Reactive astrocyte nomenclature, definitions, and future directions

Impairment of Glycolysis-Derived l-Serine Production in Astrocytes Contributes to Cognitive Deficits in Alzheimer’s Disease

(2020) Juliette Le Douce et al.   Cell Metabolism

Aberrant Tonic Inhibition of Dopaminergic Neuronal Activity Causes Motor Symptoms in Animal Models of Parkinson’s Disease

(2020) Jun Young Heo et al.   CURRENT BIOLOGY

Traumatic brain injury increases plasma astrocyte‐derived exosome levels of neurotoxic complement proteins

(2020) Edward J. Goetzl et al.   FASEB JOURNAL

Emerging technologies to study glial cells

(2020) Hélène Hirbec et al.   GLIA

AMP‐activated protein kinase (AMPK) regulates astrocyte oxidative metabolism by balancing TCA cycle dynamics

(2020) Caroline M. Voss et al.   GLIA

MAFG-driven astrocytes promote CNS inflammation

(2020) Michael A. Wheeler et al.   NATURE

Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer’s disease

(2020) Yingyue Zhou et al.   NATURE MEDICINE

Improved tools to study astrocytes

(2020) Xinzhu Yu et al.   NATURE REVIEWS NEUROSCIENCE

Identification of region-specific astrocyte subtypes at single cell resolution

(2020) Mykhailo Y. Batiuk et al.   Nature Communications

Zika virus infection leads to mitochondrial failure, oxidative stress and DNA damage in human iPSC-derived astrocytes

(2020) Pítia Flores Ledur et al.   Scientific Reports

Single-nucleus RNA-seq identifies Huntington disease astrocyte states

(2020) Osama Al-Dalahmah et al.   Acta Neuropathologica Communications

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Quantitative Imaging of Changes in Astrocytic and Neuronal Adenosine Triphosphate Using Two Different Variants of ATeam

(2020) Rodrigo Lerchundi et al.   Frontiers in Cellular Neuroscience

Siponimod (BAF312) Activates Nrf2 While Hampering NFκB in Human Astrocytes, and Protects From Astrocyte-Induced Neurodegeneration

(2020) Emanuela Colombo et al.   Frontiers in Immunology

Spatial Transcriptomics and In Situ Sequencing to Study Alzheimer’s Disease

(2020) Wei-Ting Chen et al.   CELL

Astrocytes and microglia play orchestrated roles and respect phagocytic territories during neuronal corpse removal in vivo

(2020) Eyiyemisi C. Damisah et al.   Science Advances

Making sense of astrocytic calcium signals — from acquisition to interpretation

(2020) Alexey Semyanov et al.   NATURE REVIEWS NEUROSCIENCE

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

(2019) Nicole Reichenbach et al.   EMBO Molecular Medicine

Astrocyte function from information processing to cognition and cognitive impairment

(2019) Mirko Santello et al.   NATURE NEUROSCIENCE

Astrocyte Biomarkers in Alzheimer’s Disease

(2019) Stephen F. Carter et al.   TRENDS IN MOLECULAR MEDICINE

Patient-Specific iPSC-Derived Astrocytes Contribute to Non-Cell-Autonomous Neurodegeneration in Parkinson's Disease

(2019) Angelique di Domenico et al.   Stem Cell Reports

Micro-RNAs secreted through astrocyte-derived extracellular vesicles cause neuronal network degeneration in C9orf72 ALS

(2019) André Varcianna et al.   EBioMedicine

Newly developed reversible MAO-B inhibitor circumvents the shortcomings of irreversible inhibitors in Alzheimer’s disease

(2019) Jong-Hyun Park et al.   Science Advances

Cerebral organoids at the air–liquid interface generate diverse nerve tracts with functional output

(2019) Stefano L. Giandomenico et al.   NATURE NEUROSCIENCE

NFIA is a gliogenic switch enabling rapid derivation of functional human astrocytes from pluripotent stem cells

(2019) Jason Tchieu et al.   NATURE BIOTECHNOLOGY

Metabolic Reprogramming in Astrocytes Distinguishes Region-Specific Neuronal Susceptibility in Huntington Mice

(2019) Aris A. Polyzos et al.   Cell Metabolism

Neuron-Astrocyte Metabolic Coupling Protects against Activity-Induced Fatty Acid Toxicity

(2019) Maria S. Ioannou et al.   CELL

Single-cell transcriptomic analysis of Alzheimer’s disease

(2019) Hansruedi Mathys et al.   NATURE

Characterization of the 18 kDa translocator protein (TSPO) expression in post‐mortem normal and Alzheimer's disease brains

(2019) Yaxing Gui et al.   BRAIN PATHOLOGY

Tumor-associated reactive astrocytes aid the evolution of immunosuppressive environment in glioblastoma

(2019) Dieter Henrik Heiland et al.   Nature Communications

Questions and (some) answers on reactive astrocytes

(2019) Carole Escartin et al.   GLIA

Accurate quantification of astrocyte and neurotransmitter fluorescence dynamics for single-cell and population-level physiology

(2019) Yizhi Wang et al.   NATURE NEUROSCIENCE

Properties of human astrocytes and NG2 glia

(2019) Peter Bedner et al.   GLIA

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Astrocyte molecular signatures in Huntington’s disease

(2019) Blanca Diaz-Castro et al.   Science Translational Medicine

Ultrastructural Evidence for a Role of Astrocytes and Glycogen-Derived Lactate in Learning-Dependent Synaptic Stabilization

(2019) E Vezzoli et al.   CEREBRAL CORTEX

Potassium and glutamate transport is impaired in scar-forming tumor-associated astrocytes

(2019) Susan C. Campbell et al.   NEUROCHEMISTRY INTERNATIONAL

GSEA of mouse and human mitochondriomes reveals fatty acid oxidation in astrocytes

(2018) Abel Eraso-Pichot et al.   GLIA

P2Y1 receptor blockade normalizes network dysfunction and cognition in an Alzheimer’s disease model

(2018) Nicole Reichenbach et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A stocked toolbox for understanding the role of astrocytes in disease

(2018) Akshata Almad et al.   Nature Reviews Neurology

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer’s Disease Phenotypes in Human iPSC-Derived Brain Cell Types

(2018) Yuan-Ta Lin et al.   NEURON

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuroprotective Drug for Nerve Trauma Revealed Using Artificial Intelligence

(2018) David Romeo-Guitart et al.   Scientific Reports

The Aging Astrocyte Transcriptome from Multiple Regions of the Mouse Brain

(2018) Matthew M. Boisvert et al.   Cell Reports

Regulation of Astrocyte Functions in Multiple Sclerosis

(2018) Michael A. Wheeler et al.   Cold Spring Harbor Perspectives in Medicine

Clasmatodendrosis is associated with dendritic spines and does not represent autophagic astrocyte death in influenza-associated encephalopathy

(2018) Masaya Tachibana et al.   BRAIN & DEVELOPMENT

The S100B story: From biomarker to active factor in neural injury

(2018) Fabrizio Michetti et al.   JOURNAL OF NEUROCHEMISTRY

Important Shapeshifter: Mechanisms Allowing Astrocytes to Respond to the Changing Nervous System During Development, Injury and Disease

(2018) Juliane Schiweck et al.   Frontiers in Cellular Neuroscience

Human ESC-Derived Chimeric Mouse Models of Huntington’s Disease Reveal Cell-Intrinsic Defects in Glial Progenitor Cell Differentiation

(2018) Mikhail Osipovitch et al.   Cell Stem Cell

Biomaterial Approaches to Modulate Reactive Astroglial Response

(2018) Jonathan M. Zuidema et al.   CELLS TISSUES ORGANS

Astrocytes and microglia: Models and tools

(2018) Kevin A. Guttenplan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Lactate Deficit in an Alzheimer Disease Mouse Model: The Relationship With Neuronal Damage

(2018) Mao Zhang et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Human Induced Pluripotent Stem Cell-Derived Astrocytes Are Differentially Activated by Multiple Sclerosis-Associated Cytokines

(2018) Sylvain Perriot et al.   Stem Cell Reports

Modulation of astrocyte reactivity improves functional deficits in mouse models of Alzheimer’s disease

(2018) Kelly Ceyzériat et al.   Acta Neuropathologica Communications

Subcellular reorganization and altered phosphorylation of the astrocytic gap junction protein connexin43 in human and experimental temporal lobe epilepsy

(2017) Tushar Deshpande et al.   GLIA

Phagocytic clearance of presynaptic dystrophies by reactive astrocytes in Alzheimer's disease

(2017) Angela Gomez-Arboledas et al.   GLIA

New astroglial injury-defined biomarkers for neurotrauma assessment

(2017) Julia Halford et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

SOX9 Is an Astrocyte-Specific Nuclear Marker in the Adult Brain Outside the Neurogenic Regions

(2017) Wei Sun et al.   JOURNAL OF NEUROSCIENCE

Cell diversity and network dynamics in photosensitive human brain organoids

(2017) Giorgia Quadrato et al.   NATURE

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Identification of diverse astrocyte populations and their malignant analogs

(2017) Chia-Ching John Lin et al.   NATURE NEUROSCIENCE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Human Astrocyte Maturation Captured in 3D Cerebral Cortical Spheroids Derived from Pluripotent Stem Cells

(2017) Steven A. Sloan et al.   NEURON

Transient Opening of the Mitochondrial Permeability Transition Pore Induces Microdomain Calcium Transients in Astrocyte Processes

(2017) Amit Agarwal et al.   NEURON

Neural Circuit-Specialized Astrocytes: Transcriptomic, Proteomic, Morphological, and Functional Evidence

(2017) Hua Chai et al.   NEURON

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

(2017) Noriko Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Three-dimensional Ca2+imaging advances understanding of astrocyte biology

(2017) Erika Bindocci et al.   SCIENCE

A neuroprotective astrocyte state is induced by neuronal signal EphB1 but fails in ALS models

(2017) Giulia E. Tyzack et al.   Nature Communications

Astrocyte Function is Modified by Alzheimer's Disease-like Pathology in Aged Mice

(2017) Oliver Peters et al.   JOURNAL OF ALZHEIMERS DISEASE

In Vivo Evidence for a Lactate Gradient from Astrocytes to Neurons

(2016) Philipp Mächler et al.   Cell Metabolism

Targeted activation of CREB in reactive astrocytes is neuroprotective in focal acute cortical injury

(2016) Luis Pardo et al.   GLIA

Impaired Autophagy in APOE4 Astrocytes

(2016) Shira Simonovitch et al.   JOURNAL OF ALZHEIMERS DISEASE

Blockade of Astrocytic Calcineurin/NFAT Signaling Helps to Normalize Hippocampal Synaptic Function and Plasticity in a Rat Model of Traumatic Brain Injury

(2016) Jennifer L. Furman et al.   JOURNAL OF NEUROSCIENCE

Dysfunctional Calcium and Glutamate Signaling in Striatal Astrocytes from Huntington's Disease Model Mice

(2016) R. Jiang et al.   JOURNAL OF NEUROSCIENCE

Astrocyte scar formation aids central nervous system axon regeneration

(2016) Mark A. Anderson et al.   NATURE

A polarizing question: do M1 and M2 microglia exist?

(2016) Richard M Ransohoff   NATURE NEUROSCIENCE

Functional diversity of astrocytes in neural circuit regulation

(2016) Lucile Ben Haim et al.   NATURE REVIEWS NEUROSCIENCE

Purification and Characterization of Progenitor and Mature Human Astrocytes Reveals Transcriptional and Functional Differences with Mouse

(2016) Ye Zhang et al.   NEURON

Astrocytes in physiological aging and Alzheimer’s disease

(2016) J.J. Rodríguez-Arellano et al.   NEUROSCIENCE

Astrocytes: Key Regulators of Neuroinflammation

(2016) Emanuela Colombo et al.   TRENDS IN IMMUNOLOGY

Vascular amyloidosis impairs the gliovascular unit in a mouse model of Alzheimer’s disease

(2015) Ian F. Kimbrough et al.   BRAIN

Astrocyte uncoupling as a cause of human temporal lobe epilepsy

(2015) Peter Bedner et al.   BRAIN

Neuroinflammatory TNFα Impairs Memory via Astrocyte Signaling

(2015) Samia Habbas et al.   CELL

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

GFAP and vimentin deficiency alters gene expression in astrocytes and microglia in wild-type mice and changes the transcriptional response of reactive glia in mouse model for Alzheimer's disease

(2015) Willem Kamphuis et al.   GLIA

Traumatically injured astrocytes release a proteomic signature modulated by STAT3-dependent cell survival

(2015) Jaclynn Levine et al.   GLIA

Astrocyte reactivity after brain injury-: The role of galectins 1 and 3

(2015) Swetlana Sirko et al.   GLIA

Astrocytes Are Primed by Chronic Neurodegeneration to Produce Exaggerated Chemokine and Cell Infiltration Responses to Acute Stimulation with the Cytokines IL-1  and TNF- 

(2015) E. Hennessy et al.   JOURNAL OF NEUROSCIENCE

The JAK/STAT3 Pathway Is a Common Inducer of Astrocyte Reactivity in Alzheimer's and Huntington's Diseases

(2015) L. Ben Haim et al.   JOURNAL OF NEUROSCIENCE

Astrocyte barriers to neurotoxic inflammation

(2015) Michael V. Sofroniew   NATURE REVIEWS NEUROSCIENCE

Aging causes morphological alterations in astrocytes and microglia in human substantia nigra pars compacta

(2015) H.J. Jyothi et al.   NEUROBIOLOGY OF AGING

Characterization of Panglial Gap Junction Networks in the Thalamus, Neocortex, and Hippocampus Reveals a Unique Population of Glial Cells

(2014) Stephanie Griemsmann et al.   CEREBRAL CORTEX

Phenotypic Heterogeneity and Plasticity of Isocortical and Hippocampal Astrocytes in the Human Brain

(2014) A. A. Sosunov et al.   JOURNAL OF NEUROSCIENCE

GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease

(2014) Seonmi Jo et al.   NATURE MEDICINE

Astrocyte Kir4.1 ion channel deficits contribute to neuronal dysfunction in Huntington's disease model mice

(2014) Xiaoping Tong et al.   NATURE NEUROSCIENCE

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis

(2014) Ashley E. Frakes et al.   NEURON

Astrocyte response to motor neuron injury promotes structural synaptic plasticity via STAT3-regulated TSP-1 expression

(2014) Giulia E. Tyzack et al.   Nature Communications

A Phenotypic Change But Not Proliferation Underlies Glial Responses in Alzheimer Disease

(2013) Alberto Serrano-Pozo et al.   AMERICAN JOURNAL OF PATHOLOGY

Reactive glia show increased immunoproteasome activity in Alzheimer’s disease

(2013) Marie Orre et al.   BRAIN

Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog

(2013) Swetlana Sirko et al.   Cell Stem Cell

Forebrain Engraftment by Human Glial Progenitor Cells Enhances Synaptic Plasticity and Learning in Adult Mice

(2013) Xiaoning Han et al.   Cell Stem Cell

Glial Scar Borders Are Formed by Newly Proliferated, Elongated Astrocytes That Interact to Corral Inflammatory and Fibrotic Cells via STAT3-Dependent Mechanisms after Spinal Cord Injury

(2013) I. B. Wanner et al.   JOURNAL OF NEUROSCIENCE

Cerebral organoids model human brain development and microcephaly

(2013) Madeline A. Lancaster et al.   NATURE

Complex and region-specific changes in astroglial markers in the aging brain

(2013) José J. Rodríguez et al.   NEUROBIOLOGY OF AGING

Enriched environment and physical activity reverse astrogliodegeneration in the hippocampus of AD transgenic mice

(2013) J J Rodríguez et al.   Cell Death & Disease

Human Stem Cell-Derived Spinal Cord Astrocytes with Defined Mature or Reactive Phenotypes

(2013) Laurent Roybon et al.   Cell Reports

STAT3-Mediated astrogliosis protects myelin development in neonatal brain injury

(2012) Hiroko Nobuta et al.   ANNALS OF NEUROLOGY

Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice

(2012) Andrew W. Kraft et al.   FASEB JOURNAL

Stimulation of the neurotrophin receptor TrkB on astrocytes drives nitric oxide production and neurodegeneration

(2012) Emanuela Colombo et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Targeting Astrocytes Ameliorates Neurologic Changes in a Mouse Model of Alzheimer's Disease

(2012) J. L. Furman et al.   JOURNAL OF NEUROSCIENCE

Genomic Analysis of Reactive Astrogliosis

(2012) J. L. Zamanian et al.   JOURNAL OF NEUROSCIENCE

Alexander Disease

(2012) A. Messing et al.   JOURNAL OF NEUROSCIENCE

Evidence for Astrocytosis in Prodromal Alzheimer Disease Provided by 11C-Deuterium-L-Deprenyl: A Multitracer PET Paradigm Combining 11C-Pittsburgh Compound B and 18F-FDG

(2012) S. F. Carter et al.   JOURNAL OF NUCLEAR MEDICINE

The Neuron-Astrocyte-Microglia Triad in Normal Brain Ageing and in a Model of Neuroinflammation in the Rat Hippocampus

(2012) Francesca Cerbai et al.   PLoS One

YKL-40: A Novel Prognostic Fluid Biomarker for Preclinical Alzheimer's Disease

(2010) Rebecca Craig-Schapiro et al.   BIOLOGICAL PSYCHIATRY

Astrocytes within multiple sclerosis lesions upregulate sodium channel Nav1.5

(2010) J. A. Black et al.   BRAIN

Astrocyte targeted overexpression of Hsp72 or SOD2 reduces neuronal vulnerability to forebrain ischemia

(2010) Lijun Xu et al.   GLIA

Astrocyte glutamine synthetase: Importance in hyperammonemic syndromes and potential target for therapy

(2010) Saul W. Brusilow et al.   Neurotherapeutics

The Glial Nature of Embryonic and Adult Neural Stem Cells

(2009) Arnold Kriegstein et al.   Annual Review of Neuroscience

Uniquely Hominid Features of Adult Human Astrocytes

(2009) N. A. Oberheim et al.   JOURNAL OF NEUROSCIENCE

Synchronous Hyperactivity and Intercellular Calcium Waves in Astrocytes in Alzheimer Mice

(2009) K. V. Kuchibhotla et al.   SCIENCE

Focal degeneration of astrocytes in amyotrophic lateral sclerosis

(2008) D Rossi et al.   CELL DEATH AND DIFFERENTIATION

STAT3 is a Critical Regulator of Astrogliosis and Scar Formation after Spinal Cord Injury

(2008) J. E. Herrmann et al.   JOURNAL OF NEUROSCIENCE

A Transcriptome Database for Astrocytes, Neurons, and Oligodendrocytes: A New Resource for Understanding Brain Development and Function

(2008) J. D. Cahoy et al.   JOURNAL OF NEUROSCIENCE

Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain

(2008) A. Buffo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alpha-smooth muscle actin (α-SMA) and nestin expression in reactive astrocytes in multiple sclerosis lesions: potential regulatory role of transforming growth factor-beta 1 (TGF-β1)

(2007) M. Moreels et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY