4.8 Article

Cobalt-Catalyzed Intramolecular Oxidative C(sp3)-H/N-H Carbonylation of Aliphatic Amides

Journal

ORGANIC LETTERS
Volume 19, Issue 8, Pages 2170-2173

Publisher

AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.7b00825

Keywords

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Funding

  1. National Natural Science Foundation of China [21390402, 21520102003]
  2. Ministry of Science and Technology of China [2012YQ120060]
  3. Fundamental Research Funds for the Central Universities
  4. Program of Introducing Talents of Discipline to Universities of China (111 Program)

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A cobalt-catalyzed reaction protocol is developed to achieve the intramolecular oxidative C(sp(3))-H/N-H carbonylation of aliphatic amides with CO. Various substituted propariainides are selectively transformed into corresponding succinimides in good to high yields. Notably, predominant selectivity for the carbonylation at the alpha-methyl groups of linear aliphatic amides is observed in this reaction system.

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