Pathogenic LRRK2 control of primary cilia and Hedgehog signaling in neurons and astrocytes of mouse brain

Pathogenic LRRK2 regulates ciliation probability upstream of tau tubulin kinase 2 via Rab10 and RILPL1 proteins

(2021) Yuriko Sobu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preclinical modeling of chronic inhibition of the Parkinson’s disease associated kinase LRRK2 reveals altered function of the endolysosomal system in vivo

(2021) Jillian H. Kluss et al.   Molecular Neurodegeneration

LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockade

(2021) Herschel S Dhekne et al.   Life Science Alliance

Dopaminergic co-transmission with sonic hedgehog inhibits abnormal involuntary movements in models of Parkinson’s disease and L-Dopa induced dyskinesia

(2021) Lauren Malave et al.   Communications Biology

Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2

(2020) Dieter Waschbüsch et al.   STRUCTURE

TTBK2 and primary cilia are essential for the connectivity and survival of cerebellar Purkinje neurons

(2020) Emily Bowie et al.   eLife

GLI transcriptional repression regulates tissue-specific enhancer activity in response to Hedgehog signaling

(2020) Rachel K Lex et al.   eLife

Pathway-specific dysregulation of striatal excitatory synapses by LRRK2 mutations

(2020) Chuyu Chen et al.   eLife

Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues

(2020) Lucia Iannotta et al.   Cells

Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites

(2020) Raja S. Nirujogi et al.   BIOCHEMICAL JOURNAL

Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity

(2020) Alexia F. Kalogeropulou et al.   BIOCHEMICAL JOURNAL

Primary cilia safeguard cortical neurons in neonatal mouse forebrain from environmental stress-induced dendritic degeneration

(2020) Seiji Ishii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biochemical mechanisms of vertebrate hedgehog signaling

(2019) Jennifer H. Kong et al.   DEVELOPMENT

The Emerging Nature of Astrocyte Diversity

(2019) Baljit S. Khakh et al.   Annual Review of Neuroscience

Sonic hedgehog signaling in astrocytes mediates cell type-specific synaptic organization

(2019) Steven A Hill et al.   eLife

RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits

(2019) Antonio Jesús Lara Ordóñez et al.   HUMAN MOLECULAR GENETICS

Membrane association but not identity is required for LRRK2 activation and phosphorylation of Rab GTPases

(2019) Rachel C. Gomez et al.   JOURNAL OF CELL BIOLOGY

PPM1H phosphatase counteracts LRRK2 signaling by selectively dephosphorylating Rab proteins

(2019) Kerryn Berndsen et al.   eLife

The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human

(2018) Rafeeq Mir et al.   BIOCHEMICAL JOURNAL

Striatal synapses, circuits, and Parkinson's disease

(2018) Shenyu Zhai et al.   CURRENT OPINION IN NEUROBIOLOGY

Quantitative Comparison of Primary Cilia Marker Expression and Length in the Mouse Brain

(2018) Éva Sipos et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylation

(2018) Jesús Madero-Pérez et al.   Molecular Neurodegeneration

LRRK2 kinase in Parkinson's disease

(2018) Dario R. Alessi et al.   SCIENCE

CellProfiler 3.0: Next-generation image processing for biology

(2018) Claire McQuin et al.   PLOS BIOLOGY

The G2019S mutation in LRRK2 imparts resiliency to kinase inhibition

(2018) Kaela Kelly et al.   EXPERIMENTAL NEUROLOGY

LRRK2 and Rab GTPases

(2018) Suzanne R. Pfeffer   BIOCHEMICAL SOCIETY TRANSACTIONS

Neuronal and astrocytic primary cilia in the mature brain

(2018) Ashley Sterpka et al.   PHARMACOLOGICAL RESEARCH

A pathway for Parkinson’s Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain

(2018) Herschel S Dhekne et al.   eLife

LRRK2 phosphorylates membrane-bound Rabs and is activated by GTP-bound Rab7L1 to promote recruitment to the trans-Golgi network

(2017) Zhiyong Liu et al.   HUMAN MOLECULAR GENETICS

Rab GTPases: master regulators that establish the secretory and endocytic pathways

(2017) Suzanne R. Pfeffer   MOLECULAR BIOLOGY OF THE CELL

Systematic proteomic analysis of LRRK2-mediated Rab GTPase phosphorylation establishes a connection to ciliogenesis

(2017) Martin Steger et al.   eLife

Parkinson disease

(2017) Werner Poewe et al.   Nature Reviews Disease Primers

Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors

(2016) G. Ito et al.   BIOCHEMICAL JOURNAL

Functional Indicators of Glutamate Transport in Single Striatal Astrocytes and the Influence of Kir4.1 in Normal and Huntington Mice

(2016) Anton Dvorzhak et al.   JOURNAL OF NEUROSCIENCE

Neurons diversify astrocytes in the adult brain through sonic hedgehog signaling

(2016) W. T. Farmer et al.   SCIENCE

Primary Cilia and Mammalian Hedgehog Signaling

(2016) Fiona Bangs et al.   Cold Spring Harbor Perspectives in Biology

Phosphoproteomics reveals that Parkinson's disease kinase LRRK2 regulates a subset of Rab GTPases

(2016) Martin Steger et al.   eLife

LRRK2 and RAB7L1 coordinately regulate axonal morphology and lysosome integrity in diverse cellular contexts

(2016) Tomoki Kuwahara et al.   Scientific Reports

Circuit-specific signaling in astrocyte-neuron networks in basal ganglia pathways

(2015) R. Martin et al.   SCIENCE

Differential LRRK2 expression in the cortex, striatum, and substantia nigra in transgenic and nontransgenic rodents

(2014) Andrew B. West et al.   JOURNAL OF COMPARATIVE NEUROLOGY

An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex

(2014) Y. Zhang et al.   JOURNAL OF NEUROSCIENCE

A HomozygousKCNJ10Mutation in Jack Russell Terriers and Related Breeds with Spinocerebellar Ataxia with Myokymia, Seizures, or Both

(2014) D. Gilliam et al.   JOURNAL OF VETERINARY INTERNAL MEDICINE

Vacuolar protein sorting 35 (Vps35) rescues locomotor deficits and shortened lifespan in Drosophila expressing a Parkinson’s disease mutant of Leucine-rich repeat kinase 2 (LRRK2)

(2014) Radek Linhart et al.   Molecular Neurodegeneration

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Astroglial potassium clearance contributes to short-term plasticity of synaptically evoked currents at the tripartite synapse

(2013) Jérémie Sibille et al.   JOURNAL OF PHYSIOLOGY-LONDON

GDNF Is Predominantly Expressed in the PV+ Neostriatal Interneuronal Ensemble in Normal Mouse and after Injury of the Nigrostriatal Pathway

(2012) M. Hidalgo-Figueroa et al.   JOURNAL OF NEUROSCIENCE

LRRK2 expression is enriched in the striosomal compartment of mouse striatum

(2012) Wim Mandemakers et al.   NEUROBIOLOGY OF DISEASE

Sonic Hedgehog Maintains Cellular and Neurochemical Homeostasis in the Adult Nigrostriatal Circuit

(2012) Luis E. Gonzalez-Reyes et al.   NEURON

Development and distribution of neuronal cilia in mouse neocortex

(2011) Jon I. Arellano et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Development of a Method for the Purification and Culture of Rodent Astrocytes

(2011) Lynette C. Foo et al.   NEURON

Potassium channel activity and glutamate uptake are impaired in astrocytes of seizure-susceptible DBA/2 mice

(2010) Mikhail Inyushin et al.   EPILEPSIA

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10

(2009) U. I. Scholl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA