Imidazoline 2 binding sites reflecting astroglia pathology in Parkinson’s disease: an in vivo11C-BU99008 PET study

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

(2019) Angelique di Domenico et al.   Stem Cell Reports

Noninvasive PK11195-PET Image Analysis Techniques Can Detect Abnormal Cerebral Microglial Activation in Parkinson's Disease

(2018) Yeona Kang et al.   JOURNAL OF NEUROIMAGING

Evaluation of11C-BU99008, a positron emission tomography ligand for the Imidazoline2binding site in human brain

(2018) Robin J. Tyacke et al.   JOURNAL OF NUCLEAR MEDICINE

Microglial activation in Parkinson’s disease using [18F]-FEPPA

(2017) Christine Ghadery et al.   Journal of Neuroinflammation

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Imidazoline I 2 receptors: An update

(2017) Jun-Xu Li   PHARMACOLOGY & THERAPEUTICS

Extrastriatal spreading of microglial activation in Parkinson’s disease: a positron emission tomography study

(2016) Tatsuhiro Terada et al.   ANNALS OF NUCLEAR MEDICINE

Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation

(2015) Junchao Tong et al.   NEUROBIOLOGY OF DISEASE

Accurate automatic estimation of total intracranial volume: A nuisance variable with less nuisance

(2015) Ian B. Malone et al.   NEUROIMAGE

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain

(2014) C. A. Parker et al.   JOURNAL OF NUCLEAR MEDICINE

Antihyperalgesic effects of imidazoline I2receptor ligands in rat models of inflammatory and neuropathic pain

(2013) Jun-Xu Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline2 binding site

(2012) Robin J. Tyacke et al.   SYNAPSE

Erratum: IFN-γ signaling, with the synergistic contribution of TNF-α, mediates cell specific microglial and astroglial activation in experimental models of Parkinson’s disease

(2012) C Barcia et al.   Cell Death & Disease

Imidazoline I2 receptors: Target for new analgesics?

(2011) Jun-Xu Li et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Genetic mouse models for Parkinson's disease display severe pathology in glial cell mitochondria

(2011) S. Schmidt et al.   HUMAN MOLECULAR GENETICS

Glia: Initiators and progressors of pathology in Parkinson's disease

(2011) Glenda M. Halliday et al.   MOVEMENT DISORDERS

Synaptic Pruning by Microglia Is Necessary for Normal Brain Development

(2011) R. C. Paolicelli et al.   SCIENCE

Direct Transfer of α-Synuclein from Neuron to Astroglia Causes Inflammatory Responses in Synucleinopathies

(2010) He-Jin Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neuroinflammation is a key player in Parkinson’s disease and a prime target for therapy

(2010) Li Qian et al.   JOURNAL OF NEURAL TRANSMISSION

Differential pattern of brain-specific CSF proteins tau and amyloid-beta in Parkinsonian syndromes

(2010) Sigurd D. Süssmuth et al.   MOVEMENT DISORDERS

Staging of serotonergic dysfunction in Parkinson's Disease: An in vivo 11C-DASB PET study

(2010) Marios Politis et al.   NEUROBIOLOGY OF DISEASE

Improving intersubject image registration using tissue-class information benefits robustness and accuracy of multi-atlas based anatomical segmentation

(2010) Rolf A. Heckemann et al.   NEUROIMAGE

On the formation and nature of the imidazoline I2 binding site on human monoamine oxidase-B

(2010) G. Reid McDonald et al.   PHARMACOLOGICAL RESEARCH

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

Microglial MyD88 signaling regulates acute neuronal toxicity of LPS-stimulated microglia in vitro

(2009) J.M. Dean et al.   BRAIN BEHAVIOR AND IMMUNITY

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

(2009) Valerie Cullen et al.   Molecular Brain

Astroglia in dementia and Alzheimer's disease

(2008) J J Rodríguez et al.   CELL DEATH AND DIFFERENTIATION

Microglial cells and Parkinson’s disease

(2008) Li Qian et al.   IMMUNOLOGIC RESEARCH

Neuroinflammation mediated by IL-1β increases susceptibility of dopamine neurons to degeneration in an animal model of Parkinson's disease

(2008) James B Koprich et al.   Journal of Neuroinflammation

Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity

(2008) Liyan Qiao et al.   Molecular Brain