Overexpression of α-synuclein in an astrocyte cell line promotes autophagy inhibition and apoptosis

Alpha-synuclein: relating metals to structure, function and inhibition

(2016) J. S. McDowall et al.   Metallomics

Neuroinflammation in Parkinson’s disease and its potential as therapeutic target

(2015) Qinqin Wang et al.   Translational Neurodegeneration

Overexpression of Human E46K Mutant α-Synuclein Impairs Macroautophagy via Inactivation of JNK1-Bcl-2 Pathway

(2014) Jia-Qing Yan et al.   MOLECULAR NEUROBIOLOGY

HMGB1 is involved in autophagy inhibition caused by SNCA/α-synuclein overexpression

(2013) Ju-Xian Song et al.   Autophagy

White matter astrocytes in health and disease

(2013) I. Lundgaard et al.   NEUROSCIENCE

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Rotenone-induced parkinsonism elicits behavioral impairments and differential expression of parkin, heat shock proteins and caspases in the rat

(2012) M. Sonia Angeline et al.   NEUROSCIENCE

The Role of Alpha-Synuclein Oligomerization and Aggregation in Cellular and Animal Models of Parkinson’s Disease

(2012) Oi Wan Wan et al.   PLoS One

New roles for mitochondria in cell death in the reperfused myocardium

(2011) S.-B. Ong et al.   CARDIOVASCULAR RESEARCH

Mutant A53T α-Synuclein Induces Neuronal Death by Increasing Mitochondrial Autophagy

(2011) Vinay Choubey et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

Autophagy protects the rotenone-induced cell death in α-synuclein overexpressing SH-SY5Y cells

(2010) Shorafidinkhuja Dadakhujaev et al.   NEUROSCIENCE LETTERS

Metabolic Activity Determines Efficacy of Macroautophagic Clearance of Pathological Oligomeric α-Synuclein

(2009) Wai Haung Yu et al.   AMERICAN JOURNAL OF PATHOLOGY

α-Synuclein is differentially expressed in mitochondria from different rat brain regions and dose-dependently down-regulates complex I activity

(2009) Guangwei Liu et al.   NEUROSCIENCE LETTERS

Nrf2-mediated neuroprotection in the MPTP mouse model of Parkinson's disease: Critical role for the astrocyte

(2009) Pei-Chun Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial association of alpha-synuclein causes oxidative stress

(2008) M. S. Parihar et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mitochondrial translocation of α-synuclein is promoted by intracellular acidification

(2008) Nelson B. Cole et al.   EXPERIMENTAL CELL RESEARCH

Mitochondrial Import and Accumulation of α-Synuclein Impair Complex I in Human Dopaminergic Neuronal Cultures and Parkinson Disease Brain

(2008) Latha Devi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

(2008) Derek Narendra et al.   JOURNAL OF CELL BIOLOGY