Astrocytic Oxidative/Nitrosative Stress Contributes to Parkinson’s Disease Pathogenesis: The Dual Role of Reactive Astrocytes

Increased DJ-1 and α-Synuclein in Plasma Neural-Derived Exosomes as Potential Markers for Parkinson’s Disease

(2019) Zhen-Hua Zhao et al.   Frontiers in Aging Neuroscience

Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer’s disease

(2019) Darshpreet Kaur et al.   INFLAMMOPHARMACOLOGY

Extracellular Potassium and Glutamate Interact To Modulate Mitochondria in Astrocytes

(2018) Theresa S. Rimmele et al.   ACS Chemical Neuroscience

Detection and Characterization of Reactive Oxygen and Nitrogen Species in Biological Systems by Monitoring Species-Specific Products

(2018) Micael Hardy et al.   ANTIOXIDANTS & REDOX SIGNALING

ɑ-Synuclein strains and seeding in Parkinson’s disease, incidental Lewy body disease, dementia with Lewy bodies and multiple system atrophy: similarities and differences

(2018) W. Peelaerts et al.   CELL AND TISSUE RESEARCH

Salidroside Protection Against Oxidative Stress Injury Through the Wnt/β-Catenin Signaling Pathway in Rats with Parkinson’s Disease

(2018) Dong-Mei Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Detrimental Effects of Paraquat on Astrocytes-Regulating Synaptic Functions

(2018) Zheng Li et al.   Dose-Response

Determinants of dopaminergic neuron loss in Parkinson's disease

(2018) D.James Surmeier   FEBS Journal

Targeting Aged Astrocytes May Be a New Therapeutic Strategy in Parkinson's Disease

(2018) Kirsten M. Scott et al.   MOVEMENT DISORDERS

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Astrocyte-specific DJ-1 overexpression protects against rotenone-induced neurotoxicity in a rat model of Parkinson's disease

(2018) Briana R. De Miranda et al.   NEUROBIOLOGY OF DISEASE

17β-estradiol and tamoxifen protect mice from manganese-induced dopaminergic neurotoxicity

(2018) Edward Pajarillo et al.   NEUROTOXICOLOGY

Siblings with unusual presentation of early onset Parkinson's disease with dual heterozygous PARK2 and PARK 9 mutation

(2018) Koustav Chatterjee et al.   PARKINSONISM & RELATED DISORDERS

Vulnerability of glia and vessels of rat substantia nigra in rotenone Parkinson model

(2018) Sanaa A. M. Elgayar et al.   ULTRASTRUCTURAL PATHOLOGY

Functional Astrocyte Heterogeneity and Implications for Their Role in Shaping Neurotransmission

(2018) Wendy Xin et al.   Frontiers in Cellular Neuroscience

Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death

(2018) Liuke Sun et al.   Scientific Reports

Oxidative stress, aging, and diseases

(2018) Ilaria Liguori et al.   Clinical Interventions in Aging

Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease

(2018) Géraldine Gelders et al.   Journal of Immunology Research

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

(2018) Veronica Ghiglieri et al.   Frontiers in Neurology

Astroglial DJ-1 over-expression up-regulates proteins involved in redox regulation and is neuroprotective in vivo

(2018) Ann Kristin Frøyset et al.   Redox Biology

Extracts of Physalis peruviana Protect Astrocytic Cells Under Oxidative Stress With Rotenone

(2018) Natalia Areiza-Mazo et al.   Frontiers in Chemistry

Astrocytes, Microglia, and Parkinson's Disease

(2018) Eun-Hye Joe et al.   Experimental Neurobiology

Alterations of the nigrostriatal pathway in a 6-OHDA rat model of Parkinson’s disease evaluated with multimodal MRI

(2018) Vincent Perlbarg et al.   PLoS One

The role of posttranslational modifications of α-synuclein and LRRK2 in Parkinson's disease: Potential contributions of environmental factors

(2018) Edward Pajarillo et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation

(2018) Komudi Singh et al.   GLIA

Antioxidant and Anti-Apoptotic Activity of Octadecaneuropeptide Against 6-OHDA Toxicity in Cultured Rat Astrocytes

(2018) Hadhemi Kaddour et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

New Perspectives on Roles of Alpha-Synuclein in Parkinson’s Disease

(2018) Guoxin Zhang et al.   Frontiers in Aging Neuroscience

In vivo ROS production and use of oxidative stress-derived biomarkers to detect the onset of diseases such as Alzheimer’s disease, Parkinson’s disease, and diabetes

(2017) Aya Umeno et al.   FREE RADICAL RESEARCH

Microglia amplify inflammatory activation of astrocytes in manganese neurotoxicity

(2017) Kelly S. Kirkley et al.   Journal of Neuroinflammation

Prolonged Dysfunction of Astrocytes and Activation of Microglia Accelerate Degeneration of Dopaminergic Neurons in the Rat Substantia Nigra and Block Compensation of Early Motor Dysfunction Induced by 6-OHDA

(2017) Katarzyna Kuter et al.   MOLECULAR NEUROBIOLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Review: Astrocytes in Alzheimer's disease and other age-associated dementias: a supporting player with a central role

(2017) C. J. Garwood et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

The Role of Astrocyte Dysfunction in Parkinson’s Disease Pathogenesis

(2017) Heather D.E. Booth et al.   TRENDS IN NEUROSCIENCES

Targeted inhibition of RAGE in substantia nigra of rats blocks 6-OHDA–induced dopaminergic denervation

(2017) Juciano Gasparotto et al.   Scientific Reports

Oxidative Stress and Environmental Exposures are Associated with Multiple System Atrophy in Chinese Patients

(2016) Linli Zhou et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System

(2016) Jerzy Leszek et al.   CNS & Neurological Disorders-Drug Targets

Atp13a2Deficiency Aggravates Astrocyte-Mediated Neuroinflammation via NLRP3 Inflammasome Activation

(2016) Chen Qiao et al.   CNS Neuroscience & Therapeutics

LRRK2 G2019S transgenic mice display increased susceptibility to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-mediated neurotoxicity

(2016) Senthilkumar S. Karuppagounder et al.   JOURNAL OF CHEMICAL NEUROANATOMY

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

DJ-1 mutation decreases astroglial release of inflammatory mediators

(2016) A.K. Ashley et al.   NEUROTOXICOLOGY

Redox Modulations, Antioxidants, and Neuropsychiatric Disorders

(2016) Erik A. Fraunberger et al.   Oxidative Medicine and Cellular Longevity

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Neuroinflammation in the pathophysiology of Parkinson’s disease and therapeutic evidence of anti-inflammatory drugs

(2015) Taysa Bervian Bassani et al.   ARQUIVOS DE NEURO-PSIQUIATRIA

Expression of the Astrocyte Water Channel Aquaporin-4 in the Mouse Brain

(2015) Jacqueline A. Hubbard et al.   ASN Neuro

Parkinsonian toxin-induced oxidative stress inhibits basal autophagy in astrocytes via NQO2/quinone oxidoreductase 2: Implications for neuroprotection

(2015) Elzbieta Janda et al.   Autophagy

Coenzyme Q10 Protects Astrocytes from ROS-Induced Damage through Inhibition of Mitochondria-Mediated Cell Death Pathway

(2015) Li Jing et al.   International Journal of Biological Sciences

Factoring in astrocytes

(2015) Darran Yates   NATURE REVIEWS NEUROSCIENCE

Increased expression of the dopamine transporter leads to loss of dopamine neurons, oxidative stress and l-DOPA reversible motor deficits

(2015) S.T. Masoud et al.   NEUROBIOLOGY OF DISEASE

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation

(2015) Karthik Raju et al.   Science Signaling

Elusive roles for reactive astrocytes in neurodegenerative diseases

(2015) Lucile Ben Haim et al.   Frontiers in Cellular Neuroscience

Astrocytes in Neurodegenerative Disease: Table 1.

(2015) Hemali Phatnani et al.   Cold Spring Harbor Perspectives in Biology

Oxidative stress and Parkinson’s disease

(2015) Javier Blesa et al.   Frontiers in Neuroanatomy

Regulation of brain glutamate metabolism by nitric oxide and S-nitrosylation

(2015) Karthik Raju et al.   Science Signaling

Diverse subtypes of astrocytes and their development during corticogenesis

(2015) Hidenori Tabata   Frontiers in Neuroscience

Cinnamon Treatment Upregulates Neuroprotective Proteins Parkin and DJ-1 and Protects Dopaminergic Neurons in a Mouse Model of Parkinson’s Disease

(2014) Saurabh Khasnavis et al.   Journal of Neuroimmune Pharmacology

Is Parkinson's Disease a Vesicular Dopamine Storage Disorder? Evidence from a Study in Isolated Synaptic Vesicles of Human and Nonhuman Primate Striatum

(2014) C. Pifl et al.   JOURNAL OF NEUROSCIENCE

Yin Yang 1 Is a Repressor of Glutamate Transporter EAAT2, and It Mediates Manganese-Induced Decrease of EAAT2 Expression in Astrocytes

(2014) P. Karki et al.   MOLECULAR AND CELLULAR BIOLOGY

Genetic Dys-regulation of Astrocytic Glutamate Transporter EAAT2 and its Implications in Neurological Disorders and Manganese Toxicity

(2014) Pratap Karki et al.   NEUROCHEMICAL RESEARCH

Disruption of astrocyte–vascular coupling and the blood–brain barrier by invading glioma cells

(2014) Stacey Watkins et al.   Nature Communications

The contribution of astrocytes to the regulation of cerebral blood flow

(2014) Clare Howarth   Frontiers in Neuroscience

Inhibition of the Fe(III)-Catalyzed Dopamine Oxidation by ATP and Its Relevance to Oxidative Stress in Parkinson’s Disease

(2013) Dianlu Jiang et al.   ACS Chemical Neuroscience

Pink1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced akt and increased p38 mapk activation, and downregulation of egfr

(2013) Insup Choi et al.   GLIA

Glutamate, Glutamate Receptors, and Downstream Signaling Pathways

(2013) Stacey S. Willard et al.   International Journal of Biological Sciences

Aberrant Protein S-Nitrosylation in Neurodegenerative Diseases

(2013) Tomohiro Nakamura et al.   NEURON

Resveratrol Confers Protection against Rotenone-Induced Neurotoxicity by Modulating Myeloperoxidase Levels in Glial Cells

(2013) Chi Young Chang et al.   PLoS One

Calcium-dependent N-cadherin up-regulation mediates reactive astrogliosis and neuroprotection after brain injury

(2013) K. Kanemaru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interleukin-1β and tumor necrosis factor-α: reliable targets for protective therapies in Parkinson’s Disease?

(2013) María C. Leal et al.   Frontiers in Cellular Neuroscience

Role of astrocytes in manganese mediated neurotoxicity

(2013) Marta Sidoryk-Wegrzynowicz et al.   BMC Pharmacology & Toxicology

Targeting Nrf2-Mediated Gene Transcription by Extremely Potent Synthetic Triterpenoids Attenuate Dopaminergic Neurotoxicity in the MPTP Mouse Model of Parkinson's Disease

(2012) Navneet Ammal Kaidery et al.   ANTIOXIDANTS & REDOX SIGNALING

DJ-1 Expression Modulates Astrocyte-Mediated Protection Against Neuronal Oxidative Stress

(2012) Steven J. Mullett et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Lipopolysaccharide-Induced Microglial Activation and Neuroprotection against Experimental Brain Injury Is Independent of Hematogenous TLR4

(2012) Z. Chen et al.   JOURNAL OF NEUROSCIENCE

Astrocyte-derived GDNF is a potent inhibitor of microglial activation

(2012) Sandra Moreira Rocha et al.   NEUROBIOLOGY OF DISEASE

Astrocyte Activation: A Key Step in Rotenone Induced Cytotoxicity and DNA Damage

(2012) Supriya Swarnkar et al.   NEUROCHEMICAL RESEARCH

CNI-1493 Attenuates Neuroinflammation and Dopaminergic Neurodegeneration in the Acute MPTP Mouse Model of Parkinson's Disease

(2012) Carmen Noelker et al.   Neurodegenerative Diseases

Erratum: IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson’s disease

(2012) C Barcia et al.   Cell Death & Disease

Oxidative Stress and Antioxidant Defense

(2012) Esra Birben et al.   World Allergy Organization Journal

Rotenone, Paraquat, and Parkinson’s Disease

(2011) Caroline M. Tanner et al.   ENVIRONMENTAL HEALTH PERSPECTIVES

The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons

(2011) Wendou Yu et al.   HUMAN MOLECULAR GENETICS

Ethyl Pyruvate Rescues Nigrostriatal Dopaminergic Neurons by Regulating Glial Activation in a Mouse Model of Parkinson's Disease

(2011) S. H. Huh et al.   JOURNAL OF IMMUNOLOGY

Gene Deletion of nos2 Protects Against Manganese-Induced Neurological Dysfunction in Juvenile Mice

(2011) Karin M. Streifel et al.   TOXICOLOGICAL SCIENCES

The familial Parkinson's disease gene DJ-1 (PARK7) is expressed in red cells and plays a role in protection against oxidative damage

(2010) Xiuling Xu et al.   BLOOD CELLS MOLECULES AND DISEASES

The mechanism of action of MPTP-induced neuroinflammation and its modulation by melatonin in rat astrocytoma cells, C6

(2010) Rituraj Niranjan et al.   FREE RADICAL RESEARCH

Dopamine Induces Ca2+Signaling in Astrocytes through Reactive Oxygen Species Generated by Monoamine Oxidase

(2010) Annika Vaarmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paroxetine Prevents Loss of Nigrostriatal Dopaminergic Neurons by Inhibiting Brain Inflammation and Oxidative Stress in an Experimental Model of Parkinson's Disease

(2010) Y. C. Chung et al.   JOURNAL OF IMMUNOLOGY

The role of parkin in familial and sporadic Parkinson's disease

(2010) Ted M. Dawson et al.   MOVEMENT DISORDERS

The Role of Oxidative Stress in Amyotrophic Lateral Sclerosis and Parkinson’s Disease

(2010) Athan Baillet et al.   NEUROCHEMICAL RESEARCH

Astrocytes and therapeutics for Parkinson’s disease

(2010) Phillip M. Rappold et al.   Neurotherapeutics

Alpha-Synuclein Stimulation of Astrocytes: Potential Role for Neuroinflammation and Neuroprotection

(2010) He-Jin Lee et al.   Oxidative Medicine and Cellular Longevity

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

High extracellular glutamate modulates expression of glutamate transporters and glutamine synthetase in cultured astrocytes

(2009) Claudia Lehmann et al.   BRAIN RESEARCH

Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated gene DJ-1

(2009) Jens Waak et al.   FASEB JOURNAL

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Estrogen and tamoxifen reverse manganese-induced glutamate transporter impairment in astrocytes

(2009) Eun-Sook Y. Lee et al.   JOURNAL OF NEUROCHEMISTRY

Degeneration in Different Parkinsonian Syndromes Relates to Astrocyte Type and Astrocyte Protein Expression

(2009) Yun Ju C. Song et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Protection Against Oxidative Stress-Induced Neurodegeneration by a Modulator for DJ-1, the Wild-Type of Familial Parkinson’s Disease-Linked PARK7

(2009) Takashi Yanagida et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Protein denitrosylation: enzymatic mechanisms and cellular functions

(2009) Moran Benhar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Neuroinflammation in the living brain of Parkinson's disease

(2009) Yasuomi Ouchi et al.   PARKINSONISM & RELATED DISORDERS

Manganese inhibits the ability of astrocytes to promote neuronal differentiation

(2009) Gennaro Giordano et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Oxidative and nitrosative stress in Parkinson's disease

(2008) Anthony H.K. Tsang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Glial Dysfunction in Parkin Null Mice: Effects of Aging

(2008) R. M. Solano et al.   JOURNAL OF NEUROSCIENCE

DJ-1 knock-down in astrocytes impairs astrocyte-mediated neuroprotection against rotenone

(2008) Steven J. Mullett et al.   NEUROBIOLOGY OF DISEASE

Astrocyte-secreted GDNF and glutathione antioxidant system protect neurons against 6OHDA cytotoxicity

(2008) Jagdeep K. Sandhu et al.   NEUROBIOLOGY OF DISEASE

Differential astroglial activation in 6-hydroxydopamine models of Parkinson’s disease

(2008) Jeannette Henning et al.   NEUROSCIENCE RESEARCH

Characterization of the transcriptional profile in primary astrocytes after oxidative stress induced by Paraquat

(2007) Birgitte Thuesen Olesen et al.   NEUROTOXICOLOGY