Alpha-Synuclein as a Prominent Actor in the Inflammatory Synaptopathy of Parkinson’s Disease

α-Synuclein Oligomers Induce Glutamate Release from Astrocytes and Excessive Extrasynaptic NMDAR Activity in Neurons, Thus Contributing to Synapse Loss

(2021) Dorit Trudler et al.   JOURNAL OF NEUROSCIENCE

Structure and function of a neocortical synapse

(2021) Simone Holler et al.   NATURE

Microglia regulate synaptic development and plasticity

(2021) Megumi Andoh et al.   Developmental Neurobiology

Neurons and Glia Interplay in α-Synucleinopathies

(2021) Panagiota Mavroeidi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neuro-Immune Cross-Talk in the Striatum: From Basal Ganglia Physiology to Circuit Dysfunction

(2021) Andrea Mancini et al.   Frontiers in Immunology

Initiation and propagation of α-synuclein aggregation in the nervous system

(2020) Baraa A. Hijaz et al.   Molecular Neurodegeneration

Immunization therapies for Parkinson’s disease: state of the art and considerations for future clinical trials

(2020) Angelo Antonini et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

SUMOylation in α-Synuclein Homeostasis and Pathology

(2020) Mor Savyon et al.   Frontiers in Aging Neuroscience

Inflammation in Parkinson’s Disease: Mechanisms and Therapeutic Implications

(2020) Marta Pajares et al.   Cells

Microglia and astrocyte dysfunction in parkinson's disease

(2020) Tae-In Kam et al.   NEUROBIOLOGY OF DISEASE

Neuron-Astrocyte Interactions in Parkinson’s Disease

(2020) Ikuko Miyazaki et al.   Cells

Star power: the emerging role of astrocytes as neuronal partners during cortical plasticity

(2020) Jérôme Wahis et al.   CURRENT OPINION IN NEUROBIOLOGY

Novel Immunotherapeutic Approaches to Target Alpha-Synuclein and Related Neuroinflammation in Parkinson’s Disease

(2019) Maria Zella et al.   Cells

The prion-like spreading of α-synuclein: From in vitro to in vivo models of Parkinson’s disease

(2019) Jessica Y. Vargas et al.   AGEING RESEARCH REVIEWS

Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration

(2019) Valentina Durante et al.   BRAIN

Temporal evolution of microglia and α-synuclein accumulation following foetal grafting in Parkinson’s disease

(2019) C Warren Olanow et al.   BRAIN

Alpha-synuclein (αSyn) preformed fibrils induce endogenous αSyn aggregation, compromise synaptic activity and enhance synapse loss in cultured excitatory hippocampal neurons

(2019) Qihui Wu et al.   JOURNAL OF NEUROSCIENCE

Glial phagocytic clearance in Parkinson’s disease

(2019) Marie-Eve Tremblay et al.   Molecular Neurodegeneration

Brain Angiotensinergic Regulation of the Immune System: Implications for Cardiovascular and Neuroendocrine Responses

(2019) Michele Iovino et al.   Endocrine Metabolic & Immune Disorders-Drug Targets

Microglia affect α-synuclein cell-to-cell transfer in a mouse model of Parkinson’s disease

(2019) Sonia George et al.   Molecular Neurodegeneration

splitGFP Technology Reveals Dose-Dependent ER-Mitochondria Interface Modulation by α-Synuclein A53T and A30P Mutants

(2019) Tito Calì et al.   Cells

Pharmacological Targeting of Microglial Activation: New Therapeutic Approach

(2019) Cai-Yun Liu et al.   Frontiers in Cellular Neuroscience

Blunting neuroinflammation with resolvin D1 prevents early pathology in a rat model of Parkinson’s disease

(2019) Paraskevi Krashia et al.   Nature Communications

Peripheral monocyte entry is required for alpha-Synuclein induced inflammation and Neurodegeneration in a model of Parkinson disease

(2018) Ashley S. Harms et al.   EXPERIMENTAL NEUROLOGY

Determinants of dopaminergic neuron loss in Parkinson's disease

(2018) D.James Surmeier   FEBS Journal

Lewy body-like alpha-synuclein inclusions trigger reactive microgliosis prior to nigral degeneration

(2018) Megan F. Duffy et al.   Journal of Neuroinflammation

Targeted Therapies for Parkinson's Disease: From Genetics to the Clinic

(2018) S. Pablo Sardi et al.   MOVEMENT DISORDERS

Mechanisms of α-Synuclein Induced Synaptopathy in Parkinson's Disease

(2018) Jessika C. Bridi et al.   Frontiers in Neuroscience

Linking Neuroinflammation and Neurodegeneration in Parkinson’s Disease

(2018) Géraldine Gelders et al.   Journal of Immunology Research

Alpha-Synuclein: From Early Synaptic Dysfunction to Neurodegeneration

(2018) Veronica Ghiglieri et al.   Frontiers in Neurology

Centrality of Early Synaptopathy in Parkinson’s Disease

(2018) Paola Imbriani et al.   Frontiers in Neurology

α-Synuclein fibril-induced paradoxical structural and functional defects in hippocampal neurons

(2018) Jessica M. Froula et al.   Acta Neuropathologica Communications

Impact of monomeric, oligomeric and fibrillar alpha-synuclein on astrocyte reactivity and toxicity to neurons

(2018) Cecilia Chavarría et al.   BIOCHEMICAL JOURNAL

Nuclear localization and phosphorylation modulate pathological effects of Alpha-Synuclein

(2018) Raquel Pinho et al.   HUMAN MOLECULAR GENETICS

Synaptic dysfunction in neurodegenerative and neurodevelopmental diseases: an overview of induced pluripotent stem-cell-based disease models

(2018) Era Taoufik et al.   Open Biology

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

cAMP levels in lymphocytes and CD4+ regulatory T-cell functions are affected by dopamine receptor gene polymorphisms

(2017) Marco Cosentino et al.   IMMUNOLOGY

Human Astrocytes Transfer Aggregated Alpha-Synuclein via Tunneling Nanotubes

(2017) Jinar Rostami et al.   JOURNAL OF NEUROSCIENCE

Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage

(2017) Veronica Lindström et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Past, present, and future of Parkinson's disease: A special essay on the 200th Anniversary of the Shaking Palsy

(2017) J.A. Obeso et al.   MOVEMENT DISORDERS

Motor complications in Parkinson's disease: Striatal molecular and electrophysiological mechanisms of dyskinesias

(2017) Barbara Picconi et al.   MOVEMENT DISORDERS

The effect of α-synuclein on gliosis and IL-1α, TNFα, IFNγ, TGFβ expression in murine brain

(2017) Anna Sznejder-Pachołek et al.   Pharmacological Reports

Molecular and Cellular Mechanisms of Synaptopathies

(2017) Alvaro O. Ardiles et al.   NEURAL PLASTICITY

The Contribution ofα-Synuclein Spreading to Parkinson’s Disease Synaptopathy

(2017) Francesca Longhena et al.   NEURAL PLASTICITY

α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration

(2017) Ashley S. Harms et al.   Acta Neuropathologica Communications

Suppression of Map Kinases Inhibits Microglial Activation and Attenuates Neuronal Cell Death Induced by α-Synuclein Protofibrils

(2017) H. Wilms et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

Parkinson's disease-associated genetic variation is linked to quantitative expression of inflammatory genes

(2017) Steven Pierce et al.   PLoS One

Alpha-synuclein activates BV2 microglia dependent on its aggregation state

(2016) Alana Hoffmann et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Alpha-Synuclein Produces Early Behavioral Alterations via Striatal Cholinergic Synaptic Dysfunction by Interacting With GluN2D N -Methyl-D-Aspartate Receptor Subunit

(2016) Alessandro Tozzi et al.   BIOLOGICAL PSYCHIATRY

The astrocytic response to the dopaminergic denervation of the striatum

(2016) Ingrid Morales et al.   JOURNAL OF NEUROCHEMISTRY

Synaptopathies: synaptic dysfunction in neurological disorders - A review from students to students

(2016) Katarzyna Lepeta et al.   JOURNAL OF NEUROCHEMISTRY

Synaptic failure and α-synuclein

(2016) Laura Calo et al.   MOVEMENT DISORDERS

Early synaptic dysfunction in Parkinson's disease: Insights from animal models

(2016) Tommaso Schirinzi et al.   MOVEMENT DISORDERS

Structural disorder of monomeric α-synuclein persists in mammalian cells

(2016) Francois-Xavier Theillet et al.   NATURE

Glia and alpha-synuclein in neurodegeneration: A complex interaction

(2016) Dominik Brück et al.   NEUROBIOLOGY OF DISEASE

Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology

(2016) K. Del Tredici et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Review: Parkinson's disease: from synaptic loss to connectome dysfunction

(2016) Arianna Bellucci et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Overexpression of α-synuclein simultaneously increases glutamate NMDA receptor phosphorylation and reduces glucocerebrosidase activity

(2016) Junfeng Yang et al.   NEUROSCIENCE LETTERS

Caspase-1 causes truncation and aggregation of the Parkinson’s disease-associated protein α-synuclein

(2016) Wei Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-Synuclein Oligomers—Neurotoxic Molecules in Parkinson's Disease and Other Lewy Body Disorders

(2016) Martin Ingelsson   Frontiers in Neuroscience

Genomics implicates adaptive and innate immunity in Alzheimer's and Parkinson's diseases

(2016) Sarah A. Gagliano et al.   Annals of Clinical and Translational Neurology

Extracellular α-synuclein alters synaptic transmission in brain neurons by perforating the neuronal plasma membrane

(2015) Carla R. Pacheco et al.   JOURNAL OF NEUROCHEMISTRY

Regulation of the Neurodegenerative Process Associated to Parkinson’s Disease by CD4+ T-cells

(2015) Hugo González et al.   Journal of Neuroimmune Pharmacology

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Low levels of astroglial markers in Parkinson’s disease: relationship to α-synuclein accumulation

(2015) Junchao Tong et al.   NEUROBIOLOGY OF DISEASE

Alpha-synuclein modulates NR2B-containing NMDA receptors and decreases their levels after rotenone exposure

(2015) Laura Navarria et al.   NEUROCHEMISTRY INTERNATIONAL

NMDA receptor GluN2A/GluN2B subunit ratio as synaptic trait of levodopa-induced dyskinesias: from experimental models to patients

(2015) Manuela Mellone et al.   Frontiers in Cellular Neuroscience

Novel subcellular localization for α-synuclein: possible functional consequences

(2015) Cristina Guardia-Laguarta et al.   Frontiers in Neuroanatomy

The Synaptic Function of α-Synuclein

(2015) Jacqueline Burré   Journal of Parkinsons Disease

Disruption in the Blood-Brain Barrier: The Missing Link between Brain and Body Inflammation in Bipolar Disorder?

(2015) Jay P. Patel et al.   NEURAL PLASTICITY

Complex Deregulation and Expression of Cytokines and Mediators of the Immune Response in Parkinson's Disease Brain is Region Dependent

(2014) Paula Garcia-Esparcia et al.   BRAIN PATHOLOGY

 -Synuclein Is Localized to Mitochondria-Associated ER Membranes

(2014) C. Guardia-Laguarta et al.   JOURNAL OF NEUROSCIENCE

Extracellular α-synuclein—a novel and crucial factor in Lewy body diseases

(2014) He-Jin Lee et al.   Nature Reviews Neurology

A novel α-synuclein mutation A53E associated with atypical multiple system atrophy and Parkinson's disease-type pathology

(2014) Petra Pasanen et al.   NEUROBIOLOGY OF AGING

Evidence of Inflammatory System Involvement in Parkinson’s Disease

(2014) Yinxia Chao et al.   Biomed Research International

Pathological alpha-synuclein propagates through neural networks

(2014) Masami Masuda-Suzukake et al.   Acta Neuropathologica Communications

Neuroimmunological Processes in Parkinson's Disease and their Relation to α-Synuclein: Microglia as the Referee between Neuronal Processes and Peripheral Immunity

(2013) Vanesa Sanchez-Guajardo et al.   ASN Neuro

Lewy Body-like α-Synuclein Aggregates Resist Degradation and Impair Macroautophagy

(2013) Selcuk A. Tanik et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

alpha-Synuclein and intracellular trafficking: impact on the spreading of Parkinson’s disease pathology

(2013) Sibylle E. Eisbach et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Large  -synuclein oligomers inhibit neuronal SNARE-mediated vesicle docking

(2013) B.-K. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuron-released oligomeric α-synuclein is an endogenous agonist of TLR2 for paracrine activation of microglia

(2013) Changyoun Kim et al.   Nature Communications

Mechanisms underlying the impairment of hippocampal long-term potentiation and memory in experimental Parkinson’s disease

(2012) Cinzia Costa et al.   BRAIN

Inflammatory events at blood-brain barrier in neuroinflammatory and neurodegenerative disorders: Implications for clinical disease

(2012) Helga E. de Vries et al.   EPILEPSIA

Regionally-specific microglial activation in young mice over-expressing human wildtype alpha-synuclein

(2012) Melanie B. Watson et al.   EXPERIMENTAL NEUROLOGY

α-Synuclein Controls Mitochondrial Calcium Homeostasis by Enhancing Endoplasmic Reticulum-Mitochondria Interactions

(2012) Tito Calì et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel One-step Immunoassays to Quantify α-Synuclein

(2012) Michael Bidinosti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

L-glutamate released from activated microglia downregulates astrocytic L-glutamate transporter expression in neuroinflammation: the ‘collusion’ hypothesis for increased extracellular L-glutamate concentration in neuroinflammation

(2012) Junpei Takaki et al.   Journal of Neuroinflammation

Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impair LTP Via NMDA-Receptor Activation

(2012) M. J. Diogenes et al.   JOURNAL OF NEUROSCIENCE

The many faces of α-synuclein: from structure and toxicity to therapeutic target

(2012) Hilal A. Lashuel et al.   NATURE REVIEWS NEUROSCIENCE

A Progressive Mouse Model of Parkinson’s Disease: The Thy1-aSyn (“Line 61”) Mice

(2012) Marie-Francoise Chesselet et al.   Neurotherapeutics

An extracellular mechanism that can explain the neurotoxic effects of α-synuclein aggregates in the brain

(2012) C. Pacheco et al.   Frontiers in Physiology

Autophagic pathways in Parkinson disease and related disorders

(2011) Maria Xilouri et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

α-Synuclein Sequesters Dnmt1 from the Nucleus

(2011) Paula Desplats et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells

(2011) Christian Hansen et al.   JOURNAL OF CLINICAL INVESTIGATION

The acute inflammatory response to intranigral α-synuclein differs significantly from intranigral lipopolysaccharide and is exacerbated by peripheral inflammation

(2011) Yvonne Couch et al.   Journal of Neuroinflammation

Evaluation of Markers of Oxidative Stress, Antioxidant Function and Astrocytic Proliferation in the Striatum and Frontal Cortex of Parkinson’s Disease Brains

(2011) Rajeswara Babu Mythri et al.   NEUROCHEMICAL RESEARCH

Non-Steroidal Anti-Inflammatory Drug Use and the Risk of Parkinson’s Disease

(2011) Angelika D. Manthripragada et al.   NEUROEPIDEMIOLOGY

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

Alpha-synuclein release by neurons activates the inflammatory response in a microglial cell line

(2011) Lydia Alvarez-Erviti et al.   NEUROSCIENCE RESEARCH

Protein aggregate spreading in neurodegenerative diseases: Problems and perspectives

(2011) Seung-Jae Lee et al.   NEUROSCIENCE RESEARCH

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

SNARE protein redistribution and synaptic failure in a transgenic mouse model of Parkinson’s disease

(2010) Pablo Garcia-Reitböck et al.   BRAIN

α-Synuclein impairs macroautophagy: implications for Parkinson’s disease

(2010) Ashley R. Winslow et al.   JOURNAL OF CELL BIOLOGY

The role of alpha-synuclein in neurotransmission and synaptic plasticity

(2010) Furong Cheng et al.   JOURNAL OF CHEMICAL NEUROANATOMY

Induction of the unfolded protein response by α-synuclein in experimental models of Parkinson’s disease

(2010) Arianna Bellucci et al.   JOURNAL OF NEUROCHEMISTRY

Cell-Produced  -Synuclein Is Secreted in a Calcium-Dependent Manner by Exosomes and Impacts Neuronal Survival

(2010) E. Emmanouilidou et al.   JOURNAL OF NEUROSCIENCE

Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease

(2010) Taye H Hamza et al.   NATURE GENETICS

Anti-inflammatory drugs and risk of Parkinson disease: A meta-analysis

(2010) J. J. Gagne et al.   NEUROLOGY

Increased Expression of α-Synuclein Reduces Neurotransmitter Release by Inhibiting Synaptic Vesicle Reclustering after Endocytosis

(2010) Venu M. Nemani et al.   NEURON

Presynaptic NMDARs in the Hippocampus Facilitate Transmitter Release at Theta Frequency

(2010) Lindsay McGuinness et al.   NEURON

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

(2010) Vanesa Sanchez-Guajardo et al.   PLoS One

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Astrocytic expression of Parkinson's disease-related A53T α-synuclein causes neurodegeneration in mice

(2010) Xing-Long Gu et al.   Molecular Brain

Tripartite synapses: astrocytes process and control synaptic information

(2009) Gertrudis Perea et al.   TRENDS IN NEUROSCIENCES

Genomic investigation of α-synuclein multiplication and parkinsonism

(2008) Owen A. Ross et al.   ANNALS OF NEUROLOGY

Microglial phagocytosis is enhanced by monomeric α-synuclein, not aggregated α-synuclein: Implications for Parkinson's disease

(2008) Ji-Young Park et al.   GLIA

Targeted Overexpression of Human α-Synuclein Triggers Microglial Activation and an Adaptive Immune Response in a Mouse Model of Parkinson Disease

(2008) Shaji Theodore et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Lewy body–like pathology in long-term embryonic nigral transplants in Parkinson's disease

(2008) Jeffrey H Kordower et al.   NATURE MEDICINE

Neuroinflammation and synaptic plasticity: theoretical basis for a novel, immune-centred, therapeutic approach to neurological disorders

(2008) Massimiliano Di Filippo et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Glial reactions in Parkinson's disease

(2007) Patrick L. McGeer et al.   MOVEMENT DISORDERS