Journal
ORGANIC LETTERS
Volume 18, Issue 12, Pages 2970-2973Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.6b01319
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Funding
- NSF [CHE-1362057, CHE-1149367]
- NSFC [21228204]
- NSF IDBR [CHE-1455554]
- NSF MRI [CHE-1428787]
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1149367] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Chemistry [1619590] Funding Source: National Science Foundation
- Div Of Biological Infrastructure
- Direct For Biological Sciences [1455554] Funding Source: National Science Foundation
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Triazole amine was identified as an effective directing group in promoting C-H alkynylation under silver-free conditions. No other external oxidant was required, and the alkynylation products were received in good to excellent yields. X-ray crystallographic analysis confirmed a direct C-H activation intermediate. Other typical directing groups, including pyridine amine (PIP) and 8-aminoquinoline (QA), gave almost no reaction under identical conditions, which highlighted the unique reactivity of the triazole directing group in direct C-H functionalization.
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