Reactive astrogliosis: A friend or foe in the pathogenesis of Alzheimer’s disease

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Tauvid™: The First FDA-Approved PET Tracer for Imaging Tau Pathology in Alzheimer’s Disease

(2021) Caitlin Jie et al.   Pharmaceuticals

In vitro Characterization of the Regional Binding Distribution of Amyloid PET Tracer Florbetaben and the Glia Tracers Deprenyl and PK11195 in Autopsy Alzheimer’s Brain Tissue

(2021) Ruiqing Ni et al.   JOURNAL OF ALZHEIMERS DISEASE

Astroglial tracer BU99008 detects multiple binding sites in Alzheimer’s disease brain

(2021) Amit Kumar et al.   MOLECULAR PSYCHIATRY

Astrocyte Biomarkers in Alzheimer Disease: A Systematic Review and Meta-analysis

(2021) Bruna Bellaver et al.   NEUROLOGY

Plasma glial fibrillary acidic protein detects Alzheimer pathology and predicts future conversion to Alzheimer dementia in patients with mild cognitive impairment

(2021) Claudia Cicognola et al.   Alzheimers Research & Therapy

Plasma GFAP is an early marker of amyloid-β but not tau pathology in Alzheimer’s disease

(2021) Joana B Pereira et al.   BRAIN

Astrocyte reactivity with late-onset cognitive impairment assessed in vivo using 11C-BU99008 PET and its relationship with amyloid load

(2021) Valeria Calsolaro et al.   MOLECULAR PSYCHIATRY

Microglial activation and tau propagate jointly across Braak stages

(2021) Tharick A. Pascoal et al.   NATURE MEDICINE

Developing the ATX(N) classification for use across the Alzheimer disease continuum

(2021) Harald Hampel et al.   Nature Reviews Neurology

The relationship of soluble TREM2 to other biomarkers of sporadic Alzheimer’s disease

(2021) So-Hee Park et al.   Scientific Reports

Tau oligomer induced HMGB1 release contributes to cellular senescence and neuropathology linked to Alzheimer’s disease and frontotemporal dementia

(2021) Sagar Gaikwad et al.   Cell Reports

Increased GFAP concentrations in the cerebrospinal fluid of patients with unipolar depression

(2021) Maike Michel et al.   Translational Psychiatry

The phenomenon of clasmatodendrosis

(2021) Denis Balaban et al.   Heliyon

Differences Between Plasma and Cerebrospinal Fluid Glial Fibrillary Acidic Protein Levels Across the Alzheimer Disease Continuum

(2021) Andréa L. Benedet et al.   JAMA Neurology

Immune cell regulation of glia during CNS injury and disease

(2020) Andrew D. Greenhalgh et al.   NATURE REVIEWS NEUROSCIENCE

Amyloid‐β oligomers in cellular models of Alzheimer’s disease

(2020) Igor C. Fontana et al.   JOURNAL OF NEUROCHEMISTRY

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Cortical microstructural correlates of astrocytosis in autosomal-dominant Alzheimer disease

(2020) Eduard Vilaplana et al.   NEUROLOGY

18F-SMBT-1: A Selective and Reversible Positron-Emission Tomography Tracer for Monoamine Oxidase-B Imaging

(2020) Ryuichi Harada et al.   JOURNAL OF NUCLEAR MEDICINE

Amyloid, tau, and astrocyte pathology in autosomal-dominant Alzheimer’s disease variants: AβPParc and PSEN1DE9

(2020) Laetitia Lemoine et al.   MOLECULAR PSYCHIATRY

APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer’s disease

(2020) Aivi T. Nguyen et al.   ACTA NEUROPATHOLOGICA

Evaluation of the novel 18 F‐labeled PET tracer SMBT‐1 for imaging astrogliosis in healthy elderly controls and A+/T+/(N+) Alzheimer's disease patients

(2020) Victor LL Villemagne et al.   Alzheimers & Dementia

Emerge and Engage topline results: Phase 3 studies of aducanumab in early Alzheimer’s disease

(2020) Samantha Budd Haeberlein et al.   Alzheimers & Dementia

Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production

(2020) Heejung Chun et al.   NATURE NEUROSCIENCE

Chi3l1/YKL-40 is controlled by the astrocyte circadian clock and regulates neuroinflammation and Alzheimer’s disease pathogenesis

(2020) Brian V. Lananna et al.   Science Translational Medicine

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

(2019) Nicole Reichenbach et al.   EMBO Molecular Medicine

Early increase of CSF sTREM2 in Alzheimer’s disease is associated with tau related-neurodegeneration but not with amyloid-β pathology

(2019) Marc Suárez-Calvet et al.   Molecular Neurodegeneration

Astrocyte Biomarkers in Alzheimer’s Disease

(2019) Stephen F. Carter et al.   TRENDS IN MOLECULAR MEDICINE

Astrocyte Heterogeneity: Impact to Brain Aging and Disease

(2019) Isadora Matias et al.   Frontiers in Aging Neuroscience

The Alzheimer’s Disease Clinical Spectrum

(2019) Alireza Atri   MEDICAL CLINICS OF NORTH AMERICA

Extracellular Monomeric Tau Is Internalized by Astrocytes

(2019) Juan Ramón Perea et al.   Frontiers in Neuroscience

A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies

(2019) Daniela Perani et al.   Alzheimers & Dementia

TREM2 function impedes tau seeding in neuritic plaques

(2019) Cheryl E. G. Leyns et al.   NATURE NEUROSCIENCE

Astroglial atrophy in Alzheimer’s disease

(2019) Alexei Verkhratsky et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Astrocytes: Role and Functions in Brain Pathologies

(2019) Rosalba Siracusa et al.   Frontiers in Pharmacology

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Plasma levels of soluble TREM2 and neurofilament light chain in TREM2 rare variant carriers

(2019) Nicholas J. Ashton et al.   Alzheimers Research & Therapy

NIA-AA Research Framework: Toward a biological definition of Alzheimer's disease

(2018) Clifford R. Jack et al.   Alzheimers & Dementia

Microglia and Astrocytes in Alzheimer's Disease: Implications for Therapy

(2018) Marc Fakhoury   Current Neuropharmacology

Evaluation of11C-BU99008, a positron emission tomography ligand for the Imidazoline2binding site in human brain

(2018) Robin J. Tyacke et al.   JOURNAL OF NUCLEAR MEDICINE

Imaging tau and amyloid-β proteinopathies in Alzheimer disease and other conditions

(2018) Victor L. Villemagne et al.   Nature Reviews Neurology

Physiology of Astroglia

(2018) Alexei Verkhratsky et al.   PHYSIOLOGICAL REVIEWS

Ca2+, Astrocyte Activation and Calcineurin/NFAT Signaling in Age-Related Neurodegenerative Diseases

(2018) Pradoldej Sompol et al.   Frontiers in Aging Neuroscience

Deciphering the Astrocyte Reaction in Alzheimer’s Disease

(2018) Beatriz G. Perez-Nievas et al.   Frontiers in Aging Neuroscience

TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading

(2018) Heidi Martini-Stoica et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The amyloid hypothesis on trial

(2018) Simon Makin   NATURE

Elucidating the Interactive Roles of Glia in Alzheimer's Disease Using Established and Newly Developed Experimental Models

(2018) Heejung Chun et al.   Frontiers in Neurology

Longitudinal association between astrocyte function and glucose metabolism in autosomal dominant Alzheimer’s disease

(2018) Stephen F. Carter et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Astrocytes and microglia: Models and tools

(2018) Kevin A. Guttenplan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Astrocytes and Aging

(2018) Alexandra L. Palmer et al.   Frontiers in Aging Neuroscience

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Amyloid-beta peptide decreases expression and function of glutamate transporters in nervous system cells

(2017) Huichun Tong et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Calcineurin/NFAT Signaling in Activated Astrocytes Drives Network Hyperexcitability in Aβ-Bearing Mice

(2017) Pradoldej Sompol et al.   JOURNAL OF NEUROSCIENCE

Pathological Tau Strains from Human Brains Recapitulate the Diversity of Tauopathies in Nontransgenic Mouse Brain

(2017) Sneha Narasimhan et al.   JOURNAL OF NEUROSCIENCE

YKL-40 in the brain and cerebrospinal fluid of neurodegenerative dementias

(2017) Franc Llorens et al.   Molecular Neurodegeneration

Tau PET imaging: present and future directions

(2017) Laure Saint-Aubert et al.   Molecular Neurodegeneration

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Imidazoline I 2 receptors: An update

(2017) Jun-Xu Li   PHARMACOLOGY & THERAPEUTICS

Glial Cells and Their Function in the Adult Brain: A Journey through the History of Their Ablation

(2017) Sarah Jäkel et al.   Frontiers in Cellular Neuroscience

Involvement of Astrocytes in Alzheimer’s Disease from a Neuroinflammatory and Oxidative Stress Perspective

(2017) Rodrigo E. González-Reyes et al.   Frontiers in Molecular Neuroscience

Amyloid β-Exposed Human Astrocytes Overproduce Phospho-Tau and Overrelease It within Exosomes, Effects Suppressed by Calcilytic NPS 2143—Further Implications for Alzheimer's Therapy

(2017) Anna Chiarini et al.   Frontiers in Neuroscience

Cortical laminar tau deposits and activated astrocytes in Alzheimer’s disease visualised by 3H-THK5117 and 3H-deprenyl autoradiography

(2017) Laetitia Lemoine et al.   Scientific Reports

Amyloid β-induced astrogliosis is mediated by β1-integrin via NADPH oxidase 2 in Alzheimer's disease

(2016) Ane Wyssenbach et al.   AGING CELL

Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

(2016) Bruno Dubois et al.   Alzheimers & Dementia

Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function

(2016) Melanie M. Pleiss et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Reactive gliosis in the pathogenesis of CNS diseases

(2016) Milos Pekny et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Diverging longitudinal changes in astrocytosis and amyloid PET in autosomal dominant Alzheimer’s disease

(2016) Elena Rodriguez-Vieitez et al.   BRAIN

Complex and Differential Glial Responses in Alzheimers Disease and Ageing

(2016) José J. Rodríguez et al.   Current Alzheimer Research

Defeating Alzheimer's disease and other dementias: a priority for European science and society

(2016) Bengt Winblad et al.   LANCET NEUROLOGY

Accumulation of amyloid-β by astrocytes result in enlarged endosomes and microvesicle-induced apoptosis of neurons

(2016) Sofia Söllvander et al.   Molecular Neurodegeneration

The antibody aducanumab reduces Aβ plaques in Alzheimer’s disease

(2016) Jeff Sevigny et al.   NATURE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

Astrocytes: a central element in neurological diseases

(2015) Milos Pekny et al.   ACTA NEUROPATHOLOGICA

Astrocyte uncoupling as a cause of human temporal lobe epilepsy

(2015) Peter Bedner et al.   BRAIN

Astrocytosis precedes amyloid plaque deposition in Alzheimer APPswe transgenic mouse brain: a correlative positron emission tomography and in vitro imaging study

(2015) Elena Rodriguez-Vieitez et al.   EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING

Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival

(2015) Jaclynn Levine et al.   GLIA

NFκB-Activated Astroglial Release of Complement C3 Compromises Neuronal Morphology and Function Associated with Alzheimer’s Disease

(2015) Hong Lian et al.   NEURON

Glial fibrillary acidic protein: from intermediate filament assembly and gliosis to neurobiomarker

(2015) Zhihui Yang et al.   TRENDS IN NEUROSCIENCES

Early astrocytosis in autosomal dominant Alzheimer’s disease measured in vivo by multi-tracer positron emission tomography

(2015) Michael Schöll et al.   Scientific Reports

Fibrillar Amyloid Plaque Formation Precedes Microglial Activation

(2015) Christian K. E. Jung et al.   PLoS One

DIFFERENT TIME COURSE OF ASTROCYTOSIS AND AMYLOID DEPOSITION IN ALZHEIMER'S APPSWE TRANSGENICE MICE: A MULTI-TRACER MICROPET STUDY

(2014) Ruiqing Ni et al.   Alzheimers & Dementia

Rare Individual Amyloid-β Oligomers Act on Astrocytes to Initiate Neuronal Damage

(2014) Priyanka Narayan et al.   BIOCHEMISTRY

CSF levels of YKL-40 are increased in MS and decrease with immunosuppressive treatment

(2014) Clas Malmeström et al.   JOURNAL OF NEUROIMMUNOLOGY

Evaluation of 11C-BU99008, a PET Ligand for the Imidazoline2 Binding Sites in Rhesus Brain

(2014) C. A. Parker et al.   JOURNAL OF NUCLEAR MEDICINE

Advancing research diagnostic criteria for Alzheimer's disease: the IWG-2 criteria

(2014) Bruno Dubois et al.   LANCET NEUROLOGY

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Molecular Imaging in Sporadic Alzheimer's Disease Populations and Those Genetically at Risk

(2014) Agneta Nordberg   Neurodegenerative Diseases

Glial Asthenia and Functional Paralysis

(2014) Alexei Verkhratsky et al.   NEUROSCIENTIST

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

(2014) Giulia E. Tyzack et al.   Nature Communications

Microglia convert aggregated amyloid-β into neurotoxic forms through the shedding of microvesicles

(2013) P Joshi et al.   CELL DEATH AND DIFFERENTIATION

3H-Deprenyl and 3H-PIB autoradiography show different laminar distributions of astroglia and fibrillar β-amyloid in Alzheimer brain

(2013) Amelia Marutle et al.   Journal of Neuroinflammation

Microglia: Scapegoat, Saboteur, or Something Else?

(2013) A. Aguzzi et al.   SCIENCE

Immunologic Privilege in the Central Nervous System and the Blood–Brain Barrier

(2012) Leslie L Muldoon et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Alexander Disease

(2012) A. Messing et al.   JOURNAL OF NEUROSCIENCE

Imaging Imidazoline-I2 Binding Sites in Porcine Brain Using 11C-BU99008

(2012) S. Kealey et al.   JOURNAL OF NUCLEAR MEDICINE

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

Evaluation and initial in vitro and ex vivo characterization of the potential positron emission tomography ligand, BU99008 (2-(4,5-Dihydro-1H-imidazol-2-yl)-1- methyl-1H-indole), for the imidazoline2 binding site

(2012) Robin J. Tyacke et al.   SYNAPSE

Introduction to the recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Clifford R. Jack et al.   Alzheimers & Dementia

Reactive Glia not only Associates with Plaques but also Parallels Tangles in Alzheimer's Disease

(2011) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Structural Remodeling of Astrocytes in the Injured CNS

(2011) Daniel Sun et al.   NEUROSCIENTIST

Alzheimer's Disease

(2011) D. J. Selkoe   Cold Spring Harbor Perspectives in Biology

Molecular imaging in Alzheimer's disease: new perspectives on biomarkers for early diagnosis and drug development

(2011) Agneta Nordberg   Alzheimers Research & Therapy

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

(2010) Rebecca Craig-Schapiro et al.   BIOLOGICAL PSYCHIATRY

Positron emission tomography imaging and clinical progression in relation to molecular pathology in the first Pittsburgh Compound B positron emission tomography patient with Alzheimer’s disease

(2010) Ahmadul Kadir et al.   BRAIN

Amyloid-  Aggregates Cause Alterations of Astrocytic Metabolic Phenotype: Impact on Neuronal Viability

(2010) I. Allaman et al.   JOURNAL OF NEUROSCIENCE

Revising the definition of Alzheimer's disease: a new lexicon

(2010) Bruno Dubois et al.   LANCET NEUROLOGY

Astrocytes in Alzheimer’s disease

(2010) Alexei Verkhratsky et al.   Neurotherapeutics

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Overexpression of human S100B exacerbates cerebral amyloidosis and gliosis in the Tg2576 mouse model of Alzheimer's disease

(2009) Takashi Mori et al.   GLIA

Cognitive Decline in Alzheimer's Disease Is Associated with Selective Changes in Calcineurin/NFAT Signaling

(2009) H. M. Abdul et al.   JOURNAL OF NEUROSCIENCE

Molecular dissection of reactive astrogliosis and glial scar formation

(2009) Michael V. Sofroniew   TRENDS IN NEUROSCIENCES

Monoamine oxidase inactivation: From pathophysiology to therapeutics☆

(2008) Marco Bortolato et al.   ADVANCED DRUG DELIVERY REVIEWS

Focal degeneration of astrocytes in amyotrophic lateral sclerosis

(2008) D Rossi et al.   CELL DEATH AND DIFFERENTIATION