Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death
Published 2018 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Lack of PINK1 alters glia innate immune responses and enhances inflammation-induced, nitric oxide-mediated neuron death
Authors
Keywords
-
Journal
Scientific Reports
Volume 8, Issue 1, Pages -
Publisher
Springer Nature
Online
2018-01-05
DOI
10.1038/s41598-017-18786-w
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Progression of pathology in PINK1-deficient mouse brain from splicing via ubiquitination, ER stress, and mitophagy changes to neuroinflammation
- (2017) Sylvia Torres-Odio et al. Journal of Neuroinflammation
- Non-cell-autonomous Neurotoxicity of α-synuclein Through Microglial Toll-like Receptor 2
- (2016) Changyoun Kim et al. Experimental Neurobiology
- Alpha-Synuclein Proteins Promote Pro-Inflammatory Cascades in Microglia: Stronger Effects of the A53T Mutant
- (2016) Claire Hoenen et al. PLoS One
- Exogenous α-synuclein induces toll-like receptor 4 dependent inflammatory responses in astrocytes
- (2015) Emmy H. Rannikko et al. BMC NEUROSCIENCE
- Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy
- (2015) Andrii Domanskyi et al. HUMAN GENE THERAPY
- Differential TGF-β Signaling in Glial Subsets Underlies IL-6–Mediated Epileptogenesis in Mice
- (2015) Nitzan Levy et al. JOURNAL OF IMMUNOLOGY
- Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells
- (2015) Isabella Russo et al. Journal of Neuroinflammation
- Neuroinflammation in Multiple System Atrophy: Response to and Cause of α-Synuclein Aggregation
- (2015) Bruno Di Marco Vieira et al. Frontiers in Cellular Neuroscience
- Astrocyte-Derived TGF-β1 Accelerates Disease Progression in ALS Mice by Interfering with the Neuroprotective Functions of Microglia and T Cells
- (2015) Fumito Endo et al. Cell Reports
- Astrocytic transforming growth factor-beta signaling reduces subacute neuroinflammation after stroke in mice
- (2014) Egle Cekanaviciute et al. GLIA
- TGFβ produced by IL-10 redirected astrocytes attenuates microglial activation
- (2014) Diana M. Norden et al. GLIA
- Potentiation of neurotoxicity in double-mutant mice with Pink1 ablation and A53T-SNCA overexpression
- (2014) Suzana Gispert et al. HUMAN MOLECULAR GENETICS
- Alpha-synuclein-induced neurodegeneration is exacerbated in PINK1 knockout mice
- (2014) Marusela Oliveras-Salvá et al. NEUROBIOLOGY OF AGING
- Inflammation-Induced Alteration of Astrocyte Mitochondrial Dynamics Requires Autophagy for Mitochondrial Network Maintenance
- (2013) Elisa Motori et al. Cell Metabolism
- A survey from 2012 of evidence for the role of neuroinflammation in neurotoxin animal models of Parkinson's disease and potential molecular targets
- (2013) Chenere P. Ramsey et al. EXPERIMENTAL NEUROLOGY
- Astrocytes inhibit nitric oxide-dependent Ca2+dynamics in activated microglia: Involvement of ATP released via pannexin 1 channels
- (2013) Juan A. Orellana et al. GLIA
- Pink1 deficiency attenuates astrocyte proliferation through mitochondrial dysfunction, reduced akt and increased p38 mapk activation, and downregulation of egfr
- (2013) Insup Choi et al. GLIA
- Leucine-rich repeat kinase 2 modulates cyclooxygenase 2 and the inflammatory response in idiopathic and genetic Parkinson's disease
- (2013) Rakel Lopez de Maturana et al. NEUROBIOLOGY OF AGING
- Isolation and Culture of Mouse Cortical Astrocytes
- (2013) Sebastian Schildge et al. Jove-Journal of Visualized Experiments
- PINK1 Deficiency Enhances Inflammatory Cytokine Release from Acutely Prepared Brain Slices
- (2013) Jun Kim et al. Experimental Neurobiology
- PINK1 stimulates interleukin-1β-mediated inflammatory signaling via the positive regulation of TRAF6 and TAK1
- (2012) Hyun Jung Lee et al. CELLULAR AND MOLECULAR LIFE SCIENCES
- Toll-like receptor 4 is required for α-synuclein dependent activation of microglia and astroglia
- (2012) Lisa Fellner et al. GLIA
- Cell metabolism affects selective vulnerability in PINK1-associated Parkinson's disease
- (2012) Zhi Yao et al. JOURNAL OF CELL SCIENCE
- LRRK2 Inhibition Attenuates Microglial Inflammatory Responses
- (2012) M. S. Moehle et al. JOURNAL OF NEUROSCIENCE
- Shared and Cell Type-Specific Mitochondrial Defects and Metabolic Adaptations in Primary Cells from PINK1-Deficient Mice
- (2012) Ravi S. Akundi et al. Neurodegenerative Diseases
- Parkinson's disease-linked leucine-rich repeat kinase 2(R1441G) mutation increases proinflammatory cytokine release from activated primary microglial cells and resultant neurotoxicity
- (2012) F. Gillardon et al. NEUROSCIENCE
- A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease
- (2012) David K. Stone et al. NEUROSCIENCE LETTERS
- -Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons
- (2012) M. Decressac et al. Science Translational Medicine
- Astrocytes Are Endogenous Regulators of Basal Transmission at Central Synapses
- (2011) Aude Panatier et al. CELL
- The PINK1/Parkin pathway regulates mitochondrial dynamics and function in mammalian hippocampal and dopaminergic neurons
- (2011) Wendou Yu et al. HUMAN MOLECULAR GENETICS
- Neuroinflammation in Parkinson's disease
- (2011) Etienne C. Hirsch et al. PARKINSONISM & RELATED DISORDERS
- Increased Mitochondrial Calcium Sensitivity and Abnormal Expression of Innate Immunity Genes Precede Dopaminergic Defects in Pink1-Deficient Mice
- (2011) Ravi S. Akundi et al. PLoS One
- Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B
- (2011) Thi A. Tran et al. PLoS One
- Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions
- (2010) Jack van Horssen et al. FREE RADICAL BIOLOGY AND MEDICINE
- Association of Parkinson disease-related protein PINK1 with Alzheimer disease and multiple sclerosis brain lesions
- (2010) Micha M.M. Wilhelmus et al. FREE RADICAL BIOLOGY AND MEDICINE
- Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies
- (2010) He-Jin Lee et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Angiotensin II sustains brain inflammation in mice via TGF-β
- (2010) Tobias V. Lanz et al. JOURNAL OF CLINICAL INVESTIGATION
- TGFβ signaling in the brain increases with aging and signals to astrocytes and innate immune cells in the weeks after stroke
- (2010) Kristian P Doyle et al. Journal of Neuroinflammation
- PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate Parkin
- (2010) Derek P. Narendra et al. PLOS BIOLOGY
- Hypoxia Triggers Subcellular Compartmental Redox Signaling in Vascular Smooth Muscle Cells
- (2009) Gregory B. Waypa et al. CIRCULATION RESEARCH
- Regulation of astrocyte inflammatory responses by the Parkinson’s disease-associated gene DJ-1
- (2009) Jens Waak et al. FASEB JOURNAL
- Loss of PINK1 Function Promotes Mitophagy through Effects on Oxidative Stress and Mitochondrial Fission
- (2009) Ruben K. Dagda et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- PINK1-Associated Parkinson's Disease Is Caused by Neuronal Vulnerability to Calcium-Induced Cell Death
- (2009) Sonia Gandhi et al. MOLECULAR CELL
- Parkinson's disease-associated parkin colocalizes with Alzheimer's disease and multiple sclerosis brain lesions
- (2009) Maarten E. Witte et al. NEUROBIOLOGY OF DISEASE
- S-Nitrosylation of Drp1 Mediates β-Amyloid-Related Mitochondrial Fission and Neuronal Injury
- (2009) Dong-Hyung Cho et al. SCIENCE
- Neuroinflammation and Oxidation/Nitration of -Synuclein Linked to Dopaminergic Neurodegeneration
- (2008) H.-M. Gao et al. JOURNAL OF NEUROSCIENCE
- Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration
- (2008) T. C. Frank-Cannon et al. JOURNAL OF NEUROSCIENCE
- Analyzing real-time PCR data by the comparative CT method
- (2008) Thomas D Schmittgen et al. Nature Protocols
- PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons
- (2008) Alison Wood-Kaczmar et al. PLoS One
- Loss of PINK1 causes mitochondrial functional defects and increased sensitivity to oxidative stress
- (2008) C. A. Gautier et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- α-Synuclein activates stress signaling protein kinases in THP-1 cells and microglia
- (2006) Andis Klegeris et al. NEUROBIOLOGY OF AGING
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation