Enantiopure Sulfinyl Aniline as a Removable and Recyclable Chiral Auxiliary for Asymmetric C(sp3 )−H Bond Activation

Syntheses and Transformations of α-Amino Acids via Palladium-Catalyzed Auxiliary-Directed sp3 C–H Functionalization

(2016) Gang He et al.   ACCOUNTS OF CHEMICAL RESEARCH

Metal-Catalyzed Annulations through Activation and Cleavage of C−H Bonds

(2016) Moisés Gulías et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Iridium-catalyzed asymmetric [3+2] annulation of aromatic ketimines with alkynes via C–H activation: unexpected inversion of the enantioselectivity induced by protic acids

(2016) Midori Nagamoto et al.   CHEMICAL COMMUNICATIONS

Mild metal-catalyzed C–H activation: examples and concepts

(2016) T. Gensch et al.   CHEMICAL SOCIETY REVIEWS

The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

(2016) Tim Cernak et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Access to Spirocyclic Sultams by Chiral Cpx -Rhodium(III)-Catalyzed Annulations

(2016) Manh V. Pham et al.   CHEMISTRY-A EUROPEAN JOURNAL

A Preliminary Study of Diastereoselectivity in the PdII -Catalyzed C(sp3 )-H Alkoxylation of Cyclic Systems

(2016) Xinglin Yang et al.   CHEMISTRY-A EUROPEAN JOURNAL

Rhodium-Catalysed Enantioselective C-H Functionalization in Asymmetric Synthesis

(2016) Somayeh Motevalli et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Transition-Metal-Catalyzed Acyloxylation: Activation of C(sp2)-H and C(sp3)-H Bonds

(2016) Setareh Moghimi et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

The “Cyclopropyl Fragment” is a Versatile Player that Frequently Appears in Preclinical/Clinical Drug Molecules

(2016) Tanaji T. Talele   JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in C–H Functionalization

(2016) Huw M. L. Davies et al.   JOURNAL OF ORGANIC CHEMISTRY

An Enantioselective Oxidative C–H/C–H Cross-Coupling Reaction: Highly Efficient Method To Prepare Planar Chiral Ferrocenes

(2016) De-Wei Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and Application of Chiral Spiro Cp Ligands in Rhodium-Catalyzed Asymmetric Oxidative Coupling of Biaryl Compounds with Alkenes

(2016) Jun Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Trends in applying C–H oxidation to the total synthesis of natural products

(2016) Yuanyou Qiu et al.   NATURAL PRODUCT REPORTS

Abiological catalysis by artificial haem proteins containing noble metals in place of iron

(2016) Hanna M. Key et al.   NATURE

Palladium catalysed meta-C–H functionalization reactions

(2016) Aniruddha Dey et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Direct Observation of C–H Cyclopalladation at Tertiary Positions Enabled by an Exo-Directing Group

(2016) Zhi Ren et al.   ORGANOMETALLICS

Asymmetric C–H activation as a modern strategy towards expedient synthesis of steganone

(2016) Quentin Dherbassy et al.   TETRAHEDRON

Recent advances in transition metal (Pd, Ni)-catalyzed C(sp 3 ) H bond activation with bidentate directing groups

(2016) Xinglin Yang et al.   TETRAHEDRON LETTERS

Bidentate, Monoanionic Auxiliary-Directed Functionalization of Carbon–Hydrogen Bonds

(2015) Olafs Daugulis et al.   ACCOUNTS OF CHEMICAL RESEARCH

Exploration of Earth-Abundant Transition Metals (Fe, Co, and Ni) as Catalysts in Unreactive Chemical Bond Activations

(2015) Bo Su et al.   ACCOUNTS OF CHEMICAL RESEARCH

Chiral Cyclopentadienyls: Enabling Ligands for Asymmetric Rh(III)-Catalyzed C–H Functionalizations

(2015) Baihua Ye et al.   ACCOUNTS OF CHEMICAL RESEARCH

Enantioselective Synthesis of Spiroindenes by Enol-Directed Rhodium(III)-Catalyzed CH Functionalization and Spiroannulation

(2015) Suresh Reddy Chidipudi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Three-dimensional rational approach to the discovery of potent substituted cyclopropyl urea soluble epoxide hydrolase inhibitors

(2015) Kentaro Takai et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthesis of Planar Chiral Ferrocenes by Transition-Metal-Catalyzed Enantioselective C−H Activation

(2015) Dao-Yong Zhu et al.   ChemCatChem

TADDOL-based phosphorus(iii)-ligands in enantioselective Pd(0)-catalysed C–H functionalisations

(2015) Julia Pedroni et al.   CHEMICAL COMMUNICATIONS

Transition-Metal-Catalyzed Direct Addition of Unactivated C–H Bonds to Polar Unsaturated Bonds

(2015) Lei Yang et al.   CHEMICAL REVIEWS

Oxidative Coupling between Two Hydrocarbons: An Update of Recent C–H Functionalizations

(2015) Chao Liu et al.   CHEMICAL REVIEWS

Palladium-Catalyzed Arylation of Unactivated γ-Methylene C(sp3)H and δ-CH Bonds with an Oxazoline-Carboxylate Auxiliary

(2015) Peng-Xiang Ling et al.   CHEMISTRY-A EUROPEAN JOURNAL

1,1,1,3,3,3-Hexafluoroisopropanol as a Remarkable Medium for Atroposelective Sulfoxide-Directed Fujiwara-Moritani Reaction with Acrylates and Styrenes

(2015) Quentin Dherbassy et al.   CHEMISTRY-A EUROPEAN JOURNAL

Recent Advances in First-Row-Transition-Metal-Catalyzed Dehydrogenative Cou­pling of C(sp3)-H Bonds

(2015) Jinmin Miao et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Understanding the Effects of Bidentate Directing Groups: A Unified Rationale for sp2 and sp3 C–H Bond Activations

(2015) Hao Tang et al.   JOURNAL OF ORGANIC CHEMISTRY

Palladium(II)-Catalyzed Highly Enantioselective C–H Arylation of Cyclopropylmethylamines

(2015) Kelvin S. L. Chan et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Dearomatization of Naphthols via a Rh-Catalyzed C(sp2)–H Functionalization/Annulation Reaction

(2015) Jun Zheng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Enabled β-C–H Arylation of α-Amino Acids Using a Simple and Practical Auxiliary

(2015) Gang Chen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ligand-Enabled Stereoselective β-C(sp3)–H Fluorination: Synthesis of Unnatural Enantiopure anti-β-Fluoro-α-amino Acids

(2015) Ru-Yi Zhu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Evolution of C–H Bond Functionalization from Methane to Methodology

(2015) John F. Hartwig   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Transition metal catalyzed meta-C–H functionalization of aromatic compounds

(2015) Jiong Yang   ORGANIC & BIOMOLECULAR CHEMISTRY

Palladium-Catalyzed Site-Selective Fluorination of Unactivated C(sp3)–H Bonds

(2015) Jinmin Miao et al.   ORGANIC LETTERS

Palladium-Catalyzed Asymmetric Arylation of C(sp3)–H Bonds of Aliphatic Amides: Controlling Enantioselectivity Using Chiral Phosphoric Amides/Acids

(2015) Shao-Bai Yan et al.   ORGANIC LETTERS

Pd(II)-Catalyzed P(O)R1R2-Directed Asymmetric C–H Activation and Dynamic Kinetic Resolution for the Synthesis of Chiral Biaryl Phosphates

(2015) Yan-Na Ma et al.   ORGANIC LETTERS

Pd(II)-Catalyzed Alkylation of Tertiary Carbon via Directing-Group-Mediated C(sp3)–H Activation: Synthesis of Chiral 1,1,2-Trialkyl Substituted Cyclopropanes

(2015) Naoyuki Hoshiya et al.   ORGANIC LETTERS

Robust Ruthenium(II)-Catalyzed C–H Arylations: Carboxylate Assistance for the Efficient Synthesis of Angiotensin-II-Receptor Blockers

(2015) Lutz Ackermann   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Pd-Catalyzed Highly Enantioselective Synthesis of Planar Chiral Ferrocenylpyridine Derivatives

(2015) De-Wei Gao et al.   ORGANOMETALLICS

Palladium-Catalyzed Regioselective C–H Bond Acetoxylation–Alkoxylation of Azoxybenzenes

(2015) Meng Sun et al.   SYNLETT

Diastereoselective Substrate-Controlled Transition-Metal-Catalyzed C–H Activation: An Old Solution to a Modern Synthetic Challenge

(2015) Joanna Wencel-Delord et al.   SYNLETT

Reusable directing groups [8-aminoquinoline, picolinamide, sulfoximine] in C(sp3)–H bond activation: present and future

(2015) Raja K. Rit et al.   TETRAHEDRON

Asymmetric C–H functionalization of cyclopropanes using an isoleucine-NH2 bidentate directing group

(2015) Jinhee Kim et al.   Chemical Science

Enantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system

(2015) J. Pedroni et al.   Chemical Science

Reusable and Removable Directing Groups for C(sp2)−H Bond Functionalization of Arenes

(2015) M. Ramu Yadav et al.   Asian Journal of Organic Chemistry

Transition metal-catalyzed direct remote C–H functionalization of alkyl groups via C(sp3)–H bond activation

(2015) Guanyinsheng Qiu et al.   Organic Chemistry Frontiers

Transition metal-catalyzed C–H bond functionalizations by the use of diverse directing groups

(2015) Zhengkai Chen et al.   Organic Chemistry Frontiers

Sulfonamide-Promoted Palladium(II)-Catalyzed Alkylation of Unactivated Methylene C(sp3)H Bonds with Alkyl Iodides

(2014) Kai Chen et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Access to β-Lactams by Enantioselective Palladium(0)-Catalyzed C(sp3)H Alkylation

(2014) Julia Pedroni et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Construction of Axial Chirality by Rhodium-Catalyzed Asymmetric Dehydrogenative Heck Coupling of Biaryl Compounds with Alkenes

(2014) Jun Zheng et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Axially Chiral Biaryls through Sulfoxide-Directed Asymmetric Mild CH Activation and Dynamic Kinetic Resolution

(2014) Chinmoy Kumar Hazra et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

A New Golden Age for Donor-Acceptor Cyclopropanes

(2014) Tobias F. Schneider et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Arene C–H functionalisation using a removable/modifiable or a traceless directing group strategy

(2014) Fengzhi Zhang et al.   CHEMICAL SOCIETY REVIEWS

Enantioselective Synthesis of Planar Chiral Ferrocenes via Pd(0)-Catalyzed Intramolecular Direct C–H Bond Arylation

(2014) De-Wei Gao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium-Catalyzed Intramolecular Asymmetric C–H Functionalization/Cyclization Reaction of Metallocenes: An Efficient Approach toward the Synthesis of Planar Chiral Metallocene Compounds

(2014) Ruixian Deng et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Palladium(II)-Catalyzed Enantioselective C(sp3)–H Activation Using a Chiral Hydroxamic Acid Ligand

(2014) Kai-Jiong Xiao et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Asymmetric Synthesis of Planar Chiral Ferrocenes by Enantioselective Intramolecular C–H Arylation of N-(2-Haloaryl)ferrocenecarboxamides

(2014) Lantao Liu et al.   ORGANIC LETTERS

Ligand-Controlled C(sp3)-H Arylation and Olefination in Synthesis of Unnatural Chiral  -Amino Acids

(2014) J. He et al.   SCIENCE

Origins of Selective C(sp2)–H Activation Using Transition Metal Complexes with N,N-Bidentate Directing Groups: A Combined Theoretical–Experimental Study

(2014) Hao Tang et al.   ACS Catalysis

Palladium-catalyzed intramolecular Cp–H bond functionalization/arylation: an enantioselective approach to planar chiral quinilinoferrocenes

(2014) Xinna Ma et al.   RSC Advances

Atropodiastereoselective CH Olefination of Biphenylp-Tolyl Sulfoxides with Acrylates

(2013) Thomas Wesch et al.   ADVANCED SYNTHESIS & CATALYSIS

Stereoselective Synthesis of Chiral α-Amino-β-Lactams through Palladium(II)-Catalyzed Sequential Monoarylation/Amidation of C(sp3)H Bonds

(2013) Qi Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Asymmetric C(sp2)H Activation

(2013) Joanna Wencel-Delord et al.   CHEMISTRY-A EUROPEAN JOURNAL

Stereoselective Synthesis of β-Alkylated α-Amino Acids via Palladium-Catalyzed Alkylation of Unactivated Methylene C(sp3)–H Bonds with Primary Alkyl Halides

(2013) Shu-Yu Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

C–H bond activation enables the rapid construction and late-stage diversification of functional molecules

(2013) Joanna Wencel-Delord et al.   Nature Chemistry

C–H Functionalization of Cyclopropanes: A Practical Approach Employing a Picolinamide Auxiliary

(2013) Daniela Sustac Roman et al.   ORGANIC LETTERS

Silver-Promoted, Palladium-Catalyzed Direct Arylation of Cyclopropanes: Facile Access to Spiro 3,3′-Cyclopropyl Oxindoles

(2013) Carolyn L. Ladd et al.   ORGANIC LETTERS

Palladium-Catalyzed Arylation of Cyclopropanes via Directing Group-Mediated C(sp3)–H Bond Activation To Construct Quaternary Carbon Centers: Synthesis of cis- and trans-1,1,2-Trisubstituted Chiral Cyclopropanes

(2013) Naoyuki Hoshiya et al.   ORGANIC LETTERS

Auxiliary-Enabled Pd-Catalyzed Direct Arylation of Methylene C(sp3)–H Bond of Cyclopropanes: Highly Diastereoselective Assembling of Di- and Trisubstituted Cyclopropanecarboxamides

(2013) Ramarao Parella et al.   ORGANIC LETTERS

Pd(ii)-catalyzed alkylation of unactivated C(sp3)–H bonds: efficient synthesis of optically active unnatural α-amino acids

(2013) Kai Chen et al.   Chemical Science

Redox of ferrocene controlled asymmetric dehydrogenative Heck reaction via palladium-catalyzed dual C–H bond activation

(2013) Chao Pi et al.   Chemical Science

Scope and mechanism of asymmetric C(sp3)–H/C(Ar)–X coupling reactions: computational and experimental study

(2013) Evgeny Larionov et al.   Chemical Science

Recent development of direct asymmetric functionalization of inert C–H bonds

(2013) Chao Zheng et al.   RSC Advances

Palladium(0)-Catalyzed Enantioselective CH Arylation of Cyclopropanes: Efficient Access to Functionalized Tetrahydroquinolines

(2012) Tanguy Saget et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Chiral Monodentate Phosphines and Bulky Carboxylic Acids: Cooperative Effects in Palladium-Catalyzed Enantioselective C(sp3)-H Functionalization

(2012) Tanguy Saget et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Highly Diastereo- and Enantioselective Cyclopropanation of 1,2-Disubstituted Alkenes

(2012) Jun Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Beyond Directing Groups: Transition-Metal-Catalyzed CH Activation of Simple Arenes

(2012) Nadine Kuhl et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

CH Bond Functionalization: Emerging Synthetic Tools for Natural Products and Pharmaceuticals

(2012) Junichiro Yamaguchi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Recent advances in the total synthesis of cyclopropane-containing natural products

(2012) David Y.-K. Chen et al.   CHEMICAL SOCIETY REVIEWS

Diastereo- and Enantioselective Intramolecular C(sp3)H Arylation for the Synthesis of Fused Cyclopentanes

(2012) Nicolas Martin et al.   CHEMISTRY-A EUROPEAN JOURNAL

CH Activation: A Complementary Tool in the Total Synthesis of Complex Natural Products

(2012) David Y.-K. Chen et al.   CHEMISTRY-A EUROPEAN JOURNAL

Asymmetric C(sp3)-H/C(Ar) coupling reactions. Highly enantio-enriched indolines via regiodivergent reaction of a racemic mixture

(2012) Dmitry Katayev et al.   Chemical Science

Fused Indolines by Palladium-Catalyzed Asymmetric CC Coupling Involving an Unactivated Methylene Group

(2011) Masafumi Nakanishi et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

If CH Bonds Could Talk: Selective CH Bond Oxidation

(2011) Timothy Newhouse et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Enantioselective synthesis of 2-methyl indolines by palladium catalysed asymmetric C(sp3)–H activation/cyclisation

(2011) Saithalavi Anas et al.   CHEMICAL COMMUNICATIONS

C–H functionalization logic in total synthesis

(2011) Will R. Gutekunst et al.   CHEMICAL SOCIETY REVIEWS

Towards mild metal-catalyzed C–H bond activation

(2011) Joanna Wencel-Delord et al.   CHEMICAL SOCIETY REVIEWS

Recent developments in natural product synthesis using metal-catalysed C–H bond functionalisation

(2011) Lindsay McMurray et al.   CHEMICAL SOCIETY REVIEWS

Sulfoximine-Directed Single and Double ortho-Lithiation: Stereoselective Rearrangements of o,o′-Dilithiophenylsulfoximines to o,N-Dilithiosulfinylanilines through Anionic Fries Rearrangements of o,o′-Dilithiophenylsulfinamides

(2011) Michael Wessels et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Effect of the damping function in dispersion corrected density functional theory

(2011) Stefan Grimme et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Pd(II)-Catalyzed Enantioselective C–H Activation of Cyclopropanes

(2011) Masayuki Wasa et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A consistent and accurate ab initio parametrization of density functional dispersion correction (DFT-D) for the 94 elements H-Pu

(2010) Stefan Grimme et al.   JOURNAL OF CHEMICAL PHYSICS

Auxiliary-Assisted Palladium-Catalyzed Arylation and Alkylation of sp2and sp3Carbon−Hydrogen Bonds

(2010) Dmitry Shabashov et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Facile Double-Lithiation of a Transient Urea: Vicariousortho-Metalation of Aniline Derivatives

(2010) Chris E. Houlden et al.   ORGANIC LETTERS

Arylcyclopropanes: Properties, Synthesis and Use in Medicinal Chemistry

(2010) Alexandre Gagnon et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Hindered Ureas as Masked Isocyanates: Facile Carbamoylation of Nucleophiles under Neutral Conditions

(2009) Marc Hutchby et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Transition metal-catalyzed C–H activation reactions: diastereoselectivity and enantioselectivity

(2009) Ramesh Giri et al.   CHEMICAL SOCIETY REVIEWS

First Example of Highly Stereoselective Synthesis of 1,2,3-Trisubstituted Cyclopropanes via Chiral Selenonium Ylides

(2009) Hai-Yang Wang et al.   CHEMISTRY-A EUROPEAN JOURNAL