Treating Parkinson’s disease by astrocyte reprogramming: Progress and challenges

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson’s Disease

(2020) Jun Young Heo et al.   CURRENT BIOLOGY

Reversing a model of Parkinson’s disease with in situ converted nigral neurons

(2020) Hao Qian et al.   NATURE

Pre-clinical study of induced pluripotent stem cell-derived dopaminergic progenitor cells for Parkinson’s disease

(2020) Daisuke Doi et al.   Nature Communications

Adeno-associated Virus (AAV) versus Immune Response

(2019) Joseph Rabinowitz et al.   Viruses-Basel

Generation of neural stem cells from adult astrocytes by using a single reprogramming factor

(2019) Masoumeh Zarei‐Kheirabadi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Magnetic Resonance Imaging–Guided Phase 1 Trial of Putaminal AADC Gene Therapy for Parkinson's Disease

(2019) Chadwick W. Christine et al.   ANNALS OF NEUROLOGY

Parkinson's Disease and Parkinsonism

(2019) Michael T Hayes   AMERICAN JOURNAL OF MEDICINE

The Emerging Nature of Astrocyte Diversity

(2019) Baljit S. Khakh et al.   Annual Review of Neuroscience

Adult neurogenesis, human after all (again): Classic, optimized, and future approaches

(2019) Paul J. Lucassen et al.   BEHAVIOURAL BRAIN RESEARCH

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Unique molecular events during reprogramming of human somatic cells to induced pluripotent stem cells (iPSCs) at naïve state

(2018) Yixuan Wang et al.   eLife

Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2018) E. Ray Dorsey et al.   LANCET NEUROLOGY

Mechanisms of radial glia progenitor cell lineage progression

(2017) Robert Beattie et al.   FEBS LETTERS

miR-124 and miR-9 mediated downregulation of HDAC5 promotes neurite development through activating MEF2C-GPM6A pathway

(2017) Xi Gu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The relevance of gender in Parkinson’s disease: a review

(2017) Marina Picillo et al.   JOURNAL OF NEUROLOGY

Human iPS cell-derived dopaminergic neurons function in a primate Parkinson’s disease model

(2017) Tetsuhiro Kikuchi et al.   NATURE

Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

(2017) Pia Rivetti di Val Cervo et al.   NATURE BIOTECHNOLOGY

Outpatient titration of carbidopa/levodopa enteral suspension (Duopa)

(2016) Rajesh Pahwa et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

The clinical symptoms of Parkinson's disease

(2016) Sigurlaug Sveinbjornsdottir   JOURNAL OF NEUROCHEMISTRY

Neuromodulators signal through astrocytes to alter neural circuit activity and behaviour

(2016) Zhiguo Ma et al.   NATURE

Sequential regulatory loops as key gatekeepers for neuronal reprogramming in human cells

(2016) Yuanchao Xue et al.   NATURE NEUROSCIENCE

In Vivo Reprogramming for CNS Repair: Regenerating Neurons from Endogenous Glial Cells

(2016) Hedong Li et al.   NEURON

Serotonin in Parkinson's disease

(2015) Marios Politis et al.   BEHAVIOURAL BRAIN RESEARCH

Ascl1 Converts Dorsal Midbrain Astrocytes into Functional Neurons In Vivo

(2015) Y. Liu et al.   JOURNAL OF NEUROSCIENCE

Electrophysiological, transcriptomic and morphologic profiling of single neurons using Patch-seq

(2015) Cathryn R Cadwell et al.   NATURE BIOTECHNOLOGY

Astrocyte Depletion Impairs Redox Homeostasis and Triggers Neuronal Loss in the Adult CNS

(2015) Bettina Schreiner et al.   Cell Reports

MicroRNA-Mediated In Vitro and In Vivo Direct Conversion of Astrocytes to Neuroblasts

(2015) Maryam Ghasemi-Kasman et al.   PLoS One

Next-generation active immunization approach for synucleinopathies: implications for Parkinson’s disease clinical trials

(2014) Markus Mandler et al.   ACTA NEUROPATHOLOGICA

Regulation of microRNA biogenesis

(2014) Minju Ha et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A latent neurogenic program in astrocytes regulated by Notch signaling in the mouse

(2014) J. P. Magnusson et al.   SCIENCE

Direct Conversion of Fibroblasts to Neurons by Reprogramming PTB-Regulated MicroRNA Circuits

(2013) Yuanchao Xue et al.   CELL

In vivo reprogramming of astrocytes to neuroblasts in the adult brain

(2013) Wenze Niu et al.   NATURE CELL BIOLOGY

Augmenting CNS glucocerebrosidase activity as a therapeutic strategy for parkinsonism and other Gaucher-related synucleinopathies

(2013) S. Pablo Sardi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Environmental impact on direct neuronal reprogramming in vivo in the adult brain

(2013) Andrew Grande et al.   Nature Communications

Direct reprogramming of human astrocytes into neural stem cells and neurons

(2012) Stefania Corti et al.   EXPERIMENTAL CELL RESEARCH

Progenitors in the adult cerebral cortex: Cell cycle properties and regulation by physiological stimuli and injury

(2011) Christiane Simon et al.   GLIA

MicroRNA-mediated conversion of human fibroblasts to neurons

(2011) Andrew S. Yoo et al.   NATURE

A molecular basis for the increased vulnerability of substantia nigra dopamine neurons in aging and Parkinson's disease

(2010) C. Savio Chan et al.   MOVEMENT DISORDERS

High-Efficient Generation of Induced Pluripotent Stem Cells from Human Astrocytes

(2010) Sergio Ruiz et al.   PLoS One

Human Induced Pluripotent Stem Cells Develop Teratoma More Efficiently and Faster Than Human Embryonic Stem Cells Regardless the Site of Injection

(2010) Ivan Gutierrez-Aranda et al.   STEM CELLS

Levodopa in the treatment of Parkinson’s disease: an old drug still going strong

(2010) Angelo Antonini   Clinical Interventions in Aging

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Neurotransmission in Parkinson’s disease: beyond dopamine

(2009) P. Barone   EUROPEAN JOURNAL OF NEUROLOGY

The TLR9-MyD88 pathway is critical for adaptive immune responses to adeno-associated virus gene therapy vectors in mice

(2009) Jiangao Zhu et al.   JOURNAL OF CLINICAL INVESTIGATION

Deep brain stimulation of the subthalamic nucleus for the treatment of Parkinson's disease

(2008) Alim Louis Benabid et al.   LANCET NEUROLOGY

Levodopa for the Treatment of Parkinson's Disease

(2008) Peter A. LeWitt   NEW ENGLAND JOURNAL OF MEDICINE

Aging does not alter the number or phenotype of putative stem/progenitor cells in the neurogenic region of the hippocampus

(2006) Bharathi Hattiangady et al.   NEUROBIOLOGY OF AGING