Parkinson's Disease Phenotypes in Patient Neuronal Cultures and Brain Organoids Improved by 2‐Hydroxypropyl‐β‐Cyclodextrin Treatment

PINK1 deficiency impairs adult neurogenesis of dopaminergic neurons

(2021) Sarah J. Brown et al.   Scientific Reports

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

(2020) Yaxing Chen et al.   CELL PROLIFERATION

Neuropathological findings in PINK1-associated Parkinson's disease

(2020) Camilla Jøsok Nybø et al.   PARKINSONISM & RELATED DISORDERS

YWHA/14-3-3 proteins recognize phosphorylated TFEB by a noncanonical mode for controlling TFEB cytoplasmic localization

(2019) Yang Xu et al.   Autophagy

Guidelines for Fluorescent Guided Biallelic HDR Targeting Selection With PiggyBac System Removal for Gene Editing

(2019) Javier Jarazo et al.   Frontiers in Genetics

Automated high-throughput high-content autophagy and mitophagy analysis platform

(2019) Jonathan Arias-Fuenzalida et al.   Scientific Reports

Transcriptome and proteome profiling of neural stem cells from the human subventricular zone in Parkinson’s disease

(2019) Vanessa Donega et al.   Acta Neuropathologica Communications

Stress-induced phospho-ubiquitin formation causes parkin degradation

(2019) Lyudmila Kovalchuke et al.   Scientific Reports

The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain

(2018) Abdul-Raouf Issa et al.   Autophagy

CSF lamp2 concentrations are decreased in female Parkinson’s disease patients with LRRK2 mutations

(2018) Andrea C. Klaver et al.   BRAIN RESEARCH

The genetic architecture of mitochondrial dysfunction in Parkinson’s disease

(2018) S. B. Larsen et al.   CELL AND TISSUE RESEARCH

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand

(2018) Thomas G. McWilliams et al.   Cell Metabolism

Pharmacological Inhibition of Necroptosis Protects from Dopaminergic Neuronal Cell Death in Parkinson’s Disease Models

(2018) Angelo Iannielli et al.   Cell Reports

STRING v11: protein–protein association networks with increased coverage, supporting functional discovery in genome-wide experimental datasets

(2018) Damian Szklarczyk et al.   NUCLEIC ACIDS RESEARCH

Cerebrospinal Fluid Levels of Autophagy-related Proteins Represent Potentially Novel Biomarkers of Early-Stage Parkinson’s Disease

(2018) Jinyoung Youn et al.   Scientific Reports

3D Cultures of Parkinson's Disease-Specific Dopaminergic Neurons for High Content Phenotyping and Drug Testing

(2018) Silvia Bolognin et al.   Advanced Science

Deficiency in Neuronal TGF-β Signaling Leads to Nigrostriatal Degeneration and Activation of TGF-β Signaling Protects against MPTP Neurotoxicity in Mice

(2017) Ina Tesseur et al.   JOURNAL OF NEUROSCIENCE

RAD51C/XRCC3 Facilitates Mitochondrial DNA Replication and Maintains Integrity of the Mitochondrial Genome

(2017) Anup Mishra et al.   MOLECULAR AND CELLULAR BIOLOGY

The changing landscape of surgery for Parkinson's Disease

(2017) Christopher S. Lozano et al.   MOVEMENT DISORDERS

Necroptosis in neurodegenerative diseases: a potential therapeutic target

(2017) Shuo Zhang et al.   Cell Death & Disease

TFEB regulates lysosomal positioning by modulating TMEM55B expression and JIP4 recruitment to lysosomes

(2017) Rose Willett et al.   Nature Communications

Derivation of Human Midbrain-Specific Organoids from Neuroepithelial Stem Cells

(2017) Anna S. Monzel et al.   Stem Cell Reports

FACS-Assisted CRISPR-Cas9 Genome Editing Facilitates Parkinson's Disease Modeling

(2017) Jonathan Arias-Fuenzalida et al.   Stem Cell Reports

Characterization of hydroxypropyl-beta-cyclodextrins used in the treatment of Niemann-Pick Disease type C1

(2017) Alfred L. Yergey et al.   PLoS One

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

(2016) Daniel J Klionsky et al.   Autophagy

Complex heatmaps reveal patterns and correlations in multidimensional genomic data

(2016) Zuguang Gu et al.   BIOINFORMATICS

PINK1 Is a Negative Regulator of Growth and the Warburg Effect in Glioblastoma

(2016) S. Agnihotri et al.   CANCER RESEARCH

Modeling Development and Disease with Organoids

(2016) Hans Clevers   CELL

Understanding Dopaminergic Cell Death Pathways in Parkinson Disease

(2016) Patrick P. Michel et al.   NEURON

Neurotrophic Factor-α1: A Key Wnt-β-Catenin Dependent Anti-Proliferation Factor and ERK-Sox9 Activated Inducer of Embryonic Neural Stem Cell Differentiation to Astrocytes in Neurodevelopment

(2016) Prabhuanand Selvaraj et al.   STEM CELLS

The Autophagy–Lysosomal Pathway in Neurodegeneration: A TFEB Perspective

(2016) Heidi Martini-Stoica et al.   TRENDS IN NEUROSCIENCES

TGF-β Signaling in Dopaminergic Neurons Regulates Dendritic Growth, Excitatory-Inhibitory Synaptic Balance, and Reversal Learning

(2016) Sarah X. Luo et al.   Cell Reports

Parkin and PINK1 Patient iPSC-Derived Midbrain Dopamine Neurons Exhibit Mitochondrial Dysfunction and α-Synuclein Accumulation

(2016) Sun Young Chung et al.   Stem Cell Reports

SnapShot: Genetics of Parkinson’s Disease

(2015) José Brás et al.   CELL

TFEB Participates in the Aβ-Induced Pathogenesis of Alzheimer's Disease by Regulating the Autophagy-Lysosome Pathway

(2015) Yi-dan Zhang et al.   DNA AND CELL BIOLOGY

Altered TFEB-mediated lysosomal biogenesis in Gaucher disease iPSC-derived neuronal cells

(2015) Ola Awad et al.   HUMAN MOLECULAR GENETICS

Differentiation of neuroepithelial stem cells into functional dopaminergic neurons in 3D microfluidic cell culture

(2015) Edinson Lucumi Moreno et al.   LAB ON A CHIP

Lysosomal-associated membrane protein 2 isoforms are differentially affected in early Parkinson's disease

(2015) Karen E. Murphy et al.   MOVEMENT DISORDERS

Genetic and Chemical Activation of TFEB Mediates Clearance of Aggregated α-Synuclein

(2015) Kiri Kilpatrick et al.   PLoS One

Rapid parallel measurements of macroautophagy and mitophagy in mammalian cells using a single fluorescent biosensor

(2015) A. Sargsyan et al.   Scientific Reports

Mitochondrial Alterations by PARKIN in Dopaminergic Neurons Using PARK2 Patient-Specific and PARK2 Knockout Isogenic iPSC Lines

(2015) Atossa Shaltouki et al.   Stem Cell Reports

Rapamycin: One Drug, Many Effects

(2014) Jing Li et al.   Cell Metabolism

2-Hydroxypropyl-β-cyclodextrin Promotes Transcription Factor EB-mediated Activation of Autophagy

(2014) Wensi Song et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurodegenerative disease: Brain windfall

(2014) Katharine Gammon   NATURE

Boosting chaperone-mediated autophagy in vivo mitigates α-synuclein-induced neurodegeneration

(2013) Maria Xilouri et al.   BRAIN

The lysosomal inhibitor, chloroquine, increases cell surface BMPR-II levels and restores BMP9 signalling in endothelial cells harbouring BMPR-II mutations

(2013) B. J. Dunmore et al.   HUMAN MOLECULAR GENETICS

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

The role of autophagy in neurodegenerative disease

(2013) Ralph A Nixon   NATURE MEDICINE

Derivation and Expansion Using Only Small Molecules of Human Neural Progenitors for Neurodegenerative Disease Modeling

(2013) Peter Reinhardt et al.   PLoS One

The pathways of mitophagy for quality control and clearance of mitochondria

(2012) G Ashrafi et al.   CELL DEATH AND DIFFERENTIATION

Metabolic Regulation in Pluripotent Stem Cells during Reprogramming and Self-Renewal

(2012) Jin Zhang et al.   Cell Stem Cell

Normalization of Cholesterol Homeostasis by 2-Hydroxypropyl-β-cyclodextrin in Neurons and Glia from Niemann-Pick C1 (NPC1)-deficient Mice

(2012) Kyle B. Peake et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

100 years of Lewy pathology

(2012) Michel Goedert et al.   Nature Reviews Neurology

Retinoic acid-dependent and -independent gene-regulatory pathways of Pitx3 in meso-diencephalic dopaminergic neurons

(2011) F. M. J. Jacobs et al.   DEVELOPMENT

Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations

(2011) Charina M. Ramirez et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial Parkin Recruitment Is Impaired in Neurons Derived from Mutant PINK1 Induced Pluripotent Stem Cells

(2011) P. Seibler et al.   JOURNAL OF NEUROSCIENCE

Unesterified Cholesterol Accumulation in Late Endosomes/Lysosomes Causes Neurodegeneration and Is Prevented by Driving Cholesterol Export from This Compartment

(2011) A. Aqul et al.   JOURNAL OF NEUROSCIENCE

Pink1 regulates the oxidative phosphorylation machinery via mitochondrial fission

(2011) W. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase

(2010) M Pozuelo-Rubio   CELL DEATH AND DIFFERENTIATION

PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1

(2010) Sven Geisler et al.   NATURE CELL BIOLOGY

SOX9 induces and maintains neural stem cells

(2010) Charlotte E Scott et al.   NATURE NEUROSCIENCE

Identification of Dlk1, Ptpru and Klhl1 as novel Nurr1 target genes in meso-diencephalic dopamine neurons

(2009) F. M. J. Jacobs et al.   DEVELOPMENT

Caffeine protects against MPTP-induced blood-brain barrier dysfunction in mouse striatum

(2008) Xuesong Chen et al.   JOURNAL OF NEUROCHEMISTRY

Loss of PINK1 Function Affects Development and Results in Neurodegeneration in Zebrafish

(2008) O. Anichtchik et al.   JOURNAL OF NEUROSCIENCE