Parkin targets NOD2 to regulate astrocyte endoplasmic reticulum stress and inflammation

Astroglia as a cellular target for neuroprotection and treatment of neuro-psychiatric disorders

(2017) Beihui Liu et al.   GLIA

A Rab5 endosomal pathway mediates Parkin-dependent mitochondrial clearance

(2017) Babette C. Hammerling et al.   Nature Communications

Parkin regulation of CHOP modulates susceptibility to cardiac endoplasmic reticulum stress

(2017) Kim Han et al.   Scientific Reports

Glial biomarkers in human central nervous system disease

(2016) Gwenn A. Garden et al.   GLIA

NOD1 and NOD2 signalling links ER stress with inflammation

(2016) A. Marijke Keestra-Gounder et al.   NATURE

How neuroinflammation contributes to neurodegeneration

(2016) R. M. Ransohoff   SCIENCE

LRRK2 enhances Nod1/2-mediated inflammatory cytokine production by promoting Rip2 phosphorylation

(2016) Ruiqing Yan et al.   Protein & Cell

NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients

(2015) Sonja Johann et al.   GLIA

Endoplasmic Reticulum Stress Activates the Inflammasome via NLRP3- and Caspase-2-Driven Mitochondrial Damage

(2015) Denise N. Bronner et al.   IMMUNITY

Commensal bacteria direct selective cargo sorting to promote symbiosis

(2015) Qin Zhang et al.   NATURE IMMUNOLOGY

Endogenous Parkin Preserves Dopaminergic Substantia Nigral Neurons following Mitochondrial DNA Mutagenic Stress

(2015) Alicia M. Pickrell et al.   NEURON

Cofilin 1 activation prevents the defects in axon elongation and guidance induced by extracellular alpha-synuclein

(2015) Sharada Tilve et al.   Scientific Reports

Astrocyte-neuron crosstalk regulates the expression and subcellular localization of carbohydrate metabolism enzymes

(2014) Piotr Mamczur et al.   GLIA

Cutting Edge: Endoplasmic Reticulum Stress Licenses Macrophages To Produce Mature IL-1  in Response to TLR4 Stimulation through a Caspase-8- and TRIF-Dependent Pathway

(2014) K. Shenderov et al.   JOURNAL OF IMMUNOLOGY

The ubiquitin proteasome system in glia and its role in neurodegenerative diseases

(2014) Anne H. P. Jansen et al.   Frontiers in Molecular Neuroscience

Protective role of PARK2/Parkin in sepsis-induced cardiac contractile and mitochondrial dysfunction

(2013) Jérôme Piquereau et al.   Autophagy

P268S in NOD2 associates with susceptibility to Parkinson’s disease in Chinese population

(2013) Qilin Ma et al.   Behavioral and Brain Functions

Elevated TRAF2/6 expression in Parkinson’s disease is caused by the loss of Parkin E3 ligase activity

(2013) Ji-Yun Chung et al.   LABORATORY INVESTIGATION

The E3 Ligase Parkin Maintains Mitochondrial Integrity by Increasing Linear Ubiquitination of NEMO

(2013) Anne Kathrin Müller-Rischart et al.   MOLECULAR CELL

The ubiquitin ligase parkin mediates resistance to intracellular pathogens

(2013) Paolo S. Manzanillo et al.   NATURE

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk

(2013) David A. MacLeod et al.   NEURON

PARK2 Mediates Interleukin 6 and Monocyte Chemoattractant Protein 1 Production by Human Macrophages

(2013) Louis de Léséleuc et al.   PLoS Neglected Tropical Diseases

Thioredoxin-Interacting Protein Mediates ER Stress-Induced β Cell Death through Initiation of the Inflammasome

(2012) Christine M. Oslowski et al.   Cell Metabolism

No association between NOD2 variants and Parkinson's disease

(2012) Silke Appenzeller et al.   MOVEMENT DISORDERS

Overexpression of Parkin Ameliorates Dopaminergic Neurodegeneration Induced by 1- Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine in Mice

(2012) Minjuan Bian et al.   PLoS One

The ubiquitin E3 ligase parkin regulates the proapoptotic function of Bax

(2012) B. N. Johnson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

PARIS (ZNF746) Repression of PGC-1α Contributes to Neurodegeneration in Parkinson's Disease

(2011) Joo-Ho Shin et al.   CELL

Parkin reinvents itself to regulate fatty acid metabolism by tagging CD36

(2011) Nada A. Abumrad et al.   JOURNAL OF CLINICAL INVESTIGATION

Parkin is a lipid-responsive regulator of fat uptake in mice and mutant human cells

(2011) Kye-Young Kim et al.   JOURNAL OF CLINICAL INVESTIGATION

Intraneuronal amyloid β oligomers cause cell death via endoplasmic reticulum stress, endosomal/lysosomal leakage, and mitochondrial dysfunction in vivo

(2011) Tomohiro Umeda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Development of a Method for the Purification and Culture of Rodent Astrocytes

(2011) Lynette C. Foo et al.   NEURON

Neuroinflammation in Parkinson's disease

(2011) Etienne C. Hirsch et al.   PARKINSONISM & RELATED DISORDERS

Parkin is transcriptionally regulated by ATF4: evidence for an interconnection between mitochondrial stress and ER stress

(2010) L Bouman et al.   CELL DEATH AND DIFFERENTIATION

Astrocyte TLR4 activation induces a proinflammatory environment through the interplay between MyD88-dependent NFκB signaling, MAPK, and Jak1/Stat1 pathways

(2010) Roser Gorina et al.   GLIA

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

TLR activation of the transcription factor XBP1 regulates innate immune responses in macrophages

(2010) Fabio Martinon et al.   NATURE IMMUNOLOGY

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Reactive astrocytes as therapeutic targets for CNS disorders

(2010) Mary E. Hamby et al.   Neurotherapeutics

Microglia

(2010) Julia Kofler et al.   TOXICOLOGIC PATHOLOGY

Neuroinflammation in Parkinson's disease: Its role in neuronal death and implications for therapeutic intervention

(2009) Malú G. Tansey et al.   NEUROBIOLOGY OF DISEASE

Parkin Deficiency Increases Vulnerability to Inflammation-Related Nigral Degeneration

(2008) T. C. Frank-Cannon et al.   JOURNAL OF NEUROSCIENCE

From endoplasmic-reticulum stress to the inflammatory response

(2008) Kezhong Zhang et al.   NATURE