Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
Published 2022 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Selective reduction of astrocyte apoE3 and apoE4 strongly reduces Aβ accumulation and plaque-related pathology in a mouse model of amyloidosis
Authors
Keywords
-
Journal
Molecular Neurodegeneration
Volume 17, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2022-02-03
DOI
10.1186/s13024-022-00516-0
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Astrocytic ApoE reprograms neuronal cholesterol metabolism and histone-acetylation-mediated memory
- (2021) Xiaohui Li et al. NEURON
- Expression and secretion of apoE isoforms in astrocytes and microglia during inflammation
- (2021) Maria Fe Lanfranco et al. GLIA
- Reactive astrocyte nomenclature, definitions, and future directions
- (2021) Carole Escartin et al. NATURE NEUROSCIENCE
- Microglia use TAM receptors to detect and engulf amyloid β plaques
- (2021) Youtong Huang et al. NATURE IMMUNOLOGY
- Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer’s disease
- (2021) Nicholas F. Fitz et al. Nature Communications
- Microglia‐specific ApoE knock‐out does not alter Alzheimer's disease plaque pathogenesis or gene expression
- (2021) Caden M. Henningfield et al. GLIA
- Astrocytic ApoE underlies maturation of hippocampal neurons and cognitive recovery after traumatic brain injury in mice
- (2021) Tzong-Shiue Yu et al. Communications Biology
- The Role of APOE4 in Disrupting the Homeostatic Functions of Astrocytes and Microglia in Aging and Alzheimer’s Disease
- (2019) Celia G. Fernandez et al. Frontiers in Aging Neuroscience
- Sequential formation of different layers of dystrophic neurites in Alzheimer’s brains
- (2019) Md Golam Sharoar et al. MOLECULAR PSYCHIATRY
- Sex differences in the association of APOE ε4 genotype with longitudinal hippocampal atrophy among cognitively normal older people
- (2019) Shanshan Shen et al. EUROPEAN JOURNAL OF NEUROLOGY
- TREM2 function impedes tau seeding in neuritic plaques
- (2019) Cheryl E. G. Leyns et al. NATURE NEUROSCIENCE
- Apolipoprotein E and Alzheimer disease: pathobiology and targeting strategies
- (2019) Yu Yamazaki et al. Nature Reviews Neurology
- Alzheimer Disease: An Update on Pathobiology and Treatment Strategies
- (2019) Justin M. Long et al. CELL
- Apolipoprotein E impairs amyloid‐β fibril elongation and maturation
- (2019) Tohidul Islam et al. FEBS Journal
- Lack of hepatic apoE does not influence early Aβ deposition: observations from a new APOE knock-in model
- (2019) Tien-Phat V. Huynh et al. Molecular Neurodegeneration
- ApoE facilitates the microglial response to amyloid plaque pathology
- (2018) Jason D. Ulrich et al. JOURNAL OF EXPERIMENTAL MEDICINE
- β-Secretase BACE1 Promotes Surface Expression and Function of Kv3.4 at Hippocampal Mossy Fiber Synapses
- (2018) Stephanie Hartmann et al. JOURNAL OF NEUROSCIENCE
- APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types
- (2018) Yuan-Ta Lin et al. NEURON
- Deciphering the Astrocyte Reaction in Alzheimer’s Disease
- (2018) Beatriz G. Perez-Nievas et al. Frontiers in Aging Neuroscience
- Loss of TREM2 function increases amyloid seeding but reduces plaque-associated ApoE
- (2018) Samira Parhizkar et al. NATURE NEUROSCIENCE
- APOE ε4/ε4 diminishes neurotrophic function of human iPSC-derived astrocytes
- (2017) Jing Zhao et al. HUMAN MOLECULAR GENETICS
- A Tale of Two Genes: Microglial Apoe and Trem2
- (2017) Anna A. Pimenova et al. IMMUNITY
- The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
- (2017) Susanne Krasemann et al. IMMUNITY
- ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy
- (2017) Yang Shi et al. NATURE
- Immune hyperreactivity of Aβ plaque-associated microglia in Alzheimer's disease
- (2017) Zhuoran Yin et al. NEUROBIOLOGY OF AGING
- Selective deletion of apolipoprotein E in astrocytes ameliorates the spatial learning and memory deficits in Alzheimer's disease (APP/PS1) mice by inhibiting TGF-β/Smad2/STAT3 signaling
- (2017) Jin-yu Zheng et al. NEUROBIOLOGY OF AGING
- Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis
- (2017) Tien-Phat V. Huynh et al. NEURON
- ApoE4 Accelerates Early Seeding of Amyloid Pathology
- (2017) Chia-Chen Liu et al. NEURON
- Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer’s disease
- (2016) Katherine R. Sadleir et al. ACTA NEUROPATHOLOGICA
- Microglial genes regulating neuroinflammation in the progression of Alzheimer's disease
- (2016) Claudio Villegas-Llerena et al. CURRENT OPINION IN NEUROBIOLOGY
- TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques
- (2016) Yaming Wang et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Sex differences between APPswePS1dE9 mice in A-beta accumulation and pancreatic islet function during the development of Alzheimer’s disease
- (2016) Xin Li et al. LABORATORY ANIMALS
- TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy
- (2016) Peng Yuan et al. NEURON
- TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia
- (2016) Felix L. Yeh et al. NEURON
- Prevalence of Cerebral Amyloid Pathology in Persons Without Dementia
- (2015) Willemijn J. Jansen et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2)
- (2015) Yuka Atagi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Triggering Receptor Expressed on Myeloid Cells 2 Binds Apolipoprotein E
- (2015) Charles C. Bailey et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Three dimensions of the amyloid hypothesis: time, space and 'wingmen'
- (2015) Erik S Musiek et al. NATURE NEUROSCIENCE
- Microglia constitute a barrier that prevents neurotoxic protofibrillar Aβ42 hotspots around plaques
- (2015) Carlo Condello et al. Nature Communications
- Microglial cell dysregulation in brain aging and neurodegeneration
- (2015) Rommy von Bernhardi et al. Frontiers in Aging Neuroscience
- Cholesterol metabolism and homeostasis in the brain
- (2015) Juan Zhang et al. Protein & Cell
- Murine versus human apolipoprotein E4: differential facilitation of and co-localization in cerebral amyloid angiopathy and amyloid plaques in APP transgenic mouse models
- (2015) Fan Liao et al. Acta Neuropathologica Communications
- Targeting miR-155 restores abnormal microglia and attenuates disease in SOD1 mice
- (2014) Oleg Butovsky et al. ANNALS OF NEUROLOGY
- The Binding of Apolipoprotein E to Oligomers and Fibrils of Amyloid-β Alters the Kinetics of Amyloid Aggregation
- (2014) Kanchan Garai et al. BIOCHEMISTRY
- Apolipoproteins E and J interfere with amyloid-beta uptake by primary human astrocytes and microgliain vitro
- (2014) Sandra D. Mulder et al. GLIA
- The Alzheimer’s β-secretase BACE1 localizes to normal presynaptic terminals and to dystrophic presynaptic terminals surrounding amyloid plaques
- (2013) Patty C. Kandalepas et al. ACTA NEUROPATHOLOGICA
- Targeting ApoE4/ApoE receptor LRP1 in Alzheimer's disease
- (2013) Henna Martiskainen et al. EXPERT OPINION ON THERAPEUTIC TARGETS
- Biomarker Modeling of Alzheimer’s Disease
- (2013) Clifford R. Jack et al. NEURON
- APOE4-specific Changes in Aβ Accumulation in a New Transgenic Mouse Model of Alzheimer Disease
- (2012) Katherine L. Youmans et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- β-Site Amyloid Precursor Protein (APP)-cleaving Enzyme 1 (BACE1)-deficient Mice Exhibit a Close Homolog of L1 (CHL1) Loss-of-function Phenotype Involving Axon Guidance Defects
- (2012) Brian Hitt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Reducing Human Apolipoprotein E Levels Attenuates Age-Dependent A Accumulation in Mutant Human Amyloid Precursor Protein Transgenic Mice
- (2012) N. Bien-Ly et al. JOURNAL OF NEUROSCIENCE
- Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease
- (2012) Randall J. Bateman et al. NEW ENGLAND JOURNAL OF MEDICINE
- Haploinsufficiency of Human APOE Reduces Amyloid Deposition in a Mouse Model of Amyloid- Amyloidosis
- (2011) J. Kim et al. JOURNAL OF NEUROSCIENCE
- Amyloid-β42 alters apolipoprotein E solubility in brains of mice with five familial AD mutations
- (2011) Katherine Lynn Youmans et al. JOURNAL OF NEUROSCIENCE METHODS
- Neuronal activity regulates the regional vulnerability to amyloid-β deposition
- (2011) Adam W Bero et al. NATURE NEUROSCIENCE
- Human apoE Isoforms Differentially Regulate Brain Amyloid- Peptide Clearance
- (2011) J. M. Castellano et al. Science Translational Medicine
- Astrocytic Aβ1-42 uptake is determined by Aβ-aggregation state and the presence of amyloid-associated proteins
- (2010) Henrietta M. Nielsen et al. GLIA
- Overexpression of Low-Density Lipoprotein Receptor in the Brain Markedly Inhibits Amyloid Deposition and Increases Extracellular Aβ Clearance
- (2009) Jungsu Kim et al. NEURON
- The Role of Apolipoprotein E in Alzheimer's Disease
- (2009) Jungsu Kim et al. NEURON
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now