Glial Nrf2 signaling mediates the neuroprotection exerted by Gastrodia elata Blume in Lrrk2-G2019S Parkinson’s disease

The Nrf2-Keap1 pathway is activated by steroid hormone signaling to govern neuronal remodeling

(2021) Liang Yuh Chew et al.   Cell Reports

Multiple Pathways of LRRK2-G2019S/Rab10 Interaction in Dopaminergic Neurons

(2021) Alison Fellgett et al.   Journal of Parkinsons Disease

In Vivo Visual Screen for Dopaminergic Rab ↔ LRRK2-G2019S Interactions in Drosophila Discriminates Rab10 from Rab3

(2020) Stavroula Petridi et al.   G3-Genes Genomes Genetics

Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson’s disease

(2020) Ozge Karayel et al.   MOLECULAR & CELLULAR PROTEOMICS

Microglia and astrocyte dysfunction in parkinson's disease

(2020) Tae-In Kam et al.   NEUROBIOLOGY OF DISEASE

Interferon-γ signaling synergizes with LRRK2 in neurons and microglia derived from human induced pluripotent stem cells

(2020) Vasiliki Panagiotakopoulou et al.   Nature Communications

A Neuron-Glial Trans-Signaling Cascade Mediates LRRK2-Induced Neurodegeneration

(2019) Elie Maksoud et al.   Cell Reports

Bardoxolone ameliorates TGF-β1-associated renal fibrosis through Nrf2/Smad7 elevation

(2019) Min-Kyun Song et al.   FREE RADICAL BIOLOGY AND MEDICINE

The LRRK2 signalling system

(2018) Alice Price et al.   CELL AND TISSUE RESEARCH

Antidepressant-like effects of water extract of Gastrodia elata Blume on neurotrophic regulation in a chronic social defeat stress model

(2018) Yu-En Lin et al.   JOURNAL OF ETHNOPHARMACOLOGY

Motor and Nonmotor Complications of Levodopa: Phenomenology, Risk Factors, and Imaging Features

(2018) K. Ray Chaudhuri et al.   MOVEMENT DISORDERS

Nrf2 protects stellate cells from Smad-dependent cell activation

(2018) Vincenzo Prestigiacomo et al.   PLoS One

The sulfite oxidase Shopper controls neuronal activity by regulating glutamate homeostasis in Drosophila ensheathing glia

(2018) Nils Otto et al.   Nature Communications

Analytical Techniques and Pharmacokinetics of Gastrodia elata Blume and Its Constituents

(2017) et al.   MOLECULES

Anti-oxidative effects of 4-hydroxybenzyl alcohol in astrocytes confer protective effects in autocrine and paracrine manners

(2017) Lidan Luo et al.   PLoS One

Auxilin Underlies Progressive Locomotor Deficits and Dopaminergic Neuron Loss in a Drosophila Model of Parkinson’s Disease

(2017) Li Song et al.   Cell Reports

Drosophila Clock Is Required in Brain Pacemaker Neurons to Prevent Premature Locomotor Aging Independently of Its Circadian Function

(2017) Alexandra Vaccaro et al.   PLoS Genetics

The Mechanisms of Traditional Chinese Medicine Underlying the Prevention and Treatment of Parkinson's Disease

(2017) Xiaoliang Li et al.   Frontiers in Pharmacology

Lovastatin protects neurite degeneration inLRRK2-G2019Sparkinsonism through activating the Akt/Nrf pathway and inhibiting GSK3β activity

(2016) Chin-Hsien Lin et al.   HUMAN MOLECULAR GENETICS

Antidepressant-like effects of water extract of Gastrodia elata Blume in rats exposed to unpredictable chronic mild stress via modulation of monoamine regulatory pathways

(2016) Yu-En Lin et al.   JOURNAL OF ETHNOPHARMACOLOGY

The rhizome of Gastrodia elata Blume – An ethnopharmacological review

(2016) Hong-Dan Zhan et al.   JOURNAL OF ETHNOPHARMACOLOGY

Anti-depressant effects of Gastrodia elata Blume and its compounds gastrodin and 4-hydroxybenzyl alcohol, via the monoaminergic system and neuronal cytoskeletal remodeling

(2016) Wei-Cheng Chen et al.   JOURNAL OF ETHNOPHARMACOLOGY

Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

(2016) Gaia Skibinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking

(2015) Christian A. Lang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Effect of the myeloperoxidase inhibitor AZD3241 on microglia: a PET study in Parkinson’s disease

(2015) Aurelija Jucaite et al.   BRAIN

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Neuropharmacological Potential ofGastrodia elataBlume and Its Components

(2015) Jung-Hee Jang et al.   Evidence-based Complementary and Alternative Medicine

Pathogenic LRRK2 mutations, through increased kinase activity, produce enlarged lysosomes with reduced degradative capacity and increase ATP13A2 expression

(2015) Anastasia G. Henry et al.   HUMAN MOLECULAR GENETICS

DrosophilaCentral Nervous System Glia

(2015) Marc R. Freeman   Cold Spring Harbor Perspectives in Biology

Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2

(2015) Karen F.S. Bell et al.   Nature Communications

Quantitative Analysis of Climbing Defects in a Drosophila Model of Neurodegenerative Disorders

(2015) Surya T. Madabattula et al.   Jove-Journal of Visualized Experiments

Walking deficits and centrophobism in an α-synuclein fly model of Parkinson's disease

(2014) A. Y. Chen et al.   GENES BRAIN AND BEHAVIOR

LRRK2 pathobiology in Parkinson's disease

(2014) Ian Martin et al.   JOURNAL OF NEUROCHEMISTRY

(G2019S) LRRK2 causes early-phase dysfunction of SNpc dopaminergic neurons and impairment of corticostriatal long-term depression in the PD transgenic mouse

(2014) Jun-Shiao Chou et al.   NEUROBIOLOGY OF DISEASE

Gastrodin protects against MPP+-induced oxidative stress by up regulates heme oxygenase-1 expression through p38 MAPK/Nrf2 pathway in human dopaminergic cells

(2014) Genling Jiang et al.   NEUROCHEMISTRY INTERNATIONAL

Inhibitory Role of the KEAP1-NRF2 Pathway in TGFβ1-Stimulated Renal Epithelial Transition to Fibroblastic Cells: A Modulatory Effect on SMAD Signaling

(2014) In-geun Ryoo et al.   PLoS One

Gastrodin Protects Apoptotic Dopaminergic Neurons in a Toxin-Induced Parkinson’s Disease Model

(2013) Hemant Kumar et al.   Evidence-based Complementary and Alternative Medicine

Astrocytes engage unique molecular programs to engulf pruned neuronal debris from distinct subsets of neurons

(2013) O. E. Tasdemir-Yilmaz et al.   GENES & DEVELOPMENT

The genetics and neuropathology of Parkinson’s disease

(2012) Henry Houlden et al.   ACTA NEUROPATHOLOGICA

(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD

(2012) C-Y Chen et al.   CELL DEATH AND DIFFERENTIATION

Relay of retrograde synaptogenic signals through axonal transport of BMP receptors

(2012) R. B. Smith et al.   JOURNAL OF CELL SCIENCE

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

(2012) L. Gan et al.   JOURNAL OF NEUROSCIENCE

LRRK2 Inhibition Attenuates Microglial Inflammatory Responses

(2012) M. S. Moehle et al.   JOURNAL OF NEUROSCIENCE

NHBA isolated from Gastrodia elata exerts sedative and hypnotic effects in sodium pentobarbital-treated mice

(2012) Ying Zhang et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Herbal Medicines for Parkinson's Disease: A Systematic Review of Randomized Controlled Trials

(2012) Tae-Hun Kim et al.   PLoS One

A Versatile ΦC31 Based Reporter System for Measuring AP-1 and Nrf2 Signaling in Drosophila and in Tissue Culture

(2012) Nirmalya Chatterjee et al.   PLoS One

Ser1292 Autophosphorylation Is an Indicator of LRRK2 Kinase Activity and Contributes to the Cellular Effects of PD Mutations

(2012) Z. Sheng et al.   Science Translational Medicine

LRRK2 Mutant iPSC-Derived DA Neurons Demonstrate Increased Susceptibility to Oxidative Stress

(2011) Ha Nam Nguyen et al.   Cell Stem Cell

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease

(2011) M. C. Barone et al.   Disease Models & Mechanisms

LRRK2 directly phosphorylates Akt1 as a possible physiological substrate: Impairment of the kinase activity by Parkinson's disease-associated mutations

(2011) Etsuro Ohta et al.   FEBS LETTERS

Mutations inLRRK2increase phosphorylation of peroxiredoxin 3 exacerbating oxidative stress-induced neuronal death

(2011) Dario C. Angeles et al.   HUMAN MUTATION

LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3 

(2010) C.-H. Lin et al.   JOURNAL OF NEUROSCIENCE

Enhanced Striatal Dopamine Transmission and Motor Performance with LRRK2 Overexpression in Mice Is Eliminated by Familial Parkinson's Disease Mutation G2019S

(2010) X. Li et al.   JOURNAL OF NEUROSCIENCE

A Pair of Dopamine Neurons Target the D1-Like Dopamine Receptor DopR in the Central Complex to Promote Ethanol-Stimulated Locomotion in Drosophila

(2010) Eric C. Kong et al.   PLoS One

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

The cytosolic redox state of astrocytes: Maintenance, regulation and functional implications for metabolite trafficking

(2009) Johannes Hirrlinger et al.   BRAIN RESEARCH REVIEWS

The Nrf2–ARE cytoprotective pathway in astrocytes

(2009) Marcelo R. Vargas et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Nrf2 regulates microglial dynamics and neuroinflammation in experimental Parkinson's disease

(2009) Ana I. Rojo et al.   GLIA

Ensheathing Glia Function as Phagocytes in the Adult Drosophila Brain

(2009) J. Doherty et al.   JOURNAL OF NEUROSCIENCE

Eight different types of dopaminergic neurons innervate the Drosophila mushroom body neuropil: anatomical and physiological heterogeneity

(2009) Zhengmei Mao   Frontiers in Neural Circuits

Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila

(2008) Gerasimos P. Sykiotis et al.   DEVELOPMENTAL CELL

Pharmacokinetics of gastrodin and its metabolite p-hydroxybenzyl alcohol in rat blood, brain and bile by microdialysis coupled to LC–MS/MS

(2008) Lei-Chwen Lin et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Prevalence and correlates of neuropsychiatric symptoms in Parkinson's disease without dementia

(2008) Jaime Kulisevsky et al.   MOVEMENT DISORDERS

A Drosophila model for LRRK2-linked parkinsonism

(2008) Z. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA