau

(2010) Antonella Caccamo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Interrelationships of Leucine and Glutamate Metabolism in Cultured Astrocytes

(2010) Marc Yudkoff et al.   JOURNAL OF NEUROCHEMISTRY

Uptake, Release, and Metabolism of Citrate in Neurons and Astrocytes in Primary Cultures

(2010) Niels Westergaard et al.   JOURNAL OF NEUROCHEMISTRY

The structure and allosteric regulation of glutamate dehydrogenase

(2010) Ming Li et al.   NEUROCHEMISTRY INTERNATIONAL

Astrocyte glutamine synthetase: Importance in hyperammonemic syndromes and potential target for therapy

(2010) Saul W. Brusilow et al.   Neurotherapeutics

Glial Metabolism of Valine

(2009) Radovan Murín et al.   NEUROCHEMICAL RESEARCH

Regulatory Control of Human Cytosolic Branched-Chain Aminotransferase by Oxidation and S-Glutathionylation and Its Interactions with Redox Sensitive Neuronal Proteins†

(2008) Myra E. Conway et al.   BIOCHEMISTRY

Glial Metabolism of Isoleucine

(2008) Radovan Murín et al.   NEUROCHEMICAL RESEARCH