Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(sp3)–H Bonds
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Title
Transition-Metal-Catalyzed, Coordination-Assisted Functionalization of Nonactivated C(sp3)–H Bonds
Authors
Keywords
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Journal
CHEMICAL REVIEWS
Volume 121, Issue 24, Pages 14957-15074
Publisher
American Chemical Society (ACS)
Online
2021-10-30
DOI
10.1021/acs.chemrev.1c00519
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- C–H bond activation enables the rapid construction and late-stage diversification of functional molecules
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- Palladium-Catalyzed β-Acyloxylation of Simple Amide via sp3 C–H Activation
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- Direct Arylation of Primary and Secondary sp3 C–H Bonds with Diarylhyperiodonium Salts via Pd Catalysis
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- Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)–H Bond Activation To Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes
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- Rhodium-Catalyzed Intramolecular Silylation of Unactivated C(sp3)–H Bonds
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- Palladium-Catalyzed Unactivated C(sp3)–H Bond Activation and Intramolecular Amination of Carboxamides: A New Approach to β-Lactams
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- Auxiliary-Enabled Pd-Catalyzed Direct Arylation of Methylene C(sp3)–H Bond of Cyclopropanes: Highly Diastereoselective Assembling of Di- and Trisubstituted Cyclopropanecarboxamides
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- Pd(ii)-catalyzed alkylation of unactivated C(sp3)–H bonds: efficient synthesis of optically active unnatural α-amino acids
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- Chiral Monodentate Phosphines and Bulky Carboxylic Acids: Cooperative Effects in Palladium-Catalyzed Enantioselective C(sp3)-H Functionalization
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- CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals
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- Efficient Alkyl Ether Synthesis via Palladium-Catalyzed, Picolinamide-Directed Alkoxylation of Unactivated C(sp3)–H and C(sp2)–H Bonds at Remote Positions
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- A Practical Strategy for the Structural Diversification of Aliphatic Scaffolds through the Palladium-Catalyzed Picolinamide-Directed Remote Functionalization of Unactivated C(sp3)H Bonds
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- Fused Indolines by Palladium-Catalyzed Asymmetric CC Coupling Involving an Unactivated Methylene Group
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- Synergistic Palladium-Catalyzed C(sp3)H Activation/C(sp3)O Bond Formation: A Direct, Step-Economical Route to Benzolactones
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- Carboxylate-Assisted Transition-Metal-Catalyzed C−H Bond Functionalizations: Mechanism and Scope
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- Transition metal-catalyzed arylation of unactivated C(sp3)–H bonds
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- Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation
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- Highly Regioselective Carbonylation of Unactivated C(sp3)–H Bonds by Ruthenium Carbonyl
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- Palladium-Catalyzed Direct Ethynylation of C(sp3)–H Bonds in Aliphatic Carboxylic Acid Derivatives
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- Aerobic Pd-Catalyzed sp3C−H Olefination: A Route to Both N-Heterocyclic Scaffolds and Alkenes
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- Heterocycle Synthesis via Direct C–H/N–H Coupling
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- Pd(II)-Catalyzed Enantioselective C–H Activation of Cyclopropanes
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- Highly Efficient Syntheses of Azetidines, Pyrrolidines, and Indolines via Palladium Catalyzed Intramolecular Amination of C(sp3)–H and C(sp2)–H Bonds at γ and δ Positions
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- Total Synthesis and Structural Revision of the Piperarborenines via Sequential Cyclobutane C–H Arylation
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- Nickel-Catalyzed Chelation-Assisted Transformations Involving Ortho C–H Bond Activation: Regioselective Oxidative Cycloaddition of Aromatic Amides to Alkynes
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- Ir(I)-Catalyzed Enantioselective Secondary sp3C–H Bond Activation of 2-(Alkylamino)pyridines with Alkenes
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- Palladium-Catalyzed Alkylation ofortho-C(sp2)–H Bonds of Benzylamide Substrates with Alkyl Halides
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- Direct C−H Transformation via Iron Catalysis
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- Nickel-Catalyzed Cross-Couplings Involving Carbon−Oxygen Bonds
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- C-2 Arylation of Piperidines through Directed Transition-Metal-Catalyzed sp3CH Activation
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- Intramolecular Palladium-Catalyzed Alkane C−H Arylation from Aryl Chlorides
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- Pd(II)-Catalyzed Olefination ofsp3C−H Bonds
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- Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds
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- Pd(II)-Catalyzed Carbonylation of C(sp3)−H Bonds: A New Entry to 1,4-Dicarbonyl Compounds
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- Pyrrole Synthesis via Allylic sp3C−H Activation of Enamines Followed by Intermolecular Coupling with Unactivated Alkynes
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- Facile Benzo-Ring Construction via Palladium-Catalyzed Functionalization of Unactivated sp3C−H Bonds under Mild Reaction Conditions
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- Amide-directed arylation of sp3 C–H bonds using Pd(II) and Pd(0) catalysts
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- Total Synthesis of Celogentin C by Stereoselective CH Activation
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- Catalytic Carbene Insertion into C−H Bonds
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- C−H Activation for the Construction of C−B Bonds
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- Palladium-Catalyzed C−H Bond Functionalization with Arylsulfonyl Chlorides
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- Bimetallic Palladium Catalysis: Direct Observation of Pd(III)−Pd(III) Intermediates
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- Cationic Ir(I)-Catalyzed sp3C−H Bond Alkenylation of Amides with Alkynes
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