Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations

The genetics of Parkinson disease

(2018) Hao Deng et al.   AGEING RESEARCH REVIEWS

The emerging role of Rab GTPases in the pathogenesis of Parkinson's disease

(2018) Yujing Gao et al.   MOVEMENT DISORDERS

Neuropathology of Parkinson disease

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Neuropathology of genetic synucleinopathies with parkinsonism: Review of the literature

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Absence of Lewy pathology associated with PINK1 homozygous mutation

(2016) Masashi Takanashi et al.   NEUROLOGY

Primary age-related tauopathy (PART): a common pathology associated with human aging

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Trimmomatic: a flexible trimmer for Illumina sequence data

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Membrane recruitment of endogenous LRRK2 precedes its potent regulation of autophagy

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PINK1-PARKIN Interplay: Down to Ubiquitin Phosphorylation

(2014) Alexandra Stolz et al.   MOLECULAR CELL

G2019S LRRK2 mutant fibroblasts from Parkinson’s disease patients show increased sensitivity to neurotoxin 1-methyl-4-phenylpyridinium dependent of autophagy

(2014) Sokhna M.S. Yakhine-Diop et al.   TOXICOLOGY

Spread of neuronal degeneration in a dopaminergic,Lrrk-G2019Smodel of Parkinson disease

(2013) Samantha J. Hindle et al.   Autophagy

Inhibition of LRRK2 kinase activity stimulates macroautophagy

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Parkinson disease phenotype in Ashkenazi jews with and withoutLRRK2G2019S mutations

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Parkin disease and the Lewy body conundrum

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Interplay of LRRK2 with chaperone-mediated autophagy

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Mutant LRRK2 Elicits Calcium Imbalance and Depletion of Dendritic Mitochondria in Neurons

(2012) Salvatore J. Cherra et al.   AMERICAN JOURNAL OF PATHOLOGY

Loss of leucine-rich repeat kinase 2 causes age-dependent bi-phasic alterations of the autophagy pathway

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LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

(2011) Martin C. Herzig et al.   HUMAN MOLECULAR GENETICS

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

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The Genome Analysis Toolkit: A MapReduce framework for analyzing next-generation DNA sequencing data

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ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data

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GTPase Activity Plays a Key Role in the Pathobiology of LRRK2

(2010) Yulan Xiong et al.   PLoS Genetics

Fast and accurate short read alignment with Burrows-Wheeler transform

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Neuropathology of Parkinson's disease with the R1441G mutation inLRRK2

(2009) José-Félix Martí-Massó et al.   MOVEMENT DISORDERS

R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice

(2009) Y. Tong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LRRK2 Gly2019Ser penetrance in Arab–Berber patients from Tunisia: a case-control genetic study

(2008) Mary M Hulihan et al.   LANCET NEUROLOGY

Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

(2008) Daniel G Healy et al.   LANCET NEUROLOGY

Lrrk2 R1441C parkinsonism is clinically similar to sporadic Parkinson disease

(2008) K. Haugarvoll et al.   NEUROLOGY

Familial parkinsonism: Study of original Sagamihara PARK8 (I2020T) kindred with variable clinicopathologic outcomes

(2008) Kazuko Hasegawa et al.   PARKINSONISM & RELATED DISORDERS